Search results:
General Information
| Gene_Symbol | Gene_ID | Gene_Name | Chromosome | Alias |
|---|---|---|---|---|
| CCR7 | 1236 | chemokine (C-C motif) receptor 7 | 17 | BLR2, CDw197, CD197 |
- Evidence
- Gene
- mRNA
- CDS
- Protein
- PTM
- Enzyme
- PPi
- Pathway
- Structural
- Domain
- Ontology
- SNP
- Drug
- External Links
Evidence Information
| Pubmed ID | Year | Sample Information | Techniques | Mechanism | Fold Change | Remark |
|---|---|---|---|---|---|---|
| 26179425 | 2015 | Cell line : - Source : - Sample Type : Paraffin-embedded tissue No. of Sample : 116 Stage : TNM stage I-III | Immunohistochemistry | Up-regulation | - | CCR7 may serve as a novel prognostic biomarker. |
Gene Details
| Gene Type | protein coding |
|---|---|
| Gene Family | GPCR / Class A : Chemokine receptors : C-C motif, "CD molecules" |
| Description | The protein encoded by this gene is a member of the G protein-coupled receptor family. This receptor was identified as a gene induced by the Epstein-Barr virus (EBV), and is thought to be a mediator of EBV effects on B lymphocytes. This receptor is expressed in various lymphoid tissues and activates B and T lymphocytes. It has been shown to control the migration of memory T cells to inflamed tissues, as well as stimulate dendritic cell maturation. The chemokine (C-C motif) ligand 19 (CCL19/ECL) has been reported to be a specific ligand of this receptor. Signals mediated by this receptor regulate T cell homeostasis in lymph nodes, and may also function in the activation and polarization of T cells, and in chronic inflammation pathogenesis. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Sep 2014] |
| Chromosome | 17 |
| Location | 17q12-q21. |
| Start | 38710021 |
| End | 38721736 |
| Strand | - |
| Gene Sequence | Download Select all |
| Length | 11716 |
| OMIM ID | 600242 |
| HGNC ID | HGNC:1608 |
| Unigene ID | Hs.370036 |
| Ensembl ID | ENSG00000126353 |
| PharmGKB ID | PA26172 |
mRNA Information
| mRNA ID | NM_001301714.1 |
|---|---|
| Exon | join(1..85,9667..11716) | mRNA Sequence | Download Select all |
| Length | 2157 |
Protein Information
| Protein ID | NP_001288643.1 |
|---|---|
| Protein Name | chemokine (C-C motif) receptor 7 |
| Molecular Wt. (Da) | 35571 |
| Protein Sequence | Download Select all |
| Length | 315 |
| Uniprot ID | O00300 |
| Ensembl Protein ID | ENSP00000297350 |
Post-translational Modification Information (Source : HPRD)
No matching records could be found.
Enzyme Information
No matching records could be found.
PPi Information
(Click to view network : Source STRING) View
| Interactant Gene ID (Source: HPRD) | Gene Symbol | HPRD ID | Ref Seq ID | Technique | References |
|---|---|---|---|---|---|
| 2826 | CCR10 | 2586 | NP_057686.2 | in vitro | 10706668 |
Pathway Information
| Pathway Name | Pathway ID |
|---|---|
| Chemokine signaling pathway | hsa04062 |
| Cytokine-cytokine receptor interaction | hsa04060 |
| Transcriptional misregulation in cancer | hsa05202 |
Structure Information
No matching records could be found.
Domain Information
| ID | Location | Description |
|---|---|---|
| pfam00001 | 81-326 | 7tm_1 |
| PHA02638 | 60-356 | PHA02638 |
| PHA03087 | 61-351 | PHA03087 |
| PHA02834 | 44-346 | PHA02834 |
| PHA03235 | 67-342 | PHA03235 |
| PHA03234 | 78-344 | PHA03234 |
Ontology Information
| HPRD ID | 725 |
|---|---|
| Molecular Class | G protein coupled receptor |
| Molecular Function | Defense/immunity protein activity (GO:0003793) |
| Biological Process | Immune response (GO:0006955) |
Drug Information
No matching records could be found.