Search results:
General Information
| Gene_Symbol | Gene_ID | Gene_Name | Chromosome | Alias |
|---|---|---|---|---|
| ADH1B | 125 | alcohol dehydrogenase 1B (class I), beta polypeptide | 4 | - |
- Evidence
- Gene
- mRNA
- CDS
- Protein
- PTM
- Enzyme
- PPi
- Pathway
- Structural
- Domain
- Ontology
- SNP
- Drug
- External Links
Evidence Information
| Pubmed ID | Year | Sample Information | Techniques | Mechanism | Fold Change | Remark |
|---|---|---|---|---|---|---|
| 24599561 | 2014 | Cell line : - Source : Patients lived in Northern Israel Sample Type : population based case-control study No. of Sample : 1694 CRC cases and 1851 matched controls Stage : - | RT-PCR, RNA-sequencing, microarrays | Down-regulation | - | Frequent and significant decreases in the mRNA levels of the ADH1B, ADH1C, RDHL, RDH5 and AKR1B10 genes were observed in a majority of colorectal carcinomas. |
| 24282520 | 2013 | Cell line : - Source : Databases, including PubMed, Embase, Web of Science, the Cochrane Library, CNKI, and Wanfang online libraries. Sample Type : - No. of Sample : - Stage : - | SNP selection and genotyping | Polymorhpism | - | A path analysis based on structural equation modeling showed a direct effect of ADH1B gene polymorphisms on colorectal carcinogenesis. |
| 24552298 | 2014 | Cell line : - Source : Blokhin cancer research center,Russinan academy of medical sciences and medical center of central bank of Russian federation, Moscow. Sample Type : CRC tumor No. of Sample : 80 Stage : TNM Stage I-IV | REVMAN and Stata software, six meta-analyses. | Polymorhpism | - | The current meta-analysis has established that ADH1B (rs1229984) and PPARG (rs1801282) are two risk variants of CRC. |
Gene Details
| Gene Type | protein coding |
|---|---|
| Gene Family | Alcohol dehydrogenases |
| Description | The protein encoded by this gene is a member of the alcohol dehydrogenase family. Members of this enzyme family metabolize a wide variety of substrates, including ethanol, retinol, other aliphatic alcohols, hydroxysteroids, and lipid peroxidation products. This encoded protein, consisting of several homo- and heterodimers of alpha, beta, and gamma subunits, exhibits high activity for ethanol oxidation and plays a major role in ethanol catabolism. Three genes encoding alpha, beta and gamma subunits are tandemly organized in a genomic segment as a gene cluster. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2013] |
| Chromosome | 4 |
| Location | 4q23 |
| Start | 100227527 |
| End | 100242572 |
| Strand | - |
| Gene Sequence | Download Select all |
| Length | 15046 |
| OMIM ID | 103720 |
| HGNC ID | HGNC:250 |
| Unigene ID | Hs.4 |
| Ensembl ID | ENSG00000196616 |
| PharmGKB ID | PA24571 |
mRNA Information
| mRNA ID | NM_000668.5 |
|---|---|
| Exon | join(1..129,2557..2658,3259..3397,5141..5228,5326..5545, 7362..7622,9787..9922,10540..10678,13579..15056) | mRNA Sequence | Download Select all |
| Length | 2707 |
Protein Information
| Protein ID | NP_000659.2 |
|---|---|
| Protein Name | alcohol dehydrogenase 1B (class I), beta polypeptide |
| Molecular Wt. (Da) | 39705 |
| Protein Sequence | Download Select all |
| Length | 375 |
| Uniprot ID | Q13485 |
| Ensembl Protein ID | ENSP00000341551 |
Post-translational Modification Information (Source : HPRD)
| Residue | Type | site |
|---|---|---|
| S | Phosphorylation | 23 |
| S | Phosphorylation | 342 |
| S | Phosphorylation | 365 |
Enzyme Information
No matching records could be found.
PPi Information
(Click to view network : Source STRING) View
No matching records from HPRD source could be found.
Pathway Information
| Pathway Name | Pathway ID |
|---|---|
| Chemical carcinogenesis | hsa05204 |
| Drug metabolism - cytochrome P450 | hsa00982 |
| Fatty acid degradation | hsa00071 |
| Glycolysis / Gluconeogenesis | hsa00010 |
| Metabolic pathways | hsa01100 |
| Metabolism of xenobiotics by cytochrome P450 | hsa00980 |
| Retinol metabolism | hsa00830 |
| Tyrosine metabolism | hsa00350 |
Structure Information
No matching records could be found.
Domain Information
| ID | Location | Description |
|---|---|---|
| cd08299 | 3-375 | alcohol_DH_class_I_II_IV |
| cl16912 | 3-375 | MDR superfamily |
| cd05279 | 10-374 | Zn_ADH1 |
| cd08277 | 8-374 | liver_alcohol_DH_like |
| cd08300 | 8-374 | alcohol_DH_class_III |
| cd08301 | 8-374 | alcohol_DH_plants |
| cd08279 | 11-374 | Zn_ADH_class_III |
| cd08278 | 8-374 | benzyl_alcohol_DH |
| cd08281 | 11-373 | liver_ADH_like1 |
| cd08263 | 11-372 | Zn_ADH10 |
| cd05188 | 36-333 | MDR |
| cd08260 | 11-358 | Zn_ADH6 |
| cd08254 | 19-374 | hydroxyacyl_CoA_DH |
| cd08236 | 11-367 | sugar_DH |
| cd08233 | 11-368 | butanediol_DH_like |
| cd08261 | 11-375 | Zn_ADH7 |
| cd08234 | 11-372 | threonine_DH_like |
| cd05278 | 11-375 | FDH_like |
| cd05285 | 12-368 | sorbitol_DH |
| cd08231 | 10-374 | MDR_TM0436_like |
| cd08235 | 11-374 | iditol_2_DH_like |
| cd08284 | 13-375 | FDH_like_2 |
| cd08259 | 11-374 | Zn_ADH5 |
| cd08297 | 10-375 | CAD3 |
| cd05284 | 11-375 | arabinose_DH_like |
| cd05281 | 22-373 | TDH |
| cd08245 | 11-367 | CAD |
| cd08239 | 23-375 | THR_DH_like |
| cd08285 | 11-365 | NADP_ADH |
| cd08232 | 24-375 | idonate-5-DH |
| cd08240 | 11-375 | 6_hydroxyhexanoate_dh_like |
| cd08286 | 39-361 | FDH_like_ADH2 |
| cd08241 | 11-374 | QOR1 |
| cd05283 | 20-374 | CAD1 |
| cd08283 | 13-362 | FDH_like_1 |
| cd08282 | 13-310 | PFDH_like |
| cd08266 | 23-294 | Zn_ADH_like1 |
| cd08287 | 11-375 | FDH_like_ADH3 |
| cd08296 | 11-374 | CAD_like |
| cd08276 | 16-367 | MDR7 |
| cd08269 | 22-363 | Zn_ADH9 |
| cd08265 | 22-368 | Zn_ADH3 |
| cd08298 | 11-246 | CAD2 |
| pfam08240 | 36-161 | ADH_N |
| cl17172 | 36-161 | ADH_N superfamily |
| cd08258 | 12-306 | Zn_ADH4 |
| cd05286 | 25-282 | QOR2 |
| pfam00107 | 203-334 | ADH_zinc_N |
| cd08249 | 11-367 | enoyl_reductase_like |
| cd08272 | 11-369 | MDR6 |
| cd05289 | 11-373 | MDR_like_2 |
| cd08256 | 13-373 | Zn_ADH2 |
| cd08267 | 25-368 | MDR1 |
| cd08264 | 24-272 | Zn_ADH_like2 |
| cd08253 | 24-373 | zeta_crystallin |
| cd08268 | 22-374 | MDR2 |
| cd08271 | 10-372 | MDR5 |
| cd08255 | 61-368 | 2-desacetyl-2-hydroxyethyl_bacteriochlorophyllide_ |
| cd08262 | 11-368 | Zn_ADH8 |
| cd05276 | 24-271 | p53_inducible_oxidoreductase |
| cd08230 | 11-375 | glucose_DH |
| cd05195 | 36-217 | enoyl_red |
| cd08273 | 23-367 | MDR8 |
| cd08250 | 23-369 | Mgc45594_like |
| cd08246 | 22-294 | crotonyl_coA_red |
| cd08238 | 24-281 | sorbose_phosphate_red |
| cd08251 | 28-372 | polyketide_synthase |
| cd08243 | 11-368 | quinone_oxidoreductase_like_1 |
| cd08275 | 23-369 | MDR3 |
| cd05282 | 19-95 | ETR_like |
| cd08290 | 16-375 | ETR |
| cd08252 | 21-267 | AL_MDR |
| cd08242 | 13-245 | MDR_like |
| cd08274 | 25-239 | MDR9 |
| cd08292 | 23-90 | ETR_like_2 |
| cd08248 | 62-275 | RTN4I1 |
| cd08291 | Nov-81 | ETR_like_1 |
| cd08247 | 63-367 | AST1_like |
| cd08244 | 25-271 | MDR_enoyl_red |
| cd05288 | 140-280 | PGDH |
| cd05280 | 56-373 | MDR_yhdh_yhfp |
| cd05352 | 193-278 | MDH-like_SDR_c |
| cl21454 | 193-278 | NADB_Rossmann superfamily |
| cd05211 | 179-250 | NAD_bind_Glu_Leu_Phe_Val |
| COG1062 | 8-375 | FrmA |
| TIGR02818 | 9-375 | adh_III_F_hyde |
| PLN02740 | 1-373 | PLN02740 |
| PLN02827 | 7-373 | PLN02827 |
| TIGR03989 | 9-375 | Rxyl_3153 |
| TIGR03451 | 21-375 | mycoS_dep_FDH |
| COG1064 | 11-375 | AdhP |
| COG1063 | 11-375 | Tdh |
| PRK09422 | 11-375 | PRK09422 |
| COG0604 | 11-375 | Qor |
| TIGR00692 | 15-373 | tdh |
| PRK13771 | 11-373 | PRK13771 |
| PRK05396 | 24-373 | tdh |
| PLN02702 | 19-368 | PLN02702 |
| TIGR02819 | 37-271 | fdhA_non_GSH |
| PRK10309 | 36-258 | PRK10309 |
| TIGR03201 | 17-374 | dearomat_had |
| PRK10083 | 18-257 | PRK10083 |
| PRK09880 | 45-318 | PRK09880 |
| PTZ00354 | 23-271 | PTZ00354 |
| PLN02586 | 36-339 | PLN02586 |
| PLN02514 | 36-363 | PLN02514 |
| TIGR02824 | 11-271 | quinone_pig3 |
| PLN02178 | 36-334 | PLN02178 |
| PRK10754 | 26-282 | PRK10754 |
| TIGR02822 | 16-203 | adh_fam_2 |
| TIGR03366 | 65-312 | HpnZ_proposed |
| smart00829 | 39-217 | PKS_ER |
| TIGR01751 | 65-366 | crot-CoA-red |
| TIGR02817 | 17-90 | adh_fam_1 |
| COG2130 | 142-280 | CurA |
| PRK01390 | 193-237 | murD |
| TIGR02823 | 202-264 | oxido_YhdH |
Ontology Information
| HPRD ID | 4241 |
|---|---|
| Molecular Class | Enzyme: Dehydrogenase |
| Molecular Function | Transcription regulator activity (GO:0030528) |
| Biological Process | Regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolism (GO:0019219) |
Drug Information
| Uniprot ID | DrugBank ID | Name | Type |
|---|---|---|---|
| P00325 | DB00898 | Ethanol | SmallMoleculeDrug |
| P00325 | DB01213 | Fomepizole | SmallMoleculeDrug |