CoReCG

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General Information

Gene_Symbol	Gene_ID	Gene_Name	Chromosome	Alias
ADM	133	adrenomedullin	11	AM

Evidence
Gene
mRNA
CDS
Protein
PTM
Enzyme
PPi
Pathway
Structural
Domain
Ontology
SNP
Drug
External Links

Evidence Information

Pubmed ID	Year	Sample Information	Techniques	Mechanism	Fold Change	Remark
23634287	2013	Cell line : - Source : - Sample Type : - No. of Sample : - Stage : TNM Stage III,IV	Tissue microarray and immunohistochemistry	Up-regulation	-	AM treatment inhibits tumor growth by suppression of angiogenesis and tumor growth, suggesting that AM may be a useful therapeutic target. Tissue microarray analysis revealed a clear increase of AM, CLR, RAMP2, and RAMP3 staining in lymph node and distant metastasis when compared with primary tumors.

Gene Details

Chromosome 11 - NC_000011.10 (10304980..10307402)
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Gene Type	protein coding
Gene Family	Endogenous ligands
Description	The protein encoded by this gene is a preprohormone which is cleaved to form two biologically active peptides, adrenomedullin and proadrenomedullin N-terminal 20 peptide. Adrenomedullin is a 52 aa peptide with several functions, including vasodilation, regulation of hormone secretion, promotion of angiogenesis, and antimicrobial activity. The antimicrobial activity is antibacterial, as the peptide has been shown to kill E. coli and S. aureus at low concentration.
Chromosome	11
Location	11p15.4
Start	10304980
End	10307402
Strand	+
Gene Sequence	>gi\|568815587:10304980-10307402 Homo sapiens chromosome 11, GRCh38.p2 Primary Assembly GAGGAAAGAAAGGGAAGGCAACCGGGCAGCCCAGGCCCCGCCCCGCCGCTCCCCCACCCGTGCGCTTATA AAGCACAGGAACCAGAGCTGGCCACTCAGTGGTTTCTTGGTGACACTGGATAGAACAGCTCAAGCCTTGC CACTTCGGGCTTCTCACTGCAGCTGGGCTTGGACTTCGGAGTTTTGCCATTGCCAGTGGGACGTCTGAGA CTTTCTCCTTCAAGTACTTGGCAGATCACTCTCTTAGCAGGTAGGTGCCGCAGACCCTGCGGGTTAAGAG GTGGGGTGGGGGGCAGTGCTTGCCAAGGCCCTAAACTGGGAGCGCTGGGTGAGGGGAACAACCCACTTTG GAGGGTTCTCTGAGAGATAGATACACCCCATATCCTGGGCCCAGCTCGTGCACACAGCTGGAGGTCCAGA GACCCAGTCCCCTCTGCTCCGTCAGCCAAGTTCCAAGAAGTTGAGCAGAGACCCTCTGGGAGCCTGGCGG GGTGCAGCGGCCTCCCCTGCGGGGCCTGTCACCCGGCCGGCGCGTGCAAACGCCTCTGGCGCCTCTCTGC GCGGAGGGAGATAAGCGTCTGAGCCAGGGAAAGCGCGGGCTAAACCCGCCTCGCCGGGGCCCCTGCCCGC CCTCCGTGCCCCGCCCGGGCGGTGCAGCTGGCCCGGGTGCTCACGCTCGACTCTCTTTCTTCTTTTCCAG GGTCTGCGCTTCGCAGCCGGGATGAAGCTGGTTTCCGTCGCCCTGATGTACCTGGGTTCGCTCGCCTTCC TAGGCGCTGACACCGCTCGGTTGGATGTCGCGTCGGAGTTTCGAAAGAAGTGAGTCCGGGCAGCGCCTTC CCCCTTGCTGGTACCTGGCAGGCAAGGGGAACTGACCGTTGGTCCCGAAGGTCTAGAAGTGAATGGGAGC AGGGACAGGCCTGGGCGTCACCTGAACGCACGCGAATCGGGTCTGCTTGTGTTTTCCAGGTGGAATAAGT GGGCTCTGAGTCGTGGGAAGAGGGAACTGCGGATGTCCAGCAGCTACCCCACCGGGCTCGCTGACGTGAA GGCCGGGCCTGCCCAGACCCTTATTCGGCCCCAGGACATGAAGGGTGCCTCTCGAAGCCCCGAAGACAGG TAACTACGCCCTGTGCTGTCCAGGGACGGGAGGGAAGGAAGGTGTGCGGGAGGAGTTCTCTGTCTCCACT CCCCTGGCCCGGGGGATCGTCGGGGCTGGACCGCAGCTCAGATGGCGCGAGCAGTTTCCAGCTCCCTCTG GCTCTAGAATGGCTCCCGTTCCCGGTGTTGGGGCCAAAGCTCTGCTTGATGGGGTCTCAAGTTGCCTTTC TTCCCCCTCCCCCCGCCCGCAGCAGTCCGGATGCCGCCCGCATCCGAGTCAAGCGCTACCGCCAGAGCAT GAACAACTTCCAGGGCCTCCGGAGCTTTGGCTGCCGCTTCGGGACGTGCACGGTGCAGAAGCTGGCACAC CAGATCTACCAGTTCACAGATAAGGACAAGGACAACGTCGCCCCCAGGAGCAAGATCAGCCCCCAGGGCT ACGGCCGCCGGCGCCGGCGCTCCCTGCCCGAGGCCGGCCCGGGTCGGACTCTGGTGTCTTCTAAGCCACA AGCACACGGGGCTCCAGCCCCCCCGAGTGGAAGTGCTCCCCACTTTCTTTAGGATTTAGGCGCCCATGGT ACAAGGAATAGTCGCGCAAGCATCCCGCTGGTGCCTCCCGGGACGAAGGACTTCCCGAGCGGTGTGGGGA CCGGGCTCTGACAGCCCTGCGGAGACCCTGAGTCCGGGAGGCACCGTCCGGCGGCGAGCTCTGGCTTTGC AAGGGCCCCTCCTTCTGGGGGCTTCGCTTCCTTAGCCTTGCTCAGGTGCAAGTGCCCCAGGGGGCGGGGT GCAGAAGAATCCGAGTGTTTGCCAGGCTTAAGGAGAGGAGAAACTGAGAAATGAATGCTGAGACCCCCGG AGCAGGGGTCTGAGCCACAGCCGTGCTCGCCCACAAACTGATTTCTCACGGCGTGTCACCCCACCAGGGC GCAAGCCTCACTATTACTTGAACTTTCCAAAACCTAAAGAGGAAAAGTGCAATGCGTGTTGTACATACAG AGGTAACTATCAATATTTAAGTTTGTTGCTGTCAAGATTTTTTTTGTAACTTCAAATATAGAGATATTTT TGTACGTTATATATTGTATTAAGGGCATTTTAAAAGCAATTATATTGTCCTCCCCTATTTTAAGACGTGA ATGTCTCAGCGAGGTGTAAAGTTGTTCGCCGCGTGGAATGTGAGTGTGTTTGTGTGCATGAAAGAGAAAG ACTGATTACCTCCTGTGTGGAAGAAGGAAACACCGAGTCTCTGTATAATCTATTTACATAAAATGGGTGA TATGCGAACAGCAAACCAATAAACTGTCTCAATGCTGATTCAT Download Select all
Length	2423
OMIM ID	103275
HGNC ID	HGNC:259
Unigene ID	Hs.441047
Ensembl ID	ENSG00000148926
PharmGKB ID	-

mRNA Information

mRNA ID	NM_001124.
Exon	join(1..250,701..819,970..1119,1353..2423)
mRNA Sequence	>133 GAGGAAAGAAAGGGAAGGCAACCGGGCAGCCCAGGCCCCGCCCCGCCGCTCCCCCACCCGTGCG CTTATAAAGCACAGGAACCAGAGCTGGCCACTCAGTGGTTTCTTGGTGACACTGGATAGAACAG CTCAAGCCTTGCCACTTCGGGCTTCTCACTGCAGCTGGGCTTGGACTTCGGAGTTTTGCCATTG CCAGTGGGACGTCTGAGACTTTCTCCTTCAAGTACTTGGCAGATCACTCTCTTAGCAGGGTCTG CGCTTCGCAGCCGGGATGAAGCTGGTTTCCGTCGCCCTGATGTACCTGGGTTCGCTCGCCTTCC TAGGCGCTGACACCGCTCGGTTGGATGTCGCGTCGGAGTTTCGAAAGAAGTGGAATAAGTGGGC TCTGAGTCGTGGGAAGAGGGAACTGCGGATGTCCAGCAGCTACCCCACCGGGCTCGCTGACGTG AAGGCCGGGCCTGCCCAGACCCTTATTCGGCCCCAGGACATGAAGGGTGCCTCTCGAAGCCCCG AAGACAGCAGTCCGGATGCCGCCCGCATCCGAGTCAAGCGCTACCGCCAGAGCATGAACAACTT CCAGGGCCTCCGGAGCTTTGGCTGCCGCTTCGGGACGTGCACGGTGCAGAAGCTGGCACACCAG ATCTACCAGTTCACAGATAAGGACAAGGACAACGTCGCCCCCAGGAGCAAGATCAGCCCCCAGG GCTACGGCCGCCGGCGCCGGCGCTCCCTGCCCGAGGCCGGCCCGGGTCGGACTCTGGTGTCTTC TAAGCCACAAGCACACGGGGCTCCAGCCCCCCCGAGTGGAAGTGCTCCCCACTTTCTTTAGGAT TTAGGCGCCCATGGTACAAGGAATAGTCGCGCAAGCATCCCGCTGGTGCCTCCCGGGACGAAGG ACTTCCCGAGCGGTGTGGGGACCGGGCTCTGACAGCCCTGCGGAGACCCTGAGTCCGGGAGGCA CCGTCCGGCGGCGAGCTCTGGCTTTGCAAGGGCCCCTCCTTCTGGGGGCTTCGCTTCCTTAGCC TTGCTCAGGTGCAAGTGCCCCAGGGGGCGGGGTGCAGAAGAATCCGAGTGTTTGCCAGGCTTAA GGAGAGGAGAAACTGAGAAATGAATGCTGAGACCCCCGGAGCAGGGGTCTGAGCCACAGCCGTG CTCGCCCACAAACTGATTTCTCACGGCGTGTCACCCCACCAGGGCGCAAGCCTCACTATTACTT GAACTTTCCAAAACCTAAAGAGGAAAAGTGCAATGCGTGTTGTACATACAGAGGTAACTATCAA TATTTAAGTTTGTTGCTGTCAAGATTTTTTTTGTAACTTCAAATATAGAGATATTTTTGTACGT TATATATTGTATTAAGGGCATTTTAAAAGCAATTATATTGTCCTCCCCTATTTTAAGACGTGAA TGTCTCAGCGAGGTGTAAAGTTGTTCGCCGCGTGGAATGTGAGTGTGTTTGTGTGCATGAAAGA GAAAGACTGATTACCTCCTGTGTGGAAGAAGGAAACACCGAGTCTCTGTATAATCTATTTACAT AAAATGGGTGATATGCGAACAGCAAACCAATAAACTGTCTCAATGCTGATTCATAAAAAAAAAA AAAAAA Download Select all
Length	1606

CDS Information

Location	join(722..819,970..1119,1353..1662)
CDS Sequence	>lcl\|NM_001124.2_cds_NP_001115.1_1 [gene=ADM] [protein=ADM precursor] [protein_id=NP_001115.1] [location=272..829] ATGAAGCTGGTTTCCGTCGCCCTGATGTACCTGGGTTCGCTCGCCTTCCTAGGCGCTGACACCGCTCGGT TGGATGTCGCGTCGGAGTTTCGAAAGAAGTGGAATAAGTGGGCTCTGAGTCGTGGGAAGAGGGAACTGCG GATGTCCAGCAGCTACCCCACCGGGCTCGCTGACGTGAAGGCCGGGCCTGCCCAGACCCTTATTCGGCCC CAGGACATGAAGGGTGCCTCTCGAAGCCCCGAAGACAGCAGTCCGGATGCCGCCCGCATCCGAGTCAAGC GCTACCGCCAGAGCATGAACAACTTCCAGGGCCTCCGGAGCTTTGGCTGCCGCTTCGGGACGTGCACGGT GCAGAAGCTGGCACACCAGATCTACCAGTTCACAGATAAGGACAAGGACAACGTCGCCCCCAGGAGCAAG ATCAGCCCCCAGGGCTACGGCCGCCGGCGCCGGCGCTCCCTGCCCGAGGCCGGCCCGGGTCGGACTCTGG TGTCTTCTAAGCCACAAGCACACGGGGCTCCAGCCCCCCCGAGTGGAAGTGCTCCCCACTTTCTTTAG Download Select all
CCDS ID	CCDS7801.1

Protein Information

Protein ID	NP_001115.1
Protein Name	adrenomedullin
Molecular Wt. (Da)	8494
Protein Sequence	>133 MKLVSVALMYLGSLAFLGADTARLDVASEFRKKWNKWALSRGKRELRMSSSYPTGLADVKAGPA QTLIRPQDMKGASRSPEDSSPDAARIRVKRYRQSMNNFQGLRSFGCRFGTCTVQKLAHQIYQFT DKDKDNVAPRSKISPQGYGRRRRRSLPEAGPGRTLVSSKPQAHGAPAPPSGSAPHFL Download Select all
Length	185
Uniprot ID	P32455
Ensembl Protein ID	ENSP00000359504

Post-translational Modification Information (Source : HPRD)

Residue	Type	site
C	Disulfide Bridge	110;115
R	Amidation	41
R	Proteolytic Cleavage	23
E	Proteolytic Cleavage	29
K	Proteolytic Cleavage	33
K	Proteolytic Cleavage	36
W	Proteolytic Cleavage	37
A	Proteolytic Cleavage	38

Enzyme Information

No matching records could be found.

PPi Information

(Click to view network : Source STRING) View

No matching records from HPRD source could be found.

Pathway Information

No matching records could be found.

Structure Information

PDB ID	2FLY
Resolution
Method	SOLUTION NMR
Chains	A
Molecule	Proadrenomedullin N-20 terminal peptide
Model	View

Domain Information

ID	Location	Description
pfam00214	1-151	Calc_CGRP_IAPP

Ontology Information

HPRD ID	2971
Molecular Class	Peptide hormone
Molecular Function	Receptor activity (GO:0004872)
Biological Process	Cell communication (GO:0007154); Signal transduction (GO:0007165)

SNP Information

View SNP Geneview Report

Drug Information

No matching records could be found.

External Links

ArrayExpress GO
ICGC GO
Cancer3D GO
COSMIC GO
NCG GO
TSGene GO
Tumor Gene Family of Databases GO
CCDB GO
G2SBC GO
Osteosarcoma Database GO
RCDB GO

ArrayExpress	GO
ICGC	GO
Cancer3D	GO
COSMIC	GO
NCG	GO
TSGene	GO
Tumor Gene Family of Databases	GO
CCDB	GO
G2SBC	GO
Osteosarcoma Database	GO
RCDB	GO