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General Information
| Gene_Symbol | Gene_ID | Gene_Name | Chromosome | Alias |
|---|---|---|---|---|
| CCR1 | 1230 | chemokine (C-C motif) receptor 1 | 3 | CKR-1, MIP1aR, CD191 |
- Evidence
- Gene
- mRNA
- CDS
- Protein
- PTM
- Enzyme
- PPi
- Pathway
- Structural
- Domain
- Ontology
- SNP
- Drug
- External Links
Evidence Information
| Pubmed ID | Year | Sample Information | Techniques | Mechanism | Fold Change | Remark |
|---|---|---|---|---|---|---|
| 26383527 | 2015 | Cell line : - Source : - Sample Type : CRC tumor and normal tissue No. of Sample : 50 Stage : - | real time RT-PCR, microarray | Up-regulation | - | Data point to an important role of CCR1 and CCRL2 under conditions of organ colonization and both chemokine receptors qualify as targets of treatment during early colorectal cancer liver metastasis. |
Gene Details
| Gene Type | protein coding |
|---|---|
| Gene Family | GPCR / Class A : Chemokine receptors : C-C motif, "CD molecules" |
| Description | This gene encodes a member of the beta chemokine receptor family, which is predicted to be a seven transmembrane protein similar to G protein-coupled receptors. The ligands of this receptor include macrophage inflammatory protein 1 alpha (MIP-1 alpha), regulated on activation normal T expressed and secreted protein (RANTES), monocyte chemoattractant protein 3 (MCP-3), and myeloid progenitor inhibitory factor-1 (MPIF-1). Chemokines and their receptors mediated signal transduction are critical for the recruitment of effector immune cells to the site of inflammation. Knockout studies of the mouse homolog suggested the roles of this gene in host protection from inflammatory response, and susceptibility to virus and parasite. This gene and other chemokine receptor genes, including CCR2, CCRL2, CCR3, CCR5 and CCXCR1, are found to form a gene cluster on chromosome 3p. [provided by RefSeq, Jul 2008] |
| Chromosome | 3 |
| Location | 3p21 |
| Start | 46243200 |
| End | 46249832 |
| Strand | - |
| Gene Sequence | Download Select all |
| Length | 6633 |
| OMIM ID | 601159 |
| HGNC ID | HGNC:1602 |
| Unigene ID | Hs.301921 |
| Ensembl ID | ENSG00000163823 |
| PharmGKB ID | PA26166 |
mRNA Information
| mRNA ID | NM_001295.2 |
|---|---|
| Exon | join(1..60,4018..6633) | mRNA Sequence | Download Select all |
| Length | 2690 |
Protein Information
| Protein ID | NP_001286.1 |
|---|---|
| Protein Name | chemokine (C-C motif) receptor 1 |
| Molecular Wt. (Da) | 41042 |
| Protein Sequence | Download Select all |
| Length | 355 |
| Uniprot ID | O15527 |
| Ensembl Protein ID | ENSP00000305584 |
Post-translational Modification Information (Source : HPRD)
| Residue | Type | site |
|---|---|---|
| Y | Sulfation | 10 |
| Y | Sulfation | 10 |
| Y | Sulfation | 18 |
| Y | Sulfation | 18 |
| S | Phosphorylation | 352 |
Enzyme Information
No matching records could be found.
PPi Information
(Click to view network : Source STRING) View
| Interactant Gene ID (Source: HPRD) | Gene Symbol | HPRD ID | Ref Seq ID | Technique | References |
|---|---|---|---|---|---|
| 3716 | JAK1 | 992 | NP_002218.2 | in vivo | 14674010 |
| 5355 | PLP2 | 2121 | NP_002659.1 | in vivo;yeast 2-hybrid | 15474493 |
| 6347 | CCL2 | 1149 | NP_002973.1 | in vitro | 8631787 |
| 6348 | CCL3 | 1656 | NP_002974.1 | in vitro;in vivo | 10 660 125 102 020 400 000 000 |
| 6351 | CCL4 | 1657 | NP_002975.1 | in vitro | 7594543 |
| 6352 | CCL5 | 1751 | NP_002976.2 | in vitro;in vivo | 92 890 161 111 615 800 000 000 000 000 000 000 000 |
| 6354 | CCL7 | 1150 | CAA50405.1 | in vitro;in vivo | 85 303 547 545 673 |
| 6772 | STAT1 | 2777 | NP_009330.1 | in vivo | 14674010 |
| 6774 | STAT3 | 26 | NP_644805.1 | in vivo | 14674010 |
| 10344 | CCL26 | 5262 | NP_006063.1 | in vivo | 15039444 |
| 10488 | CREB3 | 7339 | AAC04325.1 | in vivo;yeast 2-hybrid | 15001559 |
Pathway Information
| Pathway Name | Pathway ID |
|---|---|
| Chemokine signaling pathway | hsa04062 |
| Cytokine-cytokine receptor interaction | hsa04060 |
Structure Information
No matching records could be found.
Domain Information
| ID | Location | Description |
|---|---|---|
| pfam00001 | 57-301 | 7tm_1 |
| PHA03087 | 40-315 | PHA03087 |
| PHA02638 | 40-318 | PHA02638 |
| PHA02834 | 40-318 | PHA02834 |
| PHA03235 | 43-322 | PHA03235 |
| PHA03234 | 53-309 | PHA03234 |
Ontology Information
| HPRD ID | 4032 |
|---|---|
| Molecular Class | Cell surface receptor |
| Molecular Function | Cytokine activity (GO:0005125) |
| Biological Process | Cell communication (GO:0007154); Signal transduction (GO:0007165) |
Drug Information
No matching records could be found.