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General Information
| Gene_Symbol | Gene_ID | Gene_Name | Chromosome | Alias |
|---|---|---|---|---|
| PRKCDBP | 112464 | protein kinase C, delta binding protein | 11 | SRBC, HSRBC, MGC20400, cavin-3, CAVIN3 |
- Evidence
- Gene
- mRNA
- CDS
- Protein
- PTM
- Enzyme
- PPi
- Pathway
- Structural
- Domain
- Ontology
- SNP
- Drug
- External Links
Evidence Information
| Pubmed ID | Year | Sample Information | Techniques | Mechanism | Fold Change | Remark |
|---|---|---|---|---|---|---|
| 21980136 | 2011 | Cell line : - Source : Kyung Hee University Medical Center (Seoul, Korea). Sample Type : CRC tumor and normal tissues No. of Sample : 160 Stage : - | Methylation analysis, luciferase reporter and chromatin immunoprecipitation | Methylation | - | PRKCDBP inactivation may contribute to tumor progression by reducing cellular sensitivity to TNF? and other stresses, particularly under chronic inflammatory microenvironment. |
Gene Details
| Gene Type | protein coding |
|---|---|
| Gene Family | - |
| Description | The protein encoded by this gene was identified as a binding protein of the protein kinase C, delta (PRKCD). The expression of this gene in cultured cell lines is strongly induced by serum starvation. The expression of this protein was found to be down-regulated in various cancer cell lines, suggesting the possible tumor suppressor function of this protein. [provided by RefSeq, Jul 2008] |
| Chromosome | 11 |
| Location | 11p15.4 |
| Start | 6340176 |
| End | 6341740 |
| Strand | - |
| Gene Sequence | Download Select all |
| Length | 1565 |
| OMIM ID | - |
| HGNC ID | HGNC:9400 |
| Unigene ID | Hs.434044 |
| Ensembl ID | ENSG00000170955 |
| PharmGKB ID | PA33764 |
Protein Information
| Protein ID | NP_659477.2 |
|---|---|
| Protein Name | protein kinase C, delta binding protein |
| Molecular Wt. (Da) | 0 |
| Protein Sequence | Download Select all |
| Length | 261 |
| Uniprot ID | Q685J3 |
| Ensembl Protein ID | ENSP00000302716 |
Post-translational Modification Information (Source : HPRD)
| Residue | Type | site |
|---|---|---|
| S | Phosphorylation | 165;- |
| S | Phosphorylation | 166;- |
| S | Phosphorylation | 173 |
| T | Phosphorylation | 205 |
| S | Phosphorylation | 62 |
| S | Phosphorylation | 188 |
Enzyme Information
No matching records could be found.
PPi Information
(Click to view network : Source STRING) View
No matching records from HPRD source could be found.
Pathway Information
No matching records could be found.
Structure Information
No matching records could be found.
Domain Information
| ID | Location | Description |
|---|---|---|
| pfam15237 | 19-194 | PTRF_SDPR |
| cl21098 | 19-194 | PTRF_SDPR superfamily |
Ontology Information
| HPRD ID | 6452 |
|---|---|
| Molecular Class | Unclassified |
| Molecular Function | Molecular function unknown (GO:0005554) |
| Biological Process | Biological_process unknown (GO:0000004) |
Drug Information
No matching records could be found.