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General Information
- Evidence
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Evidence Information
| Pubmed ID | Year | Sample Information | Techniques | Mechanism | Fold Change | Remark |
|---|---|---|---|---|---|---|
| 21294205 | 2011 | Cell line : - Source : Chinese patients Sample Type : Population based case control study. No. of Sample : - Stage : - | real time RT-PCR, and immunohistochemistry | Down-regulation | - | CLDN3, CLDN4, and CLDN7 were significantly downregulated, whereas CLDN1 was significantly upregulated in CRC. |
Gene Details
| Gene Type | protein coding |
|---|---|
| Gene Family | Claudins |
| Description | Tight junctions represent one mode of cell-to-cell adhesion in epithelial or endothelial cell sheets, forming continuous seals around cells and serving as a physical barrier to prevent solutes and water from passing freely through the paracellular space. These junctions are comprised of sets of continuous networking strands in the outwardly facing cytoplasmic leaflet, with complementary grooves in the inwardly facing extracytoplasmic leaflet. The protein encoded by this intronless gene, a member of the claudin family, is an integral membrane protein and a component of tight junction strands. It is also a low-affinity receptor for Clostridium perfringens enterotoxin, and shares aa sequence similarity with a putative apoptosis-related protein found in rat. [provided by RefSeq, Jul 2008] |
| Chromosome | 7 |
| Location | 7q11 |
| Start | 73183327 |
| End | 73184600 |
| Strand | - |
| Gene Sequence | Download Select all |
| Length | 1274 |
| OMIM ID | 602910 |
| HGNC ID | HGNC:2045 |
| Unigene ID | Hs.647023 |
| Ensembl ID | ENSG00000165215 |
| PharmGKB ID | PA26571 |
Protein Information
| Protein ID | NP_001297.1 |
|---|---|
| Protein Name | claudin 3 |
| Molecular Wt. (Da) | 23187 |
| Protein Sequence | Download Select all |
| Length | 220 |
| Uniprot ID | P05166 |
| Ensembl Protein ID | ENSP00000251654 |
Post-translational Modification Information (Source : HPRD)
| Residue | Type | site |
|---|---|---|
| T | Phosphorylation | 192 |
| Y | Phosphorylation | 214;- |
| Y | Phosphorylation | 219;- |
| S | Phosphorylation | 203 |
Enzyme Information
No matching records could be found.
PPi Information
(Click to view network : Source STRING) View
| Interactant Gene ID (Source: HPRD) | Gene Symbol | HPRD ID | Ref Seq ID | Technique | References |
|---|---|---|---|---|---|
| 7082 | TJP1 | 3002 | NP_003248.3 | in vitro | 10601346 |
| 7122 | CLDN5 | 3654 | NP_003268.2 | in vivo | 12909588 |
| 9883 | POM121 | 11448 | NP_742017.1 | yeast 2-hybrid | 16169070 |
Pathway Information
| Pathway Name | Pathway ID |
|---|---|
| Cell adhesion molecules (CAMs) | hsa04514 |
| Hepatitis C | hsa05160 |
| Leukocyte transendothelial migration | hsa04670 |
| Tight junction | hsa04530 |
Structure Information
No matching records could be found.
Domain Information
| ID | Location | Description |
|---|---|---|
| pfam00822 | 3-167 | PMP22_Claudin |
| cl21598 | 3-167 | Claudin_2 superfamily |
Ontology Information
| HPRD ID | 1429 |
|---|---|
| Molecular Class | Adhesion molecule |
| Molecular Function | Transmembrane receptor protein tyrosine kinase activity (GO:0004714) |
| Biological Process | Cell communication (GO:0007154); Signal transduction (GO:0007165) |
Drug Information
No matching records could be found.