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General Information



Gene_Symbol Gene_ID Gene_Name Chromosome Alias
COL5A2 1290 collagen, type V, alpha 2  2- 







  • Evidence
  • Gene
  • mRNA
  • CDS
  • Protein
  • PTM
  • Enzyme
  • PPi
  • Pathway
  • Structural
  • Domain
  • Ontology
  • SNP
  • Drug
  • External Links



Evidence Information


Pubmed ID Year Sample Information Techniques Mechanism Fold Change Remark
11375892   2001Cell line : -

Source : Umea Hospital.

Sample Type : CRC tumor and normal tissue

No. of Sample : 24

Stage : -

RT-PCR,In Situ HybridizationUp-regulation30.5 fold An analysis of other collagens showed that COL5A2 was not expressed in normal colon but was co-expressed with COL11A1 in the tumours.


Gene Details



NC_000002.11 (189896641..190044668, complement)

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Gene Type protein coding
Gene Family Collagens
Description This gene encodes an alpha chain for one of the low abundance fibrillar collagens. Fibrillar collagen molecules are trimers that can be composed of one or more types of alpha chains. Type V collagen is found in tissues containing type I collagen and appears to regulate the assembly of heterotypic fibers composed of both type I and type V collagen. This gene product is closely related to type XI collagen and it is possible that the collagen chains of types V and XI constitute a single collagen type with tissue-specific chain combinations. Mutations in this gene are associated with Ehlers-Danlos syndrome, types I and II. [provided by RefSeq, Jul 2008]  
Chromosome 2
Location 2q14-q32
Start 189896641  
End 190044668  
Strand -  
Gene Sequence

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Length 148028  
OMIM ID 120190   
HGNC ID HGNC:2210   
Unigene ID Hs.445827   
Ensembl ID ENSG00000204262   
PharmGKB ID PA26725   

mRNA Information


mRNA ID NM_000393.3
Exon join(45436..45807,114866..115090,121038..121051, 125176..125208,126556..126588,127985..128038, 132895..133005,136543..136620,138545..138589, 139543..139596,140102..140155,141278..141331, 144272..144325,145284..145337,146208..146252, 146746..146799,149878..149922,153222..153275, 156431..156529,157045..157089,157202..157300, 158533..158586,158818..158925,160258..160311, 160660..160758,161282..161335,162045..162143, 162252..162305,162397..162450,163700..163753, 164532..164585,166422..166466,166788..166886, 167888..167995,168289..168342,171103..171156, 171367..171420,171838..171891,172297..172404, 172513..172566,173090..173143,173834..173995, 174639..174746,175861..175968,177053..177106,  
mRNA Sequence

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Length 6930  



CDS Information


   
Location 276..4775
CDS Sequence

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CCDS ID CCDS33350.1



Protein Information


      
Protein IDNP_000384.2
Protein Namecollagen, type V, alpha 2
Molecular Wt. (Da)142030
Protein Sequence

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Length 1499  
Uniprot IDO60260
Ensembl Protein ID ENSP00000343589  



Post-translational Modification Information (Source : HPRD)


Residue Type site
EProteolytic Cleavage1253

Enzyme Information


No matching records could be found.

PPi Information


(Click to view network : Source STRING)      View   

No matching records from HPRD source could be found.

Pathway Information


      
Pathway Name Pathway ID
Protein digestion and absorption hsa04974


Structure Information


No matching records could be found.

Domain Information




ID Location Description
smart000381265-1499  COLFI
cl024361265-1499  COLFI superfamily
pfam014101282-1498  COLFI
pfam0009341-96  VWC
cl1773541-96  VWC superfamily
smart0021441-96  VWC
pfam01391495-553  Collagen
cl22949495-553  Collagen superfamily
pfam01391510-569  Collagen
pfam013911074-1131  Collagen
cl229491074-1131  Collagen superfamily
pfam01391819-877  Collagen
cl22949819-877  Collagen superfamily
pfam013911044-1100  Collagen
cl229491044-1100  Collagen superfamily
pfam01391480-538  Collagen
pfam01391846-905  Collagen
pfam01391814-872  Collagen
pfam013911068-1127  Collagen
pfam01391504-563  Collagen
pfam01391591-649  Collagen
cl22949591-649  Collagen superfamily
pfam01391702-759  Collagen
cl22949702-759  Collagen superfamily
pfam01391828-886  Collagen
pfam01391849-907  Collagen
cl22949849-907  Collagen superfamily
pfam01391546-603  Collagen
cl22949546-603  Collagen superfamily
pfam013911065-1123  Collagen
pfam013911059-1118  Collagen
pfam01391837-894  Collagen
pfam01391465-524  Collagen
pfam01391492-549  Collagen
pfam01391516-573  Collagen
pfam01391468-527  Collagen
pfam01391312-370  Collagen
cl22949312-370  Collagen superfamily
pfam01391570-629  Collagen
pfam01391582-641  Collagen
pfam01391270-328  Collagen
cl22949270-328  Collagen superfamily
pfam013911077-1136  Collagen
pfam01391324-383  Collagen
pfam01391531-589  Collagen
pfam01391333-391  Collagen
pfam01391471-528  Collagen
pfam01391327-384  Collagen
pfam01391285-344  Collagen
pfam013911080-1139  Collagen
pfam01391726-784  Collagen
pfam01391279-338  Collagen
pfam01391729-787  Collagen
pfam01391321-378  Collagen
pfam01391276-334  Collagen
pfam1482852-96  Amnionless
pfam01391714-773  Collagen
pfam01391549-606  Collagen
pfam01391306-365  Collagen
pfam01391354-406  Collagen
cl22949354-406  Collagen superfamily
pfam01391270-323  Collagen
pfam013911092-1146  Collagen
pfam01391744-796  Collagen
cl22949744-796  Collagen superfamily
pfam01391282-341  Collagen
pfam013911101-1147  Collagen
pfam01391458-506  Collagen
cl22949458-506  Collagen superfamily
pfam01391695-742  Collagen
PRK126781003-1146  PRK12678
PRK07764522-722  PRK07764
PRK07764425-613  PRK07764
PRK07764697-886  PRK07764
PRK07764346-553  PRK07764
PRK07764468-644  PRK07764
PHA03307531-914  PHA03307
PRK12678999-1146  PRK12678
PRK07764374-566  PRK07764
PRK07764497-714  PRK07764
PRK126781013-1146  PRK12678
PHA03247478-914  PHA03247
PHA03307467-780  PHA03307
PRK14959492-603  PRK14959
pfam040941062-1128  DUF390
PHA03169735-879  PHA03169
PRK07764475-711  PRK07764
pfam03157268-903  Glutenin_hmw
PRK07764277-509  PRK07764


Ontology Information


   
HPRD ID1330
Molecular ClassExtracellular matrix protein
Molecular FunctionTranscription regulator activity (GO:0030528)
Biological ProcessRegulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolism (GO:0019219)  



SNP Information


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Drug Information


No matching records could be found.

External Links


                                 
ArrayExpressGO
ICGCGO
Cancer3DGO
COSMICGO
NCGGO
TSGeneGO
Tumor Gene Family of DatabasesGO
CCDBGO
G2SBCGO
Osteosarcoma DatabaseGO
RCDBGO