Search results:
General Information
| Gene_Symbol | Gene_ID | Gene_Name | Chromosome | Alias |
|---|---|---|---|---|
| KLF6 | 1316 | Kruppel-like factor 6 | 10 | CPBP, GBF, Zf9, PAC1 |
- Evidence
- Gene
- mRNA
- CDS
- Protein
- PTM
- Enzyme
- PPi
- Pathway
- Structural
- Domain
- Ontology
- SNP
- Drug
- External Links
Evidence Information
| Pubmed ID | Year | Sample Information | Techniques | Mechanism | Fold Change | Remark |
|---|---|---|---|---|---|---|
| 15057748 | 2004 | Cell line : - Source : - Sample Type : - No. of Sample : 50 microdissected CRC cases, including 35 sporadic and 15 IBD-associated tumors. Stage : - | Direct sequencing, thymidine incorporation assays and Western blotting. | Mutation | - | Deregulation of KLF6 by a combination of allelic imbalance and mutation may play a role in the development of CRC.The KLF6 locus was deleted in at least 55% of tumors, and mutations were identified in 44%. |
| 16610031 | 2006 | Cell line : - Source : Teaching hospital in Seoul, Republic of Korea Sample Type : Formalin-fixed and paraffin-embedded tissue No. of Sample : 123 Stage : Duke stage A-D | Immunohistochemistry,tissue microarray | Mutation | - | Loss of KLF6 expression may be a common and early event in colorectal carcinogenesis. |
| 16856969 | 2006 | Cell line : - Source : Departments of Pathology and Pediatrics, College of Medicine, The Catholic University of Korea, Seoul, Korea. Sample Type : Formalin-fixed and paraffin-embedded tissue No. of Sample : 123 Stage : TNM Stage II-IV | PCR-SSCP sequencing | Mutation | - | KLF6 gene might play a role in the development of colorectal carcinomas. |
Gene Details
| Gene Type | protein coding |
|---|---|
| Gene Family | Kruppel-like transcription factors, "Zinc fingers, C2H2-type" |
| Description | This gene encodes a member of the Kruppel-like family of transcription factors. The zinc finger protein is a transcriptional activator, and functions as a tumor suppressor. Multiple transcript variants encoding different isoforms have been found for this gene, some of which are implicated in carcinogenesis. [provided by RefSeq, May 2009] |
| Chromosome | 10 |
| Location | 10p15 |
| Start | 3818188 |
| End | 3827473 |
| Strand | - |
| Gene Sequence | Download Select all |
| Length | 9286 |
| OMIM ID | 602053 |
| HGNC ID | HGNC:2235 |
| Unigene ID | Hs.4055 |
| Ensembl ID | ENSG00000067082 |
| PharmGKB ID | PA26751 |
mRNA Information
| mRNA ID | NM_001160124.1 |
|---|---|
| Exon | join(1..369,3068..3515,5053..5176,5692..9286) | mRNA Sequence | Download Select all |
| Length | 4553 |
Protein Information
| Protein ID | NP_001153596.1 |
|---|---|
| Protein Name | Kruppel-like factor 6 |
| Molecular Wt. (Da) | 26979 |
| Protein Sequence | Download Select all |
| Length | 241 |
| Uniprot ID | P40426 |
| Ensembl Protein ID | ENSP00000341990 |
Post-translational Modification Information (Source : HPRD)
No matching records could be found.
Enzyme Information
No matching records could be found.
PPi Information
(Click to view network : Source STRING) View
| Interactant Gene ID (Source: HPRD) | Gene Symbol | HPRD ID | Ref Seq ID | Technique | References |
|---|---|---|---|---|---|
| 1952 | CELSR2 | 5040 | NP_001399.1 | yeast 2-hybrid | 16169070 |
| 2975 | GTF3C1 | 7540 | NP_001511.2 | yeast 2-hybrid | 16169070 |
| 6667 | SP1 | 1796 | NP_612482.2 | in vitro;in vivo | 12433697 |
| 7157 | TP53 | 1859 | NP_000537.3 | in vivo | 15131018 |
| 8841 | HDAC3 | 8950 | NP_003874.2 | in vitro;in vivo | 15917248 |
| 10919 | EHMT2 | 6854 | NP_006700.3 | yeast 2-hybrid | 16189514 |
| 23649 | POLA2 | 10160 | NP_002680.2 | yeast 2-hybrid | 16169070 |
| 55937 | APOM | 6068 | NP_061974.2 | yeast 2-hybrid | 16169070 |
| 56902 | PNO1 | 14250 | NP_064528.1 | yeast 2-hybrid | 16169070 |
Pathway Information
No matching records could be found.
Structure Information
No matching records could be found.
Domain Information
| ID | Location | Description |
|---|---|---|
| pfam13465 | 246-271 | zf-H2C2_2 |
| cl22375 | 246-271 | zf-H2C2_2 superfamily |
| pfam00096 | 260-282 | zf-C2H2 |
| cl23491 | 260-282 | zf-C2H2 superfamily |
| pfam13465 | 216-232 | zf-H2C2_2 |
| cl22375 | 216-232 | zf-H2C2_2 superfamily |
| COG5048 | 177-265 | COG5048 |
| COG5048 | 205-262 | COG5048 |
Ontology Information
| HPRD ID | 1981 |
|---|---|
| Molecular Class | Transcription factor |
| Molecular Function | Ligase activity (GO:0016874) |
| Biological Process | Metabolism (GO:0008152); Energy pathways (GO:0006091) |
Drug Information
No matching records could be found.