Search results:
General Information
| Gene_Symbol | Gene_ID | Gene_Name | Chromosome | Alias |
|---|---|---|---|---|
| CTLA4 | 1493 | cytotoxic T-lymphocyte-associated protein 4 | 2 | CD152, CD, GSE, CD28, ICOS |
- Evidence
- Gene
- mRNA
- CDS
- Protein
- PTM
- Enzyme
- PPi
- Pathway
- Structural
- Domain
- Ontology
- SNP
- Drug
- External Links
Evidence Information
| Pubmed ID | Year | Sample Information | Techniques | Mechanism | Fold Change | Remark |
|---|---|---|---|---|---|---|
| 26064271 | 2015 | Cell line : - Source : PubMed, Web of Science, CNKI and WanFang databases. Sample Type : Population based case control study. No. of Sample : 8 case-control studies, 1180 cases and 2110 controls Stage : - | Meta analysis | Polymorhpism | - | - |
Gene Details
| Gene Type | protein coding |
|---|---|
| Gene Family | CD molecules, "Immunoglobulin superfamily / V-set domain containing" |
| Description | This gene is a member of the immunoglobulin superfamily and encodes a protein which transmits an inhibitory signal to T cells. The protein contains a V domain, a transmembrane domain, and a cytoplasmic tail. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. The membrane-bound isoform functions as a homodimer interconnected by a disulfide bond, while the soluble isoform functions as a monomer. Mutations in this gene have been associated with insulin-dependent diabetes mellitus, Graves disease, Hashimoto thyroiditis, celiac disease, systemic lupus erythematosus, thyroid-associated orbitopathy, and other autoimmune diseases. [provided by RefSeq, Jul 2008] |
| Chromosome | 2 |
| Location | 2q33 |
| Start | 204732511 |
| End | 204738683 |
| Strand | + |
| Gene Sequence | Download Select all |
| Length | 6173 |
| OMIM ID | 123890 |
| HGNC ID | HGNC:2505 |
| Unigene ID | Hs.247824 |
| Ensembl ID | ENSG00000163599 |
| PharmGKB ID | PA27006 |
mRNA Information
| mRNA ID | NM_005214.4 |
|---|---|
| Exon | join(1..264,2799..3146,3591..3700,4921..6173) | mRNA Sequence | Download Select all |
| Length | 2033 |
Protein Information
| Protein ID | NP_005205.2 |
|---|---|
| Protein Name | cytotoxic T-lymphocyte-associated protein 4 |
| Molecular Wt. (Da) | 0 |
| Protein Sequence | Download Select all |
| Length | 223 |
| Uniprot ID | P36871 |
| Ensembl Protein ID | ENSP00000360124 |
Post-translational Modification Information (Source : HPRD)
| Residue | Type | site |
|---|---|---|
| Y | Phosphorylation | 201 |
| Y | Phosphorylation | 201 |
| Y | Phosphorylation | 201 |
| Y | Phosphorylation | 201 |
Enzyme Information
No matching records could be found.
PPi Information
(Click to view network : Source STRING) View
| Interactant Gene ID (Source: HPRD) | Gene Symbol | HPRD ID | Ref Seq ID | Technique | References |
|---|---|---|---|---|---|
| 941 | CD80 | 202 | NP_005182.1 | in vitro | 7545666 |
| 5525 | PPP2R5A | 3384 | NP_006234.1 | in vivo;yeast 2-hybrid | 11994459 |
| 6776 | STAT5A | 3301 | NP_003143.2 | in vivo;yeast 2-hybrid | 16476059 |
Pathway Information
| Pathway Name | Pathway ID |
|---|---|
| Autoimmune thyroid disease | hsa05320 |
| Cell adhesion molecules (CAMs) | hsa04514 |
| Rheumatoid arthritis | hsa05323 |
| T cell receptor signaling pathway | hsa04660 |
Structure Information
No matching records could be found.
Domain Information
| ID | Location | Description |
|---|---|---|
| cd05721 | 39-152 | IgV_CTLA-4 |
| cl11960 | 39-152 | Ig superfamily |
| cd00099 | 46-151 | IgV |
| smart00406 | 58-131 | IGv |
| cd07706 | 65-156 | IgV_TCR_delta |
| smart00410 | 43-132 | IG_like |
| smart00409 | 43-132 | IG |
Ontology Information
| HPRD ID | 1454 |
|---|---|
| Molecular Class | Unclassified |
| Molecular Function | Receptor signaling complex scaffold activity (GO:0030159) |
| Biological Process | Cell communication (GO:0007154); Signal transduction (GO:0007165) |
Drug Information
| Uniprot ID | DrugBank ID | Name | Type |
|---|---|---|---|
| P16410 | DB06186 | Ipilimumab | BiotechDrug |