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General Information
- Evidence
- Gene
- mRNA
- CDS
- Protein
- PTM
- Enzyme
- PPi
- Pathway
- Structural
- Domain
- Ontology
- SNP
- Drug
- External Links
Evidence Information
| Pubmed ID | Year | Sample Information | Techniques | Mechanism | Fold Change | Remark |
|---|---|---|---|---|---|---|
| 21590459 | 2011 | Cell line : - Source : Fourth military medical hospital, China. Sample Type : CRC tumor and normal tissue No. of Sample : 256 Stage : - | Immunohistochemistry | Up-regulation | - | Important role of MMP-21 in the invasion and metastasis process in human colorectal cancer. It might also serve as a novel prognostic marker |
| 21656525 | 2011 | Cell line : - Source : - Sample Type : CRC tumor and normal tissue No. of Sample : 286 Stage : TNM Stage II,III | Immunohistochemistry | Up-regulation | - | These results suggested the potential role of MMP-21 in the invasion and metastasis process of human colorectal cancer. It could also be a novel molecular marker to predict prognosis of patients with stage II and stage III colorectal cancer. |
Gene Details
| Gene Type | protein coding |
|---|---|
| Gene Family | - |
| Description | This gene encodes a member of the matrix metalloproteinase family. Proteins in this family are involved in the breakdown of extracellular matrix for both normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, and disease processes, such as asthma and tumor metastasis. The encoded protein may play an important role in embryogenesis, particularly in neuronal cells, as well as in lymphocyte development and survival. [provided by RefSeq, May 2013] |
| Chromosome | 10 |
| Location | 10q26.3 |
| Start | 127455022 |
| End | 127464390 |
| Strand | - |
| Gene Sequence | Download Select all |
| Length | 9369 |
| OMIM ID | 608416 |
| HGNC ID | HGNC:14357 |
| Unigene ID | Hs.314141 |
| Ensembl ID | ENSG00000154485 |
| PharmGKB ID | PA134885721 |
Protein Information
| Protein ID | NP_671724.1 |
|---|---|
| Protein Name | matrix metallopeptidase 21 |
| Molecular Wt. (Da) | 0 |
| Protein Sequence | Download Select all |
| Length | 569 |
| Uniprot ID | A0PJX4 |
| Ensembl Protein ID | ENSP00000326445 |
Post-translational Modification Information (Source : HPRD)
No matching records could be found.
Enzyme Information
No matching records could be found.
PPi Information
(Click to view network : Source STRING) View
No matching records from HPRD source could be found.
Pathway Information
No matching records could be found.
Structure Information
No matching records could be found.
Domain Information
| ID | Location | Description |
|---|---|---|
| cd04278 | 171-327 | ZnMc_MMP |
| cl00064 | 171-327 | ZnMc superfamily |
| cd00094 | 350-536 | HX |
| cl02471 | 350-536 | HX superfamily |
| cd00094 | 322-495 | HX |
| cd00094 | 393-528 | HX |
| cd04268 | 185-326 | ZnMc_MMP_like |
| pfam01471 | 48-112 | PG_binding_1 |
| cl18368 | 48-112 | PG_binding_1 superfamily |
| cd00203 | 192-326 | ZnMc |
| cd04279 | 201-327 | ZnMc_MMP_like_1 |
| cd04277 | 192-327 | ZnMc_serralysin_like |
| smart00120 | 394-449 | HX |
| pfam00045 | 394-449 | Hemopexin |
| cd11375 | 277-293 | Peptidase_M54 |
| pfam00045 | 333-390 | Hemopexin |
| cd04273 | 272-329 | ZnMc_ADAMTS_like |
| smart00120 | 451-494 | HX |
| cd04276 | 273-312 | ZnMc_MMP_like_2 |
| COG1913 | 277-321 | COG1913 |
| smart00120 | 333-390 | HX |
| cd04275 | 268-299 | ZnMc_pappalysin_like |
| pfam00045 | 451-494 | Hemopexin |
| pfam00413 | 170-327 | Peptidase_M10 |
| smart00235 | 171-328 | ZnMc |
Ontology Information
| HPRD ID | 9903 |
|---|---|
| Molecular Class | Metallo protease |
| Molecular Function | Molecular function unknown (GO:0005554) |
| Biological Process | Cell communication (GO:0007154); Signal transduction (GO:0007165) |
Drug Information
| Uniprot ID | DrugBank ID | Name | Type |
|---|---|---|---|
| Q8N119 | DB00786 | Marimastat | SmallMoleculeDrug |