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General Information
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Evidence Information
| Pubmed ID | Year | Sample Information | Techniques | Mechanism | Fold Change | Remark |
|---|---|---|---|---|---|---|
| 24222123 | 2013 | Cell line : - Source : - Sample Type : CRC tumor and normal tissue No. of Sample : 53 Stage : - | real time RT-PCR | Down-regulation | - | - |
| 26137091 | 2015 | Cell line : - Source : Maria Sklodowska-Curie Memorial Cancer Center and Institute of Oncology (Warsaw, Poland)� Sample Type : CRC tumor and normal tissue No. of Sample : 26 cancer patients, with 15 samples of corresponding normal colonic mucosa sections, and 42 colorectal adenoma samples Stage : - | real time RT-PCR | Down-regulation | - | - |
Gene Details
| Gene Type | protein coding |
|---|---|
| Gene Family | Claudins |
| Description | This gene encodes a member of the claudin family. Claudins are integral membrane proteins and components of tight junction strands. Tight junction strands serve as a physical barrier to prevent solutes and water from passing freely through the paracellular space between epithelial or endothelial cell sheets, and also play critical roles in maintaining cell polarity and signal transductions. This gene is expressed in germinal center B-cells, placenta and stomach as well as in colon tumor. This gene is down-regulated in intestinal type gastric cancer. [provided by RefSeq, Aug 2010] |
| Chromosome | 8 |
| Location | 8p23.1 |
| Start | 8559666 |
| End | 8561617 |
| Strand | + |
| Gene Sequence | Download Select all |
| Length | 1952 |
| OMIM ID | 609203 |
| HGNC ID | HGNC:17591 |
| Unigene ID | Hs.183617 |
| Ensembl ID | - |
| PharmGKB ID | PA134961253 |
Protein Information
| Protein ID | NP_919260.2 |
|---|---|
| Protein Name | claudin 23 |
| Molecular Wt. (Da) | 0 |
| Protein Sequence | Download Select all |
| Length | 292 |
| Uniprot ID | Q8WXU2 |
| Ensembl Protein ID | ENSP00000323275 |
Post-translational Modification Information (Source : HPRD)
| Residue | Type | site |
|---|---|---|
| Y | Phosphorylation | 224;- |
| Y | Phosphorylation | 223;- |
| S | Phosphorylation | 203 |
Enzyme Information
No matching records could be found.
PPi Information
(Click to view network : Source STRING) View
No matching records from HPRD source could be found.
Pathway Information
| Pathway Name | Pathway ID |
|---|---|
| Cell adhesion molecules (CAMs) | hsa04514 |
| Hepatitis C | hsa05160 |
| Leukocyte transendothelial migration | hsa04670 |
| Tight junction | hsa04530 |
Structure Information
No matching records could be found.
Domain Information
| ID | Location | Description |
|---|---|---|
| pfam00822 | 41-137 | PMP22_Claudin |
| cl21598 | 41-137 | Claudin_2 superfamily |
| pfam13903 | 46-159 | Claudin_2 |
Ontology Information
| HPRD ID | 17519 |
|---|---|
| Molecular Class | Cell junction protein |
| Molecular Function | Molecular function unknown (GO:0005554) |
| Biological Process | Biological_process unknown (GO:0000004) |
Drug Information
No matching records could be found.