Search results:
General Information
| Gene_Symbol | Gene_ID | Gene_Name | Chromosome | Alias |
|---|---|---|---|---|
| CTGF | 1490 | connective tissue growth factor | 6 | IGFBP8, CCN2 |
- Evidence
- Gene
- mRNA
- CDS
- Protein
- PTM
- Enzyme
- PPi
- Pathway
- Structural
- Domain
- Ontology
- SNP
- Drug
- External Links
Evidence Information
| Pubmed ID | Year | Sample Information | Techniques | Mechanism | Fold Change | Remark |
|---|---|---|---|---|---|---|
| 21081514 | 2011 | Cell line : HT29, Caco 2 Source : - Sample Type : - No. of Sample : - Stage : - | - | Up-regulation | - | Upregulation of Cyr61 and�CTGF�gene expression in�colorectal cancer�suggests they have a role in tumour initiation or development.� |
Gene Details
| Gene Type | protein coding |
|---|---|
| Gene Family | - |
| Description | The protein encoded by this gene is a mitogen that is secreted by vascular endothelial cells. The encoded protein plays a role in chondrocyte proliferation and differentiation, cell adhesion in many cell types, and is related to platelet-derived growth factor. Certain polymorphisms in this gene have been linked with a higher incidence of systemic sclerosis. [provided by RefSeq, Nov 2009] |
| Chromosome | 6 |
| Location | 6q23.2 |
| Start | 132269316 |
| End | 132272518 |
| Strand | - |
| Gene Sequence | Download Select all |
| Length | 3203 |
| OMIM ID | 121009 |
| HGNC ID | HGNC:2500 |
| Unigene ID | Hs.410037 |
| Ensembl ID | ENSG00000118523 |
| PharmGKB ID | PA27003 |
mRNA Information
| mRNA ID | NM_001901.2 |
|---|---|
| Exon | join(1..272,387..609,836..1087,1219..1430,1819..3203) | mRNA Sequence | Download Select all |
| Length | 2358 |
Protein Information
| Protein ID | NP_001892.1 |
|---|---|
| Protein Name | connective tissue growth factor |
| Molecular Wt. (Da) | 35471 |
| Protein Sequence | Download Select all |
| Length | 349 |
| Uniprot ID | P00558 |
| Ensembl Protein ID | ENSP00000362413 |
Post-translational Modification Information (Source : HPRD)
| Residue | Type | site |
|---|---|---|
| N | Glycosylation | 225 |
| N | Glycosylation | 28 |
Enzyme Information
No matching records could be found.
PPi Information
(Click to view network : Source STRING) View
| Interactant Gene ID (Source: HPRD) | Gene Symbol | HPRD ID | Ref Seq ID | Technique | References |
|---|---|---|---|---|---|
| 4035 | LRP1 | 138 | NP_002323.2 | in vivo | 14585398 |
| 8943 | AP3D1 | 6260 | NP_003929.4 | in vitro | 16457822 |
Pathway Information
| Pathway Name | Pathway ID |
|---|---|
| Hippo signaling pathway | hsa04390 |
Structure Information
No matching records could be found.
Domain Information
| ID | Location | Description |
|---|---|---|
| pfam00007 | 253-345 | Cys_knot |
| cl21545 | 253-345 | GHB_like superfamily |
| smart00041 | 261-330 | CT |
| pfam00219 | 35-82 | IGFBP |
| cl02472 | 35-82 | IGFBP superfamily |
| smart00121 | 31-93 | IB |
| pfam00093 | 103-163 | VWC |
| cl17735 | 103-163 | VWC superfamily |
| smart00214 | 103-162 | VWC |
| pfam00090 | 202-242 | TSP_1 |
| cl15278 | 202-242 | TSP_1 superfamily |
| smart00209 | 202-243 | TSP1 |
Ontology Information
| HPRD ID | 1370 |
|---|---|
| Molecular Class | Extracellular matrix protein |
| Molecular Function | Transporter activity (GO:0005215) |
| Biological Process | Transport (GO:0006810) |
Drug Information
No matching records could be found.