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General Information
- Evidence
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- Enzyme
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Evidence Information
| Pubmed ID | Year | Sample Information | Techniques | Mechanism | Fold Change | Remark |
|---|---|---|---|---|---|---|
| 23245395 | 2013 | Cell line : - Source : National Cancer Center Hospital (NCCH; Tokyo), Osaka National Hospital (ONH; Osaka), Jichi Medical School Hospital (JMS; Shimotsuke), Osaka Medical Center for Cancer and Cardiovascular Diseases (Osaka), Tokyo Medical University Hospital (TMUH; Tokyo), Osaka Medical College Hospital (OMC; Osaka), and Fukuoka University Hospital (Fukuoka) Sample Type : Blood Plasma No. of Sample : 366 Stage : TNM Stage I,II,III | Flow cytometry, Western blotting, immunofluorescence, real-time PCR, luciferase assay,microarray analysis | Up-regulation | - | - |
| 21828233 | 2011 | Cell line : HT29, DLD1 Source : - Sample Type : - No. of Sample : - Stage : - | Liquid chromatography mass spectrometry, tandem mass spectrometry, Immunoblot, Reverse-phase protein microarray, Immunohistochemistry | Up-regulation | - | Adipophilin is a plasma biomarker potentially useful for the detection of early-stage colorectal cancer. An increase in plasma adipophilin was consistently observed in colorectal cancer patients, including those with stage I or stage II disease |
Gene Details
| Gene Type | protein coding |
|---|---|
| Gene Family | Perilipins |
| Description | The protein encoded by this gene belongs to the perilipin family, members of which coat intracellular lipid storage droplets. This protein is associated with the lipid globule surface membrane material, and maybe involved in development and maintenance of adipose tissue. However, it is not restricted to adipocytes as previously thought, but is found in a wide range of cultured cell lines, including fibroblasts, endothelial and epithelial cells, and tissues, such as lactating mammary gland, adrenal cortex, Sertoli and Leydig cells, and hepatocytes in alcoholic liver cirrhosis, suggesting that it may serve as a marker of lipid accumulation in diverse cell types and diseases. Alternatively spliced transcript variants have been found for this gene. |
| Chromosome | 9 |
| Location | 9p22.1 |
| Start | 19108388 |
| End | 19127606 |
| Strand | - |
| Gene Sequence | Download Select all |
| Length | 19219 |
| OMIM ID | 103195 |
| HGNC ID | HGNC:248 |
| Unigene ID | Hs.3416 |
| Ensembl ID | ENSG00000147872 |
| PharmGKB ID | - |
mRNA Information
| mRNA ID | XM_006716719.1 |
|---|---|
| Exon | join(89..188,1159..1210,1298..1493,3960..4042,6442..6727, 7776..7957,9152..9286,10958..11248,18860..19219) | mRNA Sequence | Download Select all |
| Length | 2029 |
CDS Information
| Location | join(1181..1210,1298..1493,3960..4042,6442..6727, 7776..7957,9152..9286,10958..11248,18860..18994) |
|---|---|
| CDS Sequence | Download Select all |
| CCDS ID | - |
Protein Information
| Protein ID | NP_001113.2 |
|---|---|
| Protein Name | perilipin 2 |
| Molecular Wt. (Da) | 47944 |
| Protein Sequence | Download Select all |
| Length | 437 |
| Uniprot ID | Q92908 |
| Ensembl Protein ID | ENSP00000269216 |
Post-translational Modification Information (Source : HPRD)
No matching records could be found.
Enzyme Information
No matching records could be found.
PPi Information
(Click to view network : Source STRING) View
No matching records from HPRD source could be found.
Pathway Information
No matching records could be found.
Structure Information
No matching records could be found.
Domain Information
| ID | Location | Description |
|---|---|---|
| pfam03036 | 2-396 | Perilipin |
| cl03851 | 2-396 | Perilipin superfamily |
Ontology Information
| HPRD ID | 751 |
|---|---|
| Molecular Class | Storage protein |
| Molecular Function | Cytokine activity (GO:0005125) |
| Biological Process | Cell communication (GO:0007154); Signal transduction (GO:0007165) |
Drug Information
No matching records could be found.