Search results:
General Information
| Gene_Symbol | Gene_ID | Gene_Name | Chromosome | Alias |
|---|---|---|---|---|
| CHEK2 | 11200 | checkpoint kinase 2 | 22 | CDS1, CHK2, HuCds1, PP1425, bA444G7 |
- Evidence
- Gene
- mRNA
- CDS
- Protein
- PTM
- Enzyme
- PPi
- Pathway
- Structural
- Domain
- Ontology
- SNP
- Drug
- External Links
Evidence Information
| Pubmed ID | Year | Sample Information | Techniques | Mechanism | Fold Change | Remark |
|---|---|---|---|---|---|---|
| 22901170 | 2012 | Cell line : - Source : PubMed, EMBASES, Elsevier and Springer Sample Type : - No. of Sample : - Stage : - | Data abstraction,Statistical analysis | Mutation | - | This meta-analysis demonstrates that the CHEK2 I157T variant may be another important CRC-predisposing gene, which increases CRC risk, especially in familial CRC. |
Gene Details
| Gene Type | protein coding |
|---|---|
| Gene Family | - |
| Description | In response to DNA damage and replication blocks, cell cycle progression is halted through the control of critical cell cycle regulators. The protein encoded by this gene is a cell cycle checkpoint regulator and putative tumor suppressor. It contains a forkhead-associated protein interaction domain essential for activation in response to DNA damage and is rapidly phosphorylated in response to replication blocks and DNA damage. When activated, the encoded protein is known to inhibit CDC25C phosphatase, preventing entry into mitosis, and has been shown to stabilize the tumor suppressor protein p53, leading to cell cycle arrest in G1. In addition, this protein interacts with and phosphorylates BRCA1, allowing BRCA1 to restore survival after DNA damage. Mutations in this gene have been linked with Li-Fraumeni syndrome, a highly penetrant familial cancer phenotype usually associated with inherited mutations in TP53. Also, mutations in this gene are thought to confer a predisposition to sarcomas, breast cancer, and brain tumors. This nuclear protein is a member of the CDS1 subfamily of serine/threonine protein kinases. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Apr 2012] |
| Chromosome | 22 |
| Location | 22q12.1 |
| Start | 29083731 |
| End | 29137822 |
| Strand | - |
| Gene Sequence | Download Select all |
| Length | 54092 |
| OMIM ID | 604373 |
| HGNC ID | HGNC:16627 |
| Unigene ID | Hs.291363 |
| Ensembl ID | ENSG00000183765 |
| PharmGKB ID | PA404 |
Protein Information
| Protein ID | NP_001005735.1 |
|---|---|
| Protein Name | checkpoint kinase 2 |
| Molecular Wt. (Da) | 0 |
| Protein Sequence | Download Select all |
| Length | 543 |
| Uniprot ID | Q9Y5L2 |
| Ensembl Protein ID | ENSP00000257696 |
Post-translational Modification Information (Source : HPRD)
| Residue | Type | site |
|---|---|---|
| T | Phosphorylation | 26 |
| T | Phosphorylation | 68 |
| T | Phosphorylation | 26 |
| T | Phosphorylation | 68 |
| T | Phosphorylation | 26 |
| T | Phosphorylation | 68 |
| T | Phosphorylation | 68 |
| T | Phosphorylation | 68 |
| T | Phosphorylation | 68 |
| T | Phosphorylation | 383 |
| T | Phosphorylation | 387 |
| S | Phosphorylation | 516 |
| T | Phosphorylation | 68 |
| T | Phosphorylation | 426 |
| T | Phosphorylation | 430 |
| S | Phosphorylation | 559 |
| T | Phosphorylation | 68 |
| T | Phosphorylation | 354 |
| T | Phosphorylation | 358 |
| S | Phosphorylation | 487 |
| T | Phosphorylation | 68 |
| S | Phosphorylation | 19 |
| T | Phosphorylation | 26 |
| S | Phosphorylation | 28 |
| S | Phosphorylation | 33 |
| S | Phosphorylation | 35 |
| S | Phosphorylation | 50 |
| T | Phosphorylation | 68 |
| S | Phosphorylation | 19 |
| T | Phosphorylation | 26 |
| S | Phosphorylation | 28 |
| S | Phosphorylation | 33 |
| S | Phosphorylation | 35 |
| S | Phosphorylation | 50 |
| T | Phosphorylation | 68 |
| S | Phosphorylation | 19 |
| T | Phosphorylation | 26 |
| S | Phosphorylation | 28 |
| S | Phosphorylation | 33 |
| S | Phosphorylation | 35 |
| S | Phosphorylation | 50 |
| T | Phosphorylation | 68 |
| S | Phosphorylation | 19 |
| T | Phosphorylation | 26 |
| S | Phosphorylation | 28 |
| S | Phosphorylation | 33 |
| S | Phosphorylation | 35 |
| S | Phosphorylation | 50 |
| S | Phosphorylation | 19 |
| T | Phosphorylation | 26 |
| S | Phosphorylation | 28 |
| S | Phosphorylation | 33 |
| S | Phosphorylation | 35 |
| S | Phosphorylation | 50 |
| S | Phosphorylation | 19 |
| T | Phosphorylation | 26 |
| S | Phosphorylation | 28 |
| S | Phosphorylation | 33 |
| S | Phosphorylation | 35 |
| S | Phosphorylation | 50 |
Enzyme Information
No matching records could be found.
PPi Information
No STRING Network could be found.
| Interactant Gene ID (Source: HPRD) | Gene Symbol | HPRD ID | Ref Seq ID | Technique | References |
|---|---|---|---|---|---|
| 672 | BRCA1 | 218 | NP_009231.2 | in vitro;in vivo | 1 072 417 512 111 730 |
| 993 | CDC25A | 305 | NP_001780.2 | in vitro;in vivo | 1 267 658 311 298 450 |
| 995 | CDC25C | 1146 | NP_001781.2 | in vitro | 105 570 929 278 512 000 000 000 000 000 000 000 000 |
| 1869 | E2F1 | 1806 | NP_005216.1 | in vitro;in vivo | 12717439 |
| 2074 | ERCC6 | 596 | NP_000115.1 | in vitro | 9450932 |
| 3838 | KPNA2 | 2818 | NP_002257.1 | in vitro;in vivo;yeast 2-hybrid | 12909615 |
| 4193 | MDM2 | 1272 | NP_002383.2 | in vitro;in vivo | 15862297 |
| 4194 | MDM4 | 4082 | NP_002384.2 | in vitro | 16163388 |
| 4360 | MRC1 | 1089 | NP_002429.1 | yeast 2-hybrid | 11715017 |
| 4436 | MSH2 | 389 | NP_000242.1 | in vitro;in vivo | 12447371 |
| 4683 | NBN | 4050 | NP_002476.2 | in vitro | 11438675 |
| 5520 | PPP2R2A | 9223 | NP_002708.1 | in vitro;in vivo;yeast 2-hybrid | 15380617 |
| 5521 | PPP2R2B | 5059 | NP_858062.1 | in vitro;in vivo | 16596250 |
| 5525 | PPP2R5A | 3384 | NP_006234.1 | in vitro;in vivo;yeast 2-hybrid | 15380617 |
| 5526 | PPP2R5B | 9038 | NP_006235.1 | in vitro;in vivo;yeast 2-hybrid | 15380617 |
| 5527 | PPP2R5C | 3385 | NP_002710.2 | in vitro;in vivo;yeast 2-hybrid | 15380617 |
| 5528 | PPP2R5D | 9039 | NP_006236.1 | in vitro;yeast 2-hybrid | 15380617 |
| 5529 | PPP2R5E | 9040 | NP_006237.1 | in vitro;yeast 2-hybrid | 15380617 |
| 5883 | RAD9A | 4788 | NP_004575.1 | in vitro;in vivo | 12049741 |
| 9656 | MDC1 | 16252 | NP_055456.2 | in vivo | 1 260 700 412 551 930 |
| 25842 | ASF1A | 16459 | NP_054753.1 | in vivo | 11172707 |
| 26574 | AATF | 12236 | NP_036270.1 | in vitro;in vivo | 17157788 |
Pathway Information
| Pathway Name | Pathway ID |
|---|---|
| Cell cycle | hsa04110 |
| HTLV-I infection | hsa05166 |
| p53 signaling pathway | hsa04115 |
Structure Information
No matching records could be found.
Domain Information
| ID | Location | Description |
|---|---|---|
| cd14084 | 213-486 | STKc_Chk2 |
| cl21453 | 213-486 | PKc_like superfamily |
| cd00060 | 93-201 | FHA |
| cl00062 | 93-201 | FHA superfamily |
| cd05117 | 220-485 | STKc_CAMK |
| cd14003 | 220-485 | STKc_AMPK-like |
| cd14083 | 216-485 | STKc_CaMKI |
| cd14166 | 216-486 | STKc_CaMKI_gamma |
| cd14098 | 219-485 | STKc_Rad53_Cds1 |
| cd14007 | 224-487 | STKc_Aurora |
| cd14167 | 216-486 | STKc_CaMKI_alpha |
| cd14093 | 226-486 | STKc_PhKG |
| cd14081 | 220-486 | STKc_BRSK1_2 |
| cd14095 | 219-485 | STKc_DCKL |
| cd14008 | 226-486 | STKc_LKB1_CaMKK |
| cd14079 | 220-486 | STKc_AMPK_alpha |
| cd14085 | 216-497 | STKc_CaMKIV |
| cd14080 | 220-486 | STKc_TSSK-like |
| cd14091 | 219-490 | STKc_RSK_C |
| cd14092 | 224-490 | STKc_MSK_C |
| cd14082 | 224-485 | STKc_PKD |
| cd14169 | 220-502 | STKc_CaMKI_beta |
| cd05123 | 226-485 | STKc_AGC |
| cd14086 | 218-490 | STKc_CaMKII |
| cd14663 | 220-485 | STKc_SnRK3 |
| cd14096 | 219-486 | STKc_RCK1-like |
| cd06606 | 219-486 | STKc_MAPKKK |
| cd05580 | 224-518 | STKc_PKA_like |
| cd14103 | 226-486 | STKc_MLCK |
| cd14089 | 219-485 | STKc_MAPKAPK |
| cd14009 | 226-485 | STKc_ATG1_ULK_like |
| cd14168 | 216-486 | STKc_CaMKI_delta |
| cd14073 | 220-486 | STKc_NUAK |
| cd14006 | 226-485 | STKc_MLCK-like |
| cd14078 | 216-486 | STKc_MELK |
| cd14087 | 219-486 | STKc_PSKH1 |
| cd14185 | 220-485 | STKc_DCKL3 |
| cd05581 | 218-485 | STKc_PDK1 |
| cd00180 | 226-484 | PKc |
| cd05579 | 228-490 | STKc_MAST_like |
| cd08215 | 224-484 | STKc_Nek |
| cd14121 | 226-485 | STKc_ULK3 |
| cd14099 | 218-486 | STKc_PLK |
| cd14182 | 218-487 | STKc_PhKG1 |
| cd14181 | 214-486 | STKc_PhKG2 |
| cd14069 | 220-486 | STKc_Chk1 |
| cd14071 | 220-486 | STKc_SIK |
| cd14171 | 218-486 | STKc_MAPKAPK5 |
| cd14184 | 218-485 | STKc_DCKL2 |
| cd14076 | 219-486 | STKc_Kin4 |
| cd14014 | 226-482 | STKc_PknB_like |
| cd14175 | 218-490 | STKc_RSK1_C |
| cd14075 | 220-486 | STKc_NIM1 |
| cd14209 | 218-490 | STKc_PKA |
| cd14077 | 220-486 | STKc_Kin1_2 |
| cd14074 | 220-486 | STKc_SNRK |
| cd05578 | 220-486 | STKc_Yank1 |
| cd14094 | 216-492 | STKc_CASK |
| cd14106 | 223-486 | STKc_DRAK |
| cd14176 | 218-496 | STKc_RSK2_C |
| cd14105 | 218-486 | STKc_DAPK |
| cd14165 | 220-486 | STKc_TSSK1_2-like |
| cd14172 | 218-486 | STKc_MAPKAPK3 |
| cd14090 | 220-485 | STKc_Mnk |
| cd05572 | 226-490 | STKc_cGK |
| cd14177 | 218-496 | STKc_RSK4_C |
| cd14097 | 220-486 | STKc_STK33 |
| cd05122 | 224-486 | PKc_STE |
| cd14178 | 218-490 | STKc_RSK3_C |
| cd05573 | 218-490 | STKc_ROCK_NDR_like |
| cd14072 | 220-486 | STKc_MARK |
| cd14183 | 213-489 | STKc_DCKL1 |
| cd07834 | 224-488 | STKc_MAPK |
| cd05118 | 220-486 | STKc_CMGC |
| cd14161 | 216-486 | STKc_NUAK2 |
| cd06623 | 224-487 | PKc_MAPKK_plant_like |
| cd14118 | 226-485 | STKc_CAMKK |
| cd14179 | 212-488 | STKc_MSK1_C |
| cd14162 | 220-486 | STKc_TSSK4-like |
| cd06627 | 219-486 | STKc_Cdc7_like |
| cd14088 | 218-486 | STKc_CaMK_like |
| cd14196 | 216-486 | STKc_DAPK2 |
| cd05612 | 218-490 | STKc_PRKX_like |
| cd14194 | 216-486 | STKc_DAPK1 |
| cd06626 | 227-486 | STKc_MEKK4 |
| cd14195 | 216-487 | STKc_DAPK3 |
| cd06614 | 226-487 | STKc_PAK |
| cd14170 | 218-486 | STKc_MAPKAPK2 |
| cd05584 | 224-518 | STKc_p70S6K |
| cd14174 | 221-487 | STKc_Mnk1 |
| cd14163 | 220-486 | STKc_TSSK3-like |
| cd13994 | 226-486 | STKc_HAL4_like |
| cd14191 | 217-486 | STKc_MLCK1 |
| cd14180 | 226-488 | STKc_MSK2_C |
| cd14070 | 220-486 | STKc_HUNK |
| cd14173 | 221-486 | STKc_Mnk2 |
| cd05571 | 224-518 | STKc_PKB |
| cd14004 | 220-486 | STKc_PASK |
| cd14119 | 226-486 | STKc_LKB1 |
| cd14002 | 218-486 | STKc_STK36 |
| cd07849 | 218-487 | STKc_ERK1_2_like |
| cd05611 | 224-488 | STKc_Rim15_like |
| cd14198 | 221-486 | STKc_DRAK2 |
| cd05574 | 224-488 | STKc_phototropin_like |
| cd13999 | 226-474 | STKc_MAP3K-like |
| cd05599 | 224-490 | STKc_NDR_like |
| cd14190 | 218-486 | STKc_MLCK2 |
| cd14120 | 226-484 | STKc_ULK1_2-like |
| cd07852 | 224-488 | STKc_MAPK15-like |
| cd08529 | 219-486 | STKc_FA2-like |
| cd14193 | 223-486 | STKc_MLCK4 |
| cd14164 | 220-486 | STKc_TSSK6-like |
| cd14199 | 218-487 | STKc_CaMKK2 |
| cd07855 | 216-487 | STKc_ERK5 |
| cd07851 | 216-509 | STKc_p38 |
| cd14197 | 224-486 | STKc_DRAK1 |
| cd14200 | 219-486 | STKc_CaMKK1 |
| cd08530 | 220-484 | STKc_CNK2-like |
| cd14116 | 218-486 | STKc_Aurora-A |
| cd14114 | 218-486 | STKc_Twitchin_like |
| cd06612 | 226-486 | STKc_MST1_2 |
| cd07830 | 220-486 | STKc_MAK_like |
| cd05570 | 224-494 | STKc_PKC |
| cd07840 | 226-485 | STKc_CDK9_like |
| cd07829 | 226-486 | STKc_CDK_like |
| cd06611 | 226-501 | STKc_SLK_like |
| cd07832 | 219-486 | STKc_CCRK |
| cd08221 | 219-486 | STKc_Nek9 |
| cd14202 | 219-487 | STKc_ULK1 |
| cd14192 | 224-486 | STKc_MLCK3 |
| cd14104 | 220-487 | STKc_Titin |
| cd14131 | 219-486 | PKc_Mps1 |
| cd07858 | 220-487 | STKc_TEY_MAPK |
| cd06625 | 224-485 | STKc_MEKK3_like |
| cd07841 | 220-485 | STKc_CDK7 |
| cd14201 | 219-487 | STKc_ULK2 |
| cd06632 | 222-486 | STKc_MEKK1_plant |
| cd08217 | 219-484 | STKc_Nek2 |
| cd14109 | 217-486 | PK_Unc-89_rpt1 |
| cd14117 | 218-487 | STKc_Aurora-B_like |
| cd05585 | 226-493 | STKc_YPK1_like |
| cd14662 | 220-485 | STKc_SnRK2 |
| cd05575 | 224-502 | STKc_SGK |
| cd07854 | 224-488 | STKc_MAPK4_6 |
| cd05613 | 224-494 | STKc_MSK1_N |
| cd08222 | 220-486 | STKc_Nek11 |
| cd05583 | 226-487 | STKc_MSK_N |
| cd13993 | 220-481 | STKc_Pat1_like |
| cd05596 | 217-490 | STKc_ROCK |
| cd08220 | 219-484 | STKc_Nek8 |
| cd14137 | 220-484 | STKc_GSK3 |
| cd13987 | 226-485 | STKc_SBK1 |
| cd14665 | 220-485 | STKc_SnRK2-3 |
| cd14113 | 226-486 | STKc_Trio_C |
| cd14210 | 220-486 | PKc_DYRK |
| cd05586 | 226-522 | STKc_Sck1_like |
| cd05609 | 224-490 | STKc_MAST |
| cd07833 | 225-486 | STKc_CDKL |
| cd07850 | 220-486 | STKc_JNK |
| cd05614 | 224-523 | STKc_MSK2_N |
| cd05598 | 218-502 | STKc_LATS |
| cd05601 | 224-490 | STKc_CRIK |
| cd14187 | 211-481 | STKc_PLK1 |
| cd14115 | 226-485 | STKc_Kalirin_C |
| cd05595 | 224-517 | STKc_PKB_beta |
| cd14005 | 226-486 | STKc_PIM |
| cd07843 | 229-485 | STKc_CDC2L1 |
| cd05600 | 226-493 | STKc_Sid2p_like |
| cd14186 | 218-486 | STKc_PLK4 |
| cd08223 | 219-486 | STKc_Nek4 |
| cd05604 | 224-479 | STKc_SGK3 |
| cd13989 | 226-434 | STKc_IKK |
| cd07866 | 215-485 | STKc_BUR1 |
| cd07838 | 226-486 | STKc_CDK4_6_like |
| cd14010 | 220-485 | STKc_ULK4 |
| cd14133 | 220-486 | PKc_DYRK_like |
| cd06648 | 213-486 | STKc_PAK_II |
| cd07880 | 216-505 | STKc_p38gamma |
| cd06609 | 218-486 | STKc_MST3_like |
| cd06652 | 222-483 | STKc_MEKK2 |
| cd07831 | 221-485 | STKc_MOK |
| cd06613 | 219-484 | STKc_MAP4K3_like |
| cd08528 | 219-474 | STKc_Nek10 |
| cd07856 | 220-486 | STKc_Sty1_Hog1 |
| cd06608 | 225-486 | STKc_myosinIII_N_like |
| cd05603 | 224-474 | STKc_SGK2 |
| cd07877 | 218-486 | STKc_p38alpha |
| cd05593 | 224-517 | STKc_PKB_gamma |
| cd06659 | 213-486 | STKc_PAK6 |
| cd06610 | 218-484 | STKc_OSR1_SPAK |
| cd05592 | 224-474 | STKc_nPKC_theta_like |
| cd06653 | 222-485 | STKc_MEKK3_like_u1 |
| cd14107 | 273-486 | STKc_obscurin_rpt1 |
| cd13990 | 220-485 | STKc_TLK |
| cd14134 | 216-486 | PKc_CLK |
| cd07859 | 220-509 | STKc_TDY_MAPK |
| cd05582 | 224-511 | STKc_RSK_N |
| cd05602 | 213-475 | STKc_SGK1 |
| cd14108 | 218-486 | STKc_SPEG_rpt1 |
| cd05621 | 218-536 | STKc_ROCK2 |
| cd08224 | 219-481 | STKc_Nek6_7 |
| cd14189 | 220-483 | STKc_PLK3 |
| cd06605 | 218-491 | PKc_MAPKK |
| cd06624 | 226-486 | STKc_ASK |
| cd06647 | 219-487 | STKc_PAK_I |
| cd06629 | 220-486 | STKc_Bck1_like |
| cd05590 | 224-490 | STKc_nPKC_eta |
| cd06651 | 224-487 | STKc_MEKK3 |
| cd08218 | 219-486 | STKc_Nek1 |
| cd06638 | 218-486 | STKc_myosinIIIA_N |
| cd05577 | 226-499 | STKc_GRK |
| cd05627 | 218-490 | STKc_NDR2 |
| cd07878 | 226-486 | STKc_p38beta |
| cd06639 | 218-487 | STKc_myosinIIIB_N |
| cd07853 | 224-488 | STKc_NLK |
| cd13996 | 226-482 | STKc_EIF2AK |
| cd07879 | 220-508 | STKc_p38delta |
| cd05589 | 226-511 | STKc_PKN |
| cd05622 | 218-489 | STKc_ROCK1 |
| cd05591 | 224-490 | STKc_nPKC_epsilon |
| cd14038 | 226-427 | STKc_IKK_beta |
| cd08228 | 219-474 | STKc_Nek6 |
| cd05619 | 218-493 | STKc_nPKC_theta |
| cd14019 | 218-486 | STKc_Cdc7 |
| cd08219 | 219-474 | STKc_Nek3 |
| cd14039 | 226-440 | STKc_IKK_alpha |
| cd06643 | 226-501 | STKc_SLK |
| cd05594 | 219-517 | STKc_PKB_alpha |
| cd14101 | 219-487 | STKc_PIM2 |
| cd05610 | 218-490 | STKc_MASTL |
| cd06644 | 226-501 | STKc_STK10 |
| cd05605 | 222-493 | STKc_GRK4_like |
| cd07876 | 201-486 | STKc_JNK2 |
| cd06655 | 217-487 | STKc_PAK2 |
| cd05587 | 224-427 | STKc_cPKC |
| cd08225 | 220-486 | STKc_Nek5 |
| cd05630 | 224-493 | STKc_GRK6 |
| cd05628 | 224-463 | STKc_NDR1 |
| cd05632 | 217-493 | STKc_GRK5 |
| cd06658 | 213-487 | STKc_PAK5 |
| cd06630 | 219-484 | STKc_MEKK1 |
| cd05631 | 224-499 | STKc_GRK4 |
| cd05618 | 219-475 | STKc_aPKC_iota |
| cd13997 | 226-484 | PKc_Wee1_like |
| cd14059 | 226-427 | STKc_MAP3K12_13 |
| cd07857 | 220-486 | STKc_MPK1 |
| cd00192 | 224-466 | PTKc |
| cd06628 | 220-486 | STKc_Byr2_like |
| cd07874 | 201-486 | STKc_JNK3 |
| cd05597 | 218-485 | STKc_DMPK_like |
| cd14188 | 220-483 | STKc_PLK2 |
| cd07875 | 224-486 | STKc_JNK1 |
| cd13983 | 226-486 | STKc_WNK |
| cd07836 | 226-485 | STKc_Pho85 |
| cd07845 | 226-488 | STKc_CDK10 |
| cd06657 | 213-486 | STKc_PAK4 |
| cd05588 | 224-474 | STKc_aPKC |
| cd05629 | 218-531 | STKc_NDR_like_fungal |
| cd06622 | 218-491 | PKc_PBS2_like |
| cd06654 | 217-506 | STKc_PAK1 |
| cd14111 | 227-486 | STKc_SPEG_rpt2 |
| cd07861 | 219-486 | STKc_CDK1_euk |
| cd06656 | 217-487 | STKc_PAK3 |
| cd05624 | 217-467 | STKc_MRCK_beta |
| cd05626 | 220-466 | STKc_LATS2 |
| cd07842 | 227-485 | STKc_CDK8_like |
| cd05620 | 224-487 | STKc_nPKC_delta |
| cd06631 | 270-486 | STKc_YSK4 |
| cd13985 | 219-474 | STKc_GAK_like |
| cd07835 | 226-486 | STKc_CDK1_CdkB_like |
| cd06642 | 226-504 | STKc_STK25 |
| cd06917 | 226-487 | STKc_NAK1_like |
| cd14041 | 216-486 | STKc_TLK2 |
| cd14040 | 216-486 | STKc_TLK1 |
| cd05617 | 219-475 | STKc_aPKC_zeta |
| cd05616 | 224-475 | STKc_cPKC_beta |
| cd07865 | 218-485 | STKc_CDK9 |
| cd07864 | 218-486 | STKc_CDK12 |
| cd13982 | 221-484 | STKc_IRE1 |
| cd13976 | 307-486 | PK_TRB |
| cd05615 | 226-427 | STKc_cPKC_alpha |
| cd13988 | 226-444 | STKc_TBK1 |
| cd06621 | 218-493 | PKc_Pek1_like |
| cd07860 | 226-485 | STKc_CDK2_3 |
| cd14110 | 273-486 | STKc_obscurin_rpt2 |
| cd14022 | 307-486 | PK_TRB2 |
| cd14100 | 220-486 | STKc_PIM1 |
| cd07847 | 226-485 | STKc_CDKL1_4 |
| cd05623 | 217-467 | STKc_MRCK_alpha |
| cd14046 | 224-483 | STKc_EIF2AK4_GCN2_rpt2 |
| cd14047 | 214-483 | STKc_EIF2AK2_PKR |
| cd05625 | 220-526 | STKc_LATS1 |
| cd05607 | 218-484 | STKc_GRK7 |
| cd14112 | 264-486 | STKc_Unc-89_rpt2 |
| cd13974 | 313-483 | STKc_SHIK |
| cd06620 | 224-495 | PKc_Byr1_like |
| cd13986 | 269-483 | STKc_16 |
| cd13978 | 226-427 | STKc_RIP |
| cd07846 | 218-485 | STKc_CDKL2_3 |
| cd06607 | 226-487 | STKc_TAO |
| cd06641 | 224-495 | STKc_MST3 |
| cd14132 | 218-484 | STKc_CK2_alpha |
| cd06633 | 226-505 | STKc_TAO3 |
| cd14066 | 226-438 | STKc_IRAK |
| cd14023 | 307-486 | PK_TRB1 |
| cd14102 | 220-486 | STKc_PIM3 |
| cd06640 | 226-486 | STKc_MST4 |
| cd05608 | 218-488 | STKc_GRK1 |
| cd08229 | 220-474 | STKc_Nek7 |
| cd14158 | 217-440 | STKc_IRAK4 |
| cd07839 | 226-485 | STKc_CDK5 |
| cd13979 | 226-481 | STKc_Mos |
| cd14226 | 218-487 | PKc_DYRK1 |
| cd14225 | 207-486 | PKc_DYRK4 |
| cd14012 | 244-484 | PK_eIF2AK_GCN2_rpt1 |
| cd06637 | 216-506 | STKc_TNIK |
| cd07848 | 226-484 | STKc_CDKL5 |
| cd07863 | 226-486 | STKc_CDK4 |
| cd06635 | 224-505 | STKc_TAO1 |
| cd06645 | 217-486 | STKc_MAP4K3 |
| cd14215 | 216-486 | PKc_CLK2 |
| cd06646 | 219-483 | STKc_MAP4K5 |
| cd14223 | 219-433 | STKc_GRK2 |
| cd05606 | 226-490 | STKc_beta_ARK |
| cd05116 | 224-483 | PTKc_Syk |
| cd06636 | 215-486 | STKc_MAP4K4_6_N |
| cd06634 | 224-505 | STKc_TAO2 |
| cd05633 | 218-433 | STKc_GRK3 |
| cd14000 | 226-477 | STKc_LRRK |
| cd14016 | 220-373 | STKc_CK1 |
| cd14061 | 226-427 | STKc_MLK |
| cd14135 | 220-486 | STKc_PRP4 |
| cd14224 | 207-486 | PKc_DYRK2_3 |
| cd07837 | 218-485 | STKc_CdkB_plant |
| cd14060 | 227-427 | STKc_MLTK |
| cd14048 | 260-483 | STKc_EIF2AK3_PERK |
| cd14212 | 220-486 | PKc_YAK1 |
| cd14036 | 273-481 | STKc_GAK |
| cd14214 | 216-486 | PKc_CLK3 |
| cd14052 | 224-484 | PTKc_Wee1_fungi |
| cd14050 | 224-484 | PKc_Myt1 |
| cd05060 | 224-444 | PTKc_Syk_like |
| cd06618 | 204-501 | PKc_MKK7 |
| cd07870 | 220-486 | STKc_PFTAIRE2 |
| cd14213 | 216-486 | PKc_CLK1_4 |
| cd14064 | 226-471 | PKc_TNNI3K |
| cd14148 | 226-429 | STKc_MLK2 |
| cd14145 | 219-427 | STKc_MLK1 |
| cd14024 | 307-486 | PK_TRB3 |
| cd14033 | 273-483 | STKc_WNK4 |
| cd14136 | 218-486 | STKc_SRPK |
| cd07871 | 218-486 | STKc_PCTAIRE3 |
| cd14068 | 226-477 | STKc_LRRK2 |
| cd14058 | 226-429 | STKc_TAK1 |
| cd14147 | 257-427 | STKc_MLK3 |
| cd07873 | 218-487 | STKc_PCTAIRE1 |
| cd05148 | 217-443 | PTKc_Srm_Brk |
| cd06615 | 226-490 | PKc_MEK |
| cd14146 | 254-427 | STKc_MLK4 |
| cd14027 | 226-479 | STKc_RIP1 |
| cd05056 | 217-427 | PTKc_FAK |
| cd05044 | 224-427 | PTKc_c-ros |
| cd05041 | 226-443 | PTKc_Fes_like |
| cd05038 | 223-418 | PTKc_Jak_rpt2 |
| cd14011 | 237-488 | PK_SCY1_like |
| cd13995 | 229-486 | STKc_MAP3K8 |
| cd14031 | 226-489 | STKc_WNK3 |
| cd07869 | 218-488 | STKc_PFTAIRE1 |
| cd05036 | 217-434 | PTKc_ALK_LTK |
| cd14150 | 219-468 | STKc_A-Raf |
| cd05112 | 218-443 | PTKc_Itk |
| cd07867 | 226-486 | STKc_CDC2L6 |
| cd13968 | 226-370 | PKc_like |
| cd07844 | 220-486 | STKc_PCTAIRE_like |
| cd07868 | 226-486 | STKc_CDK8 |
| cd13977 | 298-418 | STKc_PDIK1L |
| cd06617 | 292-487 | PKc_MKK3_6 |
| cd06619 | 225-486 | PKc_MKK5 |
| cd14037 | 265-474 | STKc_NAK_like |
| cd06616 | 226-488 | PKc_MKK4 |
| cd05057 | 222-510 | PTKc_EGFR_like |
| cd14149 | 208-440 | STKc_C-Raf |
| cd05082 | 217-488 | PTKc_Csk |
| cd05068 | 217-418 | PTKc_Frk_like |
| cd05115 | 226-427 | PTKc_Zap-70 |
| cd13991 | 226-430 | STKc_NIK |
| cd05072 | 217-437 | PTKc_Lyn |
| cd14049 | 226-481 | STKc_EIF2AK1_HRI |
| cd07872 | 218-492 | STKc_PCTAIRE2 |
| cd14067 | 226-437 | STKc_LRRK1 |
| cd05067 | 217-417 | PTKc_Lck_Blk |
| cd14205 | 224-418 | PTKc_Jak2_rpt2 |
| cd14032 | 273-489 | STKc_WNK2_like |
| cd05081 | 226-418 | PTKc_Jak3_rpt2 |
| cd05059 | 224-428 | PTKc_Tec_like |
| cd14138 | 226-484 | PTKc_Wee1a |
| cd07862 | 226-485 | STKc_CDK6 |
| cd13975 | 335-474 | PKc_Dusty |
| cd05073 | 217-417 | PTKc_Hck |
| cd05033 | 222-417 | PTKc_EphR |
| cd06650 | 218-425 | PKc_MEK1 |
| cd05040 | 224-417 | PTKc_Ack_like |
| cd06649 | 263-425 | PKc_MEK2 |
| cd05052 | 217-427 | PTKc_Abl |
| cd14020 | 331-486 | STKc_KIS |
| cd14030 | 226-489 | STKc_WNK1 |
| cd05108 | 219-510 | PTKc_EGFR |
| cd14211 | 226-486 | STKc_HIPK |
| cd05039 | 225-417 | PTKc_Csk_like |
| cd05034 | 224-418 | PTKc_Src_like |
| cd14229 | 226-486 | STKc_HIPK3 |
| cd05576 | 283-480 | STKc_RPK118_like |
| cd05084 | 224-474 | PTKc_Fes |
| cd08216 | 234-433 | PK_STRAD |
| cd14151 | 222-440 | STKc_B-Raf |
| cd05080 | 273-449 | PTKc_Tyk2_rpt2 |
| cd14025 | 299-479 | STKc_RIP4_like |
| cd14053 | 271-417 | STKc_ACVR2 |
| cd14062 | 273-440 | STKc_Raf |
| cd14065 | 226-417 | PKc_LIMK_like |
| cd05114 | 219-451 | PTKc_Tec_Rlk |
| cd05046 | 224-429 | PTK_CCK4 |
| cd05079 | 224-429 | PTKc_Jak1_rpt2 |
| cd13981 | 220-372 | STKc_Bub1_BubR1 |
| cd14017 | 224-373 | STKc_TTBK |
| cd14155 | 269-417 | PKc_TESK |
| cd14156 | 226-482 | PKc_LIMK_like_unk |
| cd14664 | 226-431 | STK_BAK1_like |
| cd14159 | 272-430 | STKc_IRAK1 |
| cd14001 | 247-426 | PKc_TOPK |
| cd14227 | 215-430 | STKc_HIPK2 |
| cd05085 | 226-443 | PTKc_Fer |
| cd14063 | 330-472 | PK_KSR |
| cd14013 | 298-486 | STKc_SNT7_plant |
| cd14228 | 215-430 | STKc_HIPK1 |
| cd05049 | 217-444 | PTKc_Trk |
| cd05032 | 217-418 | PTKc_InsR_like |
| pfam00498 | 113-192 | FHA |
| cd05045 | 221-458 | PTKc_RET |
| cd14018 | 326-474 | STKc_PINK1 |
| cd14139 | 219-484 | PTKc_Wee1b |
| cd05063 | 224-437 | PTKc_EphR_A2 |
| cd05110 | 224-510 | PTKc_HER4 |
| cd14222 | 272-417 | STKc_LIMK2 |
| cd05053 | 217-425 | PTKc_FGFR |
| cd05111 | 224-433 | PTK_HER3 |
| cd14154 | 272-417 | STKc_LIMK |
| cd13992 | 246-474 | PK_GC |
| cd14203 | 224-417 | PTKc_Src_Fyn_like |
| cd05089 | 226-425 | PTKc_Tie1 |
| cd14157 | 271-442 | STKc_IRAK2 |
| cd05047 | 226-425 | PTKc_Tie |
| cd05069 | 217-417 | PTKc_Yes |
| cd14125 | 220-373 | STKc_CK1_delta_epsilon |
| cd05066 | 222-437 | PTKc_EphR_A |
| cd05070 | 217-417 | PTKc_Fyn |
| cd05054 | 217-427 | PTKc_VEGFR |
| cd14026 | 226-429 | STKc_RIP2 |
| cd05113 | 217-454 | PTKc_Btk_Bmx |
| cd05083 | 222-427 | PTKc_Chk |
| cd05065 | 222-433 | PTKc_EphR_B |
| cd05098 | 217-425 | PTKc_FGFR1 |
| cd13980 | 325-482 | STKc_Vps15 |
| cd05051 | 226-375 | PTKc_DDR |
| cd14221 | 273-417 | STKc_LIMK1 |
| cd05094 | 217-418 | PTKc_TrkC |
| cd14056 | 224-430 | STKc_TGFbR_I |
| cd14204 | 217-427 | PTKc_Mer |
| cd14216 | 219-486 | STKc_SRPK1 |
| cd05071 | 217-417 | PTKc_Src |
| cd05037 | 274-482 | PTK_Jak_rpt1 |
| cd05109 | 224-510 | PTKc_HER2 |
| cd05061 | 217-498 | PTKc_InsR |
| cd05092 | 217-418 | PTKc_TrkA |
| cd05035 | 221-476 | PTKc_TAM |
| cd08227 | 270-437 | PK_STRAD_alpha |
| cd14207 | 327-466 | PTKc_VEGFR1 |
| cd14051 | 219-484 | PTKc_Wee1 |
| TIGR03724 | 291-379 | arch_bud32 |
| COG3642 | 291-379 | Bud32 |
| smart00220 | 220-486 | S_TKc |
| pfam00069 | 220-486 | Pkinase |
| PTZ00263 | 222-485 | PTZ00263 |
| COG0515 | 219-510 | SPS1 |
| PTZ00426 | 218-490 | PTZ00426 |
| smart00219 | 222-474 | TyrKc |
| smart00221 | 221-474 | STYKc |
| pfam07714 | 221-450 | Pkinase_Tyr |
| PTZ00024 | 224-498 | PTZ00024 |
| PTZ00267 | 220-521 | PTZ00267 |
| PLN00034 | 226-486 | PLN00034 |
| PTZ00283 | 214-484 | PTZ00283 |
| PTZ00036 | 220-488 | PTZ00036 |
| PHA03390 | 249-486 | pk1 |
| PTZ00266 | 218-474 | PTZ00266 |
| PRK13184 | 220-482 | pknD |
| PLN00009 | 218-488 | PLN00009 |
| PHA03212 | 220-418 | PHA03212 |
| TIGR03903 | 242-481 | TOMM_kin_cyc |
| PHA03209 | 207-425 | PHA03209 |
| PHA03207 | 215-418 | PHA03207 |
| PHA03211 | 273-418 | PHA03211 |
| PHA03210 | 252-422 | PHA03210 |
| PTZ00284 | 226-430 | PTZ00284 |
| COG0478 | 268-369 | RIO2 |
| COG1716 | 116-199 | FHA |
| TIGR03354 | 115-191 | VI_FHA |
Ontology Information
| HPRD ID | 10627 |
|---|---|
| Molecular Class | Serine/threonine kinase |
| Molecular Function | RNA binding (GO:0003723) |
| Biological Process | Regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolism (GO:0019219) |
Drug Information
No matching records could be found.