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General Information
- Evidence
- Gene
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- Protein
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- Enzyme
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- Domain
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Evidence Information
| Pubmed ID | Year | Sample Information | Techniques | Mechanism | Fold Change | Remark |
|---|---|---|---|---|---|---|
| 23807779 | 2013 | Cell line : - Source : Melbourne Collaborative Cohort Study Sample Type : Population based case control study No. of Sample : 722 Stage : - | Immunohistochemistry | Up-regulation | - | - |
Gene Details
| Gene Type | protein coding |
|---|---|
| Gene Family | - |
| Description | Calpains represent a ubiquitous, well-conserved family of calcium-dependent cysteine proteases. The calpain proteins are heterodimers consisting of an invariant small subunit and variable large subunits. The large catalytic subunit has four domains: domain I, the N-terminal regulatory domain that is processed upon calpain activation; domain II, the protease domain; domain III, a linker domain of unknown function; and domain IV, the calmodulin-like calcium-binding domain. This gene encodes a large subunit. It is an atypical calpain in that it lacks the calmodulin-like calcium-binding domain and instead has a divergent C-terminal domain. It is similar in organization to calpains 5 and 6. This gene is associated with type 2 or non-insulin-dependent diabetes mellitus (NIDDM), and is located within the NIDDM1 region. Multiple alternative transcript variants have been described for this gene. [provided by RefSeq, Sep 2010] |
| Chromosome | 2 |
| Location | 2q37.3 |
| Start | 241526133 |
| End | 241538526 |
| Strand | + |
| Gene Sequence | Download Select all |
| Length | 12394 |
| OMIM ID | 605286 |
| HGNC ID | HGNC:1477 |
| Unigene ID | Hs.728234 |
| Ensembl ID | ENSG00000142330 |
| PharmGKB ID | PA26058 |
Protein Information
| Protein ID | NP_075571.1 |
|---|---|
| Protein Name | calpain 10 |
| Molecular Wt. (Da) | 0 |
| Protein Sequence | Download Select all |
| Length | 672 |
| Uniprot ID | Q9NZQ7 |
| Ensembl Protein ID | ENSP00000370985 |
Post-translational Modification Information (Source : HPRD)
No matching records could be found.
Enzyme Information
No matching records could be found.
PPi Information
(Click to view network : Source STRING) View
No matching records from HPRD source could be found.
Pathway Information
No matching records could be found.
Structure Information
No matching records could be found.
Domain Information
| ID | Location | Description |
|---|---|---|
| cd00044 | 2-319 | CysPc |
| cl00051 | 2-319 | CysPc superfamily |
| cd00214 | 335-496 | Calpain_III |
| cl00165 | 335-496 | Calpain_III superfamily |
| cd00214 | 512-653 | Calpain_III |
| cl00165 | 512-653 | Calpain_III superfamily |
| smart00230 | 11-292 | CysPc |
| pfam00648 | 13-317 | Peptidase_C2 |
| smart00720 | 338-494 | calpain_III |
| smart00720 | 514-644 | calpain_III |
| pfam01067 | 344-487 | Calpain_III |
| pfam01067 | 514-647 | Calpain_III |
Ontology Information
| HPRD ID | 6992 |
|---|---|
| Molecular Class | Cysteine protease |
| Molecular Function | DNA binding (GO:0003677) |
| Biological Process | Regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolism (GO:0019219) |
Drug Information
No matching records could be found.