Search results:
General Information
| Gene_Symbol | Gene_ID | Gene_Name | Chromosome | Alias |
|---|---|---|---|---|
| CSF1R | 1436 | colony stimulating factor 1 receptor | 5 | C-FMS, CSFR, CD115 |
- Evidence
- Gene
- mRNA
- CDS
- Protein
- PTM
- Enzyme
- PPi
- Pathway
- Structural
- Domain
- Ontology
- SNP
- Drug
- External Links
Evidence Information
| Pubmed ID | Year | Sample Information | Techniques | Mechanism | Fold Change | Remark |
|---|---|---|---|---|---|---|
| 23108143 | 2013 | Cell line : - Source : Hospital Universitario Puerta de Hierro (Madrid, Spain) and the Asturias Tumor Bank of the Institute of Oncology (Asturias, Spain). American Type Culture Collection . Sample Type : - No. of Sample : - Stage : - | real time RT-PCR,Bisulfite pyrosequencing,Immunohistochemistry,MTT assay,Cytotoxicity assays,ELISA | Up-regulation | - | 100% of the patients with human colon tumors that overexpressed GM-CSF and its receptor subunits .expression of GM-CSF and its receptor subunits by colon tumors may be a useful marker for prognosis as well as for patient stratification in cancer immunotherapy. |
Gene Details
| Gene Type | protein coding |
|---|---|
| Gene Family | CD molecules, "Immunoglobulin superfamily / Immunoglobulin-like domain containing" |
| Description | The protein encoded by this gene is the receptor for colony stimulating factor 1, a cytokine which controls the production, differentiation, and function of macrophages. This receptor mediates most if not all of the biological effects of this cytokine. Ligand binding activates the receptor kinase through a process of oligomerization and transphosphorylation. The encoded protein is a tyrosine kinase transmembrane receptor and member of the CSF1/PDGF receptor family of tyrosine-protein kinases. Mutations in this gene have been associated with a predisposition to myeloid malignancy. The first intron of this gene contains a transcriptionally inactive ribosomal protein L7 processed pseudogene oriented in the opposite direction. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2013] |
| Chromosome | 5 |
| Location | 5q32 |
| Start | 149432854 |
| End | 149492935 |
| Strand | - |
| Gene Sequence | Download Select all |
| Length | 60082 |
| OMIM ID | 164770 |
| HGNC ID | HGNC:2433 |
| Unigene ID | Hs.586219 |
| Ensembl ID | ENSG00000182578 |
| PharmGKB ID | PA26936 |
mRNA Information
| mRNA ID | NM_005211.3 |
|---|---|
| Exon | join(1..112,26766..26994,32349..32606,33037..33321, 35125..35261,35938..36097,39880..40072,42802..42917, 43071..43191,43310..43500,45043..45158,51524..51650, 51778..51882,52401..52511,53511..53673,55781..55869, 55989..56086,57032..57154,57236..57347,58037..58136, 58943..59051,59149..60082) | mRNA Sequence | Download Select all |
| Length | 4006 |
Protein Information
| Protein ID | NP_005202.2 |
|---|---|
| Protein Name | colony stimulating factor 1 receptor |
| Molecular Wt. (Da) | 0 |
| Protein Sequence | Download Select all |
| Length | 972 |
| Uniprot ID | O15530 |
| Ensembl Protein ID | ENSP00000268673 |
Post-translational Modification Information (Source : HPRD)
| Residue | Type | site |
|---|---|---|
| Y | Phosphorylation | 723 |
| Y | Phosphorylation | 809 |
Enzyme Information
No matching records could be found.
PPi Information
(Click to view network : Source STRING) View
| Interactant Gene ID (Source: HPRD) | Gene Symbol | HPRD ID | Ref Seq ID | Technique | References |
|---|---|---|---|---|---|
| 1435 | CSF1 | 388 | NP_000748.3 | in vivo | 24 087 598 355 686 |
| 2534 | FYN | 655 | NP_002028.1 | in vivo | 7681396 |
| 2885 | GRB2 | 150 | NP_002077.1 | in vitro;in vivo;yeast 2-hybrid | 938 040 882 620 599 000 000 |
| 3635 | INPP5D | 9033 | NP_001017915.1 | yeast 2-hybrid | 15735664 |
| 3636 | INPPL1 | 2900 | NP_001558.3 | yeast 2-hybrid | 15735664 |
| 5921 | RASA1 | 745 | NP_002881.1 | in vivo | 2172781 |
| 6464 | SHC1 | 2780 | NP_001123512.1 | in vitro;in vivo | 7520523 |
| 6654 | SOS1 | 1681 | NP_005624.2 | in vitro;in vivo | 7520523 |
Pathway Information
| Pathway Name | Pathway ID |
|---|---|
| Cytokine-cytokine receptor interaction | hsa04060 |
| Endocytosis | hsa04144 |
| Hematopoietic cell lineage | hsa04640 |
| Osteoclast differentiation | hsa04380 |
| Pathways in cancer | hsa05200 |
| PI3K-Akt signaling pathway | hsa04151 |
| Rap1 signaling pathway | hsa04015 |
| Ras signaling pathway | hsa04014 |
| Transcriptional misregulation in cancer | hsa05202 |
Structure Information
No matching records could be found.
Domain Information
| ID | Location | Description |
|---|---|---|
| cd05106 | 543-914 | PTKc_CSF-1R |
| cl21453 | 543-914 | PKc_like superfamily |
| cd04975 | 299-400 | Ig4_SCFR_like |
| cl11960 | 299-400 | Ig superfamily |
| cd00096 | 416-495 | Ig |
| cl11960 | 416-495 | Ig superfamily |
| cd00096 | 220-291 | Ig |
| cl11960 | 220-291 | Ig superfamily |
| cd05055 | 546-914 | PTKc_PDGFR |
| cd05104 | 546-913 | PTKc_Kit |
| cd05105 | 546-906 | PTKc_PDGFR_alpha |
| cd05107 | 546-906 | PTKc_PDGFR_beta |
| cd05054 | 574-913 | PTKc_VEGFR |
| cd05102 | 574-917 | PTKc_VEGFR3 |
| cd05103 | 574-910 | PTKc_VEGFR2 |
| cd14207 | 574-906 | PTKc_VEGFR1 |
| cd00192 | 586-911 | PTKc |
| cd05053 | 569-906 | PTKc_FGFR |
| cd05099 | 569-906 | PTKc_FGFR4 |
| cd05101 | 568-906 | PTKc_FGFR2 |
| cd05098 | 568-906 | PTKc_FGFR1 |
| cd05100 | 569-906 | PTKc_FGFR3 |
| cd05045 | 581-912 | PTKc_RET |
| cd05032 | 575-912 | PTKc_InsR_like |
| cd05036 | 576-911 | PTKc_ALK_LTK |
| cd05034 | 586-910 | PTKc_Src_like |
| cd05048 | 576-911 | PTKc_Ror |
| cd05039 | 575-911 | PTKc_Csk_like |
| cd05050 | 576-911 | PTKc_Musk |
| cd05068 | 573-912 | PTKc_Frk_like |
| cd05051 | 576-912 | PTKc_DDR |
| cd05049 | 576-912 | PTKc_Trk |
| cd05044 | 586-912 | PTKc_c-ros |
| cd05148 | 575-903 | PTKc_Srm_Brk |
| cd05041 | 588-911 | PTKc_Fes_like |
| cd05061 | 575-912 | PTKc_InsR |
| cd05052 | 575-906 | PTKc_Abl |
| cd05047 | 588-906 | PTKc_Tie |
| cd05060 | 586-910 | PTKc_Syk_like |
| cd05089 | 575-926 | PTKc_Tie1 |
| cd05092 | 574-911 | PTKc_TrkA |
| cd05072 | 575-912 | PTKc_Lyn |
| cd05085 | 585-906 | PTKc_Fer |
| cd05059 | 582-910 | PTKc_Tec_like |
| cd05088 | 580-918 | PTKc_Tie2 |
| cd05046 | 577-912 | PTK_CCK4 |
| cd05056 | 575-918 | PTKc_FAK |
| cd05083 | 575-913 | PTKc_Chk |
| cd13999 | 588-910 | STKc_MAP3K-like |
| cd05067 | 574-912 | PTKc_Lck_Blk |
| cd05038 | 577-907 | PTKc_Jak_rpt2 |
| cd05095 | 576-912 | PTKc_DDR2 |
| cd05082 | 575-912 | PTKc_Csk |
| cd05097 | 576-912 | PTKc_DDR_like |
| cd05057 | 576-919 | PTKc_EGFR_like |
| cd05073 | 573-912 | PTKc_Hck |
| cd05033 | 586-911 | PTKc_EphR |
| cd05084 | 585-911 | PTKc_Fes |
| cd05035 | 582-912 | PTKc_TAM |
| cd05058 | 588-908 | PTKc_Met_Ron |
| cd05075 | 582-906 | PTKc_Axl |
| cd05091 | 576-911 | PTKc_Ror2 |
| cd14203 | 586-912 | PTKc_Src_Fyn_like |
| cd05062 | 575-912 | PTKc_IGF-1R |
| cd05040 | 586-912 | PTKc_Ack_like |
| cd05094 | 579-910 | PTKc_TrkC |
| cd05113 | 579-911 | PTKc_Btk_Bmx |
| cd05069 | 573-912 | PTKc_Yes |
| cd05093 | 579-915 | PTKc_TrkB |
| cd14204 | 579-906 | PTKc_Mer |
| cd05096 | 576-912 | PTKc_DDR1 |
| cd05070 | 573-912 | PTKc_Fyn |
| cd05090 | 576-906 | PTKc_Ror1 |
| cd05074 | 578-911 | PTKc_Tyro3 |
| cd05071 | 573-912 | PTKc_Src |
| cd05043 | 591-912 | PTK_Ryk |
| cd00180 | 588-906 | PKc |
| cd05114 | 582-915 | PTKc_Tec_Rlk |
| cd05063 | 586-912 | PTKc_EphR_A2 |
| cd05066 | 580-910 | PTKc_EphR_A |
| cd05108 | 586-919 | PTKc_EGFR |
| cd05112 | 580-903 | PTKc_Itk |
| cd05116 | 586-903 | PTKc_Syk |
| cd05109 | 586-919 | PTKc_HER2 |
| cd05065 | 586-910 | PTKc_EphR_B |
| cd05080 | 577-912 | PTKc_Tyk2_rpt2 |
| cd05115 | 588-906 | PTKc_Zap-70 |
| cd14058 | 588-915 | STKc_TAK1 |
| cd05079 | 577-906 | PTKc_Jak1_rpt2 |
| cd05111 | 577-919 | PTK_HER3 |
| cd14205 | 577-906 | PTKc_Jak2_rpt2 |
| cd05081 | 577-906 | PTKc_Jak3_rpt2 |
| cd05110 | 586-919 | PTKc_HER4 |
| cd05064 | 576-912 | PTKc_EphR_A10 |
| cd14206 | 588-911 | PTKc_Aatyk3 |
| cd14059 | 588-910 | STKc_MAP3K12_13 |
| cd06606 | 585-857 | STKc_MAPKKK |
| cd05042 | 586-906 | PTKc_Aatyk |
| cd05087 | 586-906 | PTKc_Aatyk1 |
| cd14061 | 588-912 | STKc_MLK |
| cd13978 | 588-903 | STKc_RIP |
| cd14062 | 588-911 | STKc_Raf |
| cd14060 | 589-911 | STKc_MLTK |
| cd06627 | 581-908 | STKc_Cdc7_like |
| cd14146 | 588-906 | STKc_MLK4 |
| cd05086 | 588-906 | PTKc_Aatyk2 |
| cd14150 | 586-916 | STKc_A-Raf |
| cd14014 | 588-902 | STKc_PknB_like |
| cd14065 | 588-910 | PKc_LIMK_like |
| cd08215 | 586-909 | STKc_Nek |
| cd14148 | 747-906 | STKc_MLK2 |
| cd14147 | 747-911 | STKc_MLK3 |
| cd14151 | 573-916 | STKc_B-Raf |
| cd05122 | 583-856 | PKc_STE |
| cd14145 | 755-906 | STKc_MLK1 |
| cd14155 | 588-912 | PKc_TESK |
| cd14158 | 585-912 | STKc_IRAK4 |
| cd05037 | 582-910 | PTK_Jak_rpt1 |
| cd14003 | 581-906 | STKc_AMPK-like |
| cd05117 | 583-845 | STKc_CAMK |
| cd14063 | 582-910 | PK_KSR |
| cd13992 | 626-912 | PK_GC |
| cd14149 | 575-911 | STKc_C-Raf |
| cd14066 | 588-850 | STKc_IRAK |
| cd06614 | 582-848 | STKc_PAK |
| cd06629 | 585-902 | STKc_Bck1_like |
| cd13979 | 582-902 | STKc_Mos |
| cd08225 | 586-906 | STKc_Nek5 |
| cd14064 | 742-912 | PKc_TNNI3K |
| cd06628 | 585-906 | STKc_Byr2_like |
| cd14154 | 588-911 | STKc_LIMK |
| cd05581 | 580-902 | STKc_PDK1 |
| cd14080 | 583-906 | STKc_TSSK-like |
| cd05118 | 586-850 | STKc_CMGC |
| cd14121 | 588-905 | STKc_ULK3 |
| cd06632 | 583-906 | STKc_MEKK1_plant |
| cd14156 | 749-915 | PKc_LIMK_like_unk |
| cd06623 | 580-905 | PKc_MAPKK_plant_like |
| cd13975 | 750-912 | PKc_Dusty |
| cd14221 | 758-911 | STKc_LIMK1 |
| cd13997 | 588-906 | PKc_Wee1_like |
| cd14099 | 585-908 | STKc_PLK |
| cd14202 | 574-856 | STKc_ULK1 |
| cd06608 | 578-906 | STKc_myosinIII_N_like |
| cd08530 | 586-914 | STKc_CNK2-like |
| cd05078 | 582-906 | PTK_Jak2_rpt1 |
| cd06611 | 578-906 | STKc_SLK_like |
| cd14007 | 583-908 | STKc_Aurora |
| cd14027 | 588-910 | STKc_RIP1 |
| cd14000 | 588-910 | STKc_LRRK |
| cd14222 | 588-906 | STKc_LIMK2 |
| cd06644 | 564-906 | STKc_STK10 |
| cd08217 | 586-907 | STKc_Nek2 |
| cd07840 | 588-858 | STKc_CDK9_like |
| cd14009 | 588-847 | STKc_ATG1_ULK_like |
| cd13993 | 581-904 | STKc_Pat1_like |
| cd07833 | 580-926 | STKc_CDKL |
| cd08529 | 585-906 | STKc_FA2-like |
| cd14002 | 589-921 | STKc_STK36 |
| cd07829 | 588-889 | STKc_CDK_like |
| cd08223 | 742-906 | STKc_Nek4 |
| cd14042 | 613-910 | PK_GC-A_B |
| cd14052 | 586-848 | PTKc_Wee1_fungi |
| cd07830 | 583-907 | STKc_MAK_like |
| cd13996 | 588-906 | STKc_EIF2AK |
| cd14069 | 585-845 | STKc_Chk1 |
| cd08224 | 744-912 | STKc_Nek6_7 |
| cd14186 | 744-906 | STKc_PLK4 |
| cd07834 | 586-849 | STKc_MAPK |
| cd14152 | 582-919 | STKc_KSR1 |
| cd14208 | 582-906 | PTK_Jak3_rpt1 |
| cd06612 | 761-859 | STKc_MST1_2 |
| cd06631 | 585-848 | STKc_YSK4 |
| cd06641 | 742-906 | STKc_MST3 |
| cd14103 | 588-858 | STKc_MLCK |
| cd06605 | 580-907 | PKc_MAPKK |
| cd06613 | 588-902 | STKc_MAP4K3_like |
| cd06619 | 762-902 | PKc_MKK5 |
| cd05123 | 588-900 | STKc_AGC |
| cd06634 | 738-902 | STKc_TAO2 |
| cd06625 | 581-850 | STKc_MEKK3_like |
| cd14201 | 575-856 | STKc_ULK2 |
| cd14120 | 588-847 | STKc_ULK1_2-like |
| cd14011 | 761-906 | PK_SCY1_like |
| cd06642 | 749-919 | STKc_STK25 |
| cd06607 | 748-843 | STKc_TAO |
| cd06609 | 588-856 | STKc_MST3_like |
| cd06621 | 744-906 | PKc_Pek1_like |
| cd14053 | 591-850 | STKc_ACVR2 |
| cd08222 | 586-906 | STKc_Nek11 |
| cd13985 | 581-914 | STKc_GAK_like |
| cd14137 | 586-842 | STKc_GSK3 |
| cd14190 | 581-858 | STKc_MLCK2 |
| cd14006 | 588-858 | STKc_MLCK-like |
| cd06917 | 761-900 | STKc_NAK1_like |
| cd14131 | 742-906 | PKc_Mps1 |
| cd06643 | 588-892 | STKc_SLK |
| cd06630 | 585-848 | STKc_MEKK1 |
| cd08220 | 742-906 | STKc_Nek8 |
| cd14079 | 581-846 | STKc_AMPK_alpha |
| cd14073 | 583-908 | STKc_NUAK |
| cd06620 | 586-907 | PKc_Byr1_like |
| cd14119 | 757-906 | STKc_LKB1 |
| cd06622 | 762-906 | PKc_PBS2_like |
| cd14664 | 588-912 | STK_BAK1_like |
| cd14050 | 583-848 | PKc_Myt1 |
| cd08221 | 583-906 | STKc_Nek9 |
| cd14045 | 613-910 | PK_GC_unk |
| cd05578 | 757-858 | STKc_Yank1 |
| cd14048 | 750-906 | STKc_EIF2AK3_PERK |
| cd06633 | 738-848 | STKc_TAO3 |
| cd14025 | 749-908 | STKc_RIP4_like |
| cd07832 | 588-848 | STKc_CCRK |
| cd05580 | 580-848 | STKc_PKA_like |
| cd05860 | 300-396 | Ig4_SCFR |
| cd07855 | 586-858 | STKc_ERK5 |
| cd05589 | 588-858 | STKc_PKN |
| cd14097 | 583-906 | STKc_STK33 |
| cd13998 | 750-850 | STKc_TGFbR-like |
| cd08228 | 744-901 | STKc_Nek6 |
| cd08218 | 586-906 | STKc_Nek1 |
| cd06640 | 761-906 | STKc_MST4 |
| cd07854 | 586-848 | STKc_MAPK4_6 |
| cd06617 | 721-917 | PKc_MKK3_6 |
| cd07847 | 761-906 | STKc_CDKL1_4 |
| cd14008 | 588-846 | STKc_LKB1_CaMKK |
| cd06648 | 578-848 | STKc_PAK_II |
| cd07863 | 747-849 | STKc_CDK4 |
| cd14068 | 588-910 | STKc_LRRK2 |
| cd06635 | 738-906 | STKc_TAO1 |
| cd07841 | 584-847 | STKc_CDK7 |
| cd14047 | 588-850 | STKc_EIF2AK2_PKR |
| cd08219 | 740-908 | STKc_Nek3 |
| cd13982 | 740-906 | STKc_IRE1 |
| cd07862 | 742-849 | STKc_CDK6 |
| cd05619 | 758-900 | STKc_nPKC_theta |
| cd05616 | 758-900 | STKc_cPKC_beta |
| cd06659 | 762-856 | STKc_PAK6 |
| cd13968 | 588-798 | PKc_like |
| cd08229 | 744-901 | STKc_Nek7 |
| cd14116 | 581-906 | STKc_Aurora-A |
| cd07858 | 757-858 | STKc_TEY_MAPK |
| cd14187 | 757-906 | STKc_PLK1 |
| cd05077 | 759-906 | PTK_Jak1_rpt1 |
| cd05620 | 744-926 | STKc_nPKC_delta |
| cd06638 | 578-848 | STKc_myosinIIIA_N |
| cd07838 | 588-851 | STKc_CDK4_6_like |
| cd06616 | 773-868 | PKc_MKK4 |
| cd06626 | 583-902 | STKc_MEKK4 |
| cd14164 | 753-908 | STKc_TSSK6-like |
| cd14056 | 586-848 | STKc_TGFbR_I |
| cd14044 | 697-910 | PK_GC-C |
| cd14054 | 750-858 | STKc_BMPR2_AMHR2 |
| cd14192 | 586-858 | STKc_MLCK3 |
| cd05592 | 758-858 | STKc_nPKC_theta_like |
| cd13994 | 588-906 | STKc_HAL4_like |
| cd14162 | 585-895 | STKc_TSSK4-like |
| cd06653 | 581-850 | STKc_MEKK3_like_u1 |
| cd14078 | 586-908 | STKc_MELK |
| cd14010 | 757-850 | STKc_ULK4 |
| cd14094 | 757-905 | STKc_CASK |
| cd06637 | 747-916 | STKc_TNIK |
| cd06655 | 578-856 | STKc_PAK2 |
| cd14161 | 579-908 | STKc_NUAK2 |
| cd13989 | 588-856 | STKc_IKK |
| cd05579 | 757-856 | STKc_MAST_like |
| cd14663 | 583-906 | STKc_SnRK3 |
| cd14142 | 749-848 | STKc_ACVR1_ALK1 |
| cd14043 | 764-906 | PK_GC-2D |
| cd07836 | 737-858 | STKc_Pho85 |
| cd05590 | 586-900 | STKc_nPKC_eta |
| cd14026 | 588-903 | STKc_RIP2 |
| cd05587 | 758-858 | STKc_cPKC |
| cd14081 | 585-906 | STKc_BRSK1_2 |
| cd14153 | 582-912 | PK_KSR2 |
| cd06610 | 612-856 | STKc_OSR1_SPAK |
| cd14165 | 585-856 | STKc_TSSK1_2-like |
| cd14012 | 752-906 | PK_eIF2AK_GCN2_rpt1 |
| cd14001 | 723-911 | PKc_TOPK |
| cd06636 | 757-848 | STKc_MAP4K4_6_N |
| cd06647 | 588-856 | STKc_PAK_I |
| cd07866 | 761-849 | STKc_BUR1 |
| cd05076 | 720-906 | PTK_Tyk2_rpt1 |
| cd06652 | 581-850 | STKc_MEKK2 |
| cd07845 | 761-849 | STKc_CDK10 |
| cd05570 | 758-858 | STKc_PKC |
| cd05572 | 752-848 | STKc_cGK |
| cd07857 | 581-855 | STKc_MPK1 |
| cd14104 | 753-858 | STKc_Titin |
| cd07864 | 758-850 | STKc_CDK12 |
| cd06639 | 570-848 | STKc_myosinIIIB_N |
| cd05615 | 758-900 | STKc_cPKC_alpha |
| cd14067 | 761-913 | STKc_LRRK1 |
| cd14075 | 584-910 | STKc_NIM1 |
| cd14098 | 587-858 | STKc_Rad53_Cds1 |
| cd06624 | 588-842 | STKc_ASK |
| cd05630 | 758-882 | STKc_GRK6 |
| cd06650 | 759-857 | PKc_MEK1 |
| cd14076 | 585-856 | STKc_Kin4 |
| cd14072 | 581-906 | STKc_MARK |
| cd06649 | 759-857 | PKc_MEK2 |
| cd06618 | 775-921 | PKc_MKK7 |
| cd07851 | 575-847 | STKc_p38 |
| cd14057 | 758-911 | PK_ILK |
| cd05608 | 758-850 | STKc_GRK1 |
| cd07877 | 575-858 | STKc_p38alpha |
| cd07856 | 748-858 | STKc_Sty1_Hog1 |
| cd06646 | 738-864 | STKc_MAP4K5 |
| cd14194 | 580-858 | STKc_DAPK1 |
| cd14197 | 753-858 | STKc_DRAK1 |
| cd06615 | 762-857 | PKc_MEK |
| cd14019 | 588-850 | STKc_Cdc7 |
| cd05582 | 760-858 | STKc_RSK_N |
| cd06654 | 764-856 | STKc_PAK1 |
| cd14046 | 586-847 | STKc_EIF2AK4_GCN2_rpt2 |
| cd07859 | 758-858 | STKc_TDY_MAPK |
| cd06651 | 581-906 | STKc_MEKK3 |
| cd05605 | 758-848 | STKc_GRK4_like |
| cd14210 | 748-849 | PKc_DYRK |
| cd07839 | 758-870 | STKc_CDK5 |
| cd14195 | 583-858 | STKc_DAPK3 |
| cd06658 | 762-856 | STKc_PAK5 |
| cd14105 | 585-858 | STKc_DAPK |
| cd06656 | 764-856 | STKc_PAK3 |
| cd05607 | 748-856 | STKc_GRK7 |
| cd05611 | 758-856 | STKc_Rim15_like |
| cd07852 | 761-849 | STKc_MAPK15-like |
| cd07849 | 757-850 | STKc_ERK1_2_like |
| cd14033 | 748-906 | STKc_WNK4 |
| cd07860 | 737-848 | STKc_CDK2_3 |
| cd05595 | 758-848 | STKc_PKB_beta |
| cd05632 | 747-858 | STKc_GRK5 |
| cd14111 | 754-856 | STKc_SPEG_rpt2 |
| cd14106 | 740-858 | STKc_DRAK |
| cd07878 | 575-858 | STKc_p38beta |
| cd13986 | 741-913 | STKc_16 |
| cd14049 | 734-849 | STKc_EIF2AK1_HRI |
| cd07831 | 748-858 | STKc_MOK |
| cd06645 | 738-851 | STKc_MAP4K3 |
| cd07879 | 575-850 | STKc_p38delta |
| cd07846 | 761-870 | STKc_CDKL2_3 |
| cd14144 | 750-848 | STKc_BMPR1 |
| cd14191 | 750-858 | STKc_MLCK1 |
| cd14189 | 757-906 | STKc_PLK3 |
| cd14039 | 588-912 | STKc_IKK_alpha |
| pfam13927 | 202-282 | Ig_3 |
| cd05612 | 756-856 | STKc_PRKX_like |
| cd07848 | 761-858 | STKc_CDKL5 |
| cd06657 | 762-856 | STKc_PAK4 |
| cd13995 | 749-914 | STKc_MAP3K8 |
| cd07843 | 751-850 | STKc_CDC2L1 |
| cd14183 | 753-858 | STKc_DCKL1 |
| cd14200 | 738-856 | STKc_CaMKK1 |
| cd05603 | 758-921 | STKc_SGK2 |
| cd14219 | 755-902 | STKc_BMPR1b |
| cd05585 | 758-871 | STKc_YPK1_like |
| cd07873 | 739-870 | STKc_PCTAIRE1 |
| pfam00047 | 217-280 | ig |
| cd05577 | 746-856 | STKc_GRK |
| cd13977 | 758-846 | STKc_PDIK1L |
| cd14159 | 588-850 | STKc_IRAK1 |
| cd13983 | 750-906 | STKc_WNK |
| cd05631 | 758-856 | STKc_GRK4 |
| cd14077 | 581-846 | STKc_Kin1_2 |
| cd14220 | 750-906 | STKc_BMPR1a |
| cd14117 | 576-906 | STKc_Aurora-B_like |
| cd14212 | 748-870 | PKc_YAK1 |
| cd05613 | 581-856 | STKc_MSK1_N |
| cd08528 | 772-908 | STKc_Nek10 |
| cd05609 | 768-871 | STKc_MAST |
| cd14193 | 581-858 | STKc_MLCK4 |
| cd14143 | 749-848 | STKc_TGFbR1_ACVR1b_ACVR1c |
| cd14038 | 760-856 | STKc_IKK_beta |
| cd14086 | 754-856 | STKc_CaMKII |
| cd14109 | 753-859 | PK_Unc-89_rpt1 |
| cd13987 | 761-845 | STKc_SBK1 |
| cd07872 | 747-866 | STKc_PCTAIRE2 |
| cd07853 | 758-850 | STKc_NLK |
| cd14184 | 762-856 | STKc_DCKL2 |
| cd14199 | 745-856 | STKc_CaMKK2 |
| cd14036 | 582-914 | STKc_GAK |
| cd14004 | 761-906 | STKc_PASK |
| cd14114 | 588-858 | STKc_Twitchin_like |
| cd14141 | 754-850 | STKc_ACVR2a |
| cd13991 | 742-840 | STKc_NIK |
| cd14133 | 586-850 | PKc_DYRK_like |
| cd07880 | 761-850 | STKc_p38gamma |
| cd07835 | 737-842 | STKc_CDK1_CdkB_like |
| cd14188 | 757-906 | STKc_PLK2 |
| cd14140 | 743-850 | STKc_ACVR2b |
| cd05584 | 586-858 | STKc_p70S6K |
| cd14175 | 611-856 | STKc_RSK1_C |
| cd07871 | 735-866 | STKc_PCTAIRE3 |
| cd07842 | 752-851 | STKc_CDK8_like |
| cd05602 | 758-856 | STKc_SGK1 |
| cd14118 | 752-846 | STKc_CAMKK |
| cd07850 | 761-848 | STKc_JNK |
| cd14229 | 749-860 | STKc_HIPK3 |
| cd14209 | 758-856 | STKc_PKA |
| cd14101 | 758-906 | STKc_PIM2 |
| cd14198 | 754-858 | STKc_DRAK2 |
| cd14095 | 583-856 | STKc_DCKL |
| cd14055 | 747-850 | STKc_TGFbR2_like |
| cd14173 | 757-858 | STKc_Mnk2 |
| cd05604 | 756-856 | STKc_SGK3 |
| cd07861 | 761-848 | STKc_CDK1_euk |
| cd14167 | 579-878 | STKc_CaMKI_alpha |
| cd05593 | 758-848 | STKc_PKB_gamma |
| cd05614 | 581-856 | STKc_MSK2_N |
| cd14090 | 585-858 | STKc_Mnk |
| cd07876 | 761-848 | STKc_JNK2 |
| cd07870 | 758-870 | STKc_PFTAIRE2 |
| pfam13895 | 21-85 | Ig_2 |
| cl11960 | 21-85 | Ig superfamily |
| cd14170 | 762-905 | STKc_MAPKAPK2 |
| cd05573 | 774-849 | STKc_ROCK_NDR_like |
| cd05601 | 775-847 | STKc_CRIK |
| cd14178 | 762-856 | STKc_RSK3_C |
| cd14176 | 579-856 | STKc_RSK2_C |
| cd14196 | 583-858 | STKc_DAPK2 |
| cd14084 | 586-906 | STKc_Chk2 |
| cd07865 | 761-801 | STKc_CDK9 |
| cd14177 | 762-906 | STKc_RSK4_C |
| cd14087 | 753-856 | STKc_PSKH1 |
| cd14093 | 761-846 | STKc_PhKG |
| cd05594 | 758-848 | STKc_PKB_alpha |
| cd14112 | 732-858 | STKc_Unc-89_rpt2 |
| cd14134 | 586-849 | PKc_CLK |
| cd14110 | 751-850 | STKc_obscurin_rpt2 |
| cd07874 | 761-848 | STKc_JNK3 |
| cd14213 | 587-857 | PKc_CLK1_4 |
| cd07869 | 740-859 | STKc_PFTAIRE1 |
| cd05583 | 769-856 | STKc_MSK_N |
| cd07875 | 761-858 | STKc_JNK1 |
| cd14085 | 753-856 | STKc_CaMKIV |
| cd14020 | 757-850 | STKc_KIS |
| cd14172 | 765-905 | STKc_MAPKAPK3 |
| cd05586 | 744-856 | STKc_Sck1_like |
| cd13990 | 761-848 | STKc_TLK |
| cd14185 | 583-856 | STKc_DCKL3 |
| cd05591 | 758-850 | STKc_nPKC_epsilon |
| cd07844 | 747-859 | STKc_PCTAIRE_like |
| cd14228 | 749-858 | STKc_HIPK1 |
| cd05617 | 758-862 | STKc_aPKC_zeta |
| cd14166 | 761-878 | STKc_CaMKI_gamma |
| cd14227 | 749-858 | STKc_HIPK2 |
| cd14018 | 761-902 | STKc_PINK1 |
| cd14005 | 757-848 | STKc_PIM |
| cd14182 | 751-856 | STKc_PhKG1 |
| cd05598 | 775-847 | STKc_LATS |
| cd14125 | 738-801 | STKc_CK1_delta_epsilon |
| cd05571 | 758-848 | STKc_PKB |
| cd14037 | 586-914 | STKc_NAK_like |
| cd14180 | 766-850 | STKc_MSK2_C |
| cd07837 | 744-848 | STKc_CdkB_plant |
| cd14083 | 584-845 | STKc_CaMKI |
| cd08216 | 613-843 | PK_STRAD |
| cd14091 | 587-678 | STKc_RSK_C |
| cd14070 | 585-908 | STKc_HUNK |
| cd05575 | 758-921 | STKc_SGK |
| pfam13895 | 204-292 | Ig_2 |
| cd14211 | 748-858 | STKc_HIPK |
| cd14135 | 772-850 | STKc_PRP4 |
| cd05622 | 758-856 | STKc_ROCK1 |
| cd14082 | 739-846 | STKc_PKD |
| cd05599 | 775-847 | STKc_NDR_like |
| cd05588 | 758-856 | STKc_aPKC |
| cd05752 | 35-101 | Ig1_FcgammaR_like |
| cd05618 | 758-856 | STKc_aPKC_iota |
| pfam13927 | 401-489 | Ig_3 |
| cd05859 | 300-396 | Ig4_PDGFR-alpha |
| cd05869 | 259-295 | Ig5_NCAM-1 |
| cd14223 | 754-856 | STKc_GRK2 |
| cd05621 | 758-856 | STKc_ROCK2 |
| cd05610 | 756-805 | STKc_MASTL |
| cd14168 | 582-905 | STKc_CaMKI_delta |
| cd14071 | 761-907 | STKc_SIK |
| cd05596 | 775-848 | STKc_ROCK |
| cd14092 | 761-850 | STKc_MSK_C |
| cd04977 | 217-288 | Ig1_NCAM-1_like |
| cd14107 | 761-844 | STKc_obscurin_rpt1 |
| cd05597 | 775-849 | STKc_DMPK_like |
| pfam13927 | 20-85 | Ig_3 |
| pfam07714 | 582-910 | Pkinase_Tyr |
| smart00410 | 209-290 | IG_like |
| smart00410 | 401-495 | IG_like |
| smart00221 | 582-910 | STYKc |
| smart00219 | 582-910 | TyrKc |
| smart00220 | 583-906 | S_TKc |
| pfam00069 | 582-907 | Pkinase |
| COG0515 | 581-888 | SPS1 |
| PHA03209 | 742-860 | PHA03209 |
| PHA02988 | 776-910 | PHA02988 |
| PTZ00283 | 761-902 | PTZ00283 |
| PLN00034 | 755-906 | PLN00034 |
| PTZ00267 | 761-906 | PTZ00267 |
| PTZ00024 | 583-850 | PTZ00024 |
| PTZ00426 | 572-856 | PTZ00426 |
| smart00410 | 28-85 | IG_like |
| smart00409 | 28-85 | IG |
| PTZ00036 | 749-870 | PTZ00036 |
| PTZ00263 | 570-856 | PTZ00263 |
| smart00409 | 209-290 | IG |
| PHA03212 | 746-848 | PHA03212 |
| smart00408 | 217-285 | IGc2 |
| PHA03207 | 749-848 | PHA03207 |
| PRK13184 | 761-869 | pknD |
| PHA03211 | 748-847 | PHA03211 |
| PTZ00266 | 775-856 | PTZ00266 |
| PHA03210 | 739-858 | PHA03210 |
| smart00409 | 401-495 | IG |
| PLN00009 | 758-850 | PLN00009 |
| PHA03390 | 761-856 | pk1 |
Ontology Information
| HPRD ID | 1426 |
|---|---|
| Molecular Class | Receptor tyrosine kinase |
| Molecular Function | Chemokine activity (GO:0008009) |
| Biological Process | Immune response (GO:0006955) |
Drug Information
| Uniprot ID | DrugBank ID | Name | Type |
|---|---|---|---|
| P07333 | DB00619 | Imatinib | SmallMoleculeDrug |
| P07333 | DB01268 | Sunitinib | SmallMoleculeDrug |