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General Information



Gene_Symbol Gene_ID Gene_Name Chromosome Alias
COL4A2 1284 collagen, type IV, alpha 2  13FLJ22259, DKFZp686I14213 







  • Evidence
  • Gene
  • mRNA
  • CDS
  • Protein
  • PTM
  • Enzyme
  • PPi
  • Pathway
  • Structural
  • Domain
  • Ontology
  • SNP
  • Drug
  • External Links



Evidence Information


Pubmed ID Year Sample Information Techniques Mechanism Fold Change Remark
24485021   2014Cell line : HCT116, HT29, SW480, LIM1215

Source : Adelaide, South Australia.

Sample Type : CRCTumor and adjecent normal tissue

No. of Sample : Non-neoplastic (59), adenoma (13) or adenocarcinoma (95 comprising 24 Dukes A, 18 Dukes B 45 Dukes C and 8 Dukes D)

Stage : Duke Stage A,B,C,D

Methylation specific PCRLow DNA methylation-(BCAT1, COL4A2, DLX5, FGF5, FOXF1, FOXI2, GRASP, IKZF1, IRF4, SDC2 and SOX21) have very low methylation in peripheral blood DNA and are suitable for further evaluation as blood-based diagnostic .


Gene Details



NC_000013.10 (110959631..111165374)

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Gene Type protein coding
Gene Family Collagens
Description This gene encodes one of the six subunits of type IV collagen, the major structural component of basement membranes. The C-terminal portion of the protein, known as canstatin, is an inhibitor of angiogenesis and tumor growth. Like the other members of the type IV collagen gene family, this gene is organized in a head-to-head conformation with another type IV collagen gene so that each gene pair shares a common promoter. [provided by RefSeq, Jul 2008]  
Chromosome 13
Location 13q34
Start 110959631  
End 111165374  
Strand +  
Gene Sequence

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Length 205744  
OMIM ID 120090   
HGNC ID HGNC:2203   
Unigene ID Hs.508716   
Ensembl ID ENSG00000134871   
PharmGKB ID PA26718   

mRNA Information


mRNA ID NM_001846.2
Exon join(1..245,577..664,786..840,50189..50269,117451..117585, 117670..117714,121184..121300,122602..122673, 123118..123153,123262..123324,125042..125077, 127118..127159,128986..129084,130719..130754, 131335..131385,132506..132550,138546..138599, 139515..139581,142396..142506,143022..143171, 150060..150152,151488..151651,154831..154903, 154995..155101,158122..158323,158720..158779, 159757..159813,161934..162041,165646..165867, 170720..170881,172937..173107,175233..175376, 177622..177744,178372..178553,182162..182225, 182428..182502,183950..184057,184787..184894, 185928..185999,188059..188184,194385..194501, 195838..195999,196100..196198,196564..196710, 196865..196981,199132..199323,200652..200938,  
mRNA Sequence

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Length 6264  



CDS Information


   
Location290..5428
CDS Sequence

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CCDS ID CCDS41907.1



Protein Information


      
Protein ID NP_001837.2
Protein Namecollagen, type IV, alpha 2
Molecular Wt. (Da)0
Protein Sequence

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Length 1712  
Uniprot IDQ06830
Ensembl Protein ID ENSP00000262746  



Post-translational Modification Information (Source : HPRD)


Residue Type site
TPhosphorylation1403
YPhosphorylation1586

Enzyme Information


No matching records could be found.

PPi Information


(Click to view network : Source STRING)      View   

                              
Interactant Gene ID (Source: HPRD) Gene Symbol HPRD ID Ref Seq ID Technique References
351APP100NP_000475.1in vitro9136074   
6288SAA197NP_000322.2in vitro8995276   


Pathway Information


                                                
Pathway Name Pathway ID
AGE-RAGE signaling pathway in diabetic complications hsa04933
Amoebiasis hsa05146
ECM-receptor interaction hsa04512
Focal adhesion hsa04510
Pathways in cancer hsa05200
PI3K-Akt signaling pathway hsa04151
Protein digestion and absorption hsa04974
Small cell lung cancer hsa05222


Structure Information


No matching records could be found.

Domain Information




ID Location Description
pfam014131489-1596  C4
cl024671489-1596  C4 superfamily
pfam014131597-1711  C4
cl024671597-1711  C4 superfamily
smart001111597-1711  C4
smart001111489-1596  C4
pfam01391791-849  Collagen
cl22949791-849  Collagen superfamily
pfam01391785-842  Collagen
pfam01391794-852  Collagen
pfam01391809-868  Collagen
pfam01391781-838  Collagen
pfam01391800-857  Collagen
pfam013911341-1394  Collagen
cl229491341-1394  Collagen superfamily
pfam01391806-865  Collagen
pfam013911332-1389  Collagen
pfam013911329-1388  Collagen
pfam01391821-880  Collagen
cl22949821-880  Collagen superfamily
pfam01391782-839  Collagen
pfam01391812-871  Collagen
pfam01391857-916  Collagen
cl22949857-916  Collagen superfamily
pfam01391860-917  Collagen
pfam01391824-881  Collagen
pfam01391493-548  Collagen
cl22949493-548  Collagen superfamily
pfam01391869-926  Collagen
pfam0139167-121  Collagen
cl2294967-121  Collagen superfamily
pfam01391494-548  Collagen
pfam01391494-543  Collagen
pfam01391815-877  Collagen
pfam01391836-893  Collagen
pfam01391515-578  Collagen
pfam01391293-346  Collagen
cl22949293-346  Collagen superfamily
pfam0139161-118  Collagen
pfam013911155-1212  Collagen
cl229491155-1212  Collagen superfamily
pfam01391292-349  Collagen
pfam013911143-1202  Collagen
pfam01391830-889  Collagen
pfam01391293-349  Collagen
pfam01391494-546  Collagen
pfam01391875-934  Collagen
pfam01391887-944  Collagen
pfam013911033-1088  Collagen
cl229491033-1088  Collagen superfamily
pfam01391896-950  Collagen
cl22949896-950  Collagen superfamily
pfam01391896-950  Collagen
pfam013911134-1191  Collagen
pfam013911015-1075  Collagen
pfam013911107-1165  Collagen
cl229491107-1165  Collagen superfamily
PRK077641303-1477  PRK07764
PRK077641228-1418  PRK07764


Ontology Information


   
HPRD ID3995
Molecular ClassExtracellular matrix protein
Molecular FunctionProtein serine/threonine kinase activity (GO:0004674)
Biological ProcessCell communication (GO:0007154); Signal transduction (GO:0007165)  



SNP Information


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Drug Information


No matching records could be found.

External Links


                                 
ArrayExpressGO
ICGCGO
Cancer3DGO
COSMICGO
NCGGO
TSGeneGO
Tumor Gene Family of DatabasesGO
CCDBGO
G2SBCGO
Osteosarcoma DatabaseGO
RCDBGO