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General Information
| Gene_Symbol | Gene_ID | Gene_Name | Chromosome | Alias |
|---|---|---|---|---|
| KLF8 | 11279 | Kruppel-like factor 8 | X | BKLF3, ZNF741, DXS741 |
- Evidence
- Gene
- mRNA
- CDS
- Protein
- PTM
- Enzyme
- PPi
- Pathway
- Structural
- Domain
- Ontology
- SNP
- Drug
- External Links
Evidence Information
| Pubmed ID | Year | Sample Information | Techniques | Mechanism | Fold Change | Remark |
|---|---|---|---|---|---|---|
| 26320172 | 2015 | Cell line : - Source : Department of Pathology, Nanfang Hospital, First Affiliated Hospital of Southern Medical University, China. Sample Type : CRC tumor and normal tissue No. of Sample : 13 Stage : - | Chromatin immunoprecipitation (ChIP) assays,Immunohistochemistry of human CRC cancer samples,Constructs and establishment of stable transfectants,Cell migration and invasion assays,siRNA transfection,Western blot assays,qRT-PCR,Immunofluorescence,WST-1 cell proliferation assay. | Up-regulation | - | This work identified KLF8-induced FHL2 activation as a novel and critical signaling mechanism underlying human breast/colorectal cancer invasion and metastasis. |
Gene Details
| Gene Type | protein coding |
|---|---|
| Gene Family | Zinc fingers, C2H2-type, "Kruppel-like transcription factors" |
| Description | This gene encodes a protein which is a member of the Sp/KLF family of transcription factors. Members of this family contain a C-terminal DNA-binding domain with three Kruppel-like zinc fingers. The encoded protein is thought to play an important role in the regulation of epithelial to mesenchymal transition, a process which occurs normally during development but also during metastasis. A pseudogene has been identified on chromosome 16. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2009] |
| Chromosome | X |
| Location | Xp11.21 |
| Start | 56258814 |
| End | 56314322 |
| Strand | + |
| Gene Sequence | Download Select all |
| Length | 55509 |
| OMIM ID | 300286 |
| HGNC ID | HGNC:6351 |
| Unigene ID | Hs.646614 |
| Ensembl ID | ENSG00000102349 |
| PharmGKB ID | PA30141 |
Protein Information
| Protein ID | NP_001152768.1 |
|---|---|
| Protein Name | Kruppel-like factor 8 |
| Molecular Wt. (Da) | 0 |
| Protein Sequence | Download Select all |
| Length | 359 |
| Uniprot ID | Q7LG56 |
| Ensembl Protein ID | ENSP00000251810 |
Post-translational Modification Information (Source : HPRD)
No matching records could be found.
Enzyme Information
No matching records could be found.
PPi Information
(Click to view network : Source STRING) View
No matching records from HPRD source could be found.
Pathway Information
No matching records could be found.
Structure Information
No matching records could be found.
Domain Information
| ID | Location | Description |
|---|---|---|
| pfam13465 | 320-345 | zf-H2C2_2 |
| cl22375 | 320-345 | zf-H2C2_2 superfamily |
| pfam00096 | 334-356 | zf-C2H2 |
| cl23491 | 334-356 | zf-C2H2 superfamily |
| pfam13465 | 290-307 | zf-H2C2_2 |
| cl22375 | 290-307 | zf-H2C2_2 superfamily |
| pfam13894 | 334-356 | zf-C2H2_4 |
| cl20498 | 334-356 | zf-C2H2_4 superfamily |
| smart00355 | 334-356 | ZnF_C2H2 |
| cl18194 | 334-356 | ZnF_C2H2 superfamily |
| pfam10477 | 12-202 | EIF4E-T |
| cl11118 | 12-202 | EIF4E-T superfamily |
| COG5048 | 220-346 | COG5048 |
| COG5048 | 272-342 | COG5048 |
| COG5048 | 263-359 | COG5048 |
| COG5048 | 302-355 | COG5048 |
Ontology Information
| HPRD ID | 5621 |
|---|---|
| Molecular Class | Transcription regulatory protein |
| Molecular Function | Cytokine activity (GO:0005125) |
| Biological Process | Immune response (GO:0006955) |
Drug Information
No matching records could be found.