Search results:
General Information
| Gene_Symbol | Gene_ID | Gene_Name | Chromosome | Alias |
|---|---|---|---|---|
| SERPINA3 | 12 | serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3 | 14 | ACT, alpha-1-antichymotrypsin |
- Evidence
- Gene
- mRNA
- CDS
- Protein
- PTM
- Enzyme
- PPi
- Pathway
- Structural
- Domain
- Ontology
- SNP
- Drug
- External Links
Evidence Information
| Pubmed ID | Year | Sample Information | Techniques | Mechanism | Fold Change | Remark |
|---|---|---|---|---|---|---|
| 22866096 | 2011 | Cell line : - Source : Department of Surgery, Ryhov County Hospital, Jnkping, Sweden Sample Type : CRC tumor and Normal tissue No. of Sample : 311 Stage : TNM Stage I-IV | ELISA, immunohistochemistry | Down-regulation | - | An altered serpinA3 concentration in CRC tissue may be a potential biomarker in CRC progression. SerpinA3 was found to be down-regulated in cancerous tissue as compared to paired normal tissue, while this suppression was lower at a severe disease stage. |
Gene Details
| Gene Type | protein coding |
|---|---|
| Gene Family | Serine (or cysteine) peptidase inhibitors |
| Description | The protein encoded by this gene is a plasma protease inhibitor and member of the serine protease inhibitor class. Polymorphisms in this protein appear to be tissue specific and influence protease targeting. Variations in this protein's sequence have been implicated in Alzheimer's disease, and deficiency of this protein has been associated with liver disease. Mutations have been identified in patients with Parkinson disease and chronic obstructive pulmonary disease. |
| Chromosome | 14 |
| Location | 14q32.1 |
| Start | 94612377 |
| End | 94624053 |
| Strand | + |
| Gene Sequence | Download Select all |
| Length | 11677 |
| OMIM ID | 107280 |
| HGNC ID | HGNC:16 |
| Unigene ID | Hs.534293 |
| Ensembl ID | |
| PharmGKB ID | - |
mRNA Information
| mRNA ID | NM_001085.4 |
|---|---|
| Exon | join(1..71,2058..2708,6819..7092,9965..10115,11235..11677) | mRNA Sequence | Download Select all |
| Length | 1629 |
CDS Information
| Location | join(2066..2708,6819..7092,9965..10115,11235..11438) |
|---|---|
| CDS Sequence | Download Select all |
| CCDS ID | CCDS32150.1 |
Protein Information
| Protein ID | NP_001076.2 |
|---|---|
| Protein Name | serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3 |
| Molecular Wt. (Da) | 45032 |
| Protein Sequence | Download Select all |
| Length | 423 |
| Uniprot ID | P15976 |
| Ensembl Protein ID | ENSP00000365858 |
Post-translational Modification Information (Source : HPRD)
| Residue | Type | site |
|---|---|---|
| A | Proteolytic Cleavage | 385 |
| L | Proteolytic Cleavage | 383 |
| N | Glycosylation | 33 |
| N | Glycosylation | 186 |
| N | Glycosylation | 271 |
| N | Glycosylation | 127 |
| N | Glycosylation | 106 |
| N | Glycosylation | 93 |
Enzyme Information
No matching records could be found.
PPi Information
(Click to view network : Source STRING) View
| Interactant Gene ID (Source: HPRD) | Gene Symbol | HPRD ID | Ref Seq ID | Technique | References |
|---|---|---|---|---|---|
| 351 | APP | 100 | NP_000475.1 | in vivo | 100 483 032 190 106 |
| 3211 | HOXB1 | 855 | NP_002135.2 | in vivo | 123121 |
Pathway Information
No matching records could be found.
Structure Information
No matching records could be found.
Domain Information
| ID | Location | Description |
|---|---|---|
| cd02056 | 52-417 | alpha-1-antitrypsin_like |
| cl00137 | 52-417 | SERPIN superfamily |
| smart00093 | 58-420 | SERPIN |
| pfam00079 | 51-420 | Serpin |
| cd00172 | 52-417 | SERPIN |
| cd02058 | 49-420 | PAI-2 |
| cd02049 | 49-417 | bacterial_SERPIN |
| cd02059 | 49-420 | ovalbumin_like |
| cd02044 | 49-420 | ov-serpin |
| cd02048 | 55-420 | neuroserpin |
| COG4826 | 46-420 | SERPIN |
| cd02055 | 49-417 | PZI |
| cd02051 | 55-420 | PAI-1_nexin-1 |
| cd02045 | 49-417 | antithrombin-III_like |
| cd02047 | 53-420 | HCII |
| cd02052 | 49-420 | PEDF |
| cd02043 | 70-420 | plant_SERPIN |
| cd02057 | 49-420 | maspin_like |
| cd02053 | 49-417 | alpha2AP |
| cd02050 | 54-417 | C1_inh |
| cd02046 | 49-417 | hsp47 |
| cd02054 | 72-420 | angiotensinogen |
| PHA02948 | 61-420 | PHA02948 |
| PHA02660 | 72-420 | PHA02660 |
Ontology Information
| HPRD ID | 749 |
|---|---|
| Molecular Class | Protease inhibitor |
| Molecular Function | Transporter activity (GO:0005215) |
| Biological Process | Transport (GO:0006810) |
Drug Information
No matching records could be found.