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General Information



Gene_Symbol Gene_ID Gene_Name Chromosome Alias
UHRF2 115426 ubiquitin-like with PHD and ring finger domains 2, E3 ubiquitin protein ligase  9RNF107, NIRF, URF2, MGC33463 







  • Evidence
  • Gene
  • mRNA
  • CDS
  • Protein
  • PTM
  • Enzyme
  • PPi
  • Pathway
  • Structural
  • Domain
  • Ontology
  • SNP
  • Drug
  • External Links



Evidence Information


Pubmed ID Year Sample Information Techniques Mechanism Fold Change Remark
24573556   2014Cell line : -

Source : -

Sample Type : CRC tumor and normal tissue

No. of Sample : 203

Stage : -

real time RT-PCR, tissue microarray, western blotting,immunohistochemistryUp-regulation-UHRF2 may contribute to the progression of colon carcinogenesis and function as a novel prognostic indicator after curative operation.


Gene Details



NC_000009.11 (6413151..6507054)

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Gene Type protein coding
Gene Family RING-type (C3HC4) zinc fingers, "Zinc fingers, PHD-type"
Description This gene encodes a nuclear protein which is involved in cell-cycle regulation. The encoded protein is a ubiquitin-ligase capable of ubiquinating PCNP (PEST-containing nuclear protein), and together they may play a role in tumorigenesis. The encoded protein contains an NIRF_N domain, a PHD finger, a set- and ring-associated (SRA) domain, and a RING finger domain and several of these domains have been shown to be essential for the regulation of cell proliferation. This protein may also have a role in intranuclear degradation of polyglutamine aggregates. Alternative splicing results in multiple transcript variants some of which are non-protein coding. [provided by RefSeq, Feb 2012]  
Chromosome 9
Location 9p24.1
Start 6413151  
End 6507054  
Strand +  
Gene Sequence

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Length 93904  
OMIM ID 615211   
HGNC ID HGNC:12557   
Unigene ID Hs.493401   
Ensembl ID ENSG00000147854   
PharmGKB ID PA37197   

mRNA Information


mRNA ID ?NM_152896.2
Exon  
mRNA Sequence

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Length  



CDS Information


   
Location
CDS Sequence

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CCDS ID CCDS6469.1



Protein Information


      
Protein IDNP_690856.1
Protein Nameubiquitin-like with PHD and ring finger domains 2, E3 ubiquitin protein ligase
Molecular Wt. (Da)0
Protein Sequence

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Length 802  
Uniprot IDQ5FBB7
Ensembl Protein ID ENSP00000263753  



Post-translational Modification Information (Source : HPRD)


Residue Type site
SPhosphorylation667

Enzyme Information


No matching records could be found.

PPi Information


(Click to view network : Source STRING)      View   

                              
Interactant Gene ID (Source: HPRD) Gene Symbol HPRD ID Ref Seq ID Technique References
1017CDK2310NP_001789.2in vitro;in vivo15178429   
57092PCNP17826NP_065090.1in vitro;in vivo;yeast 2-hybrid1   474   136   912   176   010   


Pathway Information


No matching records could be found.

Structure Information


No matching records could be found.

Domain Information




ID Location Description
cd01797Jan-78  NIRF_N
cl00155Jan-78  UBQ superfamily
cd15617346-392  PHD_UHRF2
cl22851346-392  PHD_SF superfamily
cd00162732-775  RING
cl17238732-775  RING superfamily
pfam02182445-614  SAD_SRA
cl02620445-614  SAD_SRA superfamily
smart00466443-614  SRA
pfam12148177-261  DUF3590
cl13567177-261  DUF3590 superfamily
cd15525346-392  PHD_UHRF1_2
cd15616346-392  PHD_UHRF1
cd15543347-392  PHD_RSF1
cd01769Apr-74  UBL
cd15627347-392  PHD_BAZ1A
cd15519347-392  PHD1_Lid2p_like
pfam00240Jun-76  ubiquitin
cd15536347-392  PHD_PHRF1
pfam00628347-393  PHD
cd15544347-392  PHD_BAZ1A_like
cd15513347-392  PHD5_KMT2C_like
smart00249347-392  PHD
cd15628347-392  PHD_BAZ1B
cd15532346-392  PHD2_CHD_II
cd15515347-392  PHD1_KDM5A_like
cd15497346-392  PHD1_Snt2p_like
cd01803Jan-74  Ubiquitin
cd15504341-392  PHD_PRHA_like
cd15562346-392  PHD2_PHF14
cd15545346-392  PHD_BAZ2A_like
cd15605347-392  PHD1_Lid_like
cd15604347-392  PHD1_KDM5C_5D
cd15603347-392  PHD1_KDM5B
cd15489346-392  PHD_SF
cd15499347-392  PHD1_MTF2_PHF19_like
cd15530346-392  PHD2_d4
cd00196Apr-74  UBQ
cd15559347-392  PHD1_BPTF
cd15539347-392  PHD1_AIRE
cd15602347-392  PHD1_KDM5A
cd01807Jan-75  GDX_N
cd15595347-392  PHD2_KMT2D
cd15629346-392  PHD_BAZ2A
cd15534342-390  PHD2_PHF12_Rco1
cd15527347-392  PHD2_KAT6A_6B
cd15531347-392  PHD1_CHD_II
cd15523347-392  PHD_PHF21A
cd15594347-392  PHD2_KMT2C
smart00184733-771  RING
cd15563346-392  PHD3_PHF14
cd15590347-392  PHD2_KMT2A
cd15529347-392  PHD2_PHF10
cd15535347-392  PHD1_Rco1
cd15502347-392  PHD_Phf1p_Phf2p_like
cd15533342-392  PHD1_PHF12
cd15630347-392  PHD_BAZ2B
cd15510347-392  PHD2_KMT2C_like
cd15507346-392  PHD2_KMT2A_like
cd01806Jan-63  Nedd8
pfam00097733-771  zf-C3HC4
cd15524347-392  PHD_PHF21B
cd15591347-392  PHD2_KMT2B
pfam13639733-772  zf-RING_2
cd01809Mar-74  Scythe_N
cd15578346-392  PHD1_MTF2
cd15597347-392  PHD3_KMT2D
cd15509347-392  PHD1_KMT2C_like
cd04718369-412  BAH_plant_2
cl02608369-412  BAH superfamily
cd15492347-392  PHD_BRPF_JADE_like
pfam13923733-771  zf-C3HC4_2
cd15522347-392  PHD_TAF3
cd15537347-392  PHD_BS69
pfam14634734-773  zf-RING_5
cd15512347-392  PHD4_KMT2C_like
cd15610362-392  PHD3_KDM5A_like
cd15596347-392  PHD4_KMT2C
smart00213Mar-74  UBQ
TIGR00599724-772  rad18
COG5432724-774  RAD18
COG3440446-618  COG3440
COG5574728-772  PEX10


Ontology Information


   
HPRD ID17889
Molecular ClassUbiquitin proteasome system protein
Molecular FunctionProtein serine/threonine phosphatase activity (GO:0004722)
Biological ProcessCell communication (GO:0007154); Signal transduction (GO:0007165)  



SNP Information


View SNP Geneview Report   

Drug Information


No matching records could be found.

External Links


                                 
ArrayExpressGO
ICGCGO
Cancer3DGO
COSMICGO
NCGGO
TSGeneGO
Tumor Gene Family of DatabasesGO
CCDBGO
G2SBCGO
Osteosarcoma DatabaseGO
RCDBGO