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General Information



Gene_Symbol Gene_ID Gene_Name Chromosome Alias
CTBP2 1488 C-terminal binding protein 2  10ribeye 







  • Evidence
  • Gene
  • mRNA
  • CDS
  • Protein
  • PTM
  • Enzyme
  • PPi
  • Pathway
  • Structural
  • Domain
  • Ontology
  • SNP
  • Drug
  • External Links



Evidence Information


Pubmed ID Year Sample Information Techniques Mechanism Fold Change Remark
16508011   2006Cell line : HCT116

Source : -

Sample Type : -

No. of Sample : -

Stage : -

Yeast two-hybrid screen, transfections,Western blotting,GST pulldown assays,CoimmunoprecipitationsUp-regulation-CtBP proteins represent putative targets for p53-independent tumor suppression by ARF.

25483087   2014Cell line : HCT 116, HT 29, WiDR, LS174T, Colo 320

Source : ATCC

Sample Type : -

No. of Sample : -

Stage : -

MTT assay,colonosphere formation,western blotting, immunoprecipitations, PCR, flow cytometry,dual Luciferase AssayUp-regulation-CSCs demonstrated significant upregulation of CtBP1 and CtBP2 levels (mRNA and protein) and activity partly due to increased NADH/NAD ratio, as well as increased TCF/LEF transcriptional activity, compared to respective controls.


Gene Details



NC_000010.10 (126676418..126849624, complement)

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Gene Type protein coding
Gene Family -
Description This gene produces alternative transcripts encoding two distinct proteins. One protein is a transcriptional repressor, while the other isoform is a major component of specialized synapses known as synaptic ribbons. Both proteins contain a NAD+ binding domain similar to NAD+-dependent 2-hydroxyacid dehydrogenases. A portion of the 3' untranslated region was used to map this gene to chromosome 21q21.3; however, it was noted that similar loci elsewhere in the genome are likely. Blast analysis shows that this gene is present on chromosome 10. Several transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Feb 2014]  
Chromosome 10
Location 10q26.13
Start 126676418  
End 126849624  
Strand -  
Gene Sequence

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Length 173207  
OMIM ID 602619   
HGNC ID HGNC:2495   
Unigene ID Hs.501345   
Ensembl ID ENSG00000175029   
PharmGKB ID PA26996   

mRNA Information


mRNA ID XM_005269926.3
Exon complement(<172997..>173207)  
mRNA Sequence

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Length 5605  



CDS Information


   
Location412..2538
CDS Sequence

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CCDS ID CCDS7643.1



Protein Information


      
Protein IDXP_005269983.1
Protein NameC-terminal binding protein 2
Molecular Wt. (Da)80836
Protein Sequence

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Length 708  
Uniprot IDP49763
Ensembl Protein ID ENSP00000385365  



Post-translational Modification Information (Source : HPRD)


Residue Type site
SPhosphorylation185;-
TPhosphorylation179;-
SPhosphorylation181;-
SPhosphorylation185;-
TPhosphorylation179;-
SPhosphorylation181;-
TPhosphorylation954
TPhosphorylation954
TPhosphorylation414
SPhosphorylation968
SPhosphorylation968
SPhosphorylation428
TPhosphorylation973
TPhosphorylation973
TPhosphorylation433
TPhosphorylation624
TPhosphorylation84

Enzyme Information


No matching records could be found.

PPi Information


(Click to view network : Source STRING)      View   

                                                                                                                                                                                    
Interactant Gene ID (Source: HPRD) Gene Symbol HPRD ID Ref Seq ID Technique References
1487CTBP14015NP_001319.1in vivo9858600   
1936EEF1D560NP_115754.2in vitro;in vivo;yeast 2-hybrid10567582   
2033EP3004078NP_001420.2in vivo16356938   
2122MECOM1310NP_001098547.3in vitro9724649   
6935ZEB11798NP_110378.3yeast 2-hybrid972   464   912   714   599   
7005TEAD34411NP_003205.2yeast 2-hybrid16189514   
7050TGIF14023NP_733796.2yeast 2-hybrid16189514   
8715NOL44657NP_003778.2yeast 2-hybrid16189514   
9491PSMF117919NP_848693.2yeast 2-hybrid16189514   
11279KLF82238NP_009181.2in vitro;yeast 2-hybrid10756197   
29994BAZ2B9295NP_038478.2yeast 2-hybrid16189514   
64400AKTIP7467NP_071921.1yeast 2-hybrid16189514   


Pathway Information


                        
Pathway Name Pathway ID
Chronic myeloid leukemia hsa05220
Notch signaling pathway hsa04330
Pathways in cancer hsa05200
Wnt signaling pathway hsa04310


Structure Information


No matching records could be found.

Domain Information




ID Location Description
cd0529934-352  CtBP_dh
cl2145434-352  NADB_Rossmann superfamily
cd0519836-343  formate_dh_like
cd1217264-344  PGDH_like_2
cd1217388-348  PGDH_4
pfam0038938-358  2-Hacid_dh
cd1217584-350  2-Hacid_dh_11
cd1216287-335  2-Hacid_dh_4
cd1217888-358  2-Hacid_dh_13
cd0530148-347  GDH
cd1217737-355  2-Hacid_dh_12
cd1216898-347  Mand_dh_like
cd0161950-348  LDH_like
pfam02826139-323  2-Hacid_dh_C
cd1217183-323  2-Hacid_dh_10
cd0530386-321  PGDH_2
cd1217489-358  PGDH_like_3
cd1218664-352  LDH
cd1216187-334  GDH_like_1
cd1216949-347  PGDH_like_1
PRK1324389-360  PRK13243
PRK0648761-348  PRK06487
cd1218787-329  LDH_like_1
cd1218386-342  LDH_like_2
cd1218583-335  HGDH_LDH_like
cd1216786-366  2-Hacid_dh_8
cd1217686-321  PGDH_3
PRK0693287-329  PRK06932
cd0530282-339  FDH
cd1215687-338  HPPR
cd1215764-347  PTDH
cd1217963-327  2-Hacid_dh_14
cd1216589-350  2-Hacid_dh_6
cd0530089-360  2-Hacid_dh_1
cd1218486-335  HGDH_like
PRK1540965-358  PRK15409
cd1215886-345  ErythrP_dh
cd12180176-358  2-Hacid_dh_15
cd1215591-328  PGDH_1
PLN0292876-350  PLN02928
PLN02306107-349  PLN02306
PLN0313982-340  PLN03139
PRK1248092-329  PRK12480
cd1216688-353  2-Hacid_dh_7
cd1216490-358  GDH_like_2
cd12159168-323  2-Hacid_dh_2
cd12160187-355  2-Hacid_dh_3
cd12163150-327  2-Hacid_dh_5
cd1217063-329  2-Hacid_dh_9
PRK06436180-360  PRK06436
cd1215491-316  FDH_GDH_like
PRK1546996-346  ghrA
COG011150-360  SerA
COG105251-360  LdhA
PRK1358186-358  PRK13581
TIGR0132786-358  PGDH
PRK0841036-347  PRK08410
PRK1179087-321  PRK11790
PRK0757487-340  PRK07574
PRK0860598-329  PRK08605
PRK0025784-326  PRK00257
PRK1543879-349  PRK15438


Ontology Information


   
HPRD ID1389
Molecular ClassTranscription regulatory protein
Molecular FunctionCatalytic activity (GO:0003824)
Biological ProcessMetabolism (GO:0008152); Energy pathways (GO:0006091)  



SNP Information


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Drug Information


No matching records could be found.

External Links


                                 
ArrayExpressGO
ICGCGO
Cancer3DGO
COSMICGO
NCGGO
TSGeneGO
Tumor Gene Family of DatabasesGO
CCDBGO
G2SBCGO
Osteosarcoma DatabaseGO
RCDBGO