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General Information



Gene_Symbol Gene_ID Gene_Name Chromosome Alias
CLU 1191 clusterin  8SGP-2, SP-40, TRPM-2, KUB1, CLU1, CLU2 







  • Evidence
  • Gene
  • mRNA
  • CDS
  • Protein
  • PTM
  • Enzyme
  • PPi
  • Pathway
  • Structural
  • Domain
  • Ontology
  • SNP
  • Drug
  • External Links



Evidence Information


Pubmed ID Year Sample Information Techniques Mechanism Fold Change Remark
19623170   2009Cell line : -

Source : -

Sample Type : Serum and stool of CRC patients and control

No. of Sample : -

Stage : -

dot blot immunodosageUp-regulation-Highlights the potential of clusterin detection in stool to be a valuable tool to improve the effectiveness and efficiency of large-scale clinical cancer screening.

Significant increase of sCLU in the serum and stool of CRC patients (P=0.0002 and P<0.000, respectively) as compared with controls.

16854844   2006Cell line : -

Source : Complejo Hospitalario Universitario de Vigo (Vigo, Spain)

Sample Type : Serum sample

No. of Sample : 10

Stage : -

Affinity Chromatography, Gel Electrophoresis,2-D Gel Electrophoresis,Mass SpectrometryUp-regulation-serum clusterin and some of its isoforms could have a potential value as colorectal tumor markers and are interesting subjects for biomarker studies.

immunoquantification by slot blot showed that in total serum and in FI the clusterin levels were significantly increased in patients, whereas in FII there was no significant variation.


Gene Details



Chromosome 8 - NC_000008.11 (27596917..27615031, complement)

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Gene Type protein coding
Gene Family
Description The protein encoded by this gene is a secreted chaperone that can under some stress conditions also be found in the cell cytosol. It has been suggested to be involved in several basic biological events such as cell death, tumor progression, and neurodegenerative disorders. Alternate splicing results in both coding and non-coding variants.[  
Chromosome 8
Location 8p21-p12
Start 27596917  
End 27615031  
Strand -  
Gene Sequence

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Length 18115  
OMIM ID 185430   
HGNC ID HGNC:2095   
Unigene ID Hs.436657   
Ensembl ID ENSG00000120885   
PharmGKB ID -   

mRNA Information


mRNA ID NM_001831.3
Exon join(221..377,4432..4557,5946..6094,8508..8678, 9697..10108,10637..10741,15023..15252,16397..16572, 16782..18115)  
mRNA Sequence

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Length 2877  



CDS Information


   
Location join(251..377,4432..4557,5946..6094,8508..8678, 9697..10108,10637..10741,15023..15252,16397..16572, 16782..16791)
CDS Sequence

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CCDS ID -



Protein Information


      
Protein IDNP_001822.3
Protein Nameclusterin
Molecular Wt. (Da)50063
Protein Sequence

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Length 449  
Uniprot IDP04150
Ensembl Protein ID ENSP00000231509  



Post-translational Modification Information (Source : HPRD)


Residue Type site
NGlycosylation138
CDisulfide Bridge154;365
NGlycosylation155
CDisulfide Bridge165;357
CDisulfide Bridge168;354
CDisulfide Bridge173;347
CDisulfide Bridge181;337
NGlycosylation197
NGlycosylation343
NGlycosylation406
NGlycosylation426
NGlycosylation103
NGlycosylation145
NGlycosylation291
NGlycosylation354
NGlycosylation374
NGlycosylation86
SPhosphorylation448
SPhosphorylation396
TPhosphorylation445
SPhosphorylation446
TPhosphorylation393
SPhosphorylation394

Enzyme Information


No matching records could be found.

PPi Information


(Click to view network : Source STRING)      View   

                                                                                                                        
Interactant Gene ID (Source: HPRD) Gene Symbol HPRD ID Ref Seq ID Technique References
351APP100NP_000475.1in vitro;in vivo87   521   429   228   033   
735C9408NP_001728.1in vitro8345200   
2547XRCC61071NP_001460.1in vitro;in vivo;yeast 2-hybrid1   021   908   912   551   930   
3952LEP1249NP_000221.1in vitro;in vivo12824284   
3953LEPR3001NP_002294.2in vitro12824284   
5444PON11351NP_000437.3in vitro;in vivo8292612   
5621PRNP1453NP_000302.1in vivo15146195   
23059CLUAP110013NP_055856.1in vivo;yeast 2-hybrid15480429   


Pathway Information


      
Pathway Name Pathway ID
Complement and coagulation cascades hsa04610


Structure Information


No matching records could be found.

Domain Information




ID Location Description
smart00035228-443  CLa
cl02433228-443  CLa superfamily
smart0003023-227  CLb
cl0243123-227  CLb superfamily
pfam0109329-449  Clusterin
PTZ0000926-111  PTZ00009


Ontology Information


   
HPRD ID753
Molecular ClassComplement protein
Molecular FunctionGTPase activity (GO:0003924)
Biological ProcessCell communication (GO:0007154); Signal transduction (GO:0007165)  



SNP Information


View SNP Geneview Report   

Drug Information


No matching records could be found.

External Links


                                 
ArrayExpressGO
ICGCGO
Cancer3DGO
COSMICGO
NCGGO
TSGeneGO
Tumor Gene Family of DatabasesGO
CCDBGO
G2SBCGO
Osteosarcoma DatabaseGO
RCDBGO