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General Information
- Evidence
- Gene
- mRNA
- CDS
- Protein
- PTM
- Enzyme
- PPi
- Pathway
- Structural
- Domain
- Ontology
- SNP
- Drug
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Evidence Information
| Pubmed ID | Year | Sample Information | Techniques | Mechanism | Fold Change | Remark |
|---|---|---|---|---|---|---|
| 21113667 | 2011 | Cell line : - Source : - Sample Type : CRC tumor and normal tissue No. of Sample : 63 CRC and 126 healthy individuals Stage : - | RFLP-PCR . | Polymorhpism | - | GSTO2 NN genotype increase the risk of colorectal cancer. |
Gene Details
| Gene Type | protein coding |
|---|---|
| Gene Family | Glutathione S-transferases / Soluble |
| Description | The protein encoded by this gene is an omega class glutathione S-transferase (GST). GSTs are involved in the metabolism of xenobiotics and carcinogens. Four transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Jul 2010] |
| Chromosome | 10 |
| Location | 10q25.1 |
| Start | 106028174 |
| End | 106059176 |
| Strand | + |
| Gene Sequence | Download Select all |
| Length | 31003 |
| OMIM ID | 612314 |
| HGNC ID | HGNC:23064 |
| Unigene ID | Hs.107384 |
| Ensembl ID | ENSG00000065621 |
| PharmGKB ID | PA133787053 |
Protein Information
| Protein ID | NP_001177942.1 |
|---|---|
| Protein Name | glutathione S-transferase omega 2 |
| Molecular Wt. (Da) | 0 |
| Protein Sequence | Download Select all |
| Length | 243 |
| Uniprot ID | Q5VWQ8 |
| Ensembl Protein ID | ENSP00000259371 |
Post-translational Modification Information (Source : HPRD)
No matching records could be found.
Enzyme Information
No matching records could be found.
PPi Information
(Click to view network : Source STRING) View
No matching records from HPRD source could be found.
Pathway Information
| Pathway Name | Pathway ID |
|---|---|
| Chemical carcinogenesis | hsa05204 |
| Drug metabolism - cytochrome P450 | hsa00982 |
| Glutathione metabolism | hsa00480 |
| Metabolism of xenobiotics by cytochrome P450 | hsa00980 |
Structure Information
No matching records could be found.
Domain Information
| ID | Location | Description |
|---|---|---|
| cd03184 | 108-230 | GST_C_Omega |
| cl02776 | 108-230 | GST_C_family superfamily |
| cd03055 | Jul-94 | GST_N_Omega |
| cl00388 | Jul-94 | Thioredoxin_like superfamily |
| pfam13417 | 27-100 | GST_N_3 |
| cd00570 | 24-94 | GST_N_family |
| pfam13409 | 31-96 | GST_N_2 |
| cd03059 | 27-97 | GST_N_SspA |
| cd03053 | 24-95 | GST_N_Phi |
| cd03051 | 25-94 | GST_N_GTT2_like |
| cd03060 | 26-87 | GST_N_Omega_like |
| cd03058 | 33-97 | GST_N_Tau |
| pfam02798 | 27-95 | GST_N |
| cd03049 | 33-94 | GST_N_3 |
| cd00299 | 142-207 | GST_C_family |
| COG0695 | 24-54 | GrxC |
| cd03042 | 35-94 | GST_N_Zeta |
| cd03056 | 24-93 | GST_N_4 |
| pfam00462 | 24-54 | Glutaredoxin |
| cd03046 | 35-98 | GST_N_GTT1_like |
| cd02066 | 24-55 | GRX_family |
| COG0625 | 26-211 | GstA |
| TIGR01262 | 35-180 | maiA |
| PRK09481 | 34-190 | sspA |
| PLN02817 | 32-119 | PLN02817 |
| PLN02378 | 32-187 | PLN02378 |
| PRK15113 | 31-116 | PRK15113 |
| PLN02473 | 32-92 | PLN02473 |
Ontology Information
| HPRD ID | 17949 |
|---|---|
| Molecular Class | Enzyme: Glutathione transferase |
| Molecular Function | MHC class I receptor activity (GO:0030106); MHC class II receptor activity (GO:0045012) |
| Biological Process | Immune response (GO:0006955) |
Drug Information
| Uniprot ID | DrugBank ID | Name | Type |
|---|---|---|---|
| Q9H4Y5 | DB00143 | Glutathione | SmallMoleculeDrug |