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General Information
- Evidence
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Evidence Information
| Pubmed ID | Year | Sample Information | Techniques | Mechanism | Fold Change | Remark |
|---|---|---|---|---|---|---|
| 17699856 | 2007 | Cell line : CaCo2, RKO, SW48, DLD1, LoVo, Colo320, HT29, and SW480,MKN7, MKN45, MKN74, AZ521, NUGC4, SNU638 Source : Japanese Collection of Research Bioresources or ATCC Sample Type : - No. of Sample : - Stage : - | real timeRT- PCR, bisulfite PCR to assess DNA methylation and chromatin immunoprecipitation | Methylation | - | �Epigenetic alteration of�PRDM5�(e.g., methylation of its 5'-CpG island or trimethylation of Lys(27) of histone H3) likely plays a key role in the progression of gastrointestinal cancers and may be a useful molecular marker. |
| 25613750 | 2015 | Cell line : - Source : Royal Brisbane and Women�s Hospital (RBWH), Brisbane, Australia. Sample Type : CRC Fresh frozen tissue No. of Sample : 214 BRAF mutant (120 BRAF mutant/MSI and 94 BRAF mutant/MSS) and 122 BRAF wild type cancers Stage : AJCC Stage I-IV. | CpG Island Methylator Phenotype analysis and Methylation-Specific PCR, immunohistochemistry | Methylation | - | PRDM5 is a relevant tumour suppressor gene that is frequently targeted in colorectal tumourigenesis. |
Gene Details
| Gene Type | protein coding |
|---|---|
| Gene Family | Zinc fingers, C2H2-type |
| Description | The protein encoded by this gene is a transcription factor of the PR-domain protein family. It contains a PR-domain and multiple zinc finger motifs. Transcription factors of the PR-domain family are known to be involved in cell differentiation and tumorigenesis. [provided by RefSeq, Jul 2008] |
| Chromosome | 4 |
| Location | 4q25-q26 |
| Start | 121613070 |
| End | 121844013 |
| Strand | - |
| Gene Sequence | Download Select all |
| Length | 230944 |
| OMIM ID | 614161 |
| HGNC ID | HGNC:9349 |
| Unigene ID | Hs.666782 |
| Ensembl ID | ENSG00000138738 |
| PharmGKB ID | PA33717 |
Protein Information
| Protein ID | NP_001287752.1 |
|---|---|
| Protein Name | PR domain containing 5 |
| Molecular Wt. (Da) | 0 |
| Protein Sequence | Download Select all |
| Length | 630 |
| Uniprot ID | Q9UI38 |
| Ensembl Protein ID | ENSP00000326598 |
Post-translational Modification Information (Source : HPRD)
No matching records could be found.
Enzyme Information
No matching records could be found.
PPi Information
(Click to view network : Source STRING) View
No matching records from HPRD source could be found.
Pathway Information
No matching records could be found.
Structure Information
No matching records could be found.
Domain Information
| ID | Location | Description |
|---|---|---|
| smart00317 | 20-130 | SET |
| cl02566 | 20-130 | SET superfamily |
| pfam00856 | 20-123 | SET |
| pfam13465 | 532-556 | zf-H2C2_2 |
| cl22375 | 532-556 | zf-H2C2_2 superfamily |
| pfam13465 | 504-527 | zf-H2C2_2 |
| cl22375 | 504-527 | zf-H2C2_2 superfamily |
| pfam13465 | 560-583 | zf-H2C2_2 |
| cl22375 | 560-583 | zf-H2C2_2 superfamily |
| pfam13465 | 335-359 | zf-H2C2_2 |
| cl22375 | 335-359 | zf-H2C2_2 superfamily |
| COG5048 | 262-620 | COG5048 |
| COG5048 | 264-423 | COG5048 |
| COG5048 | 266-452 | COG5048 |
| COG5048 | 199-368 | COG5048 |
| COG5189 | 513-568 | SFP1 |
| COG5189 | 459-540 | SFP1 |
| COG5048 | 543-630 | COG5048 |
| COG5048 | 515-576 | COG5048 |
| COG5189 | 325-399 | SFP1 |
| PHA00733 | 490-536 | PHA00733 |
| PHA00733 | 516-563 | PHA00733 |
Ontology Information
| HPRD ID | 5402 |
|---|---|
| Molecular Class | Transcription factor |
| Molecular Function | GTPase activator activity (GO:0005096) |
| Biological Process | Cell communication (GO:0007154); Signal transduction (GO:0007165) |
Drug Information
No matching records could be found.