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General Information
| Gene_Symbol | Gene_ID | Gene_Name | Chromosome | Alias |
|---|---|---|---|---|
| RASSF1 | 11186 | Ras association (RalGDS/AF-6) domain family member 1 | 3 | NORE2A, REH3P21, RDA32, 123F2 |
- Evidence
- Gene
- mRNA
- CDS
- Protein
- PTM
- Enzyme
- PPi
- Pathway
- Structural
- Domain
- Ontology
- SNP
- Drug
- External Links
Evidence Information
| Pubmed ID | Year | Sample Information | Techniques | Mechanism | Fold Change | Remark |
|---|---|---|---|---|---|---|
| 18494062 | 2008 | Cell line : - Source : Departments of General Surgery, Gastroenterology, and Medical Oncology of Jinling Hospital (Nanjing, China) Sample Type : - No. of Sample : 47 gastric adenocarcinoma patients and 45 colorectal adenocarcinoma patients. Stage : - | Methylation specific PCR | Methylation | - | Aberrant CpG island methylation within the promoter region of RASSF1A is a promising biomarker for gastric and colorectal cancer. The frequencies of detection of serum RASSF1A promoter hypermethylation in gastric (34.0%) and colorectal (28.9%) adenocarcinoma patients were significantly higher than those in patients with benign gastric (3.3%) or colorectal (6.7%) disease or in healthy donors (0%) (P < 0.01). |
Gene Details
| Gene Type | protein coding |
|---|---|
| Gene Family | |
| Description | This gene encodes a protein similar to the RAS effector proteins. Loss or altered expression of this gene has been associated with the pathogenesis of a variety of cancers, which suggests the tumor suppressor function of this gene. The inactivation of this gene was found to be correlated with the hypermethylation of its CpG-island promoter region. The encoded protein was found to interact with DNA repair protein XPA. The protein was also shown to inhibit the accumulation of cyclin D1, and thus induce cell cycle arrest. Several alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported. |
| Chromosome | 3 |
| Location | 3p21.3 |
| Start | 50329786 |
| End | 50340936 |
| Strand | - |
| Gene Sequence | Download Select all |
| Length | 11151 |
| OMIM ID | 605082 |
| HGNC ID | HGNC:9882 |
| Unigene ID | Hs.476270 |
| Ensembl ID | ENSG00000068028 |
| PharmGKB ID | - |
mRNA Information
| mRNA ID | NM_001206957.1 |
|---|---|
| Exon | join(1..381,8783..8887,9081..9378,9488..9603,10210..11151) | mRNA Sequence | Download Select all |
| Length | 1859 |
CDS Information
| Location | join(132..381,2926..3032,8783..8887,9081..9378,9488..9603, 10210..10356) |
|---|---|
| CDS Sequence | Download Select all |
| CCDS ID | CCDS43096.1 |
Protein Information
| Protein ID | NP_001193886.1 |
|---|---|
| Protein Name | Ras association (RalGDS/AF-6) domain family member 1 |
| Molecular Wt. (Da) | 21768 |
| Protein Sequence | Download Select all |
| Length | 189 |
| Uniprot ID | P52333 |
| Ensembl Protein ID | ENSP00000391676 |
Post-translational Modification Information (Source : HPRD)
| Residue | Type | site |
|---|---|---|
| T | Phosphorylation | 206 |
| T | Phosphorylation | 202 |
| T | Phosphorylation | 51 |
| T | Phosphorylation | 132 |
| T | Phosphorylation | 206 |
Enzyme Information
No matching records could be found.
PPi Information
(Click to view network : Source STRING) View
| Interactant Gene ID (Source: HPRD) | Gene Symbol | HPRD ID | Ref Seq ID | Technique | References |
|---|---|---|---|---|---|
| 991 | CDC20 | 4686 | NP_001246.2 | in vivo | 14743218 |
| 1616 | DAXX | 4424 | NP_001135442.1 | in vitro;in vivo;yeast 2-hybrid | 1 681 031 818 566 590 |
| 3265 | HRAS | 1813 | NP_005334.1 | in vitro;in vivo | 10998413 |
| 4131 | MAP1B | 1139 | NP_005900.2 | in vitro;yeast 2-hybrid | 15205320 |
| 4193 | MDM2 | 1272 | NP_002383.2 | in vivo | 18566590 |
| 6789 | STK4 | 5395 | NP_006273.1 | in vivo | 15109305 |
| 7132 | TNFRSF1A | 1861 | NP_001056.1 | in vivo | 15949439 |
| 7283 | TUBG1 | 1853 | NP_001061.2 | in vitro;in vivo | 14603253 |
| 7507 | XPA | 2045 | NP_000371.1 | yeast 2-hybrid | 10888881 |
| 8797 | TNFRSF10A | 4679 | NP_003835.3 | in vivo | 15949439 |
| 55201 | MAP1S | 10461 | NP_060644.4 | in vitro;in vivo;yeast 2-hybrid | 1 520 532 015 753 380 |
| 170685 | NUDT10 | 17651 | NP_694853.1 | yeast 2-hybrid | 16169070 |
| 203068 | TUBB | 1852 | NP_001060.1 | in vitro;in vivo | 14603253 |
Pathway Information
| Pathway Name | Pathway ID |
|---|---|
| Bladder cancer | hsa05219 |
| Hippo signaling pathway | hsa04390 |
| MicroRNAs in cancer | hsa05206 |
| Non-small cell lung cancer | hsa05223 |
| Pathways in cancer | hsa05200 |
| Ras signaling pathway | hsa04014 |
Structure Information
| PDB ID | 2KZU |
|---|---|
| Resolution | |
| Method | SOLUTION NMR |
| Chains | B |
| Molecule | Ras association (RalGDS/AF-6) domain family 1 |
| Model | View |
Domain Information
| ID | Location | Description |
|---|---|---|
| cd01778 | 198-293 | RASSF1_RA |
| cl00155 | 198-293 | UBQ superfamily |
| cd00029 | 52-105 | C1 |
| cl00040 | 52-105 | C1 superfamily |
| cd01768 | 205-290 | RA |
| smart00314 | 204-291 | RA |
| pfam00788 | 216-291 | RA |
| pfam00130 | 52-105 | C1_1 |
| smart00109 | 63-105 | C1 |
| cd01784 | 205-291 | rasfadin_RA |
| cd01782 | 212-288 | AF6_RA_repeat1 |
Ontology Information
| HPRD ID | 1303 |
|---|---|
| Molecular Class | Cytoskeletal associated protein |
| Molecular Function | Transcription factor activity (GO:0003700) |
| Biological Process | Regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolism (GO:0019219) |
Drug Information
No matching records could be found.