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General Information
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Evidence Information
| Pubmed ID | Year | Sample Information | Techniques | Mechanism | Fold Change | Remark |
|---|---|---|---|---|---|---|
| 17496431 | 2007 | Cell line : - Source : - Sample Type : CRC tumor and Normal tissue No. of Sample : 129 CRCs and 44 metastatic tumors Stage : TNM Stage I-IV | Immunohistochemistry | Down-regulation | - | Claudin-4 might be a good biomarker for diagnosing the risk of distant metastasis. decreased claudin-4 expression was detected in 57% of CRCs, particularly at the invasive front. Interestingly, decreased claudin-4 expression was detected in metastatic lesions of CRC. |
Gene Details
| Gene Type | protein coding |
|---|---|
| Gene Family | Claudins |
| Description | The protein encoded by this intronless gene belongs to the claudin family. Claudins are integral membrane proteins that are components of the epithelial cell tight junctions, which regulate movement of solutes and ions through the paracellular space. This protein is a high-affinity receptor for Clostridium perfringens enterotoxin (CPE) and may play a role in internal organ development and function during pre- and postnatal life. This gene is deleted in Williams-Beuren syndrome, a neurodevelopmental disorder affecting multiple systems. |
| Chromosome | 7 |
| Location | 7q11.23 |
| Start | 73830863 |
| End | 73832693 |
| Strand | + |
| Gene Sequence | Download Select all |
| Length | 1831 |
| OMIM ID | 602909 |
| HGNC ID | HGNC:2046 |
| Unigene ID | Hs.647036 |
| Ensembl ID | ENSG00000189143 |
| PharmGKB ID | - |
Protein Information
| Protein ID | NP_001296.1 |
|---|---|
| Protein Name | claudin 4 |
| Molecular Wt. (Da) | 21946 |
| Protein Sequence | Download Select all |
| Length | 209 |
| Uniprot ID | P30550 |
| Ensembl Protein ID | ENSP00000369643 |
Post-translational Modification Information (Source : HPRD)
No matching records could be found.
Enzyme Information
No matching records could be found.
PPi Information
No STRING Network could be found.
| Interactant Gene ID (Source: HPRD) | Gene Symbol | HPRD ID | Ref Seq ID | Technique | References |
|---|---|---|---|---|---|
| 6462 | SHBG | 1646 | NP_001031.2 | yeast 2-hybrid | 15862967 |
| 7082 | TJP1 | 3002 | NP_003248.3 | in vitro | 10601346 |
Pathway Information
| Pathway Name | Pathway ID |
|---|---|
| Cell adhesion molecules (CAMs) | hsa04514 |
| Hepatitis C | hsa05160 |
| Leukocyte transendothelial migration | hsa04670 |
| Tight junction | hsa04530 |
Structure Information
No matching records could be found.
Domain Information
| ID | Location | Description |
|---|---|---|
| pfam00822 | 4-170 | PMP22_Claudin |
| cl21598 | 4-170 | Claudin_2 superfamily |
Ontology Information
| HPRD ID | 709 |
|---|---|
| Molecular Class | Cell junction protein |
| Molecular Function | Glutathione transferase activity (GO:0004364) |
| Biological Process | Metabolism (GO:0008152); Energy pathways (GO:0006091) |
Drug Information
No matching records could be found.