Search results:
General Information
| Gene_Symbol | Gene_ID | Gene_Name | Chromosome | Alias |
|---|---|---|---|---|
| CLU | 1191 | clusterin  | 8 | SGP-2, SP-40, TRPM-2, KUB1, CLU1, CLU2  |
- Evidence
- Gene
- mRNA
- CDS
- Protein
- PTM
- Enzyme
- PPi
- Pathway
- Structural
- Domain
- Ontology
- SNP
- Drug
- External Links
Evidence Information
| Pubmed ID | Year | Sample Information | Techniques | Mechanism | Fold Change | Remark |
|---|---|---|---|---|---|---|
| 19623170    | 2009 | Cell line : - Source : - Sample Type : Serum and stool of CRC patients and control No. of Sample : - Stage : - | dot blot immunodosage | Up-regulation | - | Highlights the potential of clusterin detection in stool to be a valuable tool to improve the effectiveness and efficiency of large-scale clinical cancer screening. Significant increase of sCLU in the serum and stool of CRC patients (P=0.0002 and P<0.000, respectively) as compared with controls. |
| 16854844    | 2006 | Cell line : - Source : Complejo Hospitalario Universitario de Vigo (Vigo, Spain) Sample Type : Serum sample No. of Sample : 10 Stage : - | Affinity Chromatography, Gel Electrophoresis,2-D Gel Electrophoresis,Mass Spectrometry | Up-regulation | - | serum clusterin and some of its isoforms could have a potential value as colorectal tumor markers and are interesting subjects for biomarker studies. immunoquantification by slot blot showed that in total serum and in FI the clusterin levels were significantly increased in patients, whereas in FII there was no significant variation. |
Gene Details

| Gene Type | protein coding |
|---|---|
| Gene Family | |
| Description | The protein encoded by this gene is a secreted chaperone that can under some stress conditions also be found in the cell cytosol. It has been suggested to be involved in several basic biological events such as cell death, tumor progression, and neurodegenerative disorders. Alternate splicing results in both coding and non-coding variants.[   |
| Chromosome | 8 |
| Location | 8p21-p12 |
| Start | 27596917   |
| End | 27615031   |
| Strand | -   |
| Gene Sequence |    Download   Select all |
| Length | 18115   |
| OMIM ID | 185430    |
| HGNC ID | HGNC:2095    |
| Unigene ID | Hs.436657    |
| Ensembl ID | ENSG00000120885    |
| PharmGKB ID | -    |
mRNA Information
| mRNA ID | NM_001831.3 |
|---|---|
| Exon | join(221..377,4432..4557,5946..6094,8508..8678, 9697..10108,10637..10741,15023..15252,16397..16572, 16782..18115)   | mRNA Sequence |    Download   Select all |
| Length | 2877   |
CDS Information
| Location | join(251..377,4432..4557,5946..6094,8508..8678, 9697..10108,10637..10741,15023..15252,16397..16572, 16782..16791) |
|---|---|
| CDS Sequence |    Download   Select all |
| CCDS ID | - |    
Protein Information
| Protein ID | NP_001822.3 |
|---|---|
| Protein Name | clusterin |
| Molecular Wt. (Da) | 50063 |
| Protein Sequence |    Download   Select all |
| Length | 449   |
| Uniprot ID | P04150 |    
| Ensembl Protein ID | ENSP00000231509   |    
Post-translational Modification Information (Source : HPRD)
| Residue | Type | site |
|---|---|---|
| N | Glycosylation | 138 |
| C | Disulfide Bridge | 154;365 |
| N | Glycosylation | 155 |
| C | Disulfide Bridge | 165;357 |
| C | Disulfide Bridge | 168;354 |
| C | Disulfide Bridge | 173;347 |
| C | Disulfide Bridge | 181;337 |
| N | Glycosylation | 197 |
| N | Glycosylation | 343 |
| N | Glycosylation | 406 |
| N | Glycosylation | 426 |
| N | Glycosylation | 103 |
| N | Glycosylation | 145 |
| N | Glycosylation | 291 |
| N | Glycosylation | 354 |
| N | Glycosylation | 374 |
| N | Glycosylation | 86 |
| S | Phosphorylation | 448 |
| S | Phosphorylation | 396 |
| T | Phosphorylation | 445 |
| S | Phosphorylation | 446 |
| T | Phosphorylation | 393 |
| S | Phosphorylation | 394 |
Enzyme Information
No matching records could be found.
PPi Information
(Click to view network : Source STRING)      View   
| Interactant Gene ID (Source: HPRD) | Gene Symbol | HPRD ID | Ref Seq ID | Technique | References |
|---|---|---|---|---|---|
| 351 |    APP |    100 |    NP_000475.1 |    in vitro;in vivo |    87   521   429   228   033    |
| 735 |    C9 |    408 |    NP_001728.1 |    in vitro |    8345200    |
| 2547 |    XRCC6 |    1071 |    NP_001460.1 |    in vitro;in vivo;yeast 2-hybrid |    1   021   908   912   551   930    |
| 3952 |    LEP |    1249 |    NP_000221.1 |    in vitro;in vivo |    12824284    |
| 3953 |    LEPR |    3001 |    NP_002294.2 |    in vitro |    12824284    |
| 5444 |    PON1 |    1351 |    NP_000437.3 |    in vitro;in vivo |    8292612    |
| 5621 |    PRNP |    1453 |    NP_000302.1 |    in vivo |    15146195    |
| 23059 |    CLUAP1 |    10013 |    NP_055856.1 |    in vivo;yeast 2-hybrid |    15480429    |
Pathway Information
| Pathway Name | Pathway ID |
|---|---|
| Complement and coagulation cascades |    hsa04610 |    
Structure Information
No matching records could be found.
Domain Information
| ID | Location | Description |
|---|---|---|
| smart00035 | 228-443  | CLa |
| cl02433 | 228-443  | CLa superfamily |
| smart00030 | 23-227  | CLb |
| cl02431 | 23-227  | CLb superfamily |
| pfam01093 | 29-449  | Clusterin |
| PTZ00009 | 26-111  | PTZ00009 |
Ontology Information
| HPRD ID | 753 |    
|---|---|
| Molecular Class | Complement protein |
| Molecular Function | GTPase activity (GO:0003924) |
| Biological Process | Cell communication (GO:0007154); Signal transduction (GO:0007165)   |
Drug Information
No matching records could be found.
External Links
| ArrayExpress | GO |    
|---|---|
| ICGC | GO |    
| Cancer3D | GO |    
| COSMIC | GO |    
| NCG | GO |    
| TSGene | GO |    
| Tumor Gene Family of Databases | GO |    
| CCDB | GO |    
| G2SBC | GO |    
| Osteosarcoma Database | GO |    
| RCDB | GO |    
