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General Information



Gene_Symbol Gene_ID Gene_Name Chromosome Alias
CNP 1267 2',3'-cyclic nucleotide 3' phosphodiesterase  17CNP1 







  • Evidence
  • Gene
  • mRNA
  • CDS
  • Protein
  • PTM
  • Enzyme
  • PPi
  • Pathway
  • Structural
  • Domain
  • Ontology
  • SNP
  • Drug
  • External Links



Evidence Information


Pubmed ID Year Sample Information Techniques Mechanism Fold Change Remark
17848589   2007Cell line : -

Source : Tumor Bank Network established at the Centro Nacional de Investigaciones Oncologicas (CNIO).

Sample Type : -

No. of Sample : -

Stage : -

Antibody Microarrays,Protein Labeling and Microarray Assay,Tissue Microarray Design and ImmunohistochemistryDown-regulation0.496-


Gene Details



Chromosome: 17; NC_000017.10 (40118759..40129754)

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Gene Type protein coding
Gene Family -
Description -  
Chromosome 17
Location 17q21
Start 41966741  
End 41977736  
Strand +  
Gene Sequence

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Length 10996  
OMIM ID 123830   
HGNC ID HGNC:2158   
Unigene ID Hs.273621    
Ensembl ID ENSG00000173786   
PharmGKB ID -   

mRNA Information


mRNA ID NM_033133.4
Exon join(1..147,1328..2000,5152..5291,6735..10996)  
mRNA Sequence

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Length 2096  



CDS Information


   
Locationjoin(145..147,1328..2000,5152..5291,6735..7184)
CDS Sequence

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CCDS ID CCDS11414.2



Protein Information


      
Protein IDNP_149124.3
Protein Name2',3'-cyclic nucleotide 3' phosphodiesterase
Molecular Wt. (Da)47251
Protein Sequence

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Length 421  
Uniprot IDQ92482
Ensembl Protein ID ENSP00000297991  



Post-translational Modification Information (Source : HPRD)


Residue Type site
SPhosphorylation170
SPhosphorylation312
SPhosphorylation318

Enzyme Information


   
EC3.1.4.37
Name2',3'-cyclic-nucleotide 3'-phosphodiesterase
cyclic-CMP phosphodiesterase
2',3'-cyclic AMP phosphodiesterase
cyclic 2',3'-nucleotide 3'-phosphodiesterase
cyclic 2',3'-nucleotide phosphodiesterase
2',3'-cyclic nucleoside monophosphate phosphodiesterase
2',3'-cyclic nucleotide 3'-phosphohydrolase
CNPase
2',3'-cyclic nucleotide phosphohydrolase
2':3'-cyclic nucleotide 3'-phosphodiesterase
2':3'-CNMP-3'-ase
ClassHydrolases; Acting on ester bonds; Phosphoric-diester hydrolases
Sysnamenucleoside-2',3'-cyclic-phosphate 2'-nucleotidohydrolase  
Substratenucleoside 2',3'-cyclic phosphate [CPD:C01240]; H2O  
Productnucleoside 2'-phosphate  
Reaction (IUBMB)



PPi Information


(Click to view network : Source STRING)      View   

No matching records from HPRD source could be found.

Pathway Information


No matching records could be found.

Structure Information


PDB ID1WOJ
Resolution1.8
MethodX-RAY DIFFRACTION
Chains A  
Molecule 2',3'-cyclic-nucleotide 3'-phosphodiesterase  
Model View



Domain Information




ID Location Description
cd0000953-138  AAA
cl2145553-138  P-loop_NTPase superfamily
pfam05881186-400  CNPase
cl12319186-400  CNPase superfamily
pfam1320752-156  AAA_17
pfam1340150-148  AAA_22
pfam0159138-149  6PF2K
cd0088257-165  Ras_like_GTPase
PRK0676251-84  PRK06762
pfam08302312-367  tRNA_lig_CPD
cl07058312-367  tRNA_lig_CPD superfamily
pfam1367152-166  AAA_33
COG463951-166  COG4639
PHA0253050-148  pseT
PRK0418257-83  PRK04182
smart0038254-142  AAA
COG023757-149  CoaE
pfam0641445-147  Zeta_toxin


Ontology Information


   
HPRD ID8970
Molecular ClassEnzyme: Phosphodiesterase
Molecular FunctionWater channel activity (GO:0015250)
Biological ProcessTransport (GO:0006810)  



SNP Information


View SNP Geneview Report   

Drug Information


No matching records could be found.

External Links


                                 
ArrayExpressGO
ICGCGO
Cancer3DGO
COSMICGO
NCGGO
TSGeneGO
Tumor Gene Family of DatabasesGO
CCDBGO
G2SBCGO
Osteosarcoma DatabaseGO
RCDBGO