Search results:
General Information
| Gene_Symbol | Gene_ID | Gene_Name | Chromosome | Alias |
|---|---|---|---|---|
| CRABP1 | 1381 | Cellular retinoic acid binding protein 1 | 15 | RBP5; CRABP; CRABPI; CRABP-I |
- Evidence
- Gene
- mRNA
- CDS
- Protein
- PTM
- Enzyme
- PPi
- Pathway
- Structural
- Domain
- Ontology
- SNP
- Drug
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Evidence Information
| Pubmed ID | Year | Sample Information | Techniques | Mechanism | Fold Change | Remark |
|---|---|---|---|---|---|---|
| 17167179 | 2006 | Cell line : - Source : - Sample Type : CRC tumor and Normal tissue No. of Sample : 198CRC tumorand 44 normal tissues and 30 cell lines Stage : TNM Stage I-IV | Methylation-specific PCR, bisulphite sequencing, and quantitative gene expression analysis | Methylation | - | ADAMTS1, CRABP1, and NR3C1 identified as hypermethylated genes in colorectal tumorigenesis. |
| 17270239 | 2007 | Cell line : - Source : - Sample Type : - No. of Sample : - Stage : - | DNA methylation | Methylation | - | - |
| 19002263 | 2008 | Cell line : - Source : Databases of two large prospective cohort studies; the Nurses Health Study (NHS, N=121,700 women followed since 1976) [25,26], and the Health Professionals Follow-up Study (HPFS,N=51,500 men). Sample Type : Population based case control study No. of Sample : 904 Stage : - | real-time PCR (MethyLight), Pyrosequencing to Measure LINE-1 Methylation, Immunohistochemistry. | Methylation | - | 904 colorectal cancers patient were included in this study. |
| 19117505 | 2005 | Cell line : - Source : - Sample Type : - No. of Sample : 154 including normal mucosa 39, adenomas 63, and CRC 52 Stage : - | Methylation specific PCR, DNA methylation analysis | Methylation | - | Hypermethylated CRABP1, MLH1, NR3C1, RUNX3, and SCGB3A1 were shown to be identifiers of carcinomas with microsatellite instability. |
| 21140203 | 2011 | Cell line : - Source : Nurses Health Study and Health Professionals Follow-up Study cohort and hospitals and pathology departments throughout the United States. Sample Type : Population based case control study No. of Sample : 855 Stage : - | Detected promoter hypermethylation by MethyLight, loss of expression by immunohistochemistry | Methylation | - | Assessed the CpG island methylator phenotype (CIMP) using eight methylation markers [CACNA1G, CDKN2A (p16), CRABP1, IGF2, MLH1, NEUROG1, RUNX3, and SOCS1]. |
| 22655257 | 2012 | Cell line : - Source : Institute of Pathology, University Hospital of Basel, the Institute of Clinical Pathology, Basel, Switzerland, and the Institute of Pathology, Stadtspital Triemli, Z?rich, Switzerland. Sample Type : CRC tumor and Normal tissue No. of Sample : 302 Stage : TNM Stage I-IV | DNA isolation, mutation, and microsatellite instability analysis, nested PCR, Pyrosequencing and CpG | Methylation | - | - |
| 23034738 | 2012 | Cell line : - Source : - Sample Type : CRC tumor and Normal tissue No. of Sample : 322 patients Stage : TNM Stage II,III | - | Methylation | - | Eight CpG island loci (CACNA1G, CRABP1, IGF2, MLH1, NEUROG1, CDKN2A (p16), RUNX3 and SOCS1) and five microsatellite markers were examined. IMP status was high in 25 patients (7.8%) and 21 patients (6.5%) had MSI-high tumor. |
Gene Details
| Gene Type | protein coding |
|---|---|
| Gene Family | Fatty acid binding protein family |
| Description | This gene encodes a specific binding protein for a vitamin A family member and is thought to play an important role in retinoic acid-mediated differentiation and proliferation processes. It is structurally similar to the cellular retinol-binding proteins, but binds only retinoic acid at specific sites within the nucleus, which may contribute to vitamin A-directed differentiation in epithelial tissue. [provided by RefSeq, Jul 2008] |
| Chromosome | 15 |
| Location | 15q24 |
| Start | 78340324 |
| End | 78348230 |
| Strand | + |
| Gene Sequence | Download Select all |
| Length | 7907 |
| OMIM ID | 180230 |
| HGNC ID | HGNC:2338 |
| Unigene ID | Hs.346950 |
| Ensembl ID | ENSG00000166426 |
| PharmGKB ID | - |
mRNA Information
| mRNA ID | NM_004378.2 |
|---|---|
| Exon | join(1..175,720..898,3176..3289,7604..7907) | mRNA Sequence | Download Select all |
| Length | 782 |
CDS Information
| Location | join(106..175,720..898,3176..3289,7604..7654) |
|---|---|
| CDS Sequence | Download Select all |
| CCDS ID | CCDS10301.1 |
Protein Information
| Protein ID | NP_004369.1 |
|---|---|
| Protein Name | Cellular retinoic acid binding protein 1 |
| Molecular Wt. (Da) | 15434 |
| Protein Sequence | Download Select all |
| Length | 137 |
| Uniprot ID | P55064 |
| Ensembl Protein ID | ENSP00000293599 |
Post-translational Modification Information (Source : HPRD)
| Residue | Type | site |
|---|---|---|
| S | Phosphorylation | 38 |
Enzyme Information
No matching records could be found.
PPi Information
(Click to view network : Source STRING) View
| Interactant Gene ID (Source: HPRD) | Gene Symbol | HPRD ID | Ref Seq ID | Technique | References |
|---|---|---|---|---|---|
| 4356 | MPP3 | 3069 | NP_001923.2 | yeast 2-hybrid | 16169070 |
Pathway Information
No matching records could be found.
Structure Information
No matching records could be found.
Domain Information
| ID | Location | Description |
|---|---|---|
| pfam00061 | 5-137 | Lipocalin |
| cl21528 | 5-137 | Lipocalin superfamily |
| pfam14651 | 4-136 | Lipocalin_7 |
Ontology Information
| HPRD ID | 2706 |
|---|---|
| Molecular Class | Transport/cargo protein |
| Molecular Function | Water channel activity (GO:0015250) |
| Biological Process | Transport (GO:0006810) |
Drug Information
| Uniprot ID | DrugBank ID | Name | Type |
|---|---|---|---|
| P29762 | DB00523 | Alitretinoin | SmallMoleculeDrug |
| P29762 | DB00755 | Tretinoin | SmallMoleculeDrug |