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General Information
| Gene_Symbol | Gene_ID | Gene_Name | Chromosome | Alias |
|---|---|---|---|---|
| DUSP10 | 11221 | dual specificity phosphatase 10 | 1 | MKP-5, MKP5 |
- Evidence
- Gene
- mRNA
- CDS
- Protein
- PTM
- Enzyme
- PPi
- Pathway
- Structural
- Domain
- Ontology
- SNP
- Drug
- External Links
Evidence Information
| Pubmed ID | Year | Sample Information | Techniques | Mechanism | Fold Change | Remark |
|---|---|---|---|---|---|---|
| 25973098 | 2015 | Cell line : - Source : Shaanxi Province Hospital in Xian City, China. Sample Type : CRC tumor and normal tissue No. of Sample : 203 Stage : - | tSNPs | Polymorhpism | - | DUSP10 polymorphisms influence the risk of developing CRC in Han Chinese. |
Gene Details
| Gene Type | protein coding |
|---|---|
| Gene Family | Protein tyrosine phosphatases / Class I Cys-based PTPs : MAP kinase phosphatases |
| Description | Dual specificity protein phosphatases inactivate their target kinases by dephosphorylating both the phosphoserine/threonine and phosphotyrosine residues. They negatively regulate members of the MAP kinase superfamily, which is associated with cellular proliferation and differentiation. Different members of this family of dual specificity phosphatases show distinct substrate specificities for MAP kinases, different tissue distribution and subcellular localization, and different modes of expression induction by extracellular stimuli. This gene product binds to and inactivates p38 and SAPK/JNK. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2014 |
| Chromosome | 1 |
| Location | 1q41 |
| Start | 221874764 |
| End | 221916204 |
| Strand | - |
| Gene Sequence | Download Select all |
| Length | 41441 |
| OMIM ID | 608867 |
| HGNC ID | HGNC:3065 |
| Unigene ID | Hs.497822 |
| Ensembl ID | ENSG00000143507 |
| PharmGKB ID | PA27520 |
Protein Information
| Protein ID | NP_009138.1 |
|---|---|
| Protein Name | dual specificity phosphatase 10 |
| Molecular Wt. (Da) | 0 |
| Protein Sequence | Download Select all |
| Length | 482 |
| Uniprot ID | Q9UJZ1 |
| Ensembl Protein ID | ENSP00000348886 |
Post-translational Modification Information (Source : HPRD)
No matching records could be found.
Enzyme Information
No matching records could be found.
PPi Information
(Click to view network : Source STRING) View
| Interactant Gene ID (Source: HPRD) | Gene Symbol | HPRD ID | Ref Seq ID | Technique | References |
|---|---|---|---|---|---|
| 1432 | MAPK14 | 2619 | NP_001306.1 | in vitro;yeast 2-hybrid | 103 919 431 059 729 000 000 000 |
| 5595 | MAPK3 | 3479 | NP_002737.2 | in vitro | 10597297 |
| 5599 | MAPK8 | 3100 | NP_620637.1 | in vitro;yeast 2-hybrid | 1 039 194 310 597 290 |
| 5600 | MAPK11 | 4208 | AAB05036.1 | in vitro | 11359773 |
| 5602 | MAPK10 | 4207 | NP_620448.1 | in vitro | 11359773 |
Pathway Information
| Pathway Name | Pathway ID |
|---|---|
| MAPK signaling pathway | hsa04010 |
Structure Information
No matching records could be found.
Domain Information
| ID | Location | Description |
|---|---|---|
| cd00127 | 321-459 | DSPc |
| cl21483 | 321-459 | PTPc superfamily |
| cd01446 | 149-284 | DSP_MapKP |
| cl00125 | 149-284 | RHOD superfamily |
| smart00195 | 325-461 | DSPc |
| pfam00782 | 329-461 | DSPc |
| pfam00581 | 164-278 | Rhodanese |
| smart00450 | 170-280 | RHOD |
| cd00158 | 164-277 | RHOD |
| cd01448 | 149-241 | TST_Repeat_1 |
| COG5350 | 404-448 | COG5350 |
| cd01530 | 173-207 | Cdc25 |
| smart00404 | 404-426 | PTPc_motif |
| smart00012 | 404-426 | PTPc_DSPc |
| PTZ00242 | 406-452 | PTZ00242 |
| COG2453 | 401-459 | CDC14 |
| PRK12361 | 325-448 | PRK12361 |
Ontology Information
| HPRD ID | 5276 |
|---|---|
| Molecular Class | Enzyme: Phosphohydrolase |
| Molecular Function | Catalytic activity (GO:0003824) |
| Biological Process | Regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolism (GO:0019219) |
Drug Information
No matching records could be found.