Search results:
General Information
| Gene_Symbol | Gene_ID | Gene_Name | Chromosome | Alias |
|---|---|---|---|---|
| KLK8 | 11202 | kallikrein-related peptidase 8 | 19 | HNP, TADG14, neuropsin, ovasin |
- Evidence
- Gene
- mRNA
- CDS
- Protein
- PTM
- Enzyme
- PPi
- Pathway
- Structural
- Domain
- Ontology
- SNP
- Drug
- External Links
Evidence Information
| Pubmed ID | Year | Sample Information | Techniques | Mechanism | Fold Change | Remark |
|---|---|---|---|---|---|---|
| 19367279 | 2009 | Cell line : - Source : Oncologic Hospital of Athens �Saint Savvas. Sample Type : CRC tumor No. of Sample : 122 Stage : - | Immunofluorometric ELISA measurement of kallikreins | Up-regulation | - | - |
Gene Details
| Gene Type | protein coding |
|---|---|
| Gene Family | Kallikreins, "Serine peptidases / Serine peptidases" |
| Description | Kallikreins are a subgroup of serine proteases having diverse physiological functions. Growing evidence suggests that many kallikreins are implicated in carcinogenesis and some have potential as novel cancer and other disease biomarkers. This gene is one of the fifteen kallikrein subfamily members located in tandem in a gene cluster on chromosome 19. The encoded protein may be involved in proteolytic cascade in the skin and may serve as a biomarker for ovarian cancer. Alternate splicing of this gene results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2013] |
| Chromosome | 19 |
| Location | 19q13 |
| Start | 51499264 |
| End | 51504958 |
| Strand | - |
| Gene Sequence | Download Select all |
| Length | 5695 |
| OMIM ID | 605644 |
| HGNC ID | HGNC:6369 |
| Unigene ID | Hs.104570 |
| Ensembl ID | - |
| PharmGKB ID | PA30158 |
Protein Information
| Protein ID | NP_001268360.1 |
|---|---|
| Protein Name | kallikrein-related peptidase 8 |
| Molecular Wt. (Da) | 0 |
| Protein Sequence | Download Select all |
| Length | 260 |
| Uniprot ID | Q9Y617 |
| Ensembl Protein ID | ENSP00000317606 |
Post-translational Modification Information (Source : HPRD)
No matching records could be found.
Enzyme Information
No matching records could be found.
PPi Information
No STRING Network could be found.
No matching records from HPRD source could be found.
Pathway Information
No matching records could be found.
Structure Information
No matching records could be found.
Domain Information
| ID | Location | Description |
|---|---|---|
| cd00190 | 33-255 | Tryp_SPc |
| cl21584 | 33-255 | Tryp_SPc superfamily |
| smart00020 | 32-252 | Tryp_SPc |
| pfam00089 | 35-252 | Trypsin |
| COG5640 | 11-254 | COG5640 |
| pfam09342 | 45-217 | DUF1986 |
Ontology Information
| HPRD ID | 5221 |
|---|---|
| Molecular Class | Serine protease |
| Molecular Function | Extracellular matrix structural constituent (GO:0005201) |
| Biological Process | Cell growth and/or maintenance (GO:0008151) |
Drug Information
No matching records could be found.