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General Information



Gene_Symbol Gene_ID Gene_Name Chromosome Alias
COL4A1 1282 collagen, type IV, alpha 1  13- 







  • Evidence
  • Gene
  • mRNA
  • CDS
  • Protein
  • PTM
  • Enzyme
  • PPi
  • Pathway
  • Structural
  • Domain
  • Ontology
  • SNP
  • Drug
  • External Links



Evidence Information


Pubmed ID Year Sample Information Techniques Mechanism Fold Change Remark
22200551   2012Cell line : -

Source : Ambroise Par Hospital.

Sample Type : -

No. of Sample : -

Stage : -

Microarray, microfluidic quantitative RT-PCR.Up-regulation-Extracellular matrix components (COL1A1, COL4A1, SLCO1A2) were over-represented in patients.


Gene Details



NC_000013.10 (110801310..110959496, complement)

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Gene Type protein coding
Gene Family Collagens
Description This gene encodes a type IV collagen alpha protein. Type IV collagen proteins are integral components of basement membranes. This gene shares a bidirectional promoter with a paralogous gene on the opposite strand. The protein consists of an amino-terminal 7S domain, a triple-helix forming collagenous domain, and a carboxy-terminal non-collagenous domain. It functions as part of a heterotrimer and interacts with other extracellular matrix components such as perlecans, proteoglycans, and laminins. In addition, proteolytic cleavage of the non-collagenous carboxy-terminal domain results in a biologically active fragment known as arresten, which has anti-angiogenic and tumor suppressor properties. Mutations in this gene cause porencephaly, cerebrovascular disease, and renal and muscular defects. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2014]  
Chromosome 13
Location 13q34
Start 110801310  
End 110959496  
Strand -  
Gene Sequence

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Length 158187  
OMIM ID 120130   
HGNC ID HGNC:2202   
Unigene ID Hs.17441   
Ensembl ID ENSG00000187498   
PharmGKB ID PA26717   

mRNA Information


mRNA ID NM_001845.5
Exon join(1..214,64424..64483,93143..93232,93332..93376, 94540..94584,94679..94741,95236..95289,95485..95511, 96946..97029,97116..97178,97731..97766,98268..98309, 99669..99755,100267..100293,100443..100493,101620..101664, 101752..101805,103551..103592,105636..105720, 106269..106304,108527..108691,112040..112135, 114245..114328,114874..114944,119829..120020, 120605..120773,123882..123974,124061..124165, 125769..125866,127737..127887,128122..128235, 128927..129094,129227..129316,130121..130273, 130434..130532,130645..130734,131801..131940, 132409..132535,132632..132712,133160..133258, 134388..134438,136426..136611,137396..137529, 139928..140000,140855..140926,142168..142296, 143597..143695,144716..144928  
mRNA Sequence

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Length 6545  



CDS Information


   
Location 131..5140
CDS Sequence

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CCDS ID CCDS9511.1



Protein Information


      
Protein IDNP_001836.3
Protein Namecollagen, type IV, alpha 1
Molecular Wt. (Da)0
Protein Sequence

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Length 1669  
Uniprot IDP30086
Ensembl Protein ID ENSP00000261313  



Post-translational Modification Information (Source : HPRD)


Residue Type site
KGlycosylation1265
CDisulfide Bridge1460;1551
CDisulfide Bridge1493;1548
CDisulfide Bridge1505;1511
CDisulfide Bridge1570;1665
CDisulfide Bridge1604;1662
CDisulfide Bridge1616;1622

Enzyme Information


No matching records could be found.

PPi Information


(Click to view network : Source STRING)      View   

                                                                                                                        
Interactant Gene ID (Source: HPRD) Gene Symbol HPRD ID Ref Seq ID Technique References
43ACHE10NP_056646.1in vitro12524166   
325APCS101NP_001630.1in vitro8662978   
351APP100NP_000475.1in vitro9136074   
1284COL4A2355NP_001837.2in vitro12011424   
1294COL7A1358NP_000085.1in vitro9169408   
6288SAA197NP_000322.2in vitro8995276   
6289SAA298NP_110381.2in vitro8995276   
6291SAA499NP_006503.1in vitro8995276   


Pathway Information


                                                
Pathway Name Pathway ID
AGE-RAGE signaling pathway in diabetic complications hsa04933
Amoebiasis hsa05146
ECM-receptor interaction hsa04512
Focal adhesion hsa04510
Pathways in cancer hsa05200
PI3K-Akt signaling pathway hsa04151
Protein digestion and absorption hsa04974
Small cell lung cancer hsa05222


Structure Information


No matching records could be found.

Domain Information




ID Location Description
pfam014131445-1554  C4
cl024671445-1554  C4 superfamily
smart001111555-1668  C4
cl024671555-1668  C4 superfamily
pfam014131555-1668  C4
smart001111445-1554  C4
pfam01391975-1033  Collagen
cl22949975-1033  Collagen superfamily
pfam013911103-1162  Collagen
cl229491103-1162  Collagen superfamily
pfam01391984-1041  Collagen
pfam013911088-1147  Collagen
pfam013911109-1168  Collagen
pfam01391996-1055  Collagen
pfam01391839-896  Collagen
cl22949839-896  Collagen superfamily
pfam01391951-1009  Collagen
pfam01391855-912  Collagen
pfam01391840-899  Collagen
pfam01391843-902  Collagen
pfam013911002-1056  Collagen
pfam01391876-935  Collagen
cl22949876-935  Collagen superfamily
pfam013911100-1157  Collagen
pfam013911112-1171  Collagen
pfam013911064-1123  Collagen
cl229491064-1123  Collagen superfamily
pfam01391960-1019  Collagen
pfam01391957-1014  Collagen
pfam01391861-920  Collagen
pfam013911130-1191  Collagen
pfam013911076-1135  Collagen
pfam01391954-1011  Collagen
pfam01391849-906  Collagen
pfam01391948-1007  Collagen
pfam013911082-1141  Collagen
pfam013911073-1130  Collagen
pfam01391885-936  Collagen
pfam01391947-1004  Collagen
pfam01391275-325  Collagen
cl22949275-325  Collagen superfamily
pfam01391278-323  Collagen
pfam01391882-937  Collagen
pfam013911058-1114  Collagen
pfam01391510-585  Collagen
cl22949510-585  Collagen superfamily
pfam01391645-683  Collagen
cl22949645-683  Collagen superfamily
PRK07764958-1153  PRK07764
pfam09606861-1177  Med15
pfam05642912-1115  Sporozoite_P67
PHA03247851-1155  PHA03247
PRK07764843-1048  PRK07764
PHA031691044-1189  PHA03169
pfam05642979-1172  Sporozoite_P67
PRK07764867-1055  PRK07764
PHA03169873-1017  PHA03169
pfam03157831-1378  Glutenin_hmw
PRK146661054-1170  uvrC
PRK07764976-1168  PRK07764


Ontology Information


   
HPRD ID1418
Molecular ClassExtracellular matrix protein
Molecular FunctionProtease inhibitor activity (GO:0030414)
Biological ProcessProtein metabolism (GO:0019538)  



SNP Information


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Drug Information


No matching records could be found.

External Links


                                 
ArrayExpressGO
ICGCGO
Cancer3DGO
COSMICGO
NCGGO
TSGeneGO
Tumor Gene Family of DatabasesGO
CCDBGO
G2SBCGO
Osteosarcoma DatabaseGO
RCDBGO