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General Information
- Evidence
- Gene
- mRNA
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- Protein
- PTM
- Enzyme
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- Domain
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Evidence Information
| Pubmed ID | Year | Sample Information | Techniques | Mechanism | Fold Change | Remark |
|---|---|---|---|---|---|---|
| 19172291 | 2009 | Cell line : - Source : - Sample Type : CRC tumor and normal tissues No. of Sample : - Stage : - | real time RT-PCR,Immunohistochemistry,BRAF and KRAS mutation analysis | Up-regulation | - | over-expression in CTSE, in particular, and TFF1 in sessile serrated adenomas compared to both hyperplastic polyps and tubular adenomas. |
Gene Details
| Gene Type | protein coding |
|---|---|
| Gene Family | Cathepsins |
| Description | This gene encodes a member of the A1 family of peptidases. Alternative splicing of this gene results in multiple transcript variants. At least one of these variants encodes a preproprotein that is proteolytically processed to generate the mature enzyme. This enzyme, an aspartic endopeptidase, may be involved in antigen processing and the maturation of secretory proteins. Elevated expression of this gene has been observed in neurodegeneration. [provided by RefSeq, Nov 2015] |
| Chromosome | 1 |
| Location | 1q32.1 |
| Start | 206317459 |
| End | 206332104 |
| Strand | + |
| Gene Sequence | Download Select all |
| Length | 14646 |
| OMIM ID | 116890 |
| HGNC ID | HGNC:2530 |
| Unigene ID | Hs.644082 |
| Ensembl ID | ENSG00000196188 |
| PharmGKB ID | PA27030 |
mRNA Information
| mRNA ID | NM_148964.2 |
|---|---|
| Exon | join(1..186,853..1009,1643..1760,2743..2861,7780..7979, 10016..10138,11504..11602,13563..14646) | mRNA Sequence | Download Select all |
| Length | 2180 |
Protein Information
| Protein ID | NP_683865.1 |
|---|---|
| Protein Name | cathepsin E |
| Molecular Wt. (Da) | 37503 |
| Protein Sequence | Download Select all |
| Length | 363 |
| Uniprot ID | P35232 |
| Ensembl Protein ID | ENSP00000300408 |
Post-translational Modification Information (Source : HPRD)
| Residue | Type | site |
|---|---|---|
| M | Proteolytic Cleavage | 53 |
| F | Proteolytic Cleavage | 56 |
| M | Proteolytic Cleavage | 53 |
| F | Proteolytic Cleavage | 56 |
Enzyme Information
No matching records could be found.
PPi Information
(Click to view network : Source STRING) View
| Interactant Gene ID (Source: HPRD) | Gene Symbol | HPRD ID | Ref Seq ID | Technique | References |
|---|---|---|---|---|---|
| 2 | A2M | 72 | NP_000005.2 | in vitro | 12631277 |
| 1908 | EDN3 | 570 | NP_996917.1 | in vitro | 2226872 |
| 3630 | INS | 1455 | NP_000198.1 | in vitro | 1 959 628 195 962 |
| 7917 | BAT3 | 808 | NP_004630.3 | yeast 2-hybrid | 16169070 |
| 10436 | EMG1 | 12803 | NP_006322.4 | yeast 2-hybrid | 16169070 |
Pathway Information
| Pathway Name | Pathway ID |
|---|---|
| Lysosome | hsa04142 |
Structure Information
No matching records could be found.
Domain Information
| ID | Location | Description |
|---|---|---|
| cd05486 | 78-398 | Cathespin_E |
| cl11403 | 78-398 | pepsin_retropepsin_like superfamily |
| cd05478 | 68-398 | pepsin_A |
| cd05490 | 72-398 | Cathepsin_D2 |
| cd05485 | 68-397 | Cathepsin_D_like |
| cd06098 | 69-397 | phytepsin |
| cd05487 | 70-399 | renin_like |
| cd05477 | 75-399 | gastricsin |
| cd05488 | 69-398 | Proteinase_A_fungi |
| cd05471 | 78-398 | pepsin_like |
| cd05474 | 78-399 | SAP_like |
| cd06097 | 78-398 | Aspergillopepsin_like |
| cd05470 | 80-192 | pepsin_retropepsin_like |
| cd05473 | 78-397 | beta_secretase_like |
| cd06096 | 78-395 | Plasmepsin_5 |
| cd05476 | 77-399 | pepsin_A_like_plant |
| pfam14543 | 78-240 | TAXi_N |
| cd05472 | 77-399 | cnd41_like |
| pfam07966 | 21-49 | A1_Propeptide |
| cl06833 | 21-49 | A1_Propeptide superfamily |
| cd05475 | 78-194 | nucellin_like |
| pfam00026 | 77-399 | Asp |
| PTZ00165 | 22-399 | PTZ00165 |
| PTZ00147 | 70-399 | PTZ00147 |
| PTZ00013 | 75-399 | PTZ00013 |
| PLN03146 | 77-311 | PLN03146 |
Ontology Information
| HPRD ID | 1111 |
|---|---|
| Molecular Class | Aspartic protease |
| Molecular Function | Protease inhibitor activity (GO:0030414) |
| Biological Process | Protein metabolism (GO:0019538) |
Drug Information
No matching records could be found.