Search results:
General Information
| Gene_Symbol | Gene_ID | Gene_Name | Chromosome | Alias |
|---|---|---|---|---|
| EGLN3 | 112399 | Egl nine homolog 3 (C. elegans) | 14 | PHD3; HIFPH3; HIFP4H3 |
- Evidence
- Gene
- mRNA
- CDS
- Protein
- PTM
- Enzyme
- PPi
- Pathway
- Structural
- Domain
- Ontology
- SNP
- Drug
- External Links
Evidence Information
| Pubmed ID | Year | Sample Information | Techniques | Mechanism | Fold Change | Remark |
|---|---|---|---|---|---|---|
| 19786027 | 2010 | Cell line : - Source : - Sample Type : - No. of Sample : - Stage : - | Immunoblotting, immunoprecipitation, and histochemistry | Down-regulation | - | Determination of PHD3 status could aid targeted therapy selection for patients with colorectal tumors that have increased NF-kappaB activity. PHD3 appears to be a tumor suppressor in colorectal cancer cells that inhibits IKKbeta/NF-kappaB signaling, independent of its hydroxylase activity. Expression of PHD3 is decreased in colorectal cancer tissues. Decreased expression of PHD3 is associated with higher tumor grade and metastasis. |
Gene Details
| Gene Type | protein coding |
|---|---|
| Gene Family | - |
| Description | - |
| Chromosome | 14 |
| Location | 14q13.1 |
| Start | 33924215 |
| End | 33951083 |
| Strand | + |
| Gene Sequence | Download Select all |
| Length | 26869 |
| OMIM ID | 606426 |
| HGNC ID | HGNC:14661 |
| Unigene ID | Hs.135507 |
| Ensembl ID | ENSG00000129521 |
| PharmGKB ID | - |
mRNA Information
| mRNA ID | NM_022073.3 |
|---|---|
| Exon | join(6..688,19869..19988,21872..22008,24051..24124, 25162..26869) | mRNA Sequence | Download Select all |
| Length | 2722 |
CDS Information
| Location | join(332..406,19869..19988,21872..22008,24051..24124, 25162..25193) |
|---|---|
| CDS Sequence | Download Select all |
| CCDS ID | - |
Protein Information
| Protein ID | NP_071356.1 |
|---|---|
| Protein Name | Egl nine homolog 3 (C. elegans) |
| Molecular Wt. (Da) | 27130 |
| Protein Sequence | Download Select all |
| Length | 239 |
| Uniprot ID | P42345 |
| Ensembl Protein ID | ENSP00000354558 |
Post-translational Modification Information (Source : HPRD)
No matching records could be found.
Enzyme Information
No matching records could be found.
PPi Information
(Click to view network : Source STRING) View
| Interactant Gene ID (Source: HPRD) | Gene Symbol | HPRD ID | Ref Seq ID | Technique | References |
|---|---|---|---|---|---|
| 84292 | WDR83 | 14730 | NP_115708.1 | in vitro;in vivo;yeast 2-hybrid | 16407229 |
Pathway Information
| Pathway Name | Pathway ID |
|---|---|
| HIF-1 signaling pathway | hsa04066 |
| Pathways in cancer | hsa05200 |
| Renal cell carcinoma | hsa05211 |
Structure Information
No matching records could be found.
Domain Information
| ID | Location | Description |
|---|---|---|
| smart00702 | 36-213 | P4Hc |
| cl21496 | 36-213 | 2OG-FeII_Oxy superfamily |
| pfam13640 | 120-213 | 2OG-FeII_Oxy_3 |
| pfam03171 | 122-213 | 2OG-FeII_Oxy |
| COG3751 | 67-213 | EGL9 |
Ontology Information
| HPRD ID | 83 |
|---|---|
| Molecular Class | Ubiquitin proteasome system protein |
| Molecular Function | Fucosyltransferase activity (GO:0008417) |
| Biological Process | Metabolism (GO:0008152); Energy pathways (GO:0006091) |
Drug Information
| Uniprot ID | DrugBank ID | Name | Type |
|---|---|---|---|
| Q9H6Z9 | DB00126 | Vitamin C | SmallMoleculeDrug |