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General Information



Gene_Symbol Gene_ID Gene_Name Chromosome Alias
AKAP13 11214 A kinase (PRKA) anchor protein 13  15Ht31, BRX, AKAP-Lbc, c-lbc, PROTO-LB, HA-3, ARHGEF13 







  • Evidence
  • Gene
  • mRNA
  • CDS
  • Protein
  • PTM
  • Enzyme
  • PPi
  • Pathway
  • Structural
  • Domain
  • Ontology
  • SNP
  • Drug
  • External Links



Evidence Information


Pubmed ID Year Sample Information Techniques Mechanism Fold Change Remark
19779964   2010Cell line : -

Source : -

Sample Type : CRC tumor and normal tissues

No. of Sample : -

Stage : -

Real Time RT-PCR, immunohistochemistryUp-regulation 2.259 Fold AKAP13 protein may be related to the carcinogenesis of human colorectal cancer.


Gene Details



NC_000015.9 (85923818..86292589)

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Gene Type protein coding
Gene Family A-kinase anchor proteins, "Rho guanine nucleotide exchange factors", "Pleckstrin homology (PH) domain containing"
Description The A-kinase anchor proteins (AKAPs) are a group of structurally diverse proteins which have the common function of binding to the regulatory subunit of protein kinase A (PKA) and confining the holoenzyme to discrete locations within the cell. This gene encodes a member of the AKAP family. Alternative splicing of this gene results in multiple transcript variants encoding different isoforms containing c-terminal dbl oncogene homology (DH) and pleckstrin homology (PH) domains. The DH domain is associated with guanine nucleotide exchange activation for the Rho/Rac family of small GTP binding proteins, resulting in the conversion of the inactive GTPase to the active form capable of transducing signals. The PH domain has multiple functions. Therefore, these isoforms function as scaffolding proteins to coordinate a Rho signaling pathway, function as protein kinase A-anchoring proteins and, in addition, enhance ligand-dependent activity of estrogen receptors alpha and beta. [provided by RefSeq, Jul 2012]  
Chromosome 15
Location 15q24-q25
Start 85923818  
End 86292589  
Strand +  
Gene Sequence

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Length 368772  
OMIM ID 604686   
HGNC ID HGNC:371   
Unigene ID Hs.459211   
Ensembl ID -   
PharmGKB ID PA24665   

mRNA Information


mRNA ID ?NM_001270546.1
Exon  
mRNA Sequence

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Length  



CDS Information


   
Location
CDS Sequence

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CCDS ID CCDS32319.1



Protein Information


      
Protein IDNP_001257475.1
Protein NameA kinase (PRKA) anchor protein 13
Molecular Wt. (Da)0
Protein Sequence

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Length 2813  
Uniprot IDO95967
Ensembl Protein ID ENSP00000309953  



Post-translational Modification Information (Source : HPRD)


Residue Type site
TPhosphorylation1934;-
TPhosphorylation1930;-
TPhosphorylation175;-
SPhosphorylation1604;-
SPhosphorylation1600;-
SPhosphorylation1565;-
SPhosphorylation1565;-
TPhosphorylation1747;-
TPhosphorylation1743;-
SPhosphorylation1606;-
SPhosphorylation1602;-
SPhosphorylation1559;-
SPhosphorylation1559;-
SPhosphorylation1936;-
SPhosphorylation1933;-
SPhosphorylation1929;-
SPhosphorylation1932;-
SPhosphorylation177;-
SPhosphorylation174;-
TPhosphorylation393
TPhosphorylation393
SPhosphorylation395
SPhosphorylation395
TPhosphorylation784
TPhosphorylation784
SPhosphorylation790
SPhosphorylation790
SPhosphorylation793
TPhosphorylation797
SPhosphorylation793
TPhosphorylation797
TPhosphorylation815
TPhosphorylation815
SPhosphorylation983
SPhosphorylation983
TPhosphorylation1170
TPhosphorylation1170
SPhosphorylation1411
SPhosphorylation1411
SPhosphorylation1492
SPhosphorylation1492
SPhosphorylation1649
SPhosphorylation1651
SPhosphorylation1645
SPhosphorylation1647
SPhosphorylation1754
SPhosphorylation1750
SPhosphorylation1880
SPhosphorylation1876
SPhosphorylation121
TPhosphorylation1947
TPhosphorylation1951
TPhosphorylation1943
TPhosphorylation1947
TPhosphorylation188
TPhosphorylation192
SPhosphorylation2402
SPhosphorylation2406
SPhosphorylation2398
SPhosphorylation2402
SPhosphorylation643
SPhosphorylation647
TPhosphorylation2404
TPhosphorylation2400
TPhosphorylation645
SPhosphorylation2565
SPhosphorylation2561
SPhosphorylation806
SPhosphorylation2567
SPhosphorylation2563
SPhosphorylation808
SPhosphorylation2571
SPhosphorylation2567
SPhosphorylation812
SPhosphorylation2707
SPhosphorylation2713
SPhosphorylation2703
SPhosphorylation2709
SPhosphorylation948
SPhosphorylation954
SPhosphorylation2732
SPhosphorylation2728
SPhosphorylation973
SPhosphorylation981
SPhosphorylation981
SPhosphorylation1646
SPhosphorylation1642
SPhosphorylation2349
SPhosphorylation2345
SPhosphorylation590
SPhosphorylation2765
SPhosphorylation2770
SPhosphorylation2761
SPhosphorylation2766
SPhosphorylation1006
SPhosphorylation1011
SPhosphorylation1507
SPhosphorylation1507
TPhosphorylation1888
TPhosphorylation1884
TPhosphorylation129
SPhosphorylation2216
SPhosphorylation2212
SPhosphorylation457
TPhosphorylation2471
TPhosphorylation2467
TPhosphorylation712
SPhosphorylation649
SPhosphorylation649

Enzyme Information


No matching records could be found.

PPi Information


(Click to view network : Source STRING)      View   

                                                                                                                                                      
Interactant Gene ID (Source: HPRD) Gene Symbol HPRD ID Ref Seq ID Technique References
387RHOA1323NP_001655.1in vivo1   242   363   311   696   350   
2099ESR1589NP_000116.2in vitro;in vivo9627117   
2768GNA125093NP_031379.2in vitro;in vivo1   463   689   011   546   810   
2776GNAQ2998NP_002063.2in vivo11278452   
5465PPARA1369NP_001001930.1in vitro;in vivo9627117   
5576PRKAR2A1484NP_004148.1in vitro;in vivo1   267   296   979   290   810   000   000   
6257RXRB1578NP_068811.1in vitro;in vivo9627117   
7529YWHAB3184NP_003395.1in vitro;in vivo15229649   
7531YWHAE5457NP_006752.1in vitro;in vivo15229649   
7534YWHAZ3183NP_003397.1in vitro;in vivo15229649   


Pathway Information


No matching records could be found.

Structure Information


No matching records could be found.

Domain Information




ID Location Description
cd133922232-2334  PH_AKAP13
cl171712232-2334  PH-like superfamily
cd001601995-2189  RhoGEF
cl025711995-2189  RhoGEF superfamily
smart003251998-2189  RhoGEF
cd146802232-2332  PH_p190RhoGEF
cd157942229-2348  PH_ARHGEF18
pfam006211998-2189  RhoGEF
cd133932229-2340  PH_ARHGEF2
cd133292232-2332  PH_RhoGEF
cd157892232-2329  PH_ARHGEF2_18_like
cd133912222-2333  PH_PRG
cd133902226-2328  PH_LARG
cd146792222-2335  PH_p115RhoGEF
smart002332232-2333  PH
pfam001692232-2332  PH
pfam039382621-2682  OmpH
cl214852621-2682  OmpH superfamily
smart009352621-2684  OmpH
pfam020502571-2680  FliJ
cl214772571-2680  FliJ superfamily
TIGR024732621-2681  flagell_FliJ
smart001091792-1838  C1
cl000401792-1838  C1 superfamily
pfam097442621-2681  Jnk-SapK_ap_N
cl180422621-2681  RILP-like superfamily
TIGR034952628-2681  phage_LysB
cl200642628-2681  phage_LysB superfamily
cd000291792-1838  C1
cd008212234-2328  PH
smart009352621-2681  OmpH
COG54221963-2267  ROM1
TIGR021682530-2688  SMC_prok_B
TIGR021682571-2678  SMC_prok_B
COG11962528-2682  Smc
PRK127042621-2681  PRK12704
COG11962543-2683  Smc
TIGR042112558-2683  SH3_and_anchor
TIGR021682514-2688  SMC_prok_B
PRK048632572-2681  mukB
COG04192509-2682  SbcC
pfam115592626-2684  ADIP
pfam155562622-2681  Zwint
pfam138512633-2683  GAS
pfam024631955-2694  SMC_N
COG11962473-2683  Smc
TIGR021682508-2680  SMC_prok_B
COG04192530-2687  SbcC
PRK144732621-2682  PRK14473
COG07112621-2681  AtpF
pfam138682570-2684  Trichoplein
pfam056722570-2679  MAP7
COG32062523-2684  GumC
PRK095102622-2681  tolA
pfam007692621-2681  ERM
COG11962519-2683  Smc


Ontology Information


   
HPRD ID5844
Molecular ClassGuanine nucleotide exchange factor
Molecular FunctionSerine-type peptidase activity (GO:0008236)
Biological ProcessProtein metabolism (GO:0019538)  



SNP Information


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Drug Information


No matching records could be found.

External Links


                                 
ArrayExpressGO
ICGCGO
Cancer3DGO
COSMICGO
NCGGO
TSGeneGO
Tumor Gene Family of DatabasesGO
CCDBGO
G2SBCGO
Osteosarcoma DatabaseGO
RCDBGO