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General Information
- Evidence
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- Enzyme
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Evidence Information
| Pubmed ID | Year | Sample Information | Techniques | Mechanism | Fold Change | Remark |
|---|---|---|---|---|---|---|
| 25855785 | 2015 | Cell line : - Source : - Sample Type : - No. of Sample : - Stage : - | - | Up-regulation | - | Upregulation of CRY2 caused by downregulation of FBXW7 may be a novel prognostic biomarker and may represent a new therapeutic target in colorectal cancer. |
Gene Details
| Gene Type | protein coding |
|---|---|
| Gene Family | - |
| Description | This gene encodes a flavin adenine dinucleotide-binding protein that is a key component of the circadian core oscillator complex, which regulates the circadian clock. This gene is upregulated by CLOCK/ARNTL heterodimers but then represses this upregulation in a feedback loop using PER/CRY heterodimers to interact with CLOCK/ARNTL. Polymorphisms in this gene have been associated with altered sleep patterns. The encoded protein is widely conserved across plants and animals. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2014] |
| Chromosome | 11 |
| Location | 11p11.2 |
| Start | 45868669 |
| End | 45904799 |
| Strand | + |
| Gene Sequence | Download Select all |
| Length | 36131 |
| OMIM ID | 603732 |
| HGNC ID | HGNC:2385 |
| Unigene ID | Hs.532491 |
| Ensembl ID | ENSG00000121671 |
| PharmGKB ID | PA26905 |
mRNA Information
| mRNA ID | NM_001127457.2 |
|---|---|
| Exon | join(1..164,8865..8973,11614..11756,13731..13915, 14943..15031,20495..20635,22389..22700,22936..23087, 23213..23415,23725..23817,24975..25116,33797..36131) | mRNA Sequence | Download Select all |
| Length | 4068 |
Protein Information
| Protein ID | NP_001120929.1 |
|---|---|
| Protein Name | cryptochrome circadian clock 2 |
| Molecular Wt. (Da) | 60462 |
| Protein Sequence | Download Select all |
| Length | 532 |
| Uniprot ID | Q15120 |
| Ensembl Protein ID | ENSP00000368460 |
Post-translational Modification Information (Source : HPRD)
No matching records could be found.
Enzyme Information
No matching records could be found.
PPi Information
(Click to view network : Source STRING) View
| Interactant Gene ID (Source: HPRD) | Gene Symbol | HPRD ID | Ref Seq ID | Technique | References |
|---|---|---|---|---|---|
| 5187 | PER1 | 3774 | NP_002607.2 | in vitro;in vivo | 12782655 |
| 5536 | PPP5C | 2805 | NP_006238.1 | in vitro | 9383998 |
| 8864 | PER2 | 4575 | NP_073728.1 | in vivo | 10428031 |
Pathway Information
| Pathway Name | Pathway ID |
|---|---|
| Circadian rhythm | hsa04710 |
Structure Information
No matching records could be found.
Domain Information
| ID | Location | Description |
|---|---|---|
| pfam03441 | 231-507 | FAD_binding_7 |
| cl20252 | 231-507 | FAD_binding_7 superfamily |
| pfam00875 | 24-186 | DNA_photolyase |
| cl02999 | 24-186 | DNA_photolyase superfamily |
| COG0415 | 22-510 | PhrB |
| TIGR03556 | 27-510 | photolyase_8HDF |
| TIGR02765 | 25-455 | crypto_DASH |
| PRK10674 | 27-494 | PRK10674 |
| TIGR02766 | 25-498 | crypt_chrom_pln |
Ontology Information
| HPRD ID | 5556 |
|---|---|
| Molecular Class | Transcription regulatory protein |
| Molecular Function | Protein serine/threonine kinase activity (GO:0004674) |
| Biological Process | Signal transduction (GO:0007165) |
Drug Information
No matching records could be found.