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General Information



Gene_Symbol Gene_ID Gene_Name Chromosome Alias
COL11A1 1301 collagen, type XI, alpha 1  1STL2, CO11A1 







  • Evidence
  • Gene
  • mRNA
  • CDS
  • Protein
  • PTM
  • Enzyme
  • PPi
  • Pathway
  • Structural
  • Domain
  • Ontology
  • SNP
  • Drug
  • External Links



Evidence Information


Pubmed ID Year Sample Information Techniques Mechanism Fold Change Remark
11375892   2001Cell line : -

Source : Umea Hospital.

Sample Type : CRC tumor and normal tissue

No. of Sample : 25

Stage : -

RT-PCR,In Situ HybridizationUp-regulation-Stromal expression of COL11A1 and COL5A2 is associated with malignancy in colorectal cancer.


Gene Details



NC_000001.10 (103342023..103574052, complement)

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Gene Type protein coding
Gene Family Collagens
Description This gene encodes one of the two alpha chains of type XI collagen, a minor fibrillar collagen. Type XI collagen is a heterotrimer but the third alpha chain is a post-translationally modified alpha 1 type II chain. Mutations in this gene are associated with type II Stickler syndrome and with Marshall syndrome. A single-nucleotide polymorphism in this gene is also associated with susceptibility to lumbar disc herniation. Multiple transcript variants have been identified for this gene. [provided by RefSeq, Nov 2009]  
Chromosome 1
Location 1p21
Start 103342023  
End 103574052  
Strand -  
Gene Sequence

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Length 232030  
OMIM ID 120280   
HGNC ID HGNC:2186   
Unigene ID Hs.523446   
Ensembl ID ENSG00000060718   
PharmGKB ID PA26702   

mRNA Information


mRNA ID NM_001190709.1
Exon join(81..504,25605..25772,29706..29919,33797..33959, 77333..77461,82964..83056,85581..85835,86808..86870, 89718..89759,90695..90757,92835..92909,93983..94066, 96108..96164,100061..100114,102262..102315,102456..102509, 102686..102739,103916..103969,104089..104133, 105309..105362,105786..105830,106096..106149, 106608..106652,110214..110267,111453..111497, 112535..112588,112669..112713,119006..119059, 120837..120944,124386..124439,129142..129195, 129473..129517,129664..129717,129825..129869, 133694..133747,138305..138358,143037..143090, 145817..145924,146312..146401,146658..146711, 161621..161728,168143..168250,169489..169542, 173464..173517,174021..174128,185188..185241, 187006..187059,188213..1882  
mRNA Sequence

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Length 7191  



CDS Information


   
Location319..5622
CDS Sequence

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CCDS ID CCDS53348.1



Protein Information


      
Protein IDNP_001177638.1
Protein Namecollagen, type XI, alpha 1
Molecular Wt. (Da)0
Protein Sequence

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Length 1767  
Uniprot IDQ02962
Ensembl Protein ID ENSP00000347385  



Post-translational Modification Information (Source : HPRD)


No matching records could be found.

Enzyme Information


No matching records could be found.

PPi Information


(Click to view network : Source STRING)      View   

No matching records from HPRD source could be found.

Pathway Information


      
Pathway Name Pathway ID
Protein digestion and absorption hsa04974


Structure Information


No matching records could be found.

Domain Information




ID Location Description
cd0011073-225  LamG
cl2286173-225  LamG superfamily
pfam014101593-1804  COLFI
cl024361593-1804  COLFI superfamily
smart000381576-1805  COLFI
smart0021038-229  TSPN
pfam02210112-227  Laminin_G_2
smart00282100-227  LamG
pfam01391841-900  Collagen
cl22949841-900  Collagen superfamily
pfam01391811-870  Collagen
cl22949811-870  Collagen superfamily
pfam1338590-225  Laminin_G_3
pfam01391838-896  Collagen
pfam01391832-889  Collagen
pfam01391823-882  Collagen
pfam013911378-1427  Collagen
cl229491378-1427  Collagen superfamily
pfam01391799-856  Collagen
cl22949799-856  Collagen superfamily
pfam01391826-884  Collagen
pfam01391850-902  Collagen
pfam013911096-1145  Collagen
cl229491096-1145  Collagen superfamily
pfam01391790-847  Collagen
pfam01391853-903  Collagen
pfam01391784-843  Collagen
pfam013911368-1418  Collagen
pfam013911086-1134  Collagen
pfam013911368-1416  Collagen
pfam013911084-1136  Collagen
pfam01391637-681  Collagen
cl22949637-681  Collagen superfamily
pfam01391607-675  Collagen
pfam013911111-1181  Collagen
pfam013911108-1173  Collagen
pfam01391625-677  Collagen
pfam013911393-1466  Collagen
pfam013911083-1124  Collagen
PRK07764806-902  PRK07764
PHA03169729-901  PHA03169


Ontology Information


   
HPRD ID15938
Molecular ClassExtracellular matrix protein
Molecular FunctionTranscription factor activity (GO:0003700)
Biological ProcessRegulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolism (GO:0019219)  



SNP Information


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Drug Information


No matching records could be found.

External Links


                                 
ArrayExpressGO
ICGCGO
Cancer3DGO
COSMICGO
NCGGO
TSGeneGO
Tumor Gene Family of DatabasesGO
CCDBGO
G2SBCGO
Osteosarcoma DatabaseGO
RCDBGO