Search results:
General Information
| Gene_Symbol | Gene_ID | Gene_Name | Chromosome | Alias |
|---|---|---|---|---|
| CNP | 1267 | 2',3'-cyclic nucleotide 3' phosphodiesterase  | 17 | CNP1  |
- Evidence
- Gene
- mRNA
- CDS
- Protein
- PTM
- Enzyme
- PPi
- Pathway
- Structural
- Domain
- Ontology
- SNP
- Drug
- External Links
Evidence Information
| Pubmed ID | Year | Sample Information | Techniques | Mechanism | Fold Change | Remark |
|---|---|---|---|---|---|---|
| 17848589    | 2007 | Cell line : - Source : Tumor Bank Network established at the Centro Nacional de Investigaciones Oncologicas (CNIO). Sample Type : - No. of Sample : - Stage : - | Antibody Microarrays,Protein Labeling and Microarray Assay,Tissue Microarray Design and Immunohistochemistry | Down-regulation | 0.496 | - |
Gene Details

| Gene Type | protein coding |
|---|---|
| Gene Family | - |
| Description | -   |
| Chromosome | 17 |
| Location | 17q21 |
| Start | 41966741   |
| End | 41977736   |
| Strand | +   |
| Gene Sequence |    Download   Select all |
| Length | 10996   |
| OMIM ID | 123830    |
| HGNC ID | HGNC:2158    |
| Unigene ID | Hs.273621     |
| Ensembl ID | ENSG00000173786    |
| PharmGKB ID | -    |
mRNA Information
| mRNA ID | NM_033133.4 |
|---|---|
| Exon | join(1..147,1328..2000,5152..5291,6735..10996)   | mRNA Sequence |    Download   Select all |
| Length | 2096   |
CDS Information
| Location | join(145..147,1328..2000,5152..5291,6735..7184) |
|---|---|
| CDS Sequence |    Download   Select all |
| CCDS ID | CCDS11414.2 |    
Protein Information
| Protein ID | NP_149124.3 |
|---|---|
| Protein Name | 2',3'-cyclic nucleotide 3' phosphodiesterase |
| Molecular Wt. (Da) | 47251 |
| Protein Sequence |    Download   Select all |
| Length | 421   |
| Uniprot ID | Q92482 |    
| Ensembl Protein ID | ENSP00000297991   |    
Post-translational Modification Information (Source : HPRD)
| Residue | Type | site |
|---|---|---|
| S | Phosphorylation | 170 |
| S | Phosphorylation | 312 |
| S | Phosphorylation | 318 |
Enzyme Information
| EC | 3.1.4.37 |    
|---|---|
| Name | 2',3'-cyclic-nucleotide 3'-phosphodiesterase cyclic-CMP phosphodiesterase 2',3'-cyclic AMP phosphodiesterase cyclic 2',3'-nucleotide 3'-phosphodiesterase cyclic 2',3'-nucleotide phosphodiesterase 2',3'-cyclic nucleoside monophosphate phosphodiesterase 2',3'-cyclic nucleotide 3'-phosphohydrolase CNPase 2',3'-cyclic nucleotide phosphohydrolase 2':3'-cyclic nucleotide 3'-phosphodiesterase 2':3'-CNMP-3'-ase |
| Class | Hydrolases; Acting on ester bonds; Phosphoric-diester hydrolases |
| Sysname | nucleoside-2',3'-cyclic-phosphate 2'-nucleotidohydrolase   |
| Substrate | nucleoside 2',3'-cyclic phosphate [CPD:C01240]; H2O   |
| Product | nucleoside 2'-phosphate   |
| Reaction (IUBMB) | ![]() |
PPi Information
(Click to view network : Source STRING)      View   
No matching records from HPRD source could be found.
Pathway Information
No matching records could be found.
Structure Information
| PDB ID | 1WOJ |
|---|---|
| Resolution | 1.8 |
| Method | X-RAY DIFFRACTION |
| Chains | A   |
| Molecule | 2',3'-cyclic-nucleotide 3'-phosphodiesterase   |
| Model | View |
Domain Information
| ID | Location | Description |
|---|---|---|
| cd00009 | 53-138  | AAA |
| cl21455 | 53-138  | P-loop_NTPase superfamily |
| pfam05881 | 186-400  | CNPase |
| cl12319 | 186-400  | CNPase superfamily |
| pfam13207 | 52-156  | AAA_17 |
| pfam13401 | 50-148  | AAA_22 |
| pfam01591 | 38-149  | 6PF2K |
| cd00882 | 57-165  | Ras_like_GTPase |
| PRK06762 | 51-84  | PRK06762 |
| pfam08302 | 312-367  | tRNA_lig_CPD |
| cl07058 | 312-367  | tRNA_lig_CPD superfamily |
| pfam13671 | 52-166  | AAA_33 |
| COG4639 | 51-166  | COG4639 |
| PHA02530 | 50-148  | pseT |
| PRK04182 | 57-83  | PRK04182 |
| smart00382 | 54-142  | AAA |
| COG0237 | 57-149  | CoaE |
| pfam06414 | 45-147  | Zeta_toxin |
Ontology Information
| HPRD ID | 8970 |    
|---|---|
| Molecular Class | Enzyme: Phosphodiesterase |
| Molecular Function | Water channel activity (GO:0015250) |
| Biological Process | Transport (GO:0006810)   |
Drug Information
No matching records could be found.
External Links
| ArrayExpress | GO |    
|---|---|
| ICGC | GO |    
| Cancer3D | GO |    
| COSMIC | GO |    
| NCG | GO |    
| TSGene | GO |    
| Tumor Gene Family of Databases | GO |    
| CCDB | GO |    
| G2SBC | GO |    
| Osteosarcoma Database | GO |    
| RCDB | GO |    

