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General Information
- Evidence
- Gene
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- Enzyme
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Evidence Information
| Pubmed ID | Year | Sample Information | Techniques | Mechanism | Fold Change | Remark |
|---|---|---|---|---|---|---|
| 23626715 | 2013 | Cell line : - Source : Cancer Center of Sun Yat-sun University Sample Type : CRC tumor and Normal tissue No. of Sample : 168 Stage : TNM Stage I- IV | real time RT-PCR, Western Blotting, Immunohistochemistry | Up-regulation | - | Cry1 likely plays important roles in CRC development and progression andCry1 may be a prognostic biomarker and a promising therapeutic target for CRC. Cry1 expression was up regulated in the majority of the CRC cell lines and 168 primary CRC clinical specimens at the protein level. |
Gene Details
| Gene Type | protein coding |
|---|---|
| Gene Family | |
| Description | This gene encodes a flavin adenine dinucleotide-binding protein that is a key component of the circadian core oscillator complex, which regulates the circadian clock. This gene is upregulated by CLOCK/ARNTL heterodimers but then represses this upregulation in a feedback loop using PER/CRY heterodimers to interact with CLOCK/ARNTL. Polymorphisms in this gene have been associated with altered sleep patterns. The encoded protein is widely conserved across plants and animals. Loss of the related gene in mouse results in a shortened circadian cycle in complete darkness. |
| Chromosome | 12 |
| Location | 12q23-q24. |
| Start | 106991364 |
| End | 107093857 |
| Strand | - |
| Gene Sequence | Download Select all |
| Length | 102494 |
| OMIM ID | 601933 |
| HGNC ID | HGNC:2384 |
| Unigene ID | Hs.151573 |
| Ensembl ID | ENSG00000008405 |
| PharmGKB ID | - |
mRNA Information
| mRNA ID | NM_004075.4 |
|---|---|
| Exon | join(1..1054,71666..71774,88610..88752,91910..92094, 92490..92578,93776..93916,93996..94307,95792..95943, 96168..96370,96472..96564,100822..100893,100968..101071, 101857..102494) | mRNA Sequence | Download Select all |
| Length | 3310 |
CDS Information
| Location | join(897..1054,71666..71774,88610..88752,91910..92094, 92490..92578,93776..93916,93996..94307,95792..95943, 96168..96370,96472..96564,100822..100893,100968..101071) |
|---|---|
| CDS Sequence | Download Select all |
| CCDS ID | CCDS9112.1 |
Protein Information
| Protein ID | NP_004066.1 |
|---|---|
| Protein Name | cryptochrome circadian clock 1 |
| Molecular Wt. (Da) | 66264 |
| Protein Sequence | Download Select all |
| Length | 586 |
| Uniprot ID | P06396 |
| Ensembl Protein ID | ENSP00000340888 |
Post-translational Modification Information (Source : HPRD)
| Residue | Type | site |
|---|---|---|
| Y | Phosphorylation | 494;- |
Enzyme Information
No matching records could be found.
PPi Information
(Click to view network : Source STRING) View
| Interactant Gene ID (Source: HPRD) | Gene Symbol | HPRD ID | Ref Seq ID | Technique | References |
|---|---|---|---|---|---|
| 406 | ARNTL | 3973 | NP_001169.3 | yeast 2-hybrid | 10531061 |
| 1454 | CSNK1E | 2919 | NP_001885.1 | in vivo | 11875063 |
| 5187 | PER1 | 3774 | NP_002607.2 | in vitro;in vivo;yeast 2-hybrid | 1 278 265 510 531 060 |
| 8864 | PER2 | 4575 | NP_073728.1 | in vitro;in vivo;yeast 2-hybrid | 115 332 521 053 106 000 000 000 |
| 8914 | TIMELESS | 4864 | NP_003911.2 | in vivo | 10428031 |
| 83755 | KRTAP4-12 | 13941 | NP_114060.1 | yeast 2-hybrid | 16189514 |
Pathway Information
| Pathway Name | Pathway ID |
|---|---|
| Circadian rhythm | hsa04710 |
Structure Information
No matching records could be found.
Domain Information
| ID | Location | Description |
|---|---|---|
| pfam03441 | 212-488 | FAD_binding_7 |
| cl20252 | 212-488 | FAD_binding_7 superfamily |
| pfam00875 | 5-167 | DNA_photolyase |
| cl02999 | 5-167 | DNA_photolyase superfamily |
| cd04509 | 79-136 | PBP1_ABC_transporter_GCPR_C_like |
| cl10011 | 79-136 | Periplasmic_Binding_Protein_Type_1 superfamily |
| pfam01026 | 101-150 | TatD_DNase |
| cl00281 | 101-150 | metallo-dependent_hydrolases superfamily |
| COG0415 | 6-491 | PhrB |
| TIGR03556 | 8-491 | photolyase_8HDF |
| TIGR02765 | 6-436 | crypto_DASH |
| TIGR02766 | 6-476 | crypt_chrom_pln |
| PRK10674 | 8-476 | PRK10674 |
Ontology Information
| HPRD ID | 707 |
|---|---|
| Molecular Class | Translation regulatory protein |
| Molecular Function | Glutathione transferase activity (GO:0004364) |
| Biological Process | Energy pathways (GO:0006091); Metabolism (GO:0008152); Xenobiotic metabolism (GO:0006805) |
Drug Information
No matching records could be found.