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General Information



Gene_Symbol Gene_ID Gene_Name Chromosome Alias
LZTS1 11178 leucine zipper, putative tumor suppressor 1  8FEZ1 







  • Evidence
  • Gene
  • mRNA
  • CDS
  • Protein
  • PTM
  • Enzyme
  • PPi
  • Pathway
  • Structural
  • Domain
  • Ontology
  • SNP
  • Drug
  • External Links



Evidence Information


Pubmed ID Year Sample Information Techniques Mechanism Fold Change Remark
25667121   2015Cell line : -

Source : -

Sample Type : CRC tumor

No. of Sample : 160

Stage : -

-Down-regulation-LZTS1 plays a potential tumor suppressor role in CRC progression and represents a valuable clinical prognostic marker of this disease.In analysis of 160 CRC specimens, we revealed that decreased expression of LZTS1 was correlated to aggressive characteristics and poor survival of patients with CRC.


Gene Details



NC_000008.10 (20103676..20161492, complement)

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Gene Type protein coding
Gene Family -
Description This gene encodes a tumor suppressor protein that is ubiquitously expressed in normal tissues. In uveal melanomas, expression of this protein is silenced in rapidly metastasizing and metastatic tumor cells but has normal expression in slowly metastasizing or nonmetastasizing tumor cells. This protein may have a role in cell-cycle control by interacting with the Cdk1/cyclinB1 complex. This gene is located on chromosomal region 8p22. Loss of heterozygosity (LOH) in the 8p arm is a common characteristic of many types of cancer. [provided by RefSeq, Nov 2009]  
Chromosome 8
Location 8p22
Start 20103676  
End 20161492  
Strand -  
Gene Sequence

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Length 57817  
OMIM ID 606551   
HGNC ID HGNC:13861   
Unigene ID Hs.521432   
Ensembl ID ENSG00000061337   
PharmGKB ID PA30507   

mRNA Information


mRNA ID ?NM_021020.3
Exon  
mRNA Sequence

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Length  



CDS Information


   
Location
CDS Sequence

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CCDS ID CCDS6015.1



Protein Information


      
Protein IDNP_066300.1
Protein Nameleucine zipper, putative tumor suppressor 1
Molecular Wt. (Da)0
Protein Sequence

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Length 596  
Uniprot IDQ9UKS6
Ensembl Protein ID ENSP00000298838  



Post-translational Modification Information (Source : HPRD)


No matching records could be found.

Enzyme Information


No matching records could be found.

PPi Information


(Click to view network : Source STRING)      View   

                              
Interactant Gene ID (Source: HPRD) Gene Symbol HPRD ID Ref Seq ID Technique References
983CDK1302NP_001777.1in vivo11504921   
995CDC25C1146NP_001781.2in vitro;in vivo17349584   


Pathway Information


No matching records could be found.

Structure Information


No matching records could be found.

Domain Information




ID Location Description
pfam06818380-566  Fez1
COG1196266-591  Smc
TIGR02168235-513  SMC_prok_B
COG1196262-513  Smc
TIGR02169266-587  SMC_prok_A
COG1196262-531  Smc
TIGR02169260-513  SMC_prok_A
TIGR02168264-593  SMC_prok_B
COG1196262-569  Smc
TIGR02168273-569  SMC_prok_B
COG1196341-594  Smc
TIGR02168263-488  SMC_prok_B
TIGR02169263-512  SMC_prok_A
TIGR02168395-593  SMC_prok_B
TIGR04523341-568  Mplasa_alph_rch
COG4372341-568  COG4372
PRK02224341-515  PRK02224
COG1196263-481  Smc
COG0419260-481  SbcC
COG0419260-578  SbcC
PRK12704395-516  PRK12704
PRK03918343-578  PRK03918
COG4372264-483  COG4372
pfam10186344-481  Atg14
PRK03918252-569  PRK03918
COG0419263-584  SbcC
PRK03918262-483  PRK03918
TIGR02168260-489  SMC_prok_B
COG4372417-568  COG4372
pfam07888342-567  CALCOCO1
COG1579348-514  COG1579
COG4942344-569  EnvC
TIGR01843343-569  type_I_hlyD
COG2433346-587  COG2433
pfam01576265-517  Myosin_tail_1
TIGR00618258-568  sbcc
COG1196262-481  Smc
pfam02463315-582  SMC_N
COG0419341-576  SbcC
PRK10246341-568  PRK10246
PRK03918260-479  PRK03918
COG4372348-570  COG4372
PTZ00121264-538  PTZ00121
TIGR04211394-486  SH3_and_anchor
PRK02224265-541  PRK02224
TIGR02169253-482  SMC_prok_A
pfam12128263-546  DUF3584
COG1340341-568  COG1340
COG3264462-578  MscK
TIGR02680263-487  TIGR02680
TIGR03346344-477  chaperone_ClpB
pfam12072395-515  DUF3552
pfam12128256-569  DUF3584
TIGR02169397-584  SMC_prok_A
pfam04156392-516  IncA
COG3206390-488  GumC
TIGR04523341-481  Mplasa_alph_rch
TIGR01843341-485  type_I_hlyD
TIGR03007395-570  pepcterm_ChnLen
pfam12128405-567  DUF3584
pfam05911221-523  DUF869
PRK02224386-517  PRK02224
pfam01576264-511  Myosin_tail_1
TIGR03185357-590  DNA_S_dndD
pfam15070341-587  GOLGA2L5
PRK11281415-581  PRK11281
pfam15619344-516  Lebercilin
COG0497343-570  RecN
PRK05771344-587  PRK05771
pfam13514344-546  AAA_27
pfam09726111-481  Macoilin
COG0419263-570  SbcC
pfam05557257-564  MAD
PRK03918256-478  PRK03918
TIGR04523343-479  Mplasa_alph_rch
PRK04863264-548  mukB
COG1340377-572  COG1340
pfam05483237-594  SCP-1
pfam15397342-482  DUF4618
COG4026367-479  COG4026


Ontology Information


   
HPRD ID17105
Molecular ClassUnclassified
Molecular FunctionMolecular function unknown (GO:0005554)
Biological ProcessCell proliferation (GO:0008283); Cell-cell signaling (GO:0007267)  



SNP Information


View SNP Geneview Report   

Drug Information


No matching records could be found.

External Links


                                 
ArrayExpressGO
ICGCGO
Cancer3DGO
COSMICGO
NCGGO
TSGeneGO
Tumor Gene Family of DatabasesGO
CCDBGO
G2SBCGO
Osteosarcoma DatabaseGO
RCDBGO