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General Information
| Gene_Symbol | Gene_ID | Gene_Name | Chromosome | Alias |
|---|---|---|---|---|
| CKS2 | 1164 | CDC28 protein kinase regulatory subunit 2 | 9 |
- Evidence
- Gene
- mRNA
- CDS
- Protein
- PTM
- Enzyme
- PPi
- Pathway
- Structural
- Domain
- Ontology
- SNP
- Drug
- External Links
Evidence Information
| Pubmed ID | Year | Sample Information | Techniques | Mechanism | Fold Change | Remark |
|---|---|---|---|---|---|---|
| 24137409 | 2013 | Cell line : - Source : Department of Surgery Renji Hospital (Shanghai Jiaotong University School of Medicine, Shanghai, China) Sample Type : CRC tumor and Normal tissue No. of Sample : 30 Stage : - | RT-PCR, Western blotting | Up-regulation | - | CKS2 overexpression was correlated with aggressive tumor progression in CRC, which indicated that CKS2 may serve as a good CRC biomarker. CKS2 expression was significantly upregulated in CRC compared with the adjacent non-cancer and normal colorectal tissues |
Gene Details
| Gene Type | protein coding |
|---|---|
| Gene Family | |
| Description | CKS2 protein binds to the catalytic subunit of the cyclin dependent kinases and is essential for their biological function. The CKS2 mRNA is found to be expressed in different patterns through the cell cycle in HeLa cells, which reflects specialized role for the encoded protein |
| Chromosome | 9 |
| Location | 9q22 |
| Start | 89311195 |
| End | 89316703 |
| Strand | + |
| Gene Sequence | Download Select all |
| Length | 5509 |
| OMIM ID | 116901 |
| HGNC ID | HGNC:2000 |
| Unigene ID | Hs.83758 |
| Ensembl ID | ENSG00000123975 |
| PharmGKB ID | - |
mRNA Information
| mRNA ID | NM_001827.2 |
|---|---|
| Exon | join(1..157,3976..4103,5179..5509) | mRNA Sequence | Download Select all |
| Length | 632 |
CDS Information
| Location | join(99..157,3976..4103,5179..5231) |
|---|---|
| CDS Sequence | Download Select all |
| CCDS ID | CCDS6682.1 |
Protein Information
| Protein ID | NP_001818.1 |
|---|---|
| Protein Name | CDC28 protein kinase regulatory subunit 2 |
| Molecular Wt. (Da) | 9729 |
| Protein Sequence | Download Select all |
| Length | 79 |
| Uniprot ID | P62993 |
| Ensembl Protein ID | ENSP00000317360 |
Post-translational Modification Information (Source : HPRD)
| Residue | Type | site |
|---|---|---|
| K | Acetylation | 4 |
| Y | Phosphorylation | 7 |
Enzyme Information
No matching records could be found.
PPi Information
(Click to view network : Source STRING) View
| Interactant Gene ID (Source: HPRD) | Gene Symbol | HPRD ID | Ref Seq ID | Technique | References |
|---|---|---|---|---|---|
| 1163 | CKS1B | 299 | NP_001817.1 | in vitro | 2227411 |
| 1915 | EEF1A1 | 559 | NP_001393.1 | yeast 2-hybrid | 16169070 |
| 9094 | UNC119 | 4927 | NP_005139.1 | yeast 2-hybrid | 16169070 |
| 81628 | TSC22D4 | 18231 | NP_112197.1 | yeast 2-hybrid | 16189514 |
Pathway Information
| Pathway Name | Pathway ID |
|---|---|
| Pathways in cancer | hsa05200 |
| Small cell lung cancer | hsa05222 |
Structure Information
| PDB ID | 1CKS |
|---|---|
| Resolution | 2.1 |
| Method | X-RAY DIFFRACTION |
| Chains | A, B, |
| Molecule | CYCLIN-DEPENDENT KINASE SUBUNIT, TYPE 2 |
| Model | View |
Domain Information
| ID | Location | Description |
|---|---|---|
| pfam01111 | May-74 | CKS |
| cl03104 | May-74 | CKS superfamily |
| smart01084 | May-74 | CKS |
| PLN00010 | May-79 | PLN00010 |
| PTZ00453 | May-72 | PTZ00453 |
Ontology Information
| HPRD ID | 674 |
|---|---|
| Molecular Class | Cell cycle control protein |
| Molecular Function | Structural constituent of cytoskeleton (GO:0005200) |
| Biological Process | Cell growth and/or maintenance (GO:0008151) |
Drug Information
No matching records could be found.