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General Information



Gene_Symbol Gene_ID Gene_Name Chromosome Alias
CSF3R 1441 colony stimulating factor 3 receptor (granulocyte)  1GCSFR 







  • Evidence
  • Gene
  • mRNA
  • CDS
  • Protein
  • PTM
  • Enzyme
  • PPi
  • Pathway
  • Structural
  • Domain
  • Ontology
  • SNP
  • Drug
  • External Links



Evidence Information


Pubmed ID Year Sample Information Techniques Mechanism Fold Change Remark
15879049   2005Cell line : -

Source : Department of general surgery of Jinling Hospital in Nanjing, China.

Sample Type : CRC Tumor and adjecent normal tissue

No. of Sample : 42

Stage : Stage IV

Immucohistochemical analyses,RT-PCR.Up-regulation-G-CSFR is commonly expressed in human colorectal cancers, thus supporting a possible role for G-CSF in colorectal cancer physiology.

24574781   2014Cell line : -

Source : Hospital of Nanjing Medical University (Nanjing, China).

Sample Type : CRC Tumor and adjecent normal tissue

No. of Sample : 126

Stage : TNM Stage I,II,III,IV

 ImmunohistochemistryUp-regulation-The expression of G-CSFR before preoperative irradiation may predict the radiosensitivity of rectal cancer.


Gene Details



NC_000001.10 (36931644..36948915, complement)

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Gene Type protein coding
Gene Family CD molecules, "Fibronectin type III domain containing"
Description The protein encoded by this gene is the receptor for colony stimulating factor 3, a cytokine that controls the production, differentiation, and function of granulocytes. The encoded protein, which is a member of the family of cytokine receptors, may also function in some cell surface adhesion or recognition processes. Alternatively spliced transcript variants have been described. Mutations in this gene are a cause of Kostmann syndrome, also known as severe congenital neutropenia. [provided by RefSeq, Aug 2010]  
Chromosome 1
Location 1p35-p34.3
Start 36931644  
End 36948915  
Strand -  
Gene Sequence

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Length 17272  
OMIM ID 138971   
HGNC ID HGNC:2439   
Unigene ID Hs.524517   
Ensembl ID ENSG00000119535   
PharmGKB ID PA26942   

mRNA Information


mRNA ID XM_005270493.1
Exon join(1..504,1778..1837,3799..3882,7642..7938,9428..9551, 9693..9880,10629..10798,10924..11077,11176..11249, 11669..11882,13475..13663,14058..14159,15094..15240, 15353..15493,15664..15757,16007..16085,16488..17272)  
mRNA Sequence

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Length 3406  



CDS Information


   
Location585..3092
CDS Sequence

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CCDS ID CCDS412.1



Protein Information


      
Protein IDXP_005270550.1
Protein Namecolony stimulating factor 3 receptor (granulocyte)
Molecular Wt. (Da)91884
Protein Sequence

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Length 835  
Uniprot IDP02776
Ensembl Protein ID ENSP00000296029  



Post-translational Modification Information (Source : HPRD)


Residue Type site
NGlycosylation128
CDisulfide Bridge131;142
NGlycosylation134
CDisulfide Bridge177;186
CDisulfide Bridge248;295
CDisulfide Bridge388;395
NGlycosylation389
NGlycosylation474
NGlycosylation51
NGlycosylation571
NGlycosylation579
NGlycosylation610
NGlycosylation93
NGlycosylation128
CDisulfide Bridge131;142
NGlycosylation134
CDisulfide Bridge177;186
CDisulfide Bridge248;295
CDisulfide Bridge388;395
NGlycosylation389
NGlycosylation474
NGlycosylation51
NGlycosylation571
NGlycosylation579
NGlycosylation610
NGlycosylation93
NGlycosylation128
CDisulfide Bridge131;142
NGlycosylation134
CDisulfide Bridge177;186
CDisulfide Bridge248;295
CDisulfide Bridge388;395
NGlycosylation389
NGlycosylation474
NGlycosylation51
NGlycosylation571
NGlycosylation579
NGlycosylation610
NGlycosylation93
NGlycosylation128
CDisulfide Bridge131;142
NGlycosylation134
CDisulfide Bridge177;186
CDisulfide Bridge248;295
CDisulfide Bridge388;395
NGlycosylation389
NGlycosylation474
NGlycosylation51
NGlycosylation571
NGlycosylation579
NGlycosylation610
NGlycosylation93
YPhosphorylation779
YPhosphorylation814
YPhosphorylation752
YPhosphorylation787

Enzyme Information


No matching records could be found.

PPi Information


(Click to view network : Source STRING)      View   

                                                                           
Interactant Gene ID (Source: HPRD) Gene Symbol HPRD ID Ref Seq ID Technique References
1154CISH3897NP_037456.5in vitro;in vivo15470047   
2885GRB2150NP_002077.1in vivo9824671   
3635INPP5D9033NP_001017915.1in vitro;in vivo15470047   
3932LCK1080NP_005347.3in vitro9790917   
5319PLA2G1B1396NP_000919.1in vitro14557262   


Pathway Information


                              
Pathway Name Pathway ID
Cytokine-cytokine receptor interaction hsa04060
Hematopoietic cell lineage hsa04640
Jak-STAT signaling pathway hsa04630
Pathways in cancer hsa05200
PI3K-Akt signaling pathway hsa04151


Structure Information


No matching records could be found.

Domain Information




ID Location Description
cd00063527-607  FN3
cl21522527-607  FN3 superfamily
cd00063249-329  FN3
cl21522249-329  FN3 superfamily
cd00063345-423  FN3
cl21522345-423  FN3 superfamily
cd00063430-514  FN3
cl21522430-514  FN3 superfamily
pfam0632822-111  Lep_receptor_Ig
cl0569222-111  Lep_receptor_Ig superfamily
smart00060527-607  FN3
pfam00041530-607  fn3
pfam00041430-514  fn3
smart00060345-417  FN3


Ontology Information


   
HPRD ID1392
Molecular ClassCytokine receptor
Molecular FunctionCatalytic activity (GO:0003824)
Biological ProcessMetabolism (GO:0008152); Energy pathways (GO:0006091)  



SNP Information


View SNP Geneview Report   

Drug Information


Uniprot ID DrugBank ID Name Type
Q99062DB00019PegfilgrastimBiotechDrug
Q99062DB00099FilgrastimBiotechDrug

External Links


                                 
ArrayExpressGO
ICGCGO
Cancer3DGO
COSMICGO
NCGGO
TSGeneGO
Tumor Gene Family of DatabasesGO
CCDBGO
G2SBCGO
Osteosarcoma DatabaseGO
RCDBGO