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General Information
| Gene_Symbol | Gene_ID | Gene_Name | Chromosome | Alias |
|---|---|---|---|---|
| CSF2 | 1437 | colony stimulating factor 2 (granulocyte-macrophage) | 5 | GM-CSF, GMCSF |
- Evidence
- Gene
- mRNA
- CDS
- Protein
- PTM
- Enzyme
- PPi
- Pathway
- Structural
- Domain
- Ontology
- SNP
- Drug
- External Links
Evidence Information
| Pubmed ID | Year | Sample Information | Techniques | Mechanism | Fold Change | Remark |
|---|---|---|---|---|---|---|
| 23108143 | 2013 | Cell line : - Source : ATCC Sample Type : - No. of Sample : Mouse model Stage : - | Bisulfite pyrosequencing, shGm-CSf stable transfection,Immunohistochemistry, MTT, In situ hybridization | Hypomethylation | - | Expression of GM-CSF and its receptor subunits by colon tumors may be a useful marker for prognosis as well as for patient stratification in cancer immunot |
Gene Details
| Gene Type | protein coding |
|---|---|
| Gene Family | - |
| Description | The protein encoded by this gene is a cytokine that controls the production, differentiation, and function of granulocytes and macrophages. The active form of the protein is found extracellularly as a homodimer. This gene has been localized to a cluster of related genes at chromosome region 5q31, which is known to be associated with interstitial deletions in the 5q- syndrome and acute myelogenous leukemia. Other genes in the cluster include those encoding interleukins 4, 5, and 13. [provided by RefSeq, Jul 2008] |
| Chromosome | 5 |
| Location | 5q23-q31 |
| Start | 131409485 |
| End | 131411863 |
| Strand | + |
| Gene Sequence | Download Select all |
| Length | 2379 |
| OMIM ID | 138960 |
| HGNC ID | HGNC:2434 |
| Unigene ID | Hs.1349 |
| Ensembl ID | ENSG00000164400 |
| PharmGKB ID | PA26937 |
mRNA Information
| mRNA ID | NM_000758.3 |
|---|---|
| Exon | join(1..191,290..331,1019..1144,1954..2379) | mRNA Sequence | Download Select all |
| Length | 800 |
Protein Information
| Protein ID | NP_000749.2 |
|---|---|
| Protein Name | colony stimulating factor 2 (granulocyte-macrophage) |
| Molecular Wt. (Da) | 0 |
| Protein Sequence | Download Select all |
| Length | 144 |
| Uniprot ID | O15534 |
| Ensembl Protein ID | ENSP00000314420 |
Post-translational Modification Information (Source : HPRD)
No matching records could be found.
Enzyme Information
No matching records could be found.
PPi Information
(Click to view network : Source STRING) View
No matching records from HPRD source could be found.
Pathway Information
| Pathway Name | Pathway ID |
|---|---|
| Amoebiasis | hsa05146 |
| Cytokine-cytokine receptor interaction | hsa04060 |
| Fc epsilon RI signaling pathway | hsa04664 |
| Hematopoietic cell lineage | hsa04640 |
| HTLV-I infection | hsa05166 |
| Jak-STAT signaling pathway | hsa04630 |
| Natural killer cell mediated cytotoxicity | hsa04650 |
| Rheumatoid arthritis | hsa05323 |
| Salmonella infection | hsa05132 |
| T cell receptor signaling pathway | hsa04660 |
| TNF signaling pathway | hsa04668 |
| Transcriptional misregulation in cancer | hsa05202 |
Structure Information
No matching records could be found.
Domain Information
| ID | Location | Description |
|---|---|---|
| cd00040 | 18-138 | CSF2 |
| cl23484 | 18-138 | CSF2 superfamily |
| pfam01109 | 18-139 | GM_CSF |
| cl23110 | 18-139 | GM_CSF superfamily |
| smart00040 | 18-138 | CSF2 |
| cl23042 | 18-138 | CSF2 superfamily |
Ontology Information
| HPRD ID | 5613 |
|---|---|
| Molecular Class | Cytokine |
| Molecular Function | Sugar-phosphatase activity (GO:0050308) |
| Biological Process | Metabolism (GO:0008152); Energy pathways (GO:0006091) |
Drug Information
No matching records could be found.