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General Information



Gene_Symbol Gene_ID Gene_Name Chromosome Alias
FMNL2 114793 Formin-like 2  2FHOD2 







  • Evidence
  • Gene
  • mRNA
  • CDS
  • Protein
  • PTM
  • Enzyme
  • PPi
  • Pathway
  • Structural
  • Domain
  • Ontology
  • SNP
  • Drug
  • External Links



Evidence Information


Pubmed ID Year Sample Information Techniques Mechanism Fold Change Remark
18665374   2008Cell line : SW 620, SW480/M5, LoVo, HT 29, LS 174T, SW 480

Source : Department of the Surgery Southern Hospital.

Sample Type : CRC tissue and blood sample

No. of Sample : 75 primary CRC tumors and 45 corresponding metastatic lymph nodes and normal colorectal mucosa 30 samples

Stage : -

Immunohistochemistry, Real time RT-PCR Up-regulation-FMNL2 may play an important role in the metastasis of CRC and may be a useful marker for metastasis of CRC.

18971169   2008Cell line : SW480/M5, LoVo, SW620, LS174T, SW480, HT 29

Source : -

Sample Type : -

No. of Sample : -

Stage : -

real time RT-PCR and immunohistochemistry , Boyden assay.Up-regulation-FMNL2 may play an important role in the invasion and metastasis of colorectal cancer.

FMNL2 was highly expressed in SW480/M5, LoVo and SW620 cells derived from metastatic colorectal cancers in comparison with that in LS174T, SW480 and HT29 cells, which were derived from primary colorectal cancers.

21071512   2010Cell line : -

Source : -

Sample Type : -

No. of Sample : -

Stage : -

-Up-regulation--

21506128   2011Cell line : SW480/M5

Source : -

Sample Type : -

No. of Sample : -

Stage : -

real time RT- PCR and western blottingUp-regulation-FMNL2 is a positive regulator of cell motility, invasion, and metastasis of colorectal carcinoma.

FMNL2 overexpression in metastatic cell lines and tissues of colorectal carcinoma is associated with more aggressive tumour behaviour.

23201162   2013Cell line : -

Source : -

Sample Type : CRC tumor and normal tissue

No. of Sample : 50 CRC patient sample

Stage : -

real time RT-PCR, Immunoblotting , Luciferase reporter assaysUp-regulation-Levels of miR-137 and HMGA1 are reduced, and levels of FMNL2 are increased, in CRC samples compared with adjacent normal mucosa.

FMNL2 appears to activate phosphatidylinositol-4,5-bisphosphate 3-kinase, protein kinase B (Akt), and MAPK signaling pathways.


Gene Details



Chromosome: 2; NC_000002.11 (153191751..153506348)

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Gene Type protein coding
Gene Family -
Description This gene encodes a formin-related protein. Formin-related proteins have been implicated in morphogenesis, cytokinesis, and cell polarity. Alternatively spliced transcript variants encoding different isoforms have been described but their full-length nature has yet to be determined. [provided by RefSeq, Jul 2008]  
Chromosome 2
Location 2q23.3
Start 152335170  
End 152649834  
Strand -  
Gene Sequence

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Length 314665  
OMIM ID    
HGNC ID HGNC:18267   
Unigene ID Hs.654630    
Ensembl ID ENSG00000157827   
PharmGKB ID -   

mRNA Information


mRNA ID XM_011510532.1
Exon join(1..551,186774..186857,207570..207650,213852..213928, 223571..223654,225714..225866,239967..240075, 243719..243795,245787..245880,272170..272244, 276326..276436,279682..279831,281922..282023, 283677..283989,284340..284549,287368..287388, 290269..290393,291356..291558,293130..293364, 294487..294555,294656..294736,296839..296968, 301258..301421,302404..302505,304789..304887, 305622..305745,308250..308375,312627..314657)  
mRNA Sequence

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Length 5781  



CDS Information


   
Locationjoin(435..551,186774..186857,207570..207650, 213852..213928,223571..223654,225714..225866, 239967..240075,243719..243795,245787..245880, 272170..272244,276326..276436,279682..279831, 281922..282023,283677..283989,284340..284549, 287368..287388,290269..290393,291356..291558, 293130..293364,294487..294555,294656..294736, 296839..296968,301258..301421,30
CDS Sequence

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CCDS ID -



Protein Information


      
Protein IDNP_443137.2
Protein NameFormin-like 2
Molecular Wt. (Da)123976
Protein Sequence

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Length 1092  
Uniprot IDQ10981
Ensembl Protein ID ENSP00000375748  



Post-translational Modification Information (Source : HPRD)


Residue Type site
SPhosphorylation1016;-
SPhosphorylation1016;-
SPhosphorylation1016;-
SPhosphorylation1016;-
SPhosphorylation1018;-
SPhosphorylation1018;-
SPhosphorylation1018;-
SPhosphorylation1018;-
SPhosphorylation171;-
SPhosphorylation171;-
SPhosphorylation171;-
SPhosphorylation171;-
YPhosphorylation55
YPhosphorylation55
YPhosphorylation55
YPhosphorylation55
SPhosphorylation179
SPhosphorylation179
SPhosphorylation179
SPhosphorylation179
SPhosphorylation183
SPhosphorylation183
SPhosphorylation183
SPhosphorylation183

Enzyme Information


No matching records could be found.

PPi Information


(Click to view network : Source STRING)      View   

               
Interactant Gene ID (Source: HPRD) Gene Symbol HPRD ID Ref Seq ID Technique References
55660PRPF40A10995NP_060362.3yeast 2-hybrid15231748   


Pathway Information


No matching records could be found.

Structure Information


No matching records could be found.

Domain Information




ID Location Description
pfam02181616-967  FH2
cl19758616-967  FH2 superfamily
smart00498617-1040  FH2
pfam06367278-475  Drf_FH3
cl05717278-475  Drf_FH3 superfamily
pfam0637123-275  Drf_GBD
cl0572023-275  Drf_GBD superfamily
pfam12718388-476  Tropomyosin_1
cl22857388-476  Tropomyosin_1 superfamily
TIGR00618349-501  sbcc
COG0419354-477  SbcC
COG1196279-486  Smc
COG1256349-501  FlgK
TIGR02168341-478  SMC_prok_B
TIGR04211371-478  SH3_and_anchor
pfam06160348-492  EzrA
TIGR02169291-479  SMC_prok_A
PRK12704381-478  PRK12704
TIGR02168377-486  SMC_prok_B
PRK11281353-452  PRK11281
COG0419349-478  SbcC
pfam04111341-454  APG6
pfam05483290-475  SCP-1
COG1196349-472  Smc
COG2433393-487  COG2433
pfam02994380-486  Transposase_22
COG0216388-478  PrfA
TIGR02168384-478  SMC_prok_B
COG1196388-478  Smc
pfam12128390-478  DUF3584
TIGR00019388-481  prfA
COG1196341-478  Smc
TIGR02169388-478  SMC_prok_A


Ontology Information


   
HPRD ID2813
Molecular ClassUnclassified
Molecular FunctionG-protein coupled receptor activity (GO:0004930)
Biological ProcessCell communication (GO:0007154); Signal transduction (GO:0007165)  



SNP Information


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Drug Information


No matching records could be found.

External Links


                                 
ArrayExpressGO
ICGCGO
Cancer3DGO
COSMICGO
NCGGO
TSGeneGO
Tumor Gene Family of DatabasesGO
CCDBGO
G2SBCGO
Osteosarcoma DatabaseGO
RCDBGO