CoReCG

Evidence Information

Pubmed ID	Year	Sample Information	Techniques	Mechanism	Fold Change	Remark
24389200	2014	Cell line : - Source : - Sample Type : - No. of Sample : - Stage : -	Immunohistochemistry analysis	Up-regulation	-	CRKL has the ability to regulate colon cancer malignancy and CRKL has the potential to serve as a diagnosis and prognosis marker and a therapy target of colon cancer.

Gene Details

NC_000022.10 (21271714..21308037)
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Gene Type	protein coding
Gene Family	SH2 domain containing
Description	This gene encodes a protein kinase containing SH2 and SH3 (src homology) domains which has been shown to activate the RAS and JUN kinase signaling pathways and transform fibroblasts in a RAS-dependent fashion. It is a substrate of the BCR-ABL tyrosine kinase, plays a role in fibroblast transformation by BCR-ABL, and may be oncogenic.[provided by RefSeq, Jan 2009]
Chromosome	22
Location	22q11.21
Start	21271714
End	21308037
Strand	+
Gene Sequence	Download Select all
Length	36324
OMIM ID	602007
HGNC ID	HGNC:2363
Unigene ID	Hs.5613
Ensembl ID	ENSG00000099942
PharmGKB ID	PA26881

mRNA Information

mRNA ID	NM_005207.3
Exon	join(29..848,16382..16847,32314..36352)
mRNA Sequence	Download Select all
Length	5336

CDS Information

Location	510..1421
CDS Sequence	Download Select all
CCDS ID	CCDS13785.1

Protein Information

Protein ID	NP_005198.1
Protein Name	v-crk avian sarcoma virus CT10 oncogene homolog-like
Molecular Wt. (Da)	33646
Protein Sequence	Download Select all
Length	303
Uniprot ID	Q15118
Ensembl Protein ID	ENSP00000282077

Post-translational Modification Information (Source : HPRD)

Residue	Type	site
S	Phosphorylation	107
Y	Phosphorylation	207
S	Phosphorylation	197
Y	Phosphorylation	198
T	Phosphorylation	212
Y	Phosphorylation	132
Y	Phosphorylation	251
S	Phosphorylation	41
S	Phosphorylation	42
T	Phosphorylation	43
S	Phosphorylation	184
S	Phosphorylation	222
S	Phosphorylation	195

Enzyme Information

No matching records could be found.

PPi Information

(Click to view network : Source STRING) View

Interactant Gene ID (Source: HPRD)	Gene Symbol	HPRD ID	Ref Seq ID	Technique	References
25	ABL1	1809	NP_009297.2	in vitro;in vivo	74 939 408 978 305
613	BCR	1044	NP_004318.3	in vitro;yeast 2-hybrid	8978305
867	CBL	1320	NP_005179.2	in vitro;in vivo	122 441 749 590 251 000 000 000 000 000 000 000
947	CD34	790	P28906	in vitro;in vivo	11389015
1398	CRK	1267	NP_058431.2	in vitro;in vivo	9614078
2057	EPOR	587	NP_000112.1	in vitro;in vivo	11443118
2120	ETV6	15976	NP_001978.1	in vitro	15143164
2209	FCGR1A	904	NP_000557.1	in vivo	9820532
2885	GRB2	150	NP_002077.1	in vivo	10477741
2889	RAPGEF1	2627	NP_941372.1	in vitro;in vivo	9 374 471 862 148 390 000 000 000 000
3454	IFNAR1	126	NP_000620.2	in vitro;in vivo	11167825
3480	IGF1R	932	NP_000866.1	yeast 2-hybrid	15522217
3643	INSR	975	NP_000199.2	yeast 2-hybrid	15522217
3688	ITGB1	628	NP_391987.1	in vitro	19168626
3815	KIT	1287	NP_000213.1	in vivo	9092574
5156	PDGFRA	1429	NP_006197.1	in vivo	9546424
5295	PIK3R1	1381	NP_852664.1	in vivo	9461587
5781	PTPN11	1470	NP_002825.3	in vivo	9344843
6464	SHC1	2780	NP_001123512.1	in vivo	9344843
6654	SOS1	1681	NP_005624.2	in vivo	9162067
6776	STAT5A	3301	NP_003143.2	in vitro;in vivo	111 678 259 837 784
6777	STAT5B	5037	NP_036580.2	in vitro;in vivo	11 097 834 107 206 900 000 000
6850	SYK	2514	NP_003168.2	in vitro;in vivo	11313252
7297	TYK2	1490	NP_003322.3	in vitro;in vivo	9374471
7454	WAS	2314	NP_000368.1	in vitro;in vivo	11313252
7456	WIPF1	3835	NP_003378.3	in vitro;in vivo	12504004
11184	MAP4K1	3583	NP_009112.1	in vitro;in vivo	989 106 911 279 207

Pathway Information

Pathway Name	Pathway ID
Bacterial invasion of epithelial cells	hsa05100
Chemokine signaling pathway	hsa04062
Chronic myeloid leukemia	hsa05220
ErbB signaling pathway	hsa04012
Fc gamma R-mediated phagocytosis	hsa04666
Focal adhesion	hsa04510
Insulin signaling pathway	hsa04910
MAPK signaling pathway	hsa04010
MicroRNAs in cancer	hsa05206
Neurotrophin signaling pathway	hsa04722
Pathways in cancer	hsa05200
Rap1 signaling pathway	hsa04015
Regulation of actin cytoskeleton	hsa04810
Renal cell carcinoma	hsa05211
Shigellosis	hsa05131

Structure Information

No matching records could be found.

Domain Information

ID	Location	Description
cd09926	6-106	SH2_CRK_like
cl15255	6-106	SH2 superfamily
cd11758	126-180	SH3_CRK_N
cl17036	126-180	SH3 superfamily
cd11759	237-293	SH3_CRK_C
cl17036	237-293	SH3 superfamily
pfam00017	14-88	SH2
smart00252	14-93	SH2
cd00173	14-88	SH2
cd11769	132-180	SH3_CSK
smart00326	126-179	SH3
cd00174	127-177	SH3
cd11767	128-179	SH3_Nck_3
cd10337	13-88	SH2_BCAR3
cd11768	128-180	SH3_Tec_like
pfam07653	239-293	SH3_2
cd09931	14-89	SH2_C-SH2_SHP_like
pfam00018	129-175	SH3_1
cd09933	14-91	SH2_Src_family
cd11770	127-180	SH3_Nephrocystin
cd10347	14-88	SH2_Nterm_shark_like
cd09937	14-89	SH2_csk_like
cd09941	14-89	SH2_Grb2_like
cd10354	14-88	SH2_Cterm_RasGAP
cd09943	Dec-89	SH2_Nck_family
cd11904	128-178	SH3_Nck1_3
cd11903	128-178	SH3_Nck2_3
cd11905	126-178	SH3_Tec
cd11771	127-179	SH3_Pex13p_fungal
cd09940	14-93	SH2_Vav_family
cd09935	Oct-91	SH2_ABL
cd11843	128-179	SH3_PACSIN
cd09945	14-101	SH2_SHB_SHD_SHE_SHF_like
cd09944	14-90	SH2_Grb7_family
cd11805	127-180	SH3_GRB2_like_C
cd11842	127-179	SH3_Ysc84p_like
cd11845	128-177	SH3_Src_like
cd09925	Oct-87	SH2_SHC
cd10360	14-88	SH2_Srm
cd11997	128-179	SH3_PACSIN3
cd11772	128-179	SH3_OSTF1
cd11906	128-178	SH3_BTK
cd10370	Oct-88	SH2_Src_Src42
cd11978	242-292	SH3_VAV3_2
cd11858	129-179	SH3_Myosin-I_fungi
cd11855	128-179	SH3_Sho1p
cd10341	14-97	SH2_N-SH2_PLC_gamma_like
cd11960	128-179	SH3_Abp1_eu
cd11849	128-179	SH3_SPIN90
cd11830	249-292	SH3_VAV_2
cd09930	Sep-64	SH2_cSH2_p85_like
cd10408	14-89	SH2_Nck1
pfam14604	131-179	SH3_9
cd11999	128-179	SH3_PACSIN_like
cd09932	14-93	SH2_C-SH2_PLC_gamma_like
cd10365	14-91	SH2_Src_Src
cd11819	129-179	SH3_Cortactin_like
cd11763	127-179	SH3_SNX9_like
cd10348	14-88	SH2_Cterm_shark_like
cd11998	128-179	SH3_PACSIN1-2
cd10413	13-91	SH2_Grb7
cd10361	14-89	SH2_Fps_family
cd09942	13-52	SH2_nSH2_p85_like
cd11764	127-174	SH3_Eps8
cd11951	127-178	SH3_GRAP_C
cd10409	Dec-89	SH2_Nck2
cd09934	14-89	SH2_Tec_family
cd11920	129-181	SH3_Sorbs2_1
cd10349	13-88	SH2_SH2D2A_SH2D7
cd10363	14-89	SH2_Src_HCK
cd10356	13-85	SH2_ShkA_ShkC
cd10414	14-91	SH2_Grb14
cd11827	128-180	SH3_MyoIe_If_like
cd09923	14-53	SH2_SOCS_family
cd11786	127-179	SH3_SH3RF_1
cd12046	127-179	SH3_p67phox_C
cd11817	127-177	SH3_Eve1_4
cd10367	14-88	SH2_Src_Fgr
cd11963	128-178	SH3_STAM2
cd12007	131-178	SH3_Yes
cd11907	128-178	SH3_TXK
cd10417	14-104	SH2_SH2D7
cd10402	Oct-90	SH2_C-SH2_Zap70
cd11839	246-293	SH3_Intersectin_4
cd09938	14-89	SH2_N-SH2_Zap70_Syk_like
cd12009	127-178	SH3_Blk
cd11824	129-180	SH3_PSTPIP1
pfam07653	127-180	SH3_2
cd10353	Dec-88	SH2_Nterm_RasGAP
cd10344	14-88	SH2_SLAP
cd11837	128-178	SH3_Intersectin_2
cd10387	Nov-56	SH2_SOCS6
cd10418	14-88	SH2_Src_Fyn_isoform_a_like
cd10358	14-93	SH2_PTK6_Brk
cd11862	127-174	SH3_MPP
cd10415	14-91	SH2_Grb10
cd11821	128-177	SH3_ASAP
cd11976	249-292	SH3_VAV1_2
cd10368	14-88	SH2_Src_Fyn
cd10391	14-88	SH2_SHE
cd11806	126-178	SH3_PRMT2
cd12142	248-287	SH3_D21-like
cd11933	128-181	SH3_Nebulin_C
cd10369	14-71	SH2_Src_Frk
smart00326	236-292	SH3
cd11823	129-179	SH3_Nostrin
cd10355	13-88	SH2_DAPP1_BAM32_like
cd10366	14-91	SH2_Src_Yes
cd11919	129-181	SH3_Sorbs1_1
cd10406	14-106	SH2_Vav2
cd11781	129-179	SH3_Sorbs_1
cd10352	15-79	SH2_a2chimerin_b2chimerin
cd10405	14-96	SH2_Vav1
cd11908	128-180	SH3_ITK
cd11873	256-293	SH3_CD2AP-like_1
cd11803	129-179	SH3_Endophilin_A
cd09946	14-89	SH2_HSH2_like
cd10343	13-89	SH2_SHIP
cd11804	129-178	SH3_GRB2_like_N
cd10407	14-93	SH2_Vav3
cd10412	Dec-60	SH2_SH2B3
cd11841	128-178	SH3_SH3YL1_like
cd11820	128-180	SH3_STAM
cd11964	128-178	SH3_STAM1
cd12006	131-178	SH3_Fyn_Yrk
cd10392	14-88	SH2_SHF
cd12004	128-181	SH3_Lyn
cd10340	14-88	SH2_N-SH2_SHP_like
cd11856	129-180	SH3_p47phox_like
cd11773	128-177	SH3_Sla1p_1
cd11782	129-179	SH3_Sorbs_2
cd11948	131-179	SH3_GRAP_N
cd11950	128-179	SH3_GRAP2_C
cd10419	14-88	SH2_Src_Fyn_isoform_b_like
cd12072	127-179	SH3_FNBP1L
cd10362	14-88	SH2_Src_Lck
cd11840	128-179	SH3_Intersectin_5
cd11962	130-179	SH3_Abp1_fungi_C1
cd00174	239-290	SH3
cd11823	251-291	SH3_Nostrin
cd11877	128-179	SH3_PIX
cd12054	129-181	SH3_CD2AP_2
cd11883	127-172	SH3_Sdc25
cd10396	Jul-89	SH2_Tec_Itk
cd10383	Nov-88	SH2_SOCS2
cd11935	129-179	SH3_Nebulette_C
cd12035	127-176	SH3_MPP1-like
cd11789	128-180	SH3_Nebulin_family_C
cd11911	129-179	SH3_CIP4-like
cd12052	256-292	SH3_CIN85_1
cd10399	Oct-89	SH2_Tec_Bmx
cd10346	14-91	SH2_SH2B_family
cd11829	129-178	SH3_GAS7
cd11895	128-181	SH3_FCHSD1_2
cd11833	127-180	SH3_Stac_1
cd11875	256-293	SH3_CD2AP-like_3
cd12033	127-174	SH3_MPP7
cd11761	131-180	SH3_FCHSD_1
cd11946	132-179	SH3_GRB2_N
cd11808	127-180	SH3_Alpha_Spectrin
cd09929	Oct-58	SH2_BLNK_SLP-76
cd11959	131-179	SH3_Cortactin
cd12060	261-294	SH3_alphaPIX
cd11861	127-174	SH3_DLG-like
cd10371	14-88	SH2_Src_Blk
cd12061	256-292	SH3_betaPIX
cd11826	251-291	SH3_Abi
cd11995	131-179	SH3_Intersectin1_5
cd11847	131-177	SH3_Brk
cd10718	Oct-53	SH2_CIS
cd11762	127-179	SH3_FCHSD_2
cd11934	129-181	SH3_Lasp1_C
cd12081	127-176	SH3_CASK
cd12008	131-178	SH3_Src
cd10388	14-61	SH2_SOCS7
cd11875	127-179	SH3_CD2AP-like_3
cd10382	Oct-88	SH2_SOCS1
cd10364	14-73	SH2_Src_Lyn
cd10411	14-60	SH2_SH2B2
cd11874	256-293	SH3_CD2AP-like_2
cd11815	131-179	SH3_Eve1_2
cd11958	128-177	SH3_RUSC1
cd10350	8-106	SH2_SH2D4A
cd12005	128-180	SH3_Lck
cd11830	132-180	SH3_VAV_2
cd11955	132-178	SH3_srGAP1-3
cd10397	Jul-89	SH2_Tec_Btk
cd12053	250-292	SH3_CD2AP_1
cd11922	132-179	SH3_Sorbs1_2
cd11781	250-293	SH3_Sorbs_1
cd12073	131-179	SH3_HS1
cd11928	127-179	SH3_SH3RF3_1
cd11775	131-179	SH3_Sla1p_3
cd11996	128-179	SH3_Intersectin2_5
cd11866	127-178	SH3_SKAP1-like
cd11976	129-180	SH3_VAV1_2
cd10416	13-104	SH2_SH2D2A
cd11949	127-179	SH3_GRB2_C
cd11898	129-179	SH3_SNX9
cd11812	128-178	SH3_AHI-1
cd11879	127-179	SH3_Bem1p_2
cd10357	Nov-60	SH2_ShkD_ShkE
cd11956	131-178	SH3_srGAP4
cd11765	127-178	SH3_Nck_1
cd12054	241-292	SH3_CD2AP_2
cd12057	250-294	SH3_CIN85_3
cd11953	128-174	SH3_ASPP2
cd11825	128-180	SH3_PLCgamma
cd10410	14-91	SH2_SH2B1
cd10389	14-93	SH2_SHB
cd11829	256-291	SH3_GAS7
cd10351	14-101	SH2_SH2D4B
cd11787	129-177	SH3_SH3RF_2
cd12080	127-176	SH3_MPP1
cd11877	256-293	SH3_PIX
cd11974	127-178	SH3_ASEF2
cd11874	135-179	SH3_CD2AP-like_2
cd11826	127-179	SH3_Abi
cd11924	132-179	SH3_Vinexin_2
cd11832	256-287	SH3_Shank
cd11968	247-293	SH3_SASH3
cd11985	127-180	SH3_Stac2_C
cd11809	132-178	SH3_srGAP
cd11882	128-179	SH3_GRAF-like
cd11790	128-181	SH3_Amphiphysin
cd12030	127-174	SH3_DLG4
cd11965	128-181	SH3_ASAP1
cd09927	14-115	SH2_Tensin_like
pfam14604	252-287	SH3_9
cd12076	131-180	SH3_Tks4_2
cd11972	125-185	SH3_Abi2
cd12034	127-164	SH3_MPP4
cd10401	14-104	SH2_C-SH2_Syk_like
cd11842	256-293	SH3_Ysc84p_like
cd11828	127-178	SH3_ARHGEF9_like
cd12055	256-292	SH3_CIN85_2
cd10390	14-88	SH2_SHD
cd11807	128-174	SH3_ASPP
cd11870	128-179	SH3_p67phox-like_C
cd11838	126-180	SH3_Intersectin_3
cd11961	128-179	SH3_Abp1_fungi_C2
cd11992	126-178	SH3_Intersectin2_3
cd11896	129-179	SH3_SNX33
cd11952	128-177	SH3_iASPP
cd11894	127-179	SH3_FCHSD2_2
cd12031	127-174	SH3_DLG1
cd11778	251-287	SH3_Bzz1_2
cd11885	128-178	SH3_SH3TC
cd11824	250-293	SH3_PSTPIP1
cd11930	129-178	SH3_SH3RF1_2
cd11827	250-291	SH3_MyoIe_If_like
cd11986	127-178	SH3_Stac3_1
cd11888	127-177	SH3_ARHGAP9_like
cd12045	127-178	SH3_SKAP2
cd12039	127-174	SH3_MPP3
cd11977	250-292	SH3_VAV2_2
cd12061	128-181	SH3_betaPIX
cd11818	129-177	SH3_Eve1_5
cd11864	129-179	SH3_PEX13_eumet
cd12002	129-174	SH3_NEDD9
cd11873	128-180	SH3_CD2AP-like_1
cd11978	132-180	SH3_VAV3_2
cd11966	128-178	SH3_ASAP2
cd10345	14-90	SH2_C-SH2_Zap70_Syk_like
cd11991	126-178	SH3_Intersectin1_3
cd11766	256-291	SH3_Nck_2
cd12023	129-179	SH3_NoxO1_1
cd11762	251-287	SH3_FCHSD_2
cd11766	132-180	SH3_Nck_2
cd11805	246-292	SH3_GRB2_like_C
cd11793	247-291	SH3_ephexin1_like
cd12056	126-174	SH3_CD2AP_3
cd12021	129-179	SH3_p47phox_1
cd11897	129-179	SH3_SNX18
cd11803	256-293	SH3_Endophilin_A
cd11899	132-180	SH3_Nck2_1
cd10400	Oct-61	SH2_SAP1a
cd11836	127-180	SH3_Intersectin_1
cd12032	127-174	SH3_DLG2
cd11848	131-181	SH3_SLAP-like
cd11900	132-180	SH3_Nck1_1
cd11822	247-290	SH3_SASH_like
cd11889	128-178	SH3_Cyk3p-like
cd11841	256-292	SH3_SH3YL1_like
cd11954	128-174	SH3_ASPP1
cd11971	128-182	SH3_Abi1
cd11860	127-152	SH3_DLG5
cd11995	251-293	SH3_Intersectin1_5
cd12017	126-180	SH3_Tks_3
cd11813	129-179	SH3_SGSM3
cd11828	250-293	SH3_ARHGEF9_like
cd11782	256-293	SH3_Sorbs_2
cd10398	14-89	SH2_Tec_Txk
cd11967	248-294	SH3_SASH1
cd11880	251-287	SH3_Caskin
cd12000	129-174	SH3_CASS4
cd11970	128-182	SH3_PLCgamma1
cd12029	127-174	SH3_DLG3
cd11777	131-178	SH3_CIP4_Bzz1_like
cd11973	111-178	SH3_ASEF
cd11977	132-180	SH3_VAV2_2
cd11919	256-293	SH3_Sorbs1_1
cd11796	256-287	SH3_DNMBP_N3
cd12044	127-178	SH3_SKAP1
cd11865	131-179	SH3_Nbp2-like
cd11763	251-293	SH3_SNX9_like
cd11982	256-287	SH3_Shank1
cd11810	128-177	SH3_RUSC1_like
cd11844	127-174	SH3_CAS
cd11912	128-179	SH3_Bzz1_1
cd11927	129-179	SH3_SH3RF1_1
cd11994	256-293	SH3_Intersectin2_4
cd11816	129-178	SH3_Eve1_3
cd11779	128-180	SH3_Irsp53_BAIAP2L
cd12036	127-163	SH3_MPP5
cd12016	126-180	SH3_Tks_2
cd11869	253-293	SH3_p40phox
cd11840	256-292	SH3_Intersectin_5
cd10384	Dec-56	SH2_SOCS3
cd11921	256-293	SH3_Vinexin_1
cd11996	246-293	SH3_Intersectin2_5
cd12063	250-293	SH3_Caskin2
cd11806	249-291	SH3_PRMT2
cd12062	251-293	SH3_Caskin1
cd11947	129-179	SH3_GRAP2_N
cd11931	129-178	SH3_SH3RF3_2
cd11921	129-181	SH3_Vinexin_1
cd11887	128-180	SH3_Bbc1
cd11932	129-178	SH3_SH3RF2_2
cd12038	142-178	SH3_MPP6
cd12056	256-287	SH3_CD2AP_3

Ontology Information

HPRD ID	3715
Molecular Class	Adapter molecule
Molecular Function	Phosphoric diester hydrolase activity (GO:0008081)
Biological Process	Metabolism (GO:0008152); Energy pathways (GO:0006091)

SNP Information

View SNP Geneview Report