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General Information
| Gene_Symbol | Gene_ID | Gene_Name | Chromosome | Alias |
|---|---|---|---|---|
| PTP4A3 | 11156 | protein tyrosine phosphatase type IVA, member 3 | 8 | PRL-3, PRL-R, PRL3 |
- Evidence
- Gene
- mRNA
- CDS
- Protein
- PTM
- Enzyme
- PPi
- Pathway
- Structural
- Domain
- Ontology
- SNP
- Drug
- External Links
Evidence Information
| Pubmed ID | Year | Sample Information | Techniques | Mechanism | Fold Change | Remark |
|---|---|---|---|---|---|---|
| 15534108 | 2004 | Cell line : - Source : Kobe University Hospital Sample Type : CRC tumor and normal tissue No. of Sample : 197 Stage : TNM Stage I-IV | Real Time RT-PCR,Western Blotting | Up-regulation | - | PRL-3 is expected to be a promising biomarker for identifying colorectal cancer patients at high risk for distant metastases. In human primary colorectal cancers, the frequency of up-regulated PRL-3 expression in cases with liver (84.4%) or lung (88.9%) metastasis was statistically higher than that in cases without either type of metastasis (liver, 35.9%; lung, 42.3%). |
Gene Details
| Gene Type | protein coding |
|---|---|
| Gene Family | Protein tyrosine phosphatases / Class I Cys-based PTPs : PRLs |
| Description | This gene encodes a member of the protein-tyrosine phosphatase family. Protein tyrosine phosphatases are cell signaling molecules that play regulatory roles in a variety of cellular processes. Studies of this class of protein tyrosine phosphatase in mice demonstrates that they are prenylated in vivo, suggesting their association with cell plasma membrane. The encoded protein may enhance cell proliferation, and overexpression of this gene has been implicated in tumor metastasis. Alternative splicing results in multiple transcript variants. |
| Chromosome | 8 |
| Location | 8q24.3 |
| Start | 141391993 |
| End | 141432454 |
| Strand | + |
| Gene Sequence | Download Select all |
| Length | 40462 |
| OMIM ID | 606449 |
| HGNC ID | HGNC:9636 |
| Unigene ID | Hs.43666 |
| Ensembl ID | ENSG00000184489 |
| PharmGKB ID | - |
mRNA Information
| mRNA ID | XM_005250763.1 |
|---|---|
| Exon | join(1..92,29396..30353,33056..33148,34947..35077, 35758..35832,38935..40462) | mRNA Sequence | Download Select all |
| Length | 2710 |
CDS Information
| Location | join(30249..30353,33056..33148,34947..35077,35758..35832, 38935..39052) |
|---|---|
| CDS Sequence | Download Select all |
| CCDS ID | CCDS6383.1 |
Protein Information
| Protein ID | NP_009010.2 |
|---|---|
| Protein Name | protein tyrosine phosphatase type IVA, member 3 |
| Molecular Wt. (Da) | 16645 |
| Protein Sequence | Download Select all |
| Length | 148 |
| Uniprot ID | O60674 |
| Ensembl Protein ID | ENSP00000371067 |
Post-translational Modification Information (Source : HPRD)
| Residue | Type | site |
|---|---|---|
| C | Prenylation | 170 |
| C | Prenylation | 145 |
| C | Prenylation | 170 |
| C | Prenylation | 145 |
Enzyme Information
| EC | 3.1.3.48 |
|---|---|
| Name | protein-tyrosine-phosphatase phosphotyrosine phosphatase phosphoprotein phosphatase (phosphotyrosine) phosphotyrosine histone phosphatase protein phosphotyrosine phosphatase tyrosylprotein phosphatase phosphotyrosine protein phosphatase phosphotyrosylprotein phosphatase tyrosine O-phosphate phosphatase PPT-phosphatase PTPase [phosphotyrosine]protein phosphatase PTP-phosphatase |
| Class | Hydrolases; Acting on ester bonds; Phosphoric-monoester hydrolases |
| Sysname | protein-tyrosine-phosphate phosphohydrolase |
| Substrate | protein tyrosine phosphate [CPD:C01167]; H2O |
| Product | protein tyrosine [CPD:C00585]; phosphate |
| Reaction (IUBMB) |  |
PPi Information
(Click to view network : Source STRING) View
No matching records from HPRD source could be found.
Pathway Information
No matching records could be found.
Structure Information
| PDB ID | 1R6H |
|---|---|
| Resolution | |
| Method | SOLUTION NMR |
| Chains | A |
| Molecule | protein tyrosine phosphatase type IVA, member 3 isoform 1 |
| Model | View |
Domain Information
| ID | Location | Description |
|---|---|---|
| PTZ00242 | 11-173 | PTZ00242 |
| cl21483 | 11-173 | PTPc superfamily |
| PTZ00393 | 4-157 | PTZ00393 |
| smart00404 | 67-145 | PTPc_motif |
| smart00012 | 67-145 | PTPc_DSPc |
| cd00127 | 35-138 | DSPc |
| pfam00782 | 81-142 | DSPc |
| smart00195 | 37-142 | DSPc |
| cd00047 | 42-149 | PTPc |
| PRK04247 | 17-54 | PRK04247 |
| cl00516 | 17-54 | Mrr_cat superfamily |
| pfam00102 | 34-149 | Y_phosphatase |
| COG2453 | 45-163 | CDC14 |
| smart00194 | 44-149 | PTPc |
| PRK12361 | 34-163 | PRK12361 |
Ontology Information
| HPRD ID | 1302 |
|---|---|
| Molecular Class | Tyrosine phosphatase |
| Molecular Function | Transcription factor activity (GO:0003700) |
| Biological Process | Regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolism (GO:0019219) |
Drug Information
No matching records could be found.