Search results:
General Information
| Gene_Symbol | Gene_ID | Gene_Name | Chromosome | Alias |
|---|---|---|---|---|
| GABARAP | 11337 | GABA(A) receptor-associated protein | 17 | MM46, ATG8A |
- Evidence
- Gene
- mRNA
- CDS
- Protein
- PTM
- Enzyme
- PPi
- Pathway
- Structural
- Domain
- Ontology
- SNP
- Drug
- External Links
Evidence Information
| Pubmed ID | Year | Sample Information | Techniques | Mechanism | Fold Change | Remark |
|---|---|---|---|---|---|---|
| 20583424 | 2010 | Cell line : - Source : - Sample Type : CRC tumor and normal tissue No. of Sample : 103 Stage : - | Immunohistochemistry | Up-regulation | - | GABARAP is frequently expressed in colorectal cancer. Overexpression of GABARAP is a new independent prognostic marker, which is associated with poor differentiation as well as shortened overall survival. |
Gene Details
| Gene Type | protein coding |
|---|---|
| Gene Family | - |
| Description | Gamma-aminobutyric acid A receptors [GABA(A) receptors] are ligand-gated chloride channels that mediate inhibitory neurotransmission. This gene encodes GABA(A) receptor-associated protein, which is highly positively charged in its N-terminus and shares sequence similarity with light chain-3 of microtubule-associated proteins 1A and 1B. This protein clusters neurotransmitter receptors by mediating interaction with the cytoskeleton. [provided by RefSeq, Jul 2008] |
| Chromosome | 17 |
| Location | 17p13.1 |
| Start | 7143738 |
| End | 7145753 |
| Strand | - |
| Gene Sequence | Download Select all |
| Length | 2016 |
| OMIM ID | 605125 |
| HGNC ID | HGNC:4067 |
| Unigene ID | Hs.647421 |
| Ensembl ID | ENSG00000170296 |
| PharmGKB ID | PA28480 |
Protein Information
| Protein ID | NP_009209.1 |
|---|---|
| Protein Name | GABA(A) receptor-associated protein |
| Molecular Wt. (Da) | 0 |
| Protein Sequence | Download Select all |
| Length | 117 |
| Uniprot ID | Q9GZX6 |
| Ensembl Protein ID | ENSP00000329384 |
Post-translational Modification Information (Source : HPRD)
| Residue | Type | site |
|---|---|---|
| G | Proteolytic Cleavage | 116 |
Enzyme Information
No matching records could be found.
PPi Information
(Click to view network : Source STRING) View
| Interactant Gene ID (Source: HPRD) | Gene Symbol | HPRD ID | Ref Seq ID | Technique | References |
|---|---|---|---|---|---|
| 2566 | GABRG2 | 663 | NP_944493.2 | in vitro;in vivo;yeast 2-hybrid | 12 367 594 989 235 500 000 000 |
| 2567 | GABRG3 | 2579 | NP_150092.2 | in vitro;in vivo | 11948245 |
| 4905 | NSF | 3380 | NP_006169.2 | in vitro;in vivo | 11461150 |
| 7037 | TFRC | 1812 | NP_003225.2 | in vitro;in vivo;yeast 2-hybrid | 11997026 |
| 10243 | GPHN | 4893 | NP_065857.1 | in vitro;in vivo;yeast 2-hybrid | 10900017 |
| 23192 | ATG4B | 16499 | NP_037457.3 | yeast 2-hybrid | 16169070 |
| 51160 | VPS28 | 11675 | NP_898880.1 | yeast 2-hybrid | 16169070 |
| 51660 | BRP44L | 7091 | NP_057182.1 | yeast 2-hybrid | 16169070 |
Pathway Information
| Pathway Name | Pathway ID |
|---|---|
| FoxO signaling pathway | hsa04068 |
| GABAergic synapse | hsa04727 |
| Regulation of autophagy | hsa04140 |
Structure Information
No matching records could be found.
Domain Information
| ID | Location | Description |
|---|---|---|
| cd01611 | 5-116 | GABARAP |
| cl00155 | 5-116 | UBQ superfamily |
| pfam02991 | 13-116 | Atg8 |
| PTZ00380 | 5-116 | PTZ00380 |
| pfam04110 | 37-116 | APG12 |
| cd01612 | 31-95 | APG12_C |
| cd00196 | 38-101 | UBQ |
Ontology Information
| HPRD ID | 2242 |
|---|---|
| Molecular Class | Unclassified |
| Molecular Function | Transcription regulator activity (GO:0030528) |
| Biological Process | Regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolism (GO:0019219); Cell proliferation (GO:0008283) |
Drug Information
No matching records could be found.