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General Information
- Evidence
- Gene
- mRNA
- CDS
- Protein
- PTM
- Enzyme
- PPi
- Pathway
- Structural
- Domain
- Ontology
- SNP
- Drug
- External Links
Evidence Information
| Pubmed ID | Year | Sample Information | Techniques | Mechanism | Fold Change | Remark |
|---|---|---|---|---|---|---|
| 20619442 | 2010 | Cell line : - Source : - Sample Type : CRC Tumor and adjescent tissue No. of Sample : - Stage : - | real time RT-PCR, Western blotting, immunohistochemistry | Up-regulation | - | ADORA2B was overexpressed in colorectal carcinomas grown under a hypoxic state, presumably promoting cancer cell growth. |
Gene Details
| Gene Type | protein coding |
|---|---|
| Gene Family | GPCR / Class A : Adenosine receptors |
| Description | This gene encodes an adenosine receptor that is a member of the G protein-coupled receptor superfamily. This integral membrane protein stimulates adenylate cyclase activity in the presence of adenosine. This protein also interacts with netrin-1, which is involved in axon elongation. The gene is located near the Smith-Magenis syndrome region on chromosome 17. [provided by RefSeq, Jul 2008] |
| Chromosome | 17 |
| Location | 17p12 |
| Start | 15848231 |
| End | 15879210 |
| Strand | + |
| Gene Sequence | Download Select all |
| Length | 30980 |
| OMIM ID | 600446 |
| HGNC ID | HGNC:264 |
| Unigene ID | Hs.167046 |
| Ensembl ID | ENSG00000170425 |
| PharmGKB ID | PA24585 |
mRNA Information
| mRNA ID | XM_011524118.1 |
|---|---|
| Exon | <3059..3104 | mRNA Sequence | Download Select all |
| Length | 661 |
Protein Information
| Protein ID | XP_011522420.1 |
|---|---|
| Protein Name | adenosine A2b receptor |
| Molecular Wt. (Da) | 16679 |
| Protein Sequence | Download Select all |
| Length | 152 |
| Uniprot ID | O15105 |
| Ensembl Protein ID | ENSP00000262158 |
Post-translational Modification Information (Source : HPRD)
No matching records could be found.
Enzyme Information
No matching records could be found.
PPi Information
(Click to view network : Source STRING) View
| Interactant Gene ID (Source: HPRD) | Gene Symbol | HPRD ID | Ref Seq ID | Technique | References |
|---|---|---|---|---|---|
| 100 | ADA | 38 | NP_000013.2 | in vitro;in vivo | 11125033 |
| 1630 | DCC | 391 | NP_005206.2 | in vitro;in vivo;yeast 2-hybrid | 11048721 |
| 7430 | EZR | 475 | NP_003370.2 | in vitro;in vivo | 12080047 |
| 9351 | SLC9A3R2 | 5946 | NP_001123484.1 | in vitro | 12080047 |
| 9423 | NTN1 | 3368 | NP_004813.2 | in vitro;in vivo | 11048721 |
Pathway Information
| Pathway Name | Pathway ID |
|---|---|
| Alcoholism | hsa05034 |
| Calcium signaling pathway | hsa04020 |
| Neuroactive ligand-receptor interaction | hsa04080 |
| Rap1 signaling pathway | hsa04015 |
| Vascular smooth muscle contraction | hsa04270 |
Structure Information
No matching records could be found.
Domain Information
| ID | Location | Description |
|---|---|---|
| pfam10320 | 20-301 | 7TM_GPCR_Srsx |
| cl21561 | 20-301 | 7tm_4 superfamily |
| pfam00001 | 30-290 | 7tm_1 |
| PHA03087 | 20-317 | PHA03087 |
| PHA02638 | 15-298 | PHA02638 |
| PHA02834 | 24-307 | PHA02834 |
Ontology Information
| HPRD ID | 2059 |
|---|---|
| Molecular Class | G protein coupled receptor |
| Molecular Function | Molecular function unknown (GO:0005554) |
| Biological Process | Immune response (GO:0006955) |
Drug Information
| Uniprot ID | DrugBank ID | Name | Type |
|---|---|---|---|
| P29275 | DB00277 | Theophylline | SmallMoleculeDrug |
| P29275 | DB00640 | Adenosine | SmallMoleculeDrug |
| P29275 | DB00824 | Enprofylline | SmallMoleculeDrug |
| P29275 | DB04932 | Defibrotide | BiotechDrug |