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General Information
- Evidence
- Gene
- mRNA
- CDS
- Protein
- PTM
- Enzyme
- PPi
- Pathway
- Structural
- Domain
- Ontology
- SNP
- Drug
- External Links
Evidence Information
| Pubmed ID | Year | Sample Information | Techniques | Mechanism | Fold Change | Remark |
|---|---|---|---|---|---|---|
| 15735684    | 2005 | Cell line : - Source : - Sample Type : - No. of Sample : - Stage : - | - | Methylation | - | - |
| 16007117    | 2005 | Cell line : DLD 1, SW 48, and SW 480 Source : - Sample Type : - No. of Sample : - Stage : - | RT-PCR, immunoblotting, and Methylation specific PCR | Methylation | - | WIF-1 silencing due to promoter hypermethylation is an important mechanism underlying aberrant activation of the Wnt signaling pathway. Modulation of the Wnt pathway, through reversal of WIF-1 silencing by demethylating agents, is a potential target for treatment and/or prevention of gastrointestinal cancers. |
| 16491118    | 2006 | Cell line : DLD 1, SW 48, COLO 205, CT 26, SW 480, LS 174T, HT 29, LoVo, SW 620 Source : - Sample Type : - No. of Sample : - Stage : - | Bisulfite genomic sequencing, Chromatin immunoprecipitation, Western blotting and immunofluorescence | Methylation | - | SFRP-1 and WIF-1 methylation-associated silencing occurred in all stages of colorectal tumorigenesis. |
| 17923031    | 2007 | Cell line : HCT 116, SW 480 Source : - Sample Type : CRC tumor and normal tissue No. of Sample : - Stage : - | Methylation-specific PCR, RT PCR | Methylation | - | Hypermethylation of Wnt-antagonist genes is a common early event in the evolution of colorectal tumor. Methylation of sFRP1, 2, 5 and WIF-1 genes might serve as biomarkers for the early detection of colorectal tumor. Methylation was more frequently found in colorectal tumors than in normal mucosa and adjacent normal mucosa from patients with tumor. |
| 18542073    | 2008 | Cell line : - Source : Wansbeck General Hospital (Ashington, Northumberland, UK). Sample Type : - No. of Sample : - Stage : - | Bisulphite conversion of genomic DNA and analysis of CGI methylation, methylation specific PCR | Methylation | - | CGI methylation of SFRP4, SFRP5 and WIF1 correctly identified 61.5% of polyp patients and 78.9% of neoplasia-free subject. Methylation of SFRP4, SFRP5 and WIF1 genes may play a role in the earliest stages of the development of colorectal neoplasia. Samples of mucosa and tumour tissue were obtained from a total of 19 patients colorectal cancer (11 males and 8 females) with a median age of 74 years. 13 adenomatous polyp patients were recruited (10 males and 3 females) with a median age of 67 years. The healthy and control 10 males and 10 females, median age 55 years . |
| 19773381    | 2009 | Cell line : - Source : Department of Surgery in the Samsung Medical Center, Seoul, Korea. Sample Type : CRC tumor and normal tissue No. of Sample : 243 colorectal cancer tissues, methylation Stage : - | Methylation-specific PCR. | Methylation | - | Tumor-specific methylation of APC, MGMT, RASSF2A, and Wif-1 genes might be a valuable biomarker in plasma for the early detection of colorectal cancer. |
Gene Details

| Gene Type | protein coding |
|---|---|
| Gene Family | - |
| Description | The protein encoded by this gene functions to inhibit WNT proteins, which are extracellular signaling molecules that play a role in embryonic development. This protein contains a WNT inhibitory factor (WIF) domain and five epidermal growth factor (EGF)-like domains, and is thought to be involved in mesoderm segmentation. This gene functions as a tumor suppressor gene, and has been found to be epigenetically silenced in various cancers. [provided by RefSeq, Jun 2010]   |
| Chromosome | 12 |
| Location | 12q14.3 |
| Start | 65050624   |
| End | 65121566   |
| Strand | -   |
| Gene Sequence |    Download   Select all |
| Length | 70943   |
| OMIM ID | 605186    |
| HGNC ID | HGNC:18081    |
| Unigene ID | Hs.284122     |
| Ensembl ID | ENSG00000156076    |
| PharmGKB ID | PA38291    |
mRNA Information
| mRNA ID | NM_007191.4 |
|---|---|
| Exon | join(1..523,1011..1150,43713..43821,52663..52803, 53777..53872,54831..54926,58991..59086,65441..65536, 66354..66449,70097..70943)   | mRNA Sequence |    Download   Select all |
| Length | 2240   |
CDS Information
| Location | join(376..523,1011..1150,43713..43821,52663..52803, 53777..53872,54831..54926,58991..59086,65441..65536, 66354..66449,70097..70218) |
|---|---|
| CDS Sequence |    Download   Select all |
| CCDS ID | CCDS8971.1 |    
Protein Information
| Protein ID | NP_009122.2 |
|---|---|
| Protein Name | WNT inhibitory factor 1 |
| Molecular Wt. (Da) | 38431 |
| Protein Sequence |    Download   Select all |
| Length | 379   |
| Uniprot ID | P41161 |    
| Ensembl Protein ID | ENSP00000306894   |    
Post-translational Modification Information (Source : HPRD)
No matching records could be found.
Enzyme Information
No matching records could be found.
PPi Information
(Click to view network : Source STRING)      View   
No matching records from HPRD source could be found.
Pathway Information
| Pathway Name | Pathway ID |
|---|---|
| Wnt signaling pathway |    hsa04310 |    
Structure Information
No matching records could be found.
Domain Information
| ID | Location | Description |
|---|---|---|
| smart00469 | 35-179  | WIF |
| cl02623 | 35-179  | WIF superfamily |
| pfam02019 | 38-173  | WIF |
Ontology Information
| HPRD ID | 592 |    
|---|---|
| Molecular Class | Ligand |
| Molecular Function | RNA binding (GO:0003723) |
| Biological Process | Regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolism (GO:0019219)   |
Drug Information
No matching records could be found.
External Links
| ArrayExpress | GO |    
|---|---|
| ICGC | GO |    
| Cancer3D | GO |    
| COSMIC | GO |    
| NCG | GO |    
| TSGene | GO |    
| Tumor Gene Family of Databases | GO |    
| CCDB | GO |    
| G2SBC | GO |    
| Osteosarcoma Database | GO |    
| RCDB | GO |    
