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General Information
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- Enzyme
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Evidence Information
| Pubmed ID | Year | Sample Information | Techniques | Mechanism | Fold Change | Remark |
|---|---|---|---|---|---|---|
| 25532943 | 2015 | Cell line : - Source : - Sample Type : - No. of Sample : - Stage : - | Transfection and Gene Knockout, proliferative, invasion assay | Down-regulation | - | COMT�has tumor-suppressive functions for CRC cell lines in vitro and in vivo experiments. |
Gene Details
| Gene Type | protein coding |
|---|---|
| Gene Family | - |
| Description | Catechol-O-methyltransferase catalyzes the transfer of a methyl group from S-adenosylmethionine to catecholamines, including the neurotransmitters dopamine, epinephrine, and norepinephrine. This O-methylation results in one of the major degradative pathways of the catecholamine transmitters. In addition to its role in the metabolism of endogenous substances, COMT is important in the metabolism of catechol drugs used in the treatment of hypertension, asthma, and Parkinson disease. COMT is found in two forms in tissues, a soluble form (S-COMT) and a membrane-bound form (MB-COMT). The differences between S-COMT and MB-COMT reside within the N-termini. Several transcript variants are formed through the use of alternative translation initiation sites and promoters. [provided by RefSeq, Sep 2008] |
| Chromosome | 22 |
| Location | 22q11.21 |
| Start | 19929263 |
| End | 19957498 |
| Strand | + |
| Gene Sequence | Download Select all |
| Length | 28236 |
| OMIM ID | 116790 |
| HGNC ID | HGNC:2228 |
| Unigene ID | Hs.370408 |
| Ensembl ID | ENSG00000093010 |
| PharmGKB ID | PA117 |
mRNA Information
| mRNA ID | NM_006440.4 |
|---|---|
| Exon | complement(<1..253) | mRNA Sequence | Download Select all |
| Length | 2127 |
Protein Information
| Protein ID | NP_006431.2 |
|---|---|
| Protein Name | catechol-O-methyltransferase |
| Molecular Wt. (Da) | 56376 |
| Protein Sequence | Download Select all |
| Length | 524 |
| Uniprot ID | P26367 |
| Ensembl Protein ID | ENSP00000241001 |
Post-translational Modification Information (Source : HPRD)
| Residue | Type | site |
|---|---|---|
| Y | Phosphorylation | 180 |
| Y | Phosphorylation | 130 |
Enzyme Information
No matching records could be found.
PPi Information
(Click to view network : Source STRING) View
| Interactant Gene ID (Source: HPRD) | Gene Symbol | HPRD ID | Ref Seq ID | Technique | References |
|---|---|---|---|---|---|
| 1636 | ACE | 108 | NP_000780.1 | in vivo | 12729939 |
| 9319 | TRIP13 | 5145 | NP_004228.1 | yeast 2-hybrid | 16189514 |
| 9516 | LITAF | 10354 | NP_004853.2 | yeast 2-hybrid | 16169070 |
Pathway Information
| Pathway Name | Pathway ID |
|---|---|
| Dopaminergic synapse | hsa04728 |
| Metabolic pathways | hsa01100 |
| Steroid hormone biosynthesis | hsa00140 |
| Tyrosine metabolism | hsa00350 |
Structure Information
No matching records could be found.
Domain Information
| ID | Location | Description |
|---|---|---|
| cd02440 | 112-217 | AdoMet_MTases |
| cl17173 | 112-217 | AdoMet_MTases superfamily |
| COG4122 | 51-264 | YrrM |
| pfam13578 | 113-221 | Methyltransf_24 |
| pfam01596 | 89-222 | Methyltransf_3 |
| pfam13659 | 112-225 | Methyltransf_26 |
| pfam12847 | 108-221 | Methyltransf_18 |
| PLN02589 | 48-268 | PLN02589 |
| PRK07402 | 110-181 | PRK07402 |
| TIGR04364 | 113-176 | methyltran_FxLD |
| pfam09445 | 110-190 | Methyltransf_15 |
| TIGR01444 | 111-153 | fkbM_fam |
| PRK00377 | 111-205 | cbiT |
| COG0742 | 130-216 | RsmD |
| COG0030 | 98-167 | RsmA |
| PLN02476 | 90-225 | PLN02476 |
| COG2519 | 110-191 | Gcd14 |
Ontology Information
| HPRD ID | 3129 |
|---|---|
| Molecular Class | Enzyme: Acyltransferase |
| Molecular Function | RNA binding (GO:0003723); DNA binding (GO:0003677) |
| Biological Process | Regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolism (GO:0019219) |
Drug Information
| Uniprot ID | DrugBank ID | Name | Type |
|---|---|---|---|
| P21964 | DB00255 | Diethylstilbestrol | SmallMoleculeDrug |
| P21964 | DB00286 | Conjugated Estrogens | SmallMoleculeDrug |
| P21964 | DB00494 | Entacapone | SmallMoleculeDrug |
| P21964 | DB00841 | Dobutamine | SmallMoleculeDrug |
| P21964 | DB00968 | Methyldopa | SmallMoleculeDrug |
| P21964 | DB00988 | Dopamine | SmallMoleculeDrug |
| P21964 | DB01141 | Micafungin | SmallMoleculeDrug |
| P21964 | DB01420 | Testosterone Propionate | SmallMoleculeDrug |
| P21964 | DB00118 | S-Adenosylmethionine | SmallMoleculeDrug |
| P21964 | DB00323 | Tolcapone | SmallMoleculeDrug |
| P21964 | DB00494 | Entacapone | SmallMoleculeDrug |