CoReCG

Search results:

General Information

Gene_Symbol	Gene_ID	Gene_Name	Chromosome	Alias
CLN3	1201	ceroid-lipofuscinosis, neuronal 3	16	JNCL

Evidence
Gene
mRNA
CDS
Protein
PTM
Enzyme
PPi
Pathway
Structural
Domain
Ontology
SNP
Drug
External Links

Evidence Information

Pubmed ID	Year	Sample Information	Techniques	Mechanism	Fold Change	Remark
24556023	2014	Cell line : HCT116 Source : - Sample Type : - No. of Sample : - Stage : -	Sequence-specific siRNA silencing, real time RT-PCR, Western Blotting	Up-regulation	-	CLN3 down-regulation with RNA interference can inhibit proliferation, apoptosis, and cell cycle progression of colorectal cancer cells.

Gene Details

NC_000016.9 (28488600..28505897, complement)
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Gene Type	protein coding
Gene Family	-
Description	This gene encodes a protein that is involved in lysosomal function. Mutations in this, as well as other neuronal ceroid-lipofuscinosis (CLN) genes, cause neurodegenerative diseases commonly known as Batten disease or collectively known as neuronal ceroid lipofuscinoses (NCLs). Many alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Jul 2008]
Chromosome	16
Location	16p12
Start	28488600
End	28505897
Strand	-
Gene Sequence	>gi\|568815582:c28492302-28466653 Homo sapiens chromosome 16, GRCh38.p2 Primary Assembly ATAACTGGTGCTGGCAGGCTACTGTCTCGGTCTTGGGCGCCACTGATCTAAGGTCACGGCTCTGCTTGCT GCTCCCACCCGCTCCAGTTTAAAACCTGCGGTTCCAGGGTTCTCCAGCCCCTCCCTTTTTCACGCTCCGA AGCCGAGAAGGCCCAAAGCGAAGACAGAGAGGACCCGGAAGTAGGGAAAACCTCTGAGCACGTGATGGGG GAACACGCGGGTGCTGTCACGTGATCCGACAAACGGCCTCTGCATAGTGCAGAACATTCTGCTGCTCTTA AAGGTACAGGCCTCAGGGTCCCTGCTGTAGACGGGGCGGGGGAGAGTACGATGGGTGGGGCGTGGTGGGT CGTAGGGCGCTCGAGATGGAGCCCCCAGCTTCCTTGATGGATCGCGGGGCGCGAGTGCCCTAGACAAGCC GGAGCTGGGACCGGCAATCGGGCGTTGATCCTTGTCACCTGTCGCAGACCCTCATCCCTCCCGTGGGAGC CCCCTTTGGACACTCTATGACCCTGGACCCTCGGGGGACCTGAACTTGATGCGATGGGAGGCTGTGCAGG CTCGCGGCGGCGCTTTTCGGATTCCGAGGGTGAGTATTCCCGCCCACCCTCATGGAACGACCACCTCTGG CTCGCAGCCCACCTGAGGGGAATGAGAGCTGACTCGGCCCCGGGAGGACACGCAAGGAGCGGTCGTGCAC CTGAGAGTAGGTGGGGGTCATGCCCTCTTCTCGCTCTCCCAGGGGAGGAGACCGTCCCGGAGCCCCGGCT CCCTCTGTTGGACCATCAGGGCGCGCATTGGAAGAACGCGGTGGGCTTCTGGTGAGTGGCCTGAGACTTC AGCGAGTGACAATGGCATGAGAAGAGGGAAGTGACCGGAGGAAAGGGGGAAGAAAGAGTTAAGCTGCGCA AAGGAGCTGAACCCACAAATATTTACTGAATCCACTGGTTTGCCCCAGGGGCAGCATGTAAAATTTCCAA ACTTCACTCCTTATCACCTTCCGGATTTAGCAAGATCCTCATACCTACCACCTGTAGGATTATTTACTTT TTTCTTCCAGCCAATTCAGCCTTAACGTTTTTTAGTGCACATATTTTTAAAAAGAAAACTTTAAATCACG ACTCCACTTGGAAAACCAGCGTTTTCCTAGTGAACGTTTAAATAAATGCATCACTACTAAAACTTTTTTA TTTTTTTAATTTATTTTATTTTATCTTATTTTTTTTTCTTTTTGAGACAGGGTCTTGCTCTGTTTCCCAG GTTGGAATGCAGTAGTGCAATCACAGCTCCCTGCAGCCTGGAACTCCTGGGCTCAAGTGATTCTCCCACC TCAGCCTCCAAGTAGGTGTGGCTACAGGTGTGCACCACCGCATCTGCCTAATTTTTATATTTTTTTATAG AGATGGGGGTCTCACTATGGGACCTGGGCTGGTCTCAAACTCGTGGCCTCAAGTGATCCTCCTACCTCAA CCTTCCAAAGTGCTGAGATTACAAGCATGAGCCACCATGCCGGGCCTGAACCTTTTTTTTTTTTTTTTTT TTTGAGACGGAGTCTCTCTCTGTCCTCCAGGCTGGAGTGCAGTGGCGCAATCTCGGCTCACTGCAAACTC CGCCTCCCAGGTTCACACCATTCTTTTGCCTCAGCCTCCGGAGTAGCTGAGACTACAGGCGCCTGCCACC ACGCCCGGCTATTTTTTTGTATTTTTAGTAGAGATGGGGTTTCACCGCGTTATCCAGGATGGTCTCGATC TCCTGACCTCGTGATCCGCCCGCCTCGGCCTCCCAAAGTGCTGGGATTACAGGTGTGAGCCACCGCGCCC AGCTTTTTTTTTTTTTTTTTTTAATTTTATTTTATTTTTGAGACAGAGTCTCACTCTATCACCCAGGCTG GAGAGCAGTGGCACAATCTCGGCTCACTGAAACCTCCACCTCCAAGGTTCAAGCTATTCTCCTGTCTCAG CTCCCCGAGTAGCTGGGATTACAGGTGCGTGCCACCAGACACAGCTAATTTTTTGTATTTTTAGTAAAGA CAGGATTTCACCATGTTGGTCAGGCTGGTCTAGAACTCCTGACCTTAGGTGATCCGCTTGCCTCCACTTC CCAAAGTGCTGGGATTACAGGCGTGAGCCACCGTGCCCCGCCCTGACATAGGGGCTTTGGGATCACAGAC TTGGATTCACTTCCAGCCTCCAAGGCCTCTCCCAGAAACTCTCTGTGACCACTCTCCTTTTTTTTTTTTT TTTTTGAGATAGAGTCTCGCTCTTGTAGCCCAGGCTGGAGTGCAATGGCACAATCTCGGCTTACTGCAAC CTCCGCCTTTCGGGTTCAAGTGGTTCTCCTGCCTCAGCCTCCTGAGTAGCTAGGATTACAGGCATGTGCA ACTTCGCCCAGCTAATTTTGTATTTTTTAGTAGAGACGGGGTTTCTCCATATTGCTCAGGCTGGTCTCGA ACTCCTGACCTCAGGCGATCCGCCCGCCTCGGCCCCTCAAAGTGCTGGAATTACAGGTGTGAGCCACTGC ACTCGGCCTCTTCCTTTTTATTTTTTATTTTTGTGACAGGGTCTTGCTCTGTCACCCAGGCTAGAGTGCA GTGGCATGATCACAGTTCACTGCAGCCTCTGACTCCTGGACTCAAGCAATCCTCCCACCTCAGCCTCCCA AGTAGCTGGGACTACAGTGCAAGCCACCACACCTGGCTAATTTTTAAATTTTTTGTAGAGATGGGGGTCT CACTATCTTGCCCAAGCACCAAAGCCTGTATTTTTGACCCCAACATTGAATGAGGATGGGATCTGGTGAT AGAGGGAAAAAAAAGAGGGGGCTGATTGAAGGGCACAGGTAAGGGAAGGTTTGGCACAAAGGCTACAGAT GGCTGCAGGATGAGGAGGGAGTTGAGACCTGTCCTGCTCCTTCCAGGCTGCTGGGCCTTTGCAACAACTT CTCTTATGTGGTGATGCTGAGTGCCGCCCACGACATCCTTAGCCACAAGAGGACATCGGGAAACCAGAGC CATGTAAGTGACTCTCTACCACCACCACCATGGTTAGTCCCTGTGGGAAGATGAGGGGGTGGGACAAGGT GGGGTAAAGTTTCCAGTCTCTGGCTGGGCACAGTGGCTCACACCTGTAATCCCAGCAGTTTGGGAGGCTG AGGCGGGCGGATCACTTGAAGTCAGGAGTTCGAGACCAGCCTGGCCAACATGGTGAAACTCCGACTCTAC TAAAAATACAAAAACTACCTGGGTGTGGTGGCACACACCTGTAGTCTGAGCTATTCAGGAGGCTGAGGCA GGAGAATTGCTTGAAGCCAGGAGGTGGAAGTTGCAATGAGCCAAGATCACACCACTGCACTCTAGCTTGG GCAACAGAGTGAGACACCATCTCAAAAAAAAGAAAGCTCTTGAATGTGTTATCTAAACAAAGTCCATTTA CAGGGCCATCTGTGGCCTGTGGTCTAGTAGTGTGAGACTCATATGGAAACCCCCTCTTCATTGTGCATGC AGAGACGCTGAGGTCCTGAGAAGTCAGTCACTGCTGACCCAAAGCCATCCTTCAAGTGAAGGCAGAGCTG GGACGGGAGCCAGGCTCTGTGTGTCTATCCCTCTGCCTCCAGGGTGAAAGACATGCTTTTCTCCCATTAG GTGGACCCAGGCCCAACGCCGATCCCCCACAACAGCTCATCACGATTTGACTGCAACTCTGTCTCTACGG CTGTGCGTACTCATCTCACCTGGTCCTTGCCTGACCCAGGGCCCCTGGGTCTATAGACCCCACTCCCAGC CCTTCACTACCCAGCTGGGACTGTCATGATTAAAACAGTTGAGACCTGGGCTGGGCGCACTGGCTCACAC TTGTAATCCCAGCACTTTGGGAGACCAAGGTGGGAGGATCACTTGAGCCTAGGAGTTTGAGACCAGCCTG GGCAGTATAGTGAGACCCCCATCTTAAAGAAAAAAATTAAAAAATATATATATATAAAATAATTGAGACC TTAATATAATTTCTGAGGCTGAGGCGGATGGATCACTTGAGACCAGGAGTTCAAGACCAGCCTGGCCAAC ATGGTGAAACCCCATCTGTACTAAAAATACAAAAATTAGCCAGGCATGGTGGTGCACGCCTGTAATCCCA GCTACTCAGGAGGCTGAGGCAGGAGAATCACTTGAACCCAGGAGGTGGAGGTTGTAGTGAGCCAAGATCG AGCCACTACACTCCAGCCTGGGTGGCAGAATGAGACTCACTCTCAAAATATATATATATATAGTTTCTGA GTCCTTTCTGTCTGCACCATATATTAGCTCATTTAAGCCACACAGCAGTCCTGTGAGCTAGGTGCTATGA TATTCCCATTTTCCAGATGAGGAAACTGAAGCTCAGAGAGTATAAACTCTTGACACACAACTAAGGAGTG GGAGAGCTGAGACTTGAACCCAGGCGTGCCTGACTCCAGAGCCTGTGTTTGTAGCAGGCCTGTTTGGCCA GCTCCTGCCTCTCCTTGGCCACGTGGTTGGGAGGGTTGTCCCCTGGAAGCTCTGCGGTCTCACTCTATTC TCCTGTCCCAGGCTGTGCTCCTGGCGGACATCCTCCCCACACTCGTCATCAAATTGTTGGCTCCTCTTGG CCTTCACCTGCTGCCCTACAGGTCTGGGTGAGGGTAGTGGGAGGCAGGGTGGGCAGGAGCTGAGAAAGGG GAGGCTGGGATGGCTGAGATGCTGAGAGTAGAGACCGACCTTCCCCCTCCCTTCCCTTCTCACCCCCTCA GCCCCCGGGTTCTCGTCAGTGGGATTTGTGCTGCTGGAAGCTTCGTCCTGGTTGCCTTTTCTCATTCTGT GGGGACCAGCCTGTGTGGTGAGTGTGTGGTTCTGTGTCAGATGGGGAGCCCCGAGGAACCACATCAGAGC ATTTGTGGGAAGAGTCTCCCCAGCCTCCCAGAGGAAAGGGATTCATTCTGTCACCCTTAGAAGCCTGCTA GGGCTATCAGCAGTAGGCGATGGGAGACTGGGACAATTTGGAGGGGTAGGCAGTGGAGGAGATGGGAGAA AATGGATGAATTAGATGGAGATTGAGGTGAACAAAGTCAAGACTCTGTGATGGACCAGGCACAGTGACTC ATGCCTATAATCCCAGCACTTTGGAAAGCCAAGGCAGGCAGATCACCTGAGGTCAGGAGTTCGAAACCAG CCTGGCCAACATGGAGAAACCCCGTCTCTACCAAAAATACAAAAATTAGCTGGGTGTGGTGGCAGGAGCC TGTAATCCCAGCTACTCGGGAGGCTGAGGCAGGAGAATCTCTTGAACCTGGGAGGCAGAGGTTGCAGTGA GCCGAGATCACGCCACTGTACTCCAGCCTGGGTGACAGGGCGAGACTCCGTCTCCAAAAAGAAAAGAAAA GAAAAAGACTGATGAAGGGGCAGAGACATCAAGGGTGCATGTCTGCCCCTGGTCTGATAACTGGGTGGAT GGAGGTGCCACTCTCCATGAAGGGACACGCAGGGGAGTGGGGCTCTGCTTCAGACCTGGAACCTGGCCTA TGCATGGGATCTATTGGAGCCTCTATGAGCTGATACTGAGGAGGCCATGGCCAGACACATTAGAGGCCTG GGCAGTGTGGCAAGGTGTGGTGTGACCATCCCAGTGCTTGTCCTCCCCCCAGGTGTGGTCTTCGCTAGCA TCTCATCAGGCCTTGGGGAGGTCACCTTCCTCTCCCTCACTGCCTTCTACCCCAGGTAAGCAGGTGGAGC AGGGAGTGTGGGGAGAGGCTGTCCCATGGTCAGCCTAGGTCCTCCTGAATGTTCCTGTGTTCTCCTTCCC AGGGCCGTGATCTCCTGGTGGTCCTCAGGGACTGGGGGAGCTGGGCTGCTGGGGGCCCTGTCCTACCTGG GCCTCACCCAGGCCGGCCTCTCCCCTCAGCAGACCCTGCTGTCCATGCTGGGTATCCCTGCCCTGCTGCT GGCCAGGTGAGCTGCCCTGAGCCGGGAGGGAGAGGGGTCCAAGGAGAGAAAACTTGGCCATGGCTGGGTG TGGTGGCTCACGCCTGTAATCCCAGCACTTTGGGAGGCCAAGGAGGGCAGATCGCCTAAGGTCAGGAAAC CAGCCTGGCCAACATGGTGAAACCCCGTCTCTACTAAAAATACAACAATTAGCCAGGTGTGGTGGCGGGT GCCTGTAGTCCCAACTACTCAGGAGGCTAAGGCAGGAGAATCGCTTGAACCCCGGAGGCAGTGGTGGCAG TGAGCCGAGATCGTGCCATTGCACTCCAGCCCGGGCGACAGAGTTAGACTCTGTCTCAGGAAGAAAAAAA AAAAAAGAAAGAAAAGAAAACTTGATTATGATTGCAATCTTCAAGTCCCTACCTTGCTGTGAAGGGAGGC GGAATCTGGACTCTGATAGCCCCAGGTGTGAGTCCTGGAGCTGCCACTTTTTAGCTTTGTAGCGTTGAAC AAGTTACTCCACCTCTCTGAACCCTCAGTTTCCCCATATCTCAAATGGCAGTTGTTCTTGCTTTCCTTGG AGGTGATGAGGGTAATGCATTCAGCACAGTGTGGTTCCCAAGGTGATTAGAAGTAGGATGAGGGTGGACT TTATTTGATTAGTTCCTTTTTTTTTTTTTTTTTTTTTTAATCAGTGTTGACCAGGTTGGCCTCGAATGTG TAGCCTTGCCTGCCTGAGTGCCAGGGCAACAGGCCTGAACCATGGCGACTCCCTTTTTTTTTTTTTTTTT TTTTTTTTTTTGAGACGGAGTCTCATGGTGTCACTCAGGCTGGAGTGCAGTGACTGGTGTGATCTCAGCT CACTGCAGCCTCGGCCTCCCGGGCTCTAGTGATTCTCCTGCCTCAGCCTCCCGAGTAGCTGGGACTACAG GCCCATGCCACCATGCCTGGCTAATTTTTTATATTTTTAGTAGAGACGGGGTTTCACTGTATTGGCCAGG CTGGTCTCAAACTCCTGACCTCAAGTGATCCACCTGCCTTGGCCTCCCATAATGCTAGGAATACAGGCGT GAGCCACCGCGCCCGGCCTGATTAGTTCTGTGTATTTTCATGCATATTACAAAACACTTTGGCCGGGCAT GGTGGCTCACATCTGTAATCCCAGCACTTTGGGAGGCCGAGGCGGGCGCACCACGAGGTCAGGAGTTTGA GACCAGCCTGGCCAATATGGTGAAACCCCGTCTCTACTAAAAATACAAAAATTAGCCAGGCTTGGTGGCG CTTGCCTGTAGTCCCAGCTACTTGGGAGGCTGAGGAGAAGAATCGCTTGAACCCAGGAGGCAGAGGTTGC AGTGAGCCGTGATTGTGCCACTGCACTCCAGGCTGGGCAACAGAGCGAGACTCCGTCTAAAAAAAAAAAA AACACACACTTTGAACTAGCCAGACACACCTGGCCCTTCACAAGATTAGTGCTTAGGACAAGTCTAAGTA GAAAAAGTGAGTCCATTTAAAGAAAAATATTAAGTAAAAATATATATATACAGGAGGAATATGGATATGG CAAATAACATGAAGCCAGAACCTAAGTGACTAAAATCGAGGAAGTTCTGGCCTAGCACAGAGTGAACGTA TAATTAATGGGAGCTAGAGCGACCATTAGAATAATAATGGCCAGAAAACAGAACTGACTCGCTAGGTATG AGCCAGCAGTCCGAACAAGGGCCTGCTGAGCACAGTGGCTCACAGCTGTAATCCCAGTGCTTTAGGAGGC TGAGGCTGGAGGACCACTAGAGGCTAGAAATTTGAGACCAGCCTGGGCAACATAGCGAGACTCCATTTAT ACAAAAAATGGAAAATATGAGGCGGGCTTGGTGGCACGTGCCTGTAGTCCCCGCTACTTGGGAGGCTGAG GCGGGAGGATTGCTTGAGCCTGGGAGGTCGCGGCTGCAGTGAGCTATGATTGCACCACTGCATTCCAGCC TGGATGCTGGAGAAAGACCCTGTCTCTGAAAAAAATCAAAACAAAATGAAGGCCCATGAATAGGAATAAG GAGATAAATTCAGGTCCAAAGAAAGAAGCCTTTGTCCACAATTGGAGCTCTCCCGCACAGCGTAGGAGCC TTAGAGGCAGTGAGCTACCCATCTTTGAAAGTGTTCAAAGGTAGAGGTGTTCCCTGGGAAAAGTGGCCTA GATGGTCCCTGGGGACCTTCCCAGCCAGTAGGGTTTTCTGACCCTGCCTTCATCCTACTCCTAGCTATTT CTTGTTGCTCACATCTCCTGAGGCCCAGGACCCTGGAGGGGAAGAAGAAGCAGAGAGCGCAGCCCGGCAG CCCCTCATAAGAACCGAGGCCCCGGAGTCGAAGCCAGGTAGGAGACACAGACCCTCAGAGAGGTCACTTT CTTTCTCTCTGGGTTTGGCCTTTTCCTCTCTGCAATAGGCAAAGTTAAGAGGGGAAAGAGAGTGAGTGTA CTGGTTATGGGAAAAGCCTTTGTCTATTTGAGAAATACTTGTTGAGGACGAGCACAGTGGCTCACGCCTG TAATATCCCAGCACTTTGGGAGGCTGAGGCAGGAGGACCACTTGAGCTCAGAAGTCTGAGTCCAGCCTGG GCAACAGAGCAAGACCTTGTCGCAAAAAAAAAAAAAAAAAAAAAAAAAAGAAAAGAAAGGAAGGAAGGGA GGGAGAGAAGAAGGGATATTAATTGAGTACTTACCATGTGCCAGGCATTCCAATCACAAGTGCTGAGGCC CTGCGGTGGGGATAAGCTGGGATGTTCTAGAACCAGAGAATGGCCAGTGAGACTGGGCAGGGTGGGCCAA TGGCCATCTGTGGAGCTGTACAAGAGACATTGGCCGGGCGTGGTGGTTCATACCTGTAATCCCAGCACTT TGGGAGGCTGAGGCAGATGGATCATTTGAGATCAAGAGTTTGAGACCAGTCTGGCCAACATGGTAAAACC CCGTCTCTACTAAAAATAAAAAAATTAGCCAGGTGTGGTGGTGCATGCCTGTAGTCCCAGCTACTTGGGA AGCTGAGGCACGAGAATCACTTGAACCCAGGAGGCAGAGGCTGCAGTGAGCTGAGATTGCACCACTGCAC TGCAGCCTGGGCAACTGAGTGAGACTCTGTCTCAAAAAATAAAAAAAATTAAAAATCAAAGAGACGTGAA GAGGTCTCACCTGGTTAGCTTTTATTTTCATCATGATAAAGTATGTATATTACTTGAAGTTTACCATTTT ATTATTTTTTATCTTACTTTATTTTTTTGAGGTGGAGTTTCGCTCTTGTTGCCCAGGCTGGAGTGCAATG GCGCAATCTCAGCTCACTACAACCTCTGCCTCCTGGGTTCAAGTGATTCTCCTGCCTCAGCCACCCGAGT AGCTGGGACTACAGACACCTGCCACCACACATGGCTAATTTTTGTATTTTTAGTAGAGATGGGGTTTCTC CATGTTGGCCAGGGTGGTCTTGAACTCCTGACCTCAGGTGATCCGCCCACCTCAGTCTCCCAAGGTGCTG GGATTACAAGCATGAGCCACTGCGCCCAGCCATTTTAACCATTTTTAAGTGTCCAATCCAGTGGCATGGA AGTGAGTTCCCACTGTTGCGTGGTCTGGTTAATTCTGTCATACCGGTGCCTCTTTGCCGAGTCTTCAGTG TGAAAACTTCATCTGCCCTTCTCTCTCTGTTCCCCTGCAGGCTCCAGCTCCAGCCTCTCCCTTCGGGAAA GGTGGACAGTGTTCAAGGTTCGGATGATGGCTGGGGTATGTCCCTGTGGGGCTTGCTCACCTCCAGGCCC CCCGCTTATATCTTCTGCCTTTTCCAGGGTCTGCTGTGGTACATTGTTCCCTTGGTCGTAGTTTACTTTG CCGAGTATTTCATTAACCAGGGACTTGTAAGTGAGGGGTGCTAGGAGGGGTGTGGAGGTGGCGATTGGGG CTGGGACCCACACAGCCCCGTCCATCTCCCCTGTCTGGTATTTGTTGCAGTTTGAACTCCTCTTTTTCTG GAACACTTCCCTGAGTCACGCTCAGCAATACCGCTGGTAAGAGGAGCGAGGGCAGTGGGCTGGGAGGGCG CCGTGGTGATGCAGCTGCCCTGCCCAGTAGGCACCGGGGGGAGCGGGATGGTCCCTGGAGGAGCCTCCTC TCCTCCCCCCAACCCTAACCTCAGGTACCAGATGCTGTACCAGGCTGGCGTCTTTGCCTCCCGCTCTTCT CTCCGCTGCTGTCGCATCCGTTTCACCTGGGCCCTGGCCCTGCTGCAGGTACCAAACCCCTGCCCCTCAC TTCACTCCCACCTTGGCTCCCAGCTTGGCTCCCAGCTTCCCCAAACCCCCTGCTTCCCACTATCAGTGGG AAGTGTAAATTTTTTTTTTTTTTTTTGAGACAGAGTCTCGCTCTGTCGTCCAGGCTGGAGTGCAGTAGCG CAATCTTGGCTTACTGCAACCTCTGCCTCCCGGGTTCAAGTGACTCTCCTGCCTCAGTCTCCTGAGTAGC TGGGATTACAGGCGCCCGCCACCATACCTGGCTAATTTTTGTATTTTTAGTAGAGATGGGATTTTGCCAT ATTGGCTGGTCTTGAACTCTTGACCTCAGGTGATCTGCCGGCCTCAGCCTCCCAAAGTGCTGGGATTACA GGGAAGTGTAAATTGTACACTATCATTTCTTAGCACAGGGAACCAAAGTCCAGCAGAGCTCCATGTAAAA TGTATAGCCTCAGGAGCCAAGCAAAACTGAGCTTCAGTACTCAGCCACTGTGTGACTTAGGGCAGGTCTC AGAACCTCTCTGAGCCTCAATTTCCTCATGTATAAATTGGGTGTGGCCAATACCTATTTTTCAGGGTAGT TGTAAGAAATAGAGATGAGAGAAAGAATCGAAGAACAAGATTTTGTAGTGTGTGTGTGTGTGTGTGTGCG TGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTTTTAAGCATTGGGATTGGGCCGGGCCAGGTGGCTC ATGCCTGTAATCCCAGCACTATGGGAGGCTGAGGCAGGTGGATCATTTGAGCTTGGTAGTTCAAGTCCAG CCTGGGCAACATGGCACAATCACATCTCTACAAAAATTAGCCAGGTGCAGTGGCGCACACCTGTAGTCTT AGCTACTGGGAAGCTGAGGTGGGAGGATCACTTGAACCCATGAGGTCAAGGCTGCAGTAACCAAGGTCAT GCCACTGCACTCCAGCCTAGGCAATAGAGCGAGACCCTGTCTCCCAGAAAAAGAAAAAAGAAAGGAAAAG TCGGAACCTTCCTCTGTCGCCTAGGCTGGAGTACAGTGGCATGATCATAGGTCATTTACCTCAGGCAAAG AGACAGGCTTTCAAATAATGTTTCTAACTATAAGAAAATGTACAGTTCTTTTATTCTAGATAGTTAATTA TAATAGAATTGGTGACTTTGAAGTCAGTGGGTTATTTATCTTGAGGGTGGTGAGCAAATTCAACTGCCCT TGGCAAACAGTAGTTTACAGCTTTAAGGGCGCAAACACCCTTCCTTACAACAGTCTAATAAAAGGAGTTT CATATAACCAGCATTCATTGTTTCAAGGTTACAAATCCACAGCCCCTGCAGGTAACTGTTACAATAAACT GTCAACTGTGACAGGAAAGTCTTCTGCCTTTGAAATTTAGGAACTTGGCCAGTCCTGGTGGCTCACACCT GTAATCCCAGCACTTTGGGAGGCCAAGGCAGGTGAATCACCTGAGGTCAGGATCAGGAGTTTGAGACCAG TCTGGCCAACACAGTGAAACCCCGTCTCTATTAAAAATGCAAAAATTAGTTGGGCGTGGTGGCACCTGCC TGTCATCTCAGCTACTCGCTAGGCTGAGGCAGGAGAATTGCTTGAACTCCGGATATGGAGGTTGCAGTGA GCCGAGATTGCAGTACTGTACTCCAGCCTGGGCCACAGAGCGAGACTCCATCTCCAAAAAAAAAGACTTA GGAACTCAATTCTGTGATAGCAAAATACAGAAATAGAGATTATACTTTAGGCTAGGTGTTGTGGCTCACA CCTGTAATCCCAATGCTTTTGGAGGCTAGGGTGGGAGGATCACTCGAAGCCAGGAGCTTGAGACCAGACT GGACAACATAGTGAGACCCCCCACCTCTACAAAAAATTAAAAAAAAAAATAAGCCAGGTGGGAGAATTGC TTGAGCCCAGAAGTTTGAGAGAGCAGCCTGGGTAACATCACGAGACCTCATCTCTACAAAAAACAACAAC AGGGTGTGGTGACATTCACCTGTAATCCCAGCTACTCGGGAGGCTGAGGCAGGAGGATCGCTTTAGCCCA GGAGTTCCAGGCTGCAGTGAGCCATAATCATGCCACTGTACCCCAGCCTGGGTGAGACCCTATCTCAAAA AAAAAGATTACACTTTCATATTATGGCAAAAGCATGTAAATATCCTCCAGCCTCCTTCCTTATTTATCTG AGCAGTGCTGCAAGCCCAGGGTTTGTACCCACAAAACCCCAAATTTATAACTCAGGGTGCTTGTAGATAC CACTGAAACATGTAGCTTATGGTTTTAAGCTACATGTTTTTAGCTATAATGTTTTTTGTTTTGTTTTGTT TTTTGAGATGGAGTCTCGCTCTGTTGCCCAGGCTGGAATGTAGCGGTGCAATCTTGGCTCACTGCAACCC CTGCCTCCCAGATTCAAGCGATTCTCAAGCCTCAGCCTTCCGAGTAGCTGGGATTACAGGTGCGCCACCA CGCCCAGCAAATTTTTTGTTTTGTTTTGTTTTGTTTTGTTTTTTAGAGACAGAGTTTTGCTCTTGTAGCT CAGGCTAGAGTACAATGGCGTGATCTTGGCTCACTGCAACCTCCGCCTCCCAGGTTCAGGCGATTCTTCT GCCTCAGCCTCCTGCGTAGCTGGGATTACAGGCACGTGCCACCACACCTGGCTAATTTTTGTATTTTTTA GTAGAGATGGGGTTTCGCCATGTTGGCCAGGCTGGTCTTGAACTCCTGACCTCAGGTGATCCACCCGCCT TGGCCTTCCAAAGTGCTGGGATTACAGGTGTGAGCCACCACACCTGGCTAGAGGTGTGTCCTTTTTAATG CTCATCTTTAAGTCTACCTCAGATTTAATGAATTAGGACCTCTAGGGTAAGCCCCGCTTGGGGCATTTGT ACCTAGATCCCCAGGCAATTCTTACATATACGAAAAGTATGAACCGCCACGAGGAGGCCTACACACTGCA CAAGAGGCAATGTGGCGTGGTCAGTGCTGGGAGGATGGCACCTCCTTGAGAGACTGGGGCACAGAGGTGG GACCTACACCCTGGGGTGGGGATCGAAGAGGCTTCCTGGCCAGGTGCGGTGGCTCCTGCCTATAATCCCA GCACTTTGGGAGGCTGAGGCAGGGGGGCAGCGACTGCTTGAGACCAGGAGTTCGAGCCCAGCTGAATAGG ATGCCCGGCTACTCCCACCTTGTTTTACCATAGTGAACCAACGGTTTTTCCAATAGGGGCAATTTTGCTG CCCAGCGGATGTTTGGCAACGTCTGCAGGCATGCTTTGGTTGTCACAACTGAGGGATGCTATGGGCATCT AGCGGGCAGAGGCCAGGGATCCTGCTAAATGCGCTGCCATATACAGGACAGCCCTCACCATGCAGAACAA CCAGCACCAAACGCCAAGAGTGCTGCAATTGAGAAATCCTGGTTTCGATGGTCCCACTTCCTTTAAGAAG CCTCCATTTTTTTTTTTTTTTTTTTTTTTTTTTTTATGAGACAGGATCTTGCTCTGTCACCCAGGCTGGA GTGCAGTGGCACAATCATAGCTTACTGCAGCCTCCACCTCCTAGGTTCAAGCAATCCTCCTGTCTCAGAC TCCCGAGTAGCTGGGACTGCAGGTGCGTGCCACCATGCTCAACTAATTTTTAAATTTTTTGTAGAGACGG AGTTTTGTTATGTTGCCCAGGCTGGTCTCGAACTCCTGGCCTCAAGTGATCATCCCACCTTGGTCTCCCA ATGTGCTGGTATTACCTGCATGAGCCACTGCACCAGGCTGAGGTTGAGAATTTTTTTTTTTTTTTTTTGG GATGGAGTCTCTCTCTGTTGCCCAGGCTGGAGTGCAGTGCTGCGATCTTGGCTCACTGCAGCCTCTGCCT CCCAGGTTCAAGTGATTCTCCTGCCTCAGCCTTCCAAGTAGCTGGGACTACAGAACCACTACACCCAGAT AATTTTTGTATTTTTAGTTGAGATGGGGTTTTACCATGTTTAGTAGAGACCAGGCCAGGCTGGTCTCGAA ATCCTGACCTCAGGTGATCTGCCCACCTCAGCCTCCCAAAGTGCTGGGATTACAGGTGTGAGCCACCACA CCGGGCTGGTGTTGAGATTTTATCTAGACCTGGCAGCCCTCTCCTTCACCAGTAACTCCTAAAACCAGGG ACCCCTGGAGGGGAGGCCACCTCTCCTTCCCTGCCCCGCCCTGGTCCCAGGCTTAGCCTCTCCCCCTGTT CACAGTGCCTCAACCTGGTGTTCCTGCTGGCAGACGTGTGGTTCGGCTTTCTGCCAAGCATCTACCTCGT CTTCCTGATCATTCTGTATGAGGGGCTCCTGGGAGGCGCAGCCTACGTGAACACCTTCCACAACATCGCC CTGGAGGTCAGCATTGGCCGGGCAAGGGCTGGGGGTGGCCTGTCCAGGGACACCCAGGGCAGGGATGTCT GGGACTGAAGCCTCACCCCTGCTCTCTGCCCTCCCAGACCAGTGATGAGCACCGGGAGTTTGCAATGGCG GCCACCTGCATCTCTGACACACTGGGGATCTCCCTGTCGGGGCTCCTGGCTTTGCCTCTGCATGACTTCC TCTGCCAGCTCTCCTGATACTCGGGATCCTCAGGACGCAGGTCACATTCACCTGTGGGCAGAGGGACAGG TCAGACACCCAGGCCCACCCCAGAGACCCTCCATGAACTGTGCTCCCAGCCTTCCCGGCAGGTCTGGGAG TAGGGAAGGGCTGAAGCCTTGTTTCCCTTGCAGGGGGGCCAGCCATTGTCTCCCACTTGGGGAGTTTCTT CCTGGCATCATGCCTTCTGAATAAATGCCGATTTTATCCATGGACTTCTTATATCGTTTTTGTCTCTAAA AAGAAACTTTTATTATGAAAGTAATACATGCCCACTTTCCTATATATAGACAGCATAAAGAAGGTATGTC AGCAGATTTCTCCCTTTTTTGTTTGTTTGTTTGTTTGTTTGTTTGTTTTGACAGAGTCTCACTCTGTCAC CTAGGCTGGAGTGCAATGGCGTGATCTTGGCTCACTGCAACCTCCACTTCCCGGTTCAAGCAATTCTCCT GCCTCAGCCTCCCGAGTAGCTGGGATTACAGGTGGTCACTACCATGTCTGGCTAATTTTTATATTTTTAG TACAGACGACATTTTGCCATGTTGGCCAGGCTGGTCTCAAACTCATGACCTCAGGTGATCCGCCCACCTT GGCCTCCCAAAGTGCTGAGATTACAGGTGTGAGCCACTGTACCTGGCCTCTGCCATCTTTGAGGCCTTAC GTATTCATTCATTCATGCATTCATTGTTTGGGACAATCTGTAAACAATCATGTTGGACATTCTTTCCAGC ATGAAAGTTTTCAGAGAAGTGGAAAGAATTGTGCAGTGAATCATCCTGAGTATGCGCCACCCTGTTCTAT GTTAACATTTTGTTACAGTTGTTTTATCATGTAGTCCAGCCCCCATCAAATCTATGTATTCACTGTTCCA TCAGTGAGTAGATAGAGCTAATGAATGGCAGGGTTGGCACCTGAGGCATTTTATTTTATTATTTTTTTTT ATTTTTAGAGACAGGGTTGCACTCTGTCACCCAGGCTGAAGTACAGTGGCACAGTCATGGCTCACTGTAG CCTTGACCTCCTAGACTCAAACAATCCTCACACCTTGGCCTCCCAAGCAGCTGGGACTGCAAGTGCATGC CACCAAGCCCAGCTAATTTTTTTTTTTTTTTTTGTAGAGACGCGATCTTCCTATGTTACCCAGGCTGGTC TTGAACTCTTGAGCTCAAGCAGTCCTGCCTTGGCCTCCCAAAGTACTGAGATTACAAGCATGAGCCACTG CTCCTGGCATCCTGTTATTTAGGTACAGTTTTTATACACAGTAAAATGTATAAATTGTTACATATTTTTA CAGTAAACTGAGTCTGGGCCAGGCACTGTGGCTCACACCTGTAATCCCAGCACTTTGGGAGGCTGAGGCG GGCAGATCACCTGAGGTCAGGAGTTTGAGACCAGCCTGCACAACGTGACAAAACCCCGTCTCTACGAAAA ATATAAAAAATTAGCCAGGTGTGGTGGCTTGCACCTGTAGTCCCAGCTACTTGGAAGGCTGAGGCGCAAG AATTGCTTGAACCCAGGAGGCGGAGGTTGTGGTGAGCTGAAATTGCACCACTGCACTCCAGCCTGGGCAA CAGAGCAAGACTCTGTCTCAAAAAAAAAAACAAAAAAACTGAGTCTGACTTAGTGTTTCTCATACTTCAT TGTTACCCTTTCTACTATATTTGCCATATCTGAACCTAACAGTACTTTTATTTACTTAATATTTTTCATT AAAGCAACTAACCTTTAATATACATTCAGTTATTTTAAAGGGAAACATTATTAAAATCATGAGTTTGAGG TGATATATATGTATTTTCTACTTTACTTTAAATAGTTATGTAACTATTGGAGTTTAAAATGAACATGCAA GTTCCCCCTGAGACTACTCCATTACGACCAGTGATGTTTGTGGACCCAGATCTAGGAAATGCTGACCCAC TGGTTAATAGCATGGGCTTTGGGGGCAGAAGGAACTGACTTTCAGGTGCCAACCCTGCCATTCACTAGCT CTATTACCTTGGGCAAGTCACTTCACCTCTCTGCACCTCAGTTTCCTGATCTGTCCAATGGGATAATAGT AGCACCAGCATTTCATAAGTTGCTTTTGGAAACTACATGAGATCATGTCAACACTCAATAAACATCAGCT CTGATCATGCTATGATATGACTCCTGCCTCTCACCTTTGCATTGCATTATACCCGTGTTTCTCAAACCTT AGTGTGTACTGGAGGCCTTGTTTTTTGTTTTTGTTTTCTTGGAGACCAAGAGTCTTGCCCTGTCACCCAG GCTGGAGTACAGTGGCATGATCATAGCTCACTGCAGTCTCAACCTCCTGGGCTCAAGGGGTCCTCCTGCC TCAGCCTCCTGAGTATCTAAGACTGCAGGCACGCACCACCATACCTGGCTAATTTTTATATTTTTGGTAG AGATGGGGTTTCACCATGTTGTCCAAGATAGTCTTGTACTCCAGAGCTCAAGTGATCCACCCACCTTGGC CTCCCAAAGTGCCAGGATCACAAGTGTGAGCCACTGCACCTGGCCCTGCCTGGCTAATTTTTATTTTTTT TCTGTAGAGACGAGGTCTTGCTTTGTTGCTCAGGCTGGACTGGAACTCCTGGCCTCAAGTGATCCACCTG CTTCAGCCTCCCAAAGGTCTGGGATTATTACCCATGAGCCACCACACCCAGCCACAATATTTTATTTATC CATTTGTTAGTTGATGGATATTGGGGTTTCAATTTTTTGACTTAACTATGAATCATGCTGCTATAAATGT TTGGGTAAAGTTTTTGTGTGGACACATGTTTTCCATTTCTCTTGGATAATATCAAGGAGTGGAATTGCTG GGTTGATGGTAATTTTGTTTGATCCTTTGAGGAACTACCCGACTGTTTCCCAAAGTGGCTGCAATTTTAC ATTCCACTGGCAGTGTACGAGGACTCCACGTCCCCACCAATACTTGCTCTTTTCCATTCTTTTTCCACCG CAACCTCCGTCTCCCCGGTTCAAGTGATTCTCCTGCCTCAGCCTCCCTCTTTTTTTTTTATTTTTGAGAC AGTCTCGCTCTGTTGCGCAGGATGGAGTGCAGTGGTGCTATCTCGGCTCACTGCAATCTCAGTCTCCTGA GTTCAAGTGATTCTCCCACCTCAGCCTCCCAAGTAGCTGGGATTACAGGCATGCGCCACTACACCTGGCT AATTCTTTTTTGTTGTTGTTTTTTGTTTTTGTTTTGTTTTGTTTTTTCAGATGGAGTCCTGCTCTGTCAC CAGGCTGGAGTGCAGTGACGCAGTCTCTGCTCACTGCAGCCTCCGCTTCTGGGTTCAAGCTATTCTTCTG CCTCAGCCTCCCAAGTAGCTGGGATTACAGGCACCCACCACCACACCTGGCTAATTTTTGTATTTGTTAT GGAGACGAGGTTTCGCCATGTTGGCCAGGCTGGTCTCCAACTTCTAAACTCAGGTGATCCACCGGCCTTG GCCTCCCAGAGTGCTGGGATTACAGGCATGAGCCACCGTGCCCAGCCTCTTTTCCGTTTTTGTTTTTTTT TTTTCCTTTGGTTGTCTGGTTTGGTTTTTATTATAGCCTTTCTAGTGAGTGTGAAGTGGTATCTCACTGT GGTTTTGATTTGCATGTCCCTGGTGACTAATGATGCTGAGCATCTTTTCATGTCCTTATTGACCGTACAT ATAGTTCTTTGAGAAATGTCTTCTCAGATCCTTTGCCCATTTTTAAATGGGATTGTCTTTTTTTATTAAA GAGCCAGAGATCTGAAGTCTTTTTGAGTTGTAAGATTTCTTCATATATTCTAGACAGAAGTCCCTTATAA GATACATGATTTGCAAATATTTTCTCCCATTCTGTGTTGTCTTTTTACTTTTTTGATATTGTCTTTTGGT ACGGAAAGACACTTATTTTGATGAAGTCCAATTTATCTATTTTTTGTTTGGTTGCTTGTGCTTCTGGTAA CATATCTAAGTGGGAGCCAGGTGCAGTGGCTCATGCCTGTAATCCCAGCACTTTGGGAGGCCAAGGCGGG AGGTTTGCTTGAGACCAGGAGTTCAAGACCAGCATGAGCAACATTGCAAGGTTCTATCTCTATAAAAAAT TAAAATAATGATAAAAGGAGGCCGGGCGTGGTGGCTCATGCCTATAATCCCAGCATTCTGGGAGGCAGGA GGACAACTTGGGCCAGGAGTTCAAGACCAGTCTGGGCATCATGGCAAAAAAAGAAAAAAGAAAAAATTAT CCTGGCAAGGTATGCCTGTAGTCCCAGCTACTTGGGAGGCTGAGGCGGGAGAATTGCTTGAGCCCGAGAG GTGGAGGTTGTAGTGAGCTGAGATTGAACCATTGCACTCCAGCCTGGGTGACAGGAATGAAACCCTGTCT CAAAAAATAAAAATAAAATAAGCCAGGTGTAGTGCTGCGTGCCTGTACTCCCAGCTACTCTGGAGGCTGA AGTGGGAGGATCACTTGAGCCTAGGAATTCGAGGCTGCAGTGAGCTATGATCATACCACTGCACCCCAAT GTGGGCACAGAGCAAGACCCTATCTCTTAAAAAACAAACAAAGAGGGGCGGGGTGCAGTGGCTCACGCCT GTAATCCCAGCACTTTGGGAGGCTGAGGCGGGCAGATCACGAGGTCAGGAGATCGAGACCATCCTGCCTA ACACGGTGAAACCCCATCTCCTTTTTTTTTTTTTTTTTTTTTGAAACAGAGTTTCATTCTTTTTGCCCAG ACTCCCGGGTTCAAGCGATTCTCCTGCCTCAGCCTCCTGAGTAGCGGGGATTACAAGGGTGTGCCACCAC ACCCAGCTAATTTTTTATATTTTTAATAGAGGCGGGGTTTCACCGTGTTGGCCAGGCTGGCCTCAAACTC CTGACCTCAAGTGATCCGCCCACCTCGGCCTCCCAAAGTGCTGGGATTACAGGCGTGAACCAGCGCGCCC AGCCTCCTACATTTTCTTCTAAGAGTTTTATAGTTTTAGCTCTTACATTTAGATCTTGTTTTCATTTTGA ATTAACTTTTTTGCAGGTGGTGTGATACAGCAGTCTGTGCAGAAAAAAGTTAACATAGTAGACCCTAACT GCTAACTTTATTTTTACTTTTATTTTTTATTTTGTTTAGAGACAGGGTTTTTGTCACCCAGGATGGAGTG AAGTGGCGTGATCATAGCTCACCGTAACCTTGAACTCCTGGGCTCCTCTGCCTCAGCCTCCCAATTAGCC ACCACACCCAGCTACCTTTTGTACATTTTTTTGGTAGAGACGGTGTCTCACTATGTTGCCCAGTCTGGTC TCAAACTCCTCAGCTCAAATGATCTGCCCACCTTGACCTCCAGAGATACTGGGATTACAGGCGTGGGCCA CTGCACCAGACCCAGGTTTATTCTTACACCAATACAACACTGTCTTAATTACTATAGCTTTGTAGTGAGC TTTTGAAAATAGGAAATGTGAATCCTCCAACTTTTTTTTTTTGGAGACGGAGTCTCGCTCTGTTGCTCAG ACTGGAGTGCAGTGGCACTATCTCAGCTCACTGCAAACTCCATCTTCCAGGTTCAAGTGATTCTCCTGCC TCAGCCTACCAAGTATCTGGGACTACAGGCAGGTGCCACCATGCACAGATTCCTTGGACATCCCTGAGAG GTCAATCATGAAGGTCAACTTGGTTTTCTCCCCCTCATTTGGGTTCAGAATTTAAAGTCCACACACACAG GCAGTAAGATGATTATAGATAAGGACATCATCACTCGGTTTCGGATGTTAAATTGTCTAGGTGGGTTAGG GGTGATTTGAGATCACACAACCTTGTGCCACAAAGAGGAATTCCCAGGCCAGAGGGAGACATTTTATTGC CATGTTATGATCTTATCATTGAGTTGAAAGGCAATCTTGTTTCATTTTGGATTCTTTCTTATGTTTATGT CTTATAAGGGCACTTTGAATTTCCAAGCAAATAATAATTTTGAATTAGCTTTTAATCATTGACTTCTAGC ACAGTTATATGATCAGAAACGTGCTGTGTGATTTGATTGCTCTCAAATATATTGAGATTTGCTGGAACAA AATAAGTCAGGTTAATTTTTGTAAATGTACCATGCTTGCTTAAAATGAATGTATCTACATTTGTTCCTGA GATACGGGTTGATGGACGGATGGCTACATGGATGTGATGGAGATGGTTTACTATCGGGACCTTCCGCATC CTGCTGATGTTTTGTTGCTTAGGATATGAATGGCTGAGCGGAGGCTGTAAAACCTGGCACTCTGCTTGGG TATGAGGTTCTTCCTGCCATCCTGCCATCATTTGTTTTTTATGTTTTGTCGCCAAAAGTGACCTTGAGGA ACCCTGGGAGCTCAGGAAGGAAGGAGCGCCCAGAAGCAGGGACAGGGAGCTGGTTGGGGAGGACCAGAAA TCAGGTTTGTGAAGGTTCCAGAGAGGACCTGTCCTTGCGAGGAGTGTGGGAGACTGAGATGGGGGAGGGG TCATTGGAATGATGCGGGCGCTACTTGGCATTGTCCATTGTGAGGCACCACCGGGGTCATCAGGGATTGG TGGAGAGGGAGTATAAAGCCCCAGGTTTGCTAAGGGAGGGCCCAGACCGAAGAAGGTTTGGCGGATAGCA GAACCTTTTTGTCTCCCTCTAATTGCTCCTAAGCCTCACGCTCCCTTGCCCCGCGTGTCCTGTTGCTTCC CTGATCTTCTCCGTGACCTGTAGCTAAACCTTCCACCAGCGCTTGAGAACTTAATTTGAACCGGATCCTT TCCCAGACCCCTTTCTTCTTCTCCTCCTCCACCTCCTCCAGGTGCCCAACAGCCCCCTTCTCCTCCTTTC CCTTCCCTTACTTCCCCCCTTCCCCTCCCCTTCCCCTCCCCCTCCCCTCCCCTTCCCCTCCCCTTCCCCT TCCCCTCCCCCTCCCCTTCCCCTCCCCCTCCCCTTCCCCTCCCCCTCCCCTCCCCCGCCCCAACTCAGAT CCGGCCCCGGTCCCCGTCCCCTTCCCTCCCCCCTGCCCTAAGCCACCTCCACCTCTGTCCTGGCCGCCTC AGGGCACCCTGAAAGGATCAGGACATGCGGCTGCGCTTTTGGCTCCTCATTTGGCTCCTGCTGGGATTTA TCAGCCATCAGCCCACCCCTGTGAGTAGACGCTGGACCCGCGGGGTTTCTTCCTTTTTACTGGGCTGTGT CACGCGGCATGAAATTACACAGCTCAGGCCTGTAATCCCAGCACTTTAGGGGGCCGAGGTGGGCAGATCA CTTGAGTCCAGGAGTTGAAGACTAGCCAGGGCATCATGGCGAAACCCCATCTCTACAAAAAATTCCAAAA AAGATTAGTCGGGCCTGGTGGTGCGTACCTGTTATCCCAGTTACTGGAGAGGCTGAGGTGGGAGGATCGC TTGGGCCGAGGAGCTGGACGTTGCAGTGAGCTGAGATGGCCCCGCTGCACTCTTGTCTCTAACAAACAAA ATGGACCAAAACAAAGTGAAATGTCATTTGATTTGTGTCATCTGGTTTGATGACTTTTTTTTTTTTTTTT TTAGACAGAGTCTCACTCTGTCGCCCAGGCTGGAGTGCAGTGGCAAGATCTCGGCTCACTGCAACCTCCG CTTCCGGGGTTCAAGCAATTGTCCTGCCTCAGCCTCCTGAGTAGCTCAGATTACAACGCCTGGCTAATTT TTGTATTTTTAGTAGAGACGGGGTTTCACCATGTTCGCCAGGATAGTCTCCATCTCTTGACCTCGTGATC CGCCTGCCTCGGCCTCCCAGTGCCGGGATTACAGGCGTGAGCCACCGCGCCTGGCCAAAATATATAACCT TAAGTGTAAGTTTACTAACTTTGGAAAGTACATACACCAGCATAAACCGACCCCCTTTCAAGATCTACAT TATTTTATTTATTTATTTATTTTTTTGAGACAGTTTCTCCCTTGTTGCCCAGGCTGGAGTGCAATGGGGC AATATCAGCTCACCGCAACCTCTGCTTCCCAGGTTTGAGCGATTCTCCTGCCTCAGCCTCCCGGGTGGCT GGGATTACAGACATGTGCCACCACTCCCAGCTAATTTTGTATTTTTAGTAGAGATAGGGTTTCTCCATGT TGGTCAGGCTGGTTTTGAACTCCCGACCTCAGGTGATCCGCCCGCCTCGGCCTCCCAAAGTGTTGGGATT ACAGGCGTGAACCACCGTGCCCAGCCAAGATCTACACTATTATGTCACCCCAGAAAGTGAACTCTCAGTC TTCCCAGCCAGTCTCTTTCTTATCATAGGTTAGCTTGCTTATTCTGGAATTTCGCGTATACAGATGCGTG CCATGCCATAGGTACTCTTTTGTGTCTGCTTTGTTCTGCTCAACACCATGTTTCTGAAATCATTACCATT GTTGTATGGTTCTCTAACTCCATCATTTCCATTTCAGACTCAGCATATGCTGAGTTCAACCTGTTGAAGG GCTATCTCTGTTTAATTCACCATCTTGAAAGAAACATTTAAAATTGAGATGTTTTCAAGAATATATAGTT AAATCCTGAGGAATCGATGTAGAAATGTTATCACAAGCTGTCTGAACTTACTCAGGGGAAGTCTTCGTCT TCACTCACATAAGAGTCTACTGGAATTAATATCAACAATCTTAGAGAAATCCCACACTATTCATGCCATT TTCATGATCTCCACCTTGGTAATTTTTTTTTTTTTTTTTTTTTTTTGAGACAGAGTCTCACTCTGTCACC CAGGCTGAAGTGCAGTGGTGCGATCTCGGCTCACTGCAACCTCTGCCTCCTGGGTTCAAGTGATTCTTCT GCCTCAGCCTCCCAAGTAGCTGGAACTGTAGGCACGTGCCACCATGCCCTGCTAATTTTTTGTAATTTTA GTAGAGATGGGTTTCACCGTGTTAGCTAGGATGGTCTCAATCTCCTGATCTCGTGGTCCACCCACCTCGG CTTCCCAAAGTGCTGAGATTGCAGGCGTGAGCCACCACACCCGGCCCACCTTGTTAATTTTTAAGCACTA AAATTTGATACTTATTTGTGAATGAAGTAATCTCTTCATTGTATTTTTTTTTTTTACTTATGCTGAGCTT CAAATGACAAAGATTCATATAATCCAAGAGAGAAGTATTATTTAGAGGGATTCTTTTACCATGTGATATA TAATAAATGCATCCAATGTTATACATCAATTTAAAAAACAAGTAAATAACTTTAAAGAAAAGATAACTAC TGGCCAGGTGCAGTGGCTCACACCTGTATTCCCAGCACTTTGGGAGGCCGAGGCAGGTGGATCAAGAGGT CACGAGTTGGAGACCAGCCTGGCCAAGATGGTGAAACCCTGTTTCTACTCAAAATACAAAAATTAGCCGA GTGCGGTGGCAGGCGCCTGTAATCCCAGTTACTCAGTAGCTGAGGCAGGAGAATCGCTTGAACCCGGGAG GCGGAGGTTGCAGTGAGCTGAGATCATGCCACTGCAATCTAGCCTGGGTGACAGAGCAAGACTTTGTCTC CAAACAAAAAGAAAAGATAATTACTTTATACTTAGCTTGTCTTAGCCATGAGTGACGGGCTGCATGTGGC CCAGGACAGTTTTGAATGCAGTTCAACACAAATTTGTAAACTTTCTTAAAACATTAGGAGATTTTGGCCA GGTACAGTGGCTCATGCCTGTAATCCCAGCACTTTGGGAGGCTGAGGCGGGCAGATTACCTGAGGTCAGG AGTTCGAGACCACCCTGGCCAACATGGCAAAATCCCATCTCCACAAAAAATACAAAAATTTGCTGAGTGC ATTGTCAGGCACCTGTACTCCCAGCTACTCAGGAGGCTGAGGCAGGAGAATCACTTGAACCTGAGAGGCA GAGGTTGCAGTGAGCCGAGAGCACGCCACTGCACTCCAGCCTGGGTGACAGAGTGAGACCCCATCTCAAA AACAAAACACCAAACAAAAACAAAAACAAAAAAAAATGGCTGGGCACGGTGGCTCACACCTGTAATCCCA GCACTTTGGGAGGCCGAGGCAGGCAGATCGCCTGCCAGGAGTTCAAGGCCAGACTGGCCAACATGGTGAA ACCTCATCTCTACTAAAAATACAAAAATGAGTCGGGCATGGTGGCAGAGACCTGTAATCTCAGCTACTCG GGAGGCTGAGGGAGGAGAATGGCTTGAGCCCAGGAGCTGGAGGTTGCAGTGAGCCGAGATTGCACCACTG CACTCCAGCCTGGGCGACTGAGTGGAGCGGAACTCTGTCTCCAAAAAAAAAAAAAAAAGAGTTTTTTTTT AGATCATCAGCTATTGTTAGTGTTAGTGTATGTTATGTGTGGCTCAAGACAACTTTGTTTCTTTTAATAT AGGCAGGGAAGTGAAAAGATTGGATATCCCTGCTTTATACCAAGAAAGACAACACCCCACATTTGCAATG CCTAAAAACACTACCAGCCATCTGAAAAACATGAGACTTCTAACTTCTGTTCTTTTTTGTAGCAGTGGAA TCCCACGGTGATATCTGAGGGATGTGGTTACCTTTTGGAGGAGGTTGACGGTTTCTAAGGATGATTCTTT CTGAGTGAAATATTGTCGGTGTCATTGACCTTTTCATTATTTCAACTATTATTATTCCAGGTTATCAATA GTCTGGCTGTCTATCGTCATCGTGAGACTGACTTTGGTGTAGGAGTTCGAGACCACCCTGGCCAACATGG CAAAACCCCATCTCCACAAAAATTGGATAATTTGATAATTATCATTATTGGGTTTCTGAGACGTTACACA TTTAACGTTCTCTTCTGCACAAGTTGCCTTTGTGTGAGTATACTAACTTTCTGTAGAGGTATACTTGTAA TCACAAATAAGAATAAATTATATAAAACAA Download Select all
Length	17298
OMIM ID	607042
HGNC ID	HGNC:2074
Unigene ID	Hs.534667
Ensembl ID	ENSG00000188603
PharmGKB ID	PA26601

mRNA Information

mRNA ID	NM_001286109.1
Exon	join(221..589,2917..3013,4562..4641,4762..4847,5653..5725, 5813..5956,8185..8297,9631..9677,9758..9826,9921..9976, 10105..10198,14426..14566,14668..14839,25401..25650)
mRNA Sequence	>gi\|554790413\|ref\|NM_001286109.1\| Homo sapiens ceroid-lipofuscinosis, neuronal 3 (CLN3), transcript variant 5, mRNA GTGCTGTCACGTGATCCGACAAACGGCCTCTGCATAGTGCAGAACATTCTGCTGCTCTTAAAGGTACAGG CCTCAGGGTCCCTGCTGTAGACGGGGCGGGGGAGAGTACGATGGGTGGGGCGTGGTGGGTCGTAGGGCGC TCGAGATGGAGCCCCCAGCTTCCTTGATGGATCGCGGGGCGCGAGTGCCCTAGACAAGCCGGAGCTGGGA CCGGCAATCGGGCGTTGATCCTTGTCACCTGTCGCAGACCCTCATCCCTCCCGTGGGAGCCCCCTTTGGA CACTCTATGACCCTGGACCCTCGGGGGACCTGAACTTGATGCGATGGGAGGCTGTGCAGGCTCGCGGCGG CGCTTTTCGGATTCCGAGGGCTGCTGGGCCTTTGCAACAACTTCTCTTATGTGGTGATGCTGAGTGCCGC CCACGACATCCTTAGCCACAAGAGGACATCGGGAAACCAGAGCCATGCTGTGCTCCTGGCGGACATCCTC CCCACACTCGTCATCAAATTGTTGGCTCCTCTTGGCCTTCACCTGCTGCCCTACAGCCCCCGGGTTCTCG TCAGTGGGATTTGTGCTGCTGGAAGCTTCGTCCTGGTTGCCTTTTCTCATTCTGTGGGGACCAGCCTGTG TGGTGTGGTCTTCGCTAGCATCTCATCAGGCCTTGGGGAGGTCACCTTCCTCTCCCTCACTGCCTTCTAC CCCAGGGCCGTGATCTCCTGGTGGTCCTCAGGGACTGGGGGAGCTGGGCTGCTGGGGGCCCTGTCCTACC TGGGCCTCACCCAGGCCGGCCTCTCCCCTCAGCAGACCCTGCTGTCCATGCTGGGTATCCCTGCCCTGCT GCTGGCCAGCTATTTCTTGTTGCTCACATCTCCTGAGGCCCAGGACCCTGGAGGGGAAGAAGAAGCAGAG AGCGCAGCCCGGCAGCCCCTCATAAGAACCGAGGCCCCGGAGTCGAAGCCAGGCTCCAGCTCCAGCCTCT CCCTTCGGGAAAGGTGGACAGTGTTCAAGGGTCTGCTGTGGTACATTGTTCCCTTGGTCGTAGTTTACTT TGCCGAGTATTTCATTAACCAGGGACTTTTTGAACTCCTCTTTTTCTGGAACACTTCCCTGAGTCACGCT CAGCAATACCGCTGGTACCAGATGCTGTACCAGGCTGGCGTCTTTGCCTCCCGCTCTTCTCTCCGCTGCT GTCGCATCCGTTTCACCTGGGCCCTGGCCCTGCTGCAGTGCCTCAACCTGGTGTTCCTGCTGGCAGACGT GTGGTTCGGCTTTCTGCCAAGCATCTACCTCGTCTTCCTGATCATTCTGTATGAGGGGCTCCTGGGAGGC GCAGCCTACGTGAACACCTTCCACAACATCGCCCTGGAGACCAGTGATGAGCACCGGGAGTTTGCAATGG CGGCCACCTGCATCTCTGACACACTGGGGATCTCCCTGTCGGGGCTCCTGGCTTTGCCTCTGCATGACTT CCTCTGCCAGCTCTCCTGATACTCGGGATCCTCAGGACGCAGGTCACATTCACCTGTGGGCAGAGGGACA GGTTATCAATAGTCTGGCTGTCTATCGTCATCGTGAGACTGACTTTGGTGTAGGAGTTCGAGACCACCCT GGCCAACATGGCAAAACCCCATCTCCACAAAAATTGGATAATTTGATAATTATCATTATTGGGTTTCTGA GACGTTACACATTTAACGTTCTCTTCTGCACAAGTTGCCTTTGTGTGAGTATACTAACTTTCTGTAGAGG TATACTTGTAATCACAAATAAGAATAAATTATATAAAACAA Download Select all
Length	1791

CDS Information

Location	407..1489
CDS Sequence	Download Select all
CCDS ID	CCDS10632.1

Protein Information

Protein ID	NP_001273038.1
Protein Name	ceroid-lipofuscinosis, neuronal 3
Molecular Wt. (Da)	39037
Protein Sequence	>lcl\|NM_001286109.1_prot_NP_001273038.1_1 [gene=CLN3] [protein=battenin isoform d] [protein_id=NP_001273038.1] [location=407..1489] MLSAAHDILSHKRTSGNQSHAVLLADILPTLVIKLLAPLGLHLLPYSPRVLVSGICAAGSFVLVAFSHSV GTSLCGVVFASISSGLGEVTFLSLTAFYPRAVISWWSSGTGGAGLLGALSYLGLTQAGLSPQQTLLSMLG IPALLLASYFLLLTSPEAQDPGGEEEAESAARQPLIRTEAPESKPGSSSSLSLRERWTVFKGLLWYIVPL VVVYFAEYFINQGLFELLFFWNTSLSHAQQYRWYQMLYQAGVFASRSSLRCCRIRFTWALALLQCLNLVF LLADVWFGFLPSIYLVFLIILYEGLLGGAAYVNTFHNIALETSDEHREFAMAATCISDTLGISLSGLLAL PLHDFLCQLS Download Select all
Length	360
Uniprot ID	P43354
Ensembl Protein ID	ENSP00000344479

Post-translational Modification Information (Source : HPRD)

Residue	Type	site
S	Phosphorylation	12
S	Phosphorylation	14
S	Phosphorylation	12;-
S	Phosphorylation	14;-
T	Phosphorylation	19
T	Phosphorylation	19

Enzyme Information

No matching records could be found.

PPi Information

(Click to view network : Source STRING) View

No matching records from HPRD source could be found.

Pathway Information

Pathway Name	Pathway ID
Lysosome	hsa04142

Structure Information

No matching records could be found.

Domain Information

ID	Location	Description
pfam02487	37-438	CLN3
cl15430	37-438	Nucleoside_tran superfamily

Ontology Information

HPRD ID	7198
Molecular Class	Chaperone
Molecular Function	Cell adhesion molecule activity (GO:0005194)
Biological Process	Cell communication (GO:0007154)

SNP Information

View SNP Geneview Report

Drug Information

No matching records could be found.

External Links

ArrayExpress GO
ICGC GO
Cancer3D GO
COSMIC GO
NCG GO
TSGene GO
Tumor Gene Family of Databases GO
CCDB GO
G2SBC GO
Osteosarcoma Database GO
RCDB GO

ArrayExpress	GO
ICGC	GO
Cancer3D	GO
COSMIC	GO
NCG	GO
TSGene	GO
Tumor Gene Family of Databases	GO
CCDB	GO
G2SBC	GO
Osteosarcoma Database	GO
RCDB	GO