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General Information



Gene_Symbol Gene_ID Gene_Name Chromosome Alias
CPE 1363 carboxypeptidase E  4- 







  • Evidence
  • Gene
  • mRNA
  • CDS
  • Protein
  • PTM
  • Enzyme
  • PPi
  • Pathway
  • Structural
  • Domain
  • Ontology
  • SNP
  • Drug
  • External Links



Evidence Information


Pubmed ID Year Sample Information Techniques Mechanism Fold Change Remark
24006921   2013Cell line : SW480, SW620, KM12, HCT15, HCT116, Caco 2, LoVo

Source : -

Sample Type : -

No. of Sample : -

Stage : -

real time RT-PCR,MTT and colony formation assay,Bromodeoxyuridine incorporation assayUp-regulation-CPE plays an important role in cell cycle regulation and tumorigenicity, and may serve as a potential target for CRC therapeutics.


Gene Details



NC_000004.11 (166300097..166419482)

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Gene Type protein coding
Gene Family -
Description This gene encodes a member of the M14 family of metallocarboxypeptidases. The encoded preproprotein is proteolytically processed to generate the mature peptidase. This peripheral membrane protein cleaves C-terminal amino acid residues and is involved in the biosynthesis of peptide hormones and neurotransmitters, including insulin. This protein may also function independently of its peptidase activity, as a neurotrophic factor that promotes neuronal survival, and as a sorting receptor that binds to regulated secretory pathway proteins, including prohormones. Mutations in this gene are implicated in type 2 diabetes. [provided by RefSeq, Nov 2015]  
Chromosome 4
Location 4q32.3
Start 166300097  
End 166419482  
Strand +  
Gene Sequence

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Length 119386  
OMIM ID 114855   
HGNC ID HGNC:2303   
Unigene ID Hs.75360   
Ensembl ID ENSG00000109472   
PharmGKB ID PA26824   

mRNA Information


mRNA ID NM_001873.3
Exon join(1..584,85446..85642,88744..88911,103298..103415, 105478..105660,108494..108633,114227..114326, 116615..116733,118568..119386)  
mRNA Sequence

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Length 2648  



CDS Information


   
Location 281..1711
CDS Sequence

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CCDS ID CCDS3810.1



Protein Information


      
Protein IDNP_001864.1
Protein Namecarboxypeptidase E
Molecular Wt. (Da)0
Protein Sequence

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Length 476  
Uniprot IDP05165
Ensembl Protein ID ENSP00000365456  



Post-translational Modification Information (Source : HPRD)


Residue Type site
RProteolytic Cleavage41

Enzyme Information


No matching records could be found.

PPi Information


(Click to view network : Source STRING)      View   

                                                                                                                                                                     
Interactant Gene ID (Source: HPRD) Gene Symbol HPRD ID Ref Seq ID Technique References
885CCK321NP_000720.1in vivo927   509   712   479   974   
2520GAST671NP_000796.1in vivo9369230   
2975GTF3C17540NP_001511.2yeast 2-hybrid16169070   
3630INS1455NP_000198.1in vivo109   668   577   477   119   
6092ROBO211895NP_001122401.1yeast 2-hybrid16169070   
6117RPA11565NP_002936.1yeast 2-hybrid16169070   
10813UTP14A6712NP_006640.2yeast 2-hybrid16169070   
23649POLA210160NP_002680.2yeast 2-hybrid16169070   
26073POLDIP217874NP_056399.1yeast 2-hybrid16169070   
51003MED3114382NP_057144.1yeast 2-hybrid16169070   
55791C1orf10317975NP_060842.3yeast 2-hybrid16169070   


Pathway Information


      
Pathway Name Pathway ID
Type I diabetes mellitus hsa04940


Structure Information


No matching records could be found.

Domain Information




ID Location Description
cd0386549-371  M14_CPE
cl1139349-371  Peptidase_M14_like superfamily
cd11308375-449  Peptidase_M14NE-CP-C_like
cl21470375-449  Peptidase_M14NE-CP-C_like superfamily
cd0385853-371  M14_CP_N-E_like
cd0386453-371  M14_CPN
cd0386753-370  M14_CPZ
cd0386853-371  M14_CPD_I
cd0386949-371  M14_CPX_like
cd0386351-371  M14_CPD_II
cd0386649-371  M14_CPM
pfam0024673-364  Peptidase_M14
cd0624553-371  M14_CPD_III
smart0063153-357  Zn_pept
cd00596107-365  Peptidase_M14_like
cd0385953-289  M14_CPT
pfam13620375-449  CarboxypepD_reg
cd0622678-366  M14_CPT_like
cd0386053-192  M14_CP_A-B_like
cd0690553-197  M14-like_8
cd0385779-196  M14-like_1
cd06904109-271  M14_MpaA_like
cd0624873-192  M14_CP_A-B_like_1
cd0624379-190  M14-like_1_6
cd0623978-194  M14-like_1_2
cd0622982-192  M14_Endopeptidase_I
cd0387073-191  M14_CPA
pfam13715376-437  DUF4480
cd0623456-196  M14_Nna1_like_1
cd0386298-192  M14-like_7
cd0624653-191  M14_CPB2
cd0387252-191  M14_CPA6
cd06227114-208  M14-like_2
PRK10602150-192  PRK10602
cd0624171-195  M14-like_1_4
cd0623778-194  M14_Nna1_like_3
cd0623880-189  M14-like_1_1
cd0385652-196  M14_Nna1_like
cd0624273-196  M14-like_1_5
cd06231111-191  M14-like_4
cd03462351-444  1,2-CCD
cd06253102-192  M14_ASTE_ASPA_like_3
COG286672-195  MpaA
TIGR02465351-444  chlorocat_1_2


Ontology Information


   
HPRD ID1815
Molecular ClassCarboxypeptidase
Molecular FunctionGrowth factor activity (GO:0008083)
Biological ProcessCell communication (GO:0007154); Signal transduction (GO:0007165)  



SNP Information


View SNP Geneview Report   

Drug Information


Uniprot ID DrugBank ID Name Type
P16870DB00030Insulin RegularBiotechDrug
P16870DB00071Insulin, porcineBiotechDrug

External Links


                                 
ArrayExpressGO
ICGCGO
Cancer3DGO
COSMICGO
NCGGO
TSGeneGO
Tumor Gene Family of DatabasesGO
CCDBGO
G2SBCGO
Osteosarcoma DatabaseGO
RCDBGO